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SI1680425T1 - 6-((substituirani)fenil)triazolopirimidini kot sredstva proti raku - Google Patents

6-((substituirani)fenil)triazolopirimidini kot sredstva proti raku

Info

Publication number
SI1680425T1
SI1680425T1 SI200430195T SI200430195T SI1680425T1 SI 1680425 T1 SI1680425 T1 SI 1680425T1 SI 200430195 T SI200430195 T SI 200430195T SI 200430195 T SI200430195 T SI 200430195T SI 1680425 T1 SI1680425 T1 SI 1680425T1
Authority
SI
Slovenia
Prior art keywords
phenylc
triazolopyrimidines
substituted
anticancer agents
anticancer
Prior art date
Application number
SI200430195T
Other languages
English (en)
Inventor
Nan Zhang
Semiramis Ayral-Kaloustian
Thai Hiep Nguyen
Yanzhong Wu
Wei Tong
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of SI1680425T1 publication Critical patent/SI1680425T1/sl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SI200430195T 2003-09-24 2004-09-17 6-((substituirani)fenil)triazolopirimidini kot sredstva proti raku SI1680425T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US50554403P 2003-09-24 2003-09-24
PCT/US2004/030515 WO2005030775A1 (en) 2003-09-24 2004-09-17 6-[(substituted)phenyl]triazolopyrimidines as anticancer agents
EP04788820A EP1680425B1 (en) 2003-09-24 2004-09-17 6- [(substituted)phenyl] triazolopyrimidines as anticancer agents

Publications (1)

Publication Number Publication Date
SI1680425T1 true SI1680425T1 (sl) 2007-04-30

Family

ID=34393032

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200430195T SI1680425T1 (sl) 2003-09-24 2004-09-17 6-((substituirani)fenil)triazolopirimidini kot sredstva proti raku

Country Status (30)

Country Link
US (1) US7507739B2 (sl)
EP (1) EP1680425B1 (sl)
JP (1) JP2007506744A (sl)
KR (1) KR20060098368A (sl)
CN (1) CN100519559C (sl)
AR (1) AR045810A1 (sl)
AU (1) AU2004276240A1 (sl)
BR (1) BRPI0414700A (sl)
CA (1) CA2539252A1 (sl)
CO (1) CO5690598A2 (sl)
CR (1) CR8288A (sl)
CY (1) CY1106392T1 (sl)
DE (1) DE602004004295T8 (sl)
DK (1) DK1680425T3 (sl)
EC (1) ECSP066458A (sl)
ES (1) ES2279452T3 (sl)
GT (1) GT200400190A (sl)
IL (1) IL174281A0 (sl)
MX (1) MXPA06003206A (sl)
NO (1) NO20061318L (sl)
PA (1) PA8613301A1 (sl)
PE (1) PE20050433A1 (sl)
PL (1) PL1680425T3 (sl)
PT (1) PT1680425E (sl)
RU (1) RU2006107579A (sl)
SA (1) SA04250302A (sl)
SI (1) SI1680425T1 (sl)
TW (1) TW200512211A (sl)
WO (1) WO2005030775A1 (sl)
ZA (1) ZA200602387B (sl)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6255309B1 (en) * 1999-03-19 2001-07-03 American Cyanomid Co. Fungicidal trifluoromethylalkylamino-triazolopyrimidines
HK1052646A1 (zh) * 2000-06-30 2003-09-26 Wyeth 替代三氮苯(triazolopyrimidines)作為抗癌劑
US7419982B2 (en) * 2003-09-24 2008-09-02 Wyeth Holdings Corporation Crystalline forms of 5-chloro-6-{2,6-difluoro-4-[3-(methylamino)propoxy]phenyl}-N-[(1S)-2,2,2-trifluoro-1-methylethyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine salts
RU2006107579A (ru) 2003-09-24 2007-10-27 Вайет Холдингз Корпорейшн (Us) 6-[(замещенный)фенил]триазолопиримидины в качестве противораковых препаратов
MY179926A (en) * 2003-12-08 2020-11-19 Wyeth Corp Process for the preparation of tubulin inhibitors
CN101193884A (zh) 2005-06-13 2008-06-04 惠氏公司 微管蛋白抑制剂和其制备方法
BRPI0612145A2 (pt) * 2005-06-13 2010-10-19 Wyeth Corp inibidor de tubulina e processo para sua preparação
WO2007000412A1 (de) * 2005-06-27 2007-01-04 Basf Aktiengesellschaft Verfahren zur herstellung von substituierten phenylmalonestern, zwischenverbindungen sowie deren verwendung zur herstellung von 5 , 7-dihydr0xy-6- (2,4, 6-trifluorphenyl) -(1,2 , 4) triazolo (1 , 5-a) pyrimidinen
WO2007075465A1 (en) * 2005-12-16 2007-07-05 Wyeth Dimers and adducts of 6-[(substituted) phenyl] triazolopyrimidines useful as anticancer agents
CA2632540A1 (en) * 2005-12-16 2007-07-05 Wyeth Lyophilized compositions of a triazolopyrimidine compound
JP2010515669A (ja) * 2007-01-08 2010-05-13 ビーエーエスエフ ソシエタス・ヨーロピア 有害な植物病原菌類を防除するためのアゾロピリミジンの使用
US9649317B2 (en) 2012-09-19 2017-05-16 The Trustees Of The University Of Pennsylvania Heterocyclic compounds and their use for the treatment of neurodegenerative tauopathies
US11623927B2 (en) 2018-03-02 2023-04-11 The Trustees Of The University Of Pennsylvania Substituted [1,2,4]triazolo[1,5-a]pyrimidines for stabilizing microtubules
CN114369098B (zh) * 2022-01-06 2023-03-10 苏州大学 一种三唑并嘧啶醇类化合物及其制备方法和应用

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW224044B (sl) 1991-12-30 1994-05-21 Shell Internat Res Schappej B V
US5593996A (en) * 1991-12-30 1997-01-14 American Cyanamid Company Triazolopyrimidine derivatives
JP2794510B2 (ja) 1992-03-27 1998-09-10 富士写真フイルム株式会社 ハロゲン化銀写真感光材料
IL108731A (en) 1993-03-04 1997-03-18 Shell Int Research 6, N-DISUBSTITUTED-£1, 2, 4| TRIAZOLO-£1, 5-a| PYRIMIDINE- 7-AMINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS FUNGICIDES
IL108747A (en) 1993-03-04 1999-03-12 Shell Int Research Mushroom-killing preparations containing a history of 6 metamorphoses of 5 - 7 Dihalo - 1, 2 - 4 Triazlo [A-1,5] Pyrimidine Certain such new compounds and their preparation
RU2147584C1 (ru) 1995-10-27 2000-04-20 Американ Цианамид Компани Способ получения дигалоидазолопиримидинов и способ получения дигидроксиазолопиримидинов
US5817663A (en) 1996-10-07 1998-10-06 American Cyanamid Company Pentafluorophenylazolopyrimidines
US5750766A (en) 1997-03-18 1998-05-12 American Cyanamid Company Process for the preparation of arylmalonates
ES2191288T3 (es) 1997-03-18 2003-09-01 Basf Ag Procedimiento para la preparacion de arilmalonatos.
US5948783A (en) 1997-04-14 1999-09-07 American Cyanamid Company Fungicidal trifluoromethylalkylamino-triazolopyrimidines
US6255309B1 (en) 1999-03-19 2001-07-03 American Cyanomid Co. Fungicidal trifluoromethylalkylamino-triazolopyrimidines
US6117876A (en) 1997-04-14 2000-09-12 American Cyanamid Company Fungicidal trifluorophenyl-triazolopyrimidines
TWI252231B (en) 1997-04-14 2006-04-01 American Cyanamid Co Fungicidal trifluorophenyl-triazolopyrimidines
TW460476B (en) 1997-04-14 2001-10-21 American Cyanamid Co Fungicidal trifluoromethylalkylamino-triazolopyrimidines
US5994360A (en) 1997-07-14 1999-11-30 American Cyanamid Company Fungicidal 5-alkyl-triazolopyrimidines
ATE255110T1 (de) 1998-02-11 2003-12-15 Basf Ag Fungizide 7-alkyl-triazolopyrimidine
US6020338A (en) 1998-02-11 2000-02-01 American Cyanamid Company Fungicidal 7-alkyl-triazolopyrimidines
US6124301A (en) 1998-03-17 2000-09-26 American Cyanamid Company Enhancement of the efficacy of triazolopyrimidines
JPH11322517A (ja) 1998-03-17 1999-11-24 American Cyanamid Co トリアゾロピリミジン類の効力の増進
US5981534A (en) 1998-09-25 1999-11-09 American Cyanamid Company Fungicidal 6-(2,6-difluoro-4-alkoxyphenyl)-triazolopyrimidines
EA003281B1 (ru) 1998-03-23 2003-04-24 Америкэн Цианамид Компани 6-(2-гало-4-алкоксифенил)триазолпиримидины с фунгицидным действием
US6284762B1 (en) 1998-03-23 2001-09-04 American Cyanamid Company Fungicidal 6-(2-halo-4-alkoxyphenyl)-triazolopyrimidines
US6268371B1 (en) 1998-09-10 2001-07-31 American Cyanamid Co. Fungicidal mixtures
US6117865A (en) 1998-09-10 2000-09-12 American Cyanamid Company Fungicidal trifluorophenyl-triazolopyrimidines
JP2000103790A (ja) 1998-09-25 2000-04-11 American Cyanamid Co 殺菌・殺カビ性のトリハロフェニル―トリアゾロピリミジン類
DK0988790T3 (da) 1998-09-25 2003-09-22 Basf Ag Fungicide blandinger
ATE258009T1 (de) 1998-09-25 2004-02-15 Basf Ag Nicht-wässriges suspensionskonzentrat
US6242451B1 (en) 1998-09-25 2001-06-05 Klaus-Juergen Pees Fungicidal trihalophenyl-triazolopyrimidines
US5985883A (en) 1998-09-25 1999-11-16 American Cyanamid Company Fungicidal trichlorophenyl-triazolopyrimidines
US5986135A (en) 1998-09-25 1999-11-16 American Cyanamid Company Fungicidal trifluoromethylalkylamino-triazolopyrimidines
US6277856B1 (en) 1998-09-25 2001-08-21 American Cynamid Co. Fungicidal mixtures
US6521628B1 (en) 1999-01-29 2003-02-18 Basf Aktiengesellschaft Fungicidal mixtures
US6699874B2 (en) 1999-09-24 2004-03-02 Basf Aktiengesellschaft Fungicidal mixtures
WO2001035738A2 (en) 1999-11-18 2001-05-25 Basf Corporation Non-aqueous concentrated spreading oil composition
US6559151B2 (en) 2000-05-08 2003-05-06 Basf Aktiengesellschaft 6-(2-trifluoromethyl-phenyl)-triazolopyrimidines
HK1052646A1 (zh) * 2000-06-30 2003-09-26 Wyeth 替代三氮苯(triazolopyrimidines)作為抗癌劑
KR100765025B1 (ko) 2000-08-25 2007-10-09 바스프 악티엔게젤샤프트 살진균 제제
US6459602B1 (en) * 2000-10-26 2002-10-01 O2 Micro International Limited DC-to-DC converter with improved transient response
WO2002038565A2 (de) 2000-11-13 2002-05-16 Basf Aktiengesellschaft 7-(r)-amino-triazolopyrimidine, deren herstellung und verwendung zur bekämpfung von pflanzenpathogenen pilzen
ES2226968T3 (es) 2000-12-06 2005-04-01 Wyeth 6-(2-trifluorometilfenil)-triazolopirimidinas fungicidas.
DE10063115A1 (de) 2000-12-18 2002-06-27 Bayer Ag Triazolopyrimidine
WO2002067679A1 (en) 2001-02-19 2002-09-06 Basf Aktiengesellschaft Fungicidal mixtures
JP2004531527A (ja) 2001-04-11 2004-10-14 ビーエーエスエフ アクチェンゲゼルシャフト 殺菌剤としての5−ハロゲン−6−フェニル−7−フルオロアルキルアミノ−トリアゾロピリミジン類
DE10124208A1 (de) 2001-05-18 2002-11-21 Bayer Ag Verwendung von Triazolopyrimidin-Derivaten als Mikrobizide
JP2005504743A (ja) 2001-07-18 2005-02-17 ビーエーエスエフ アクチェンゲゼルシャフト 殺菌薬としての置換された6−(2−メトキシ−フェニル)−トリアゾロピリミジン
RU2006107579A (ru) 2003-09-24 2007-10-27 Вайет Холдингз Корпорейшн (Us) 6-[(замещенный)фенил]триазолопиримидины в качестве противораковых препаратов

Also Published As

Publication number Publication date
CO5690598A2 (es) 2006-10-31
RU2006107579A (ru) 2007-10-27
IL174281A0 (en) 2006-08-01
CR8288A (es) 2006-10-04
US20050090508A1 (en) 2005-04-28
PT1680425E (pt) 2007-02-28
WO2005030775A1 (en) 2005-04-07
DE602004004295T2 (de) 2007-06-06
AU2004276240A1 (en) 2005-04-07
ES2279452T3 (es) 2007-08-16
ECSP066458A (es) 2006-09-18
DK1680425T3 (da) 2007-03-19
US7507739B2 (en) 2009-03-24
PA8613301A1 (es) 2005-11-25
HK1090374A1 (en) 2006-12-22
GT200400190A (es) 2005-05-02
CN100519559C (zh) 2009-07-29
PL1680425T3 (pl) 2007-05-31
SA04250302A (ar) 2005-12-03
EP1680425A1 (en) 2006-07-19
BRPI0414700A (pt) 2006-11-14
CA2539252A1 (en) 2005-04-07
CY1106392T1 (el) 2011-10-12
DE602004004295T8 (de) 2007-09-20
TW200512211A (en) 2005-04-01
KR20060098368A (ko) 2006-09-18
ZA200602387B (en) 2008-11-26
PE20050433A1 (es) 2005-07-21
EP1680425B1 (en) 2007-01-10
NO20061318L (no) 2006-04-21
DE602004004295D1 (de) 2007-02-22
CN1867569A (zh) 2006-11-22
MXPA06003206A (es) 2006-06-23
AR045810A1 (es) 2005-11-16
JP2007506744A (ja) 2007-03-22

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