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FR2934995B1 - Composes d'azetidines polysubstitues, leur preparation et leur application en therapeutique - Google Patents

Composes d'azetidines polysubstitues, leur preparation et leur application en therapeutique

Info

Publication number
FR2934995B1
FR2934995B1 FR0804595A FR0804595A FR2934995B1 FR 2934995 B1 FR2934995 B1 FR 2934995B1 FR 0804595 A FR0804595 A FR 0804595A FR 0804595 A FR0804595 A FR 0804595A FR 2934995 B1 FR2934995 B1 FR 2934995B1
Authority
FR
France
Prior art keywords
polysubstituted
preparation
therapeutic use
azetidine compounds
azetidine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0804595A
Other languages
English (en)
Other versions
FR2934995A1 (fr
Inventor
Patrick Bernardelli
Jean Francois Sabuco
Corinne Terrier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Aventis France
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR0804595A priority Critical patent/FR2934995B1/fr
Application filed by Sanofi Aventis France filed Critical Sanofi Aventis France
Priority to MX2011001678A priority patent/MX2011001678A/es
Priority to RU2011109180/04A priority patent/RU2011109180A/ru
Priority to KR1020117005735A priority patent/KR20110044782A/ko
Priority to CN2009801408208A priority patent/CN102186839A/zh
Priority to US13/058,913 priority patent/US20110152236A1/en
Priority to BRPI0917464A priority patent/BRPI0917464A2/pt
Priority to CA2733397A priority patent/CA2733397A1/fr
Priority to EP09737012A priority patent/EP2313393A1/fr
Priority to JP2011522538A priority patent/JP2011530575A/ja
Priority to AU2009281057A priority patent/AU2009281057A1/en
Priority to ARP090103131A priority patent/AR073043A1/es
Priority to TW098127313A priority patent/TW201011019A/zh
Priority to PCT/FR2009/001003 priority patent/WO2010018328A1/fr
Priority to UY0001032051A priority patent/UY32051A/es
Publication of FR2934995A1 publication Critical patent/FR2934995A1/fr
Application granted granted Critical
Publication of FR2934995B1 publication Critical patent/FR2934995B1/fr
Priority to IL211210A priority patent/IL211210A0/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
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FR0804595A 2008-08-14 2008-08-14 Composes d'azetidines polysubstitues, leur preparation et leur application en therapeutique Expired - Fee Related FR2934995B1 (fr)

Priority Applications (16)

Application Number Priority Date Filing Date Title
FR0804595A FR2934995B1 (fr) 2008-08-14 2008-08-14 Composes d'azetidines polysubstitues, leur preparation et leur application en therapeutique
AU2009281057A AU2009281057A1 (en) 2008-08-14 2009-08-13 Azetidine polysubstituted compounds, preparation thereof, and therapeutic application thereof
KR1020117005735A KR20110044782A (ko) 2008-08-14 2009-08-13 아제티딘 다치환된 화합물, 그의 제조법 및 그의 치료 용도
CN2009801408208A CN102186839A (zh) 2008-08-14 2009-08-13 氮杂环丁烷多取代的化合物、其制备及其治疗用途
US13/058,913 US20110152236A1 (en) 2008-08-14 2009-08-13 Azetidine polysubstituted compounds, preparation thereof, and therapeutic application thereof
BRPI0917464A BRPI0917464A2 (pt) 2008-08-14 2009-08-13 compostos de azetidinas polissubstituídas, o respectivo preparo e a respectiva aplicação em terapêutica
CA2733397A CA2733397A1 (fr) 2008-08-14 2009-08-13 Composes d'azetidines polysubstitues, leur preparation et leur application en therapeutique
EP09737012A EP2313393A1 (fr) 2008-08-14 2009-08-13 Composes d'azétidines polysubstitues, leur préparation et leur application en thérapeutique
MX2011001678A MX2011001678A (es) 2008-08-14 2009-08-13 Compuestos de azetidinas polisustituidos, su preparacion y aplicacion terapeutica.
RU2011109180/04A RU2011109180A (ru) 2008-08-14 2009-08-13 Полизамещенные азетидины, способ их получения и применение в терапии
ARP090103131A AR073043A1 (es) 2008-08-14 2009-08-13 Compuestos de azetidinas polisustituidos, composiciones farmaceuticas que los contienen, metodo de preparacion y uso de los mismos en el tratamiento de enfermedades respiratorias, metabolicas y del sistema nervioso central, entre otras.
TW098127313A TW201011019A (en) 2008-08-14 2009-08-13 Polysubstituted azetidine compounds, their preparation and their therapeutic application
PCT/FR2009/001003 WO2010018328A1 (fr) 2008-08-14 2009-08-13 Composes d'azétidines polysubstitues, leur préparation et leur application en thérapeutique
JP2011522538A JP2011530575A (ja) 2008-08-14 2009-08-13 アゼチジン多置換化合物、これらの調製、およびこれらの治療的適用
UY0001032051A UY32051A (es) 2008-08-14 2009-08-14 Compuestos de azetidinas polisustituidos, su preparación y su aplicación en terapéutica
IL211210A IL211210A0 (en) 2008-08-14 2011-02-13 Azetidine polysubstituted compounds, preparation thereof, and therapeutic application thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0804595A FR2934995B1 (fr) 2008-08-14 2008-08-14 Composes d'azetidines polysubstitues, leur preparation et leur application en therapeutique

Publications (2)

Publication Number Publication Date
FR2934995A1 FR2934995A1 (fr) 2010-02-19
FR2934995B1 true FR2934995B1 (fr) 2010-08-27

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FR0804595A Expired - Fee Related FR2934995B1 (fr) 2008-08-14 2008-08-14 Composes d'azetidines polysubstitues, leur preparation et leur application en therapeutique

Country Status (16)

Country Link
US (1) US20110152236A1 (fr)
EP (1) EP2313393A1 (fr)
JP (1) JP2011530575A (fr)
KR (1) KR20110044782A (fr)
CN (1) CN102186839A (fr)
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CA2841142C (fr) 2010-06-23 2020-12-15 Ryan D. Morin Biomarqueurs pour lymphomes non hodgkiniens et leurs utilisations
KR102511807B1 (ko) 2010-09-10 2023-03-20 에피자임, 인코포레이티드 인간 ｅｚｈ2의 억제제 및 이의 사용 방법
US9175331B2 (en) 2010-09-10 2015-11-03 Epizyme, Inc. Inhibitors of human EZH2, and methods of use thereof
JO3438B1 (ar) 2011-04-13 2019-10-20 Epizyme Inc مركبات بنزين مستبدلة بأريل أو أريل غير متجانس
TWI598336B (zh) 2011-04-13 2017-09-11 雅酶股份有限公司 經取代之苯化合物
PT3184523T (pt) 2012-04-13 2019-09-26 Eisai R&D Man Co Ltd Bromidrato de n-((4,6-dimetil-2-oxo-l,2-di-hidropiridin- 3-il)metil)-5-(etil(tetra-hidro-2h-piran-4-il)amino)-4- metil-4¿-(morfolinometil)-[l,1¿-bofenil]-3-carboxamida para utilização no tratamento de uma doença proliferativa celular do sistema hematológico
CA2888021A1 (fr) 2012-10-15 2014-04-24 Epizyme, Inc. Composes de n-((2-oxo-1,2-dihydropyridine-3-yl)-methyl)-benzamide substitues et leur utilisation dans le traitement de troubles medies parl'ezh2
AU2014337300B2 (en) 2013-10-16 2019-01-03 Eisai R&D Management Co., Ltd. Hydrochloride salt form for EZH2 inhibition
US11091447B2 (en) 2020-01-03 2021-08-17 Berg Llc UBE2K modulators and methods for their use

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CN102186839A (zh) 2011-09-14
AR073043A1 (es) 2010-10-06
CA2733397A1 (fr) 2010-02-18
AU2009281057A1 (en) 2010-02-18
FR2934995A1 (fr) 2010-02-19
MX2011001678A (es) 2011-04-05
RU2011109180A (ru) 2012-09-20
TW201011019A (en) 2010-03-16
IL211210A0 (en) 2011-04-28
BRPI0917464A2 (pt) 2015-12-01
WO2010018328A1 (fr) 2010-02-18
JP2011530575A (ja) 2011-12-22
UY32051A (es) 2010-03-26
US20110152236A1 (en) 2011-06-23
KR20110044782A (ko) 2011-04-29

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