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SI2024368T1 - Derivati 6,7,8,9-tetrahidro-5h-pirimido(4,5-d)azepin-4-il)-amina kot modulatorji trpv 1 za zdravljenje boleäśine - Google Patents

Derivati 6,7,8,9-tetrahidro-5h-pirimido(4,5-d)azepin-4-il)-amina kot modulatorji trpv 1 za zdravljenje boleäśine

Info

Publication number
SI2024368T1
SI2024368T1 SI200731477T SI200731477T SI2024368T1 SI 2024368 T1 SI2024368 T1 SI 2024368T1 SI 200731477 T SI200731477 T SI 200731477T SI 200731477 T SI200731477 T SI 200731477T SI 2024368 T1 SI2024368 T1 SI 2024368T1
Authority
SI
Slovenia
Prior art keywords
ylć
dćazepin
trpv1
tetrahydro
modulators
Prior art date
Application number
SI200731477T
Other languages
English (en)
Inventor
Brett D. Allison
Bryan James Branstetter
James Guy Breitenbucher
Michael D. Hack
Natalie A. Hawryluk
Alec D. Lebsack
Kelly J. Mcclure
Jeffrey E. Merit
Original Assignee
Janssen Pharmaceutica N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.
Publication of SI2024368T1 publication Critical patent/SI2024368T1/sl

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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SI200731477T 2006-03-21 2007-03-21 Derivati 6,7,8,9-tetrahidro-5h-pirimido(4,5-d)azepin-4-il)-amina kot modulatorji trpv 1 za zdravljenje boleäśine SI2024368T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US78541506P 2006-03-21 2006-03-21
EP07753768.6A EP2024368B1 (en) 2006-03-21 2007-03-21 6,7,8,9-tetrahydro-5h-pyrimido[4,5-d]azepin-4-yl]-amine derivatives as modulators of trpv1 for the treatment of pain
PCT/US2007/007166 WO2007109355A2 (en) 2006-03-21 2007-03-21 6,7,8, 9 -tetrahydro- 5h- pyrimido [4, 5-d] azepin-4-yl] -amine derivatives as modulators of trpvl for the treatment of pain

Publications (1)

Publication Number Publication Date
SI2024368T1 true SI2024368T1 (sl) 2014-08-29

Family

ID=38353855

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200731477T SI2024368T1 (sl) 2006-03-21 2007-03-21 Derivati 6,7,8,9-tetrahidro-5h-pirimido(4,5-d)azepin-4-il)-amina kot modulatorji trpv 1 za zdravljenje boleäśine

Country Status (31)

Country Link
US (3) US8673895B2 (sl)
EP (1) EP2024368B1 (sl)
JP (1) JP5232768B2 (sl)
KR (1) KR101461376B1 (sl)
CN (1) CN101448835B (sl)
AR (1) AR059985A1 (sl)
AU (1) AU2007227203B2 (sl)
BR (1) BRPI0709034B1 (sl)
CA (1) CA2646977C (sl)
CR (1) CR10387A (sl)
DK (1) DK2024368T3 (sl)
EA (1) EA017069B1 (sl)
EC (1) ECSP088807A (sl)
ES (1) ES2474152T3 (sl)
HK (1) HK1129888A1 (sl)
HR (1) HRP20140664T1 (sl)
MX (1) MX2008012163A (sl)
NI (1) NI200800253A (sl)
NO (1) NO341676B1 (sl)
NZ (1) NZ571343A (sl)
PE (1) PE20080145A1 (sl)
PL (1) PL2024368T3 (sl)
PT (1) PT2024368E (sl)
RS (1) RS53436B (sl)
SG (1) SG177176A1 (sl)
SI (1) SI2024368T1 (sl)
TW (1) TWI440639B (sl)
UA (1) UA92636C2 (sl)
UY (1) UY30229A1 (sl)
WO (1) WO2007109355A2 (sl)
ZA (1) ZA200808975B (sl)

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BR112012011147A2 (pt) * 2009-11-12 2021-09-08 F.Hoffmann-La Roche Ag Composto, composição farmacêutica e uso de um composto.
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BR112015019794B1 (pt) 2013-02-20 2022-09-13 Lg Chem, Ltd Composto, composição farmacêutica, agonista do receptor de esfingosina-1-fosfato, e, uso de um composto
CN103641762A (zh) * 2013-12-18 2014-03-19 中国药科大学 一类trpv1/cox-2双重抑制剂、其制备方法及其制备镇痛药物的用途
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