SG11201602269QA - Hydrochloride salt form for ezh2 inhibition - Google Patents
Hydrochloride salt form for ezh2 inhibitionInfo
- Publication number
- SG11201602269QA SG11201602269QA SG11201602269QA SG11201602269QA SG11201602269QA SG 11201602269Q A SG11201602269Q A SG 11201602269QA SG 11201602269Q A SG11201602269Q A SG 11201602269QA SG 11201602269Q A SG11201602269Q A SG 11201602269QA SG 11201602269Q A SG11201602269Q A SG 11201602269QA
- Authority
- SG
- Singapore
- Prior art keywords
- salt form
- hydrochloride salt
- ezh2 inhibition
- ezh2
- inhibition
- Prior art date
Links
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical group N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 title 1
- 101150090105 Ezh2 gene Proteins 0.000 title 1
- 230000005764 inhibitory process Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361891786P | 2013-10-16 | 2013-10-16 | |
| PCT/US2014/060724 WO2015057859A1 (en) | 2013-10-16 | 2014-10-15 | Hydrochloride salt form for ezh2 inhibition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201602269QA true SG11201602269QA (en) | 2016-04-28 |
Family
ID=52828660
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201602269QA SG11201602269QA (en) | 2013-10-16 | 2014-10-15 | Hydrochloride salt form for ezh2 inhibition |
| SG10201901977XA SG10201901977XA (en) | 2013-10-16 | 2014-10-15 | Hydrochloride salt form for ezh2 inhibition |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201901977XA SG10201901977XA (en) | 2013-10-16 | 2014-10-15 | Hydrochloride salt form for ezh2 inhibition |
Country Status (24)
| Country | Link |
|---|---|
| US (3) | US10040782B2 (en) |
| EP (2) | EP3057962B1 (en) |
| JP (2) | JP6608812B2 (en) |
| KR (1) | KR102142177B1 (en) |
| CN (1) | CN105829302B (en) |
| AU (2) | AU2014337300B2 (en) |
| CA (1) | CA2925889C (en) |
| CL (1) | CL2016000866A1 (en) |
| DK (1) | DK3057962T3 (en) |
| EA (1) | EA038869B1 (en) |
| ES (1) | ES2960953T3 (en) |
| FI (1) | FI3057962T3 (en) |
| HU (1) | HUE063984T2 (en) |
| IL (1) | IL244787B (en) |
| LT (1) | LT3057962T (en) |
| MA (1) | MA38949A1 (en) |
| MX (1) | MX2016004703A (en) |
| MY (1) | MY179802A (en) |
| PE (1) | PE20161273A1 (en) |
| PL (1) | PL3057962T3 (en) |
| PT (1) | PT3057962T (en) |
| SG (2) | SG11201602269QA (en) |
| SI (1) | SI3057962T1 (en) |
| WO (1) | WO2015057859A1 (en) |
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| JO3438B1 (en) | 2011-04-13 | 2019-10-20 | Epizyme Inc | Heteroaryl or aryl substituted gasoline compounds |
| ES2617379T3 (en) | 2012-04-13 | 2017-06-16 | Epizyme, Inc. | Salt form of a human EZH2 histone methyltransferase inhibitor |
| RU2677276C2 (en) | 2012-10-15 | 2019-01-16 | Эпизайм, Инк. | Methods of treating cancer |
| CN105829302B (en) | 2013-10-16 | 2020-09-08 | Epizyme股份有限公司 | Hydrochloride salt form for EZH2 inhibition |
| KR20210117347A (en) | 2013-12-06 | 2021-09-28 | 에피자임, 인코포레이티드 | Combination therapy for treating cancer |
| DK3157527T3 (en) | 2014-06-17 | 2023-07-03 | Epizyme Inc | EZH2 INHIBITORS FOR LYMPHOMA TREATMENT |
| IL289947B2 (en) | 2014-10-16 | 2024-06-01 | Epizyme Inc | A method for treating cancer |
| ES2947819T3 (en) | 2014-11-17 | 2023-08-21 | Epizyme Inc | Method for cancer treatment with N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino )-4-methyl-4'-(morpholinomethyl)-[1,1'-biphenyl]-3-carboxamide |
| EA201792304A1 (en) | 2015-04-20 | 2018-03-30 | Эпизайм, Инк. | COMBINED THERAPY FOR CANCER TREATMENT |
| WO2016201328A1 (en) | 2015-06-10 | 2016-12-15 | Epizyme, Inc. | Ezh2 inhibitors for treating lymphoma |
| WO2017035234A1 (en) | 2015-08-24 | 2017-03-02 | Epizyme, Inc. | Method for treating cancer |
| AU2017211331A1 (en) | 2016-01-29 | 2018-06-07 | Epizyme, Inc. | Combination therapy for treating cancer |
| JP7121660B2 (en) | 2016-06-01 | 2022-08-18 | エピザイム，インコーポレイティド | Use of EZH2 inhibitors to treat cancer |
| MA45406A (en) | 2016-06-17 | 2019-04-24 | Epizyme Inc | EZH2 INHIBITORS TO TREAT CANCER |
| BR112019014924A2 (en) | 2017-01-19 | 2020-03-31 | St. Marianna University School Of Medicine | PHARMACEUTICAL COMPOSITION USED FOR THE TREATMENT OF MYLOPATHY ASSOCIATED WITH HTLV-1 |
| WO2018183885A1 (en) | 2017-03-31 | 2018-10-04 | Epizyme, Inc. | Combination therapy for treating cancer |
| US11602529B2 (en) | 2017-06-02 | 2023-03-14 | Epizyme, Inc. | Use of EZH2 inhibitors for treating cancer |
| US11452727B2 (en) | 2017-09-05 | 2022-09-27 | Epizyme, Inc. | Combination therapy for treating cancer |
| CA3104209A1 (en) | 2018-07-09 | 2020-01-16 | Fondation Asile Des Aveugles | Inhibition of prc2 subunits to treat eye disorders |
| WO2021035194A1 (en) | 2019-08-22 | 2021-02-25 | Juno Therapeutics, Inc. | Combination therapy of a t cell therapy and an enhancer of zeste homolog 2 (ezh2) inhibitor and related methods |
| CA3162315A1 (en) * | 2019-12-20 | 2021-06-24 | Marinus Jacobus Verwijs | Crystalline hydrobromide salt of a ezh2 inhibitor, its preparation and pharmaceutical composition useful for the treatment of cancer |
| IL316421A (en) | 2022-04-27 | 2024-12-01 | Daiichi Sankyo Co Ltd | Combination of antibody-drug conjugate with ezh1 and/or ezh2 inhibitor |
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| CN105829302B (en) | 2013-10-16 | 2020-09-08 | Epizyme股份有限公司 | Hydrochloride salt form for EZH2 inhibition |
-
2014
- 2014-10-15 CN CN201480056428.6A patent/CN105829302B/en active Active
- 2014-10-15 MY MYPI2016000542A patent/MY179802A/en unknown
- 2014-10-15 PT PT148542723T patent/PT3057962T/en unknown
- 2014-10-15 ES ES14854272T patent/ES2960953T3/en active Active
- 2014-10-15 HU HUE14854272A patent/HUE063984T2/en unknown
- 2014-10-15 DK DK14854272.3T patent/DK3057962T3/en active
- 2014-10-15 KR KR1020167011534A patent/KR102142177B1/en active Active
- 2014-10-15 SG SG11201602269QA patent/SG11201602269QA/en unknown
- 2014-10-15 SG SG10201901977XA patent/SG10201901977XA/en unknown
- 2014-10-15 US US15/029,848 patent/US10040782B2/en active Active
- 2014-10-15 FI FIEP14854272.3T patent/FI3057962T3/en active
- 2014-10-15 MX MX2016004703A patent/MX2016004703A/en active IP Right Grant
- 2014-10-15 PL PL14854272.3T patent/PL3057962T3/en unknown
- 2014-10-15 AU AU2014337300A patent/AU2014337300B2/en not_active Ceased
- 2014-10-15 LT LTEPPCT/US2014/060724T patent/LT3057962T/en unknown
- 2014-10-15 EP EP14854272.3A patent/EP3057962B1/en active Active
- 2014-10-15 EP EP23203529.5A patent/EP4324525A3/en not_active Withdrawn
- 2014-10-15 PE PE2016000506A patent/PE20161273A1/en unknown
- 2014-10-15 MA MA38949A patent/MA38949A1/en unknown
- 2014-10-15 JP JP2016519378A patent/JP6608812B2/en active Active
- 2014-10-15 WO PCT/US2014/060724 patent/WO2015057859A1/en not_active Application Discontinuation
- 2014-10-15 EA EA201690650A patent/EA038869B1/en unknown
- 2014-10-15 CA CA2925889A patent/CA2925889C/en active Active
- 2014-10-15 SI SI201432051T patent/SI3057962T1/en unknown
-
2016
- 2016-03-28 IL IL244787A patent/IL244787B/en unknown
- 2016-04-13 CL CL2016000866A patent/CL2016000866A1/en unknown
-
2018
- 2018-06-05 US US16/000,539 patent/US10710987B2/en active Active
- 2018-12-11 JP JP2018231817A patent/JP2019052181A/en active Pending
-
2019
- 2019-04-02 AU AU2019202246A patent/AU2019202246A1/en not_active Abandoned
-
2020
- 2020-06-03 US US16/891,427 patent/US20210017163A1/en not_active Abandoned
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