SI1614687T1 - Nov postopek za sintezo derivatov 1,3,4,5-tetrahidro-2h-3-benzazepin-2-ona in njihova uporaba za sintezo ivabradina kot tudi njegovih adicijskih soli s farmacevtsko sprejemljivo kislino - Google Patents

Nov postopek za sintezo derivatov 1,3,4,5-tetrahidro-2h-3-benzazepin-2-ona in njihova uporaba za sintezo ivabradina kot tudi njegovih adicijskih soli s farmacevtsko sprejemljivo kislino

Info

Publication number: SI1614687T1
Authority: SI; Slovenia
Prior art keywords: ivabradine; benzazepin; tetrahydro; synthesis; derivatives
Prior art date: 2004-04-13

Application number

SI200530864T

Other languages

English (en)

Inventor

Jean-Michel Lerestif

Jean-Pierre Lecouve

Jean-Claude Souvie

Daniel Brigot

Original Assignee

Servier Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-04-13

Filing date

2005-02-21

Publication date

2010-01-29

2005-02-21 Application filed by Servier Lab filed Critical Servier Lab

2010-01-29 Publication of SI1614687T1 publication Critical patent/SI1614687T1/sl

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Heart & Thoracic Surgery (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Hospice & Palliative Care (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

SI200530864T 2004-04-13 2005-02-21 Nov postopek za sintezo derivatov 1,3,4,5-tetrahidro-2h-3-benzazepin-2-ona in njihova uporaba za sintezo ivabradina kot tudi njegovih adicijskih soli s farmacevtsko sprejemljivo kislino SI1614687T1 (sl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR0403828A FR2868775B1 (fr)	2004-04-13	2004-04-13	Nouveau procede de synthese de derives de la 1,3,4,5- tetrahydro-2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
EP05290383A EP1614687B1 (fr)	2004-04-13	2005-02-21	Nouveau procédé de synthèse de dérivés de la 1,3,4,5-tétrahydro-2H-3-benzazépin-2-one, et application à la synthèse de l'ivabradine et de ses sels d'addition à un acide pharmaceutiquement acceptable

Publications (1)

Publication Number	Publication Date
SI1614687T1 true SI1614687T1 (sl)	2010-01-29

Family

ID=34941961

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SI200530864T SI1614687T1 (sl)	2004-04-13	2005-02-21	Nov postopek za sintezo derivatov 1,3,4,5-tetrahidro-2h-3-benzazepin-2-ona in njihova uporaba za sintezo ivabradina kot tudi njegovih adicijskih soli s farmacevtsko sprejemljivo kislino

Country Status (33)

Country	Link
US (1)	US7064200B2 (sl)
EP (1)	EP1614687B1 (sl)
JP (2)	JP4515933B2 (sl)
KR (1)	KR100636499B1 (sl)
CN (1)	CN100348585C (sl)
AR (1)	AR047707A1 (sl)
AT (1)	ATE448221T1 (sl)
AU (1)	AU2005200884B2 (sl)
BR (1)	BRPI0500590B8 (sl)
CA (1)	CA2496712C (sl)
CY (1)	CY1109740T1 (sl)
DE (1)	DE602005017541D1 (sl)
DK (1)	DK1614687T3 (sl)
EA (1)	EA007743B1 (sl)
EG (1)	EG25619A (sl)
ES (1)	ES2336461T3 (sl)
FR (1)	FR2868775B1 (sl)
GE (1)	GEP20074136B (sl)
HK (1)	HK1079777A1 (sl)
HR (1)	HRP20100024T1 (sl)
MA (1)	MA27598A1 (sl)
MX (1)	MXPA05003696A (sl)
MY (1)	MY140904A (sl)
NO (1)	NO329861B1 (sl)
NZ (1)	NZ538328A (sl)
PL (1)	PL1614687T3 (sl)
PT (1)	PT1614687E (sl)
RS (1)	RS51232B (sl)
SG (1)	SG116574A1 (sl)
SI (1)	SI1614687T1 (sl)
UA (1)	UA81773C2 (sl)
WO (1)	WO2005111027A1 (sl)
ZA (1)	ZA200501468B (sl)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2868777B1 (fr) *	2004-04-13	2006-05-26	Servier Lab	Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2868775B1 (fr) *	2004-04-13	2008-04-11	Servier Lab	Nouveau procede de synthese de derives de la 1,3,4,5- tetrahydro-2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
GT200500185A (es) *	2004-08-09	2006-04-10		Moduladores del receptor de progesterona que comprenden derivados de pirrol-oxindol y sus usos
EP2471780B1 (en)	2007-05-30	2014-11-26	Ind-Swift Laboratories Limited	Crystalline Ivabradine Oxalate Salts and Polymorphs Thereof
ES2402765T3 (es)	2008-12-22	2013-05-08	Krka, D.D., Novo Mesto	Procedimiento de preparación de ivabradina
FR2940287B1 (fr) *	2008-12-24	2010-12-24	Servier Lab	Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable.
WO2011098582A2 (en)	2010-02-12	2011-08-18	Krka, D.D., Novo Mesto	Novel forms of ivabradine hydrochloride
FR2956401B1 (fr) *	2010-02-17	2012-02-03	Servier Lab	Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2971507B1 (fr) *	2011-02-14	2013-01-18	Servier Lab	Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2984320B1 (fr) *	2011-12-20	2013-11-29	Servier Lab	Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2993561B1 (fr) *	2012-07-17	2014-10-31	Servier Lab	Procede de synthese enzymatique de la (7s)-1-(3,4-dimethoxy bicyclo[4.2.0]octa-1,3,5-triene 7-yl) n-methyl methanamine, et application a la synthese de l'ivabradine et de ses sels
FR3003859B1 (fr) *	2013-03-26	2015-03-13	Servier Lab	"procede de synthese de derives de la 7,8-dimethoxy-1,3-dihydro-2h-3-benzazepin-2-one et application a la synthese de l'ivabradine"

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3119874A1 (de) *	1981-05-19	1982-12-09	Dr. Karl Thomae Gmbh, 7950 Biberach	"benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel"
DE3418270A1 (de) *	1984-05-17	1985-11-21	Dr. Karl Thomae Gmbh, 7950 Biberach	Neue aminotetralinderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
EP0204349A3 (de) *	1985-06-01	1990-01-03	Dr. Karl Thomae GmbH	Neue heteroaromatische Aminderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
DE3519735A1 (de) *	1985-06-01	1986-12-04	Dr. Karl Thomae Gmbh, 7950 Biberach	Neue heteroaromatische aminderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
FR2681862B1 (fr) *	1991-09-27	1993-11-12	Adir Cie	Nouvelles (benzocycloalkyl)alkylamines, leur procede de preparation, et les compositions pharmaceutiques qui les contiennent.
FR2868777B1 (fr) *	2004-04-13	2006-05-26	Servier Lab	Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2868775B1 (fr) *	2004-04-13	2008-04-11	Servier Lab	Nouveau procede de synthese de derives de la 1,3,4,5- tetrahydro-2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable

2004
- 2004-04-13 FR FR0403828A patent/FR2868775B1/fr not_active Expired - Fee Related
2005
- 2005-02-07 CA CA2496712A patent/CA2496712C/fr not_active Expired - Lifetime
- 2005-02-15 SG SG200500770A patent/SG116574A1/en unknown
- 2005-02-17 US US11/060,043 patent/US7064200B2/en not_active Expired - Lifetime
- 2005-02-18 BR BRPI0500590A patent/BRPI0500590B8/pt active IP Right Grant
- 2005-02-18 NZ NZ538328A patent/NZ538328A/en not_active IP Right Cessation
- 2005-02-18 MA MA28112A patent/MA27598A1/fr unknown
- 2005-02-18 UA UAA200501524A patent/UA81773C2/uk unknown
- 2005-02-18 JP JP2005041810A patent/JP4515933B2/ja not_active Expired - Lifetime
- 2005-02-18 NO NO20050888A patent/NO329861B1/no unknown
- 2005-02-18 AU AU2005200884A patent/AU2005200884B2/en not_active Expired
- 2005-02-18 CN CNB2005100542167A patent/CN100348585C/zh not_active Expired - Lifetime
- 2005-02-18 AR ARP050100586A patent/AR047707A1/es active IP Right Grant
- 2005-02-18 GE GEAP8647A patent/GEP20074136B/en unknown
- 2005-02-18 ZA ZA2005/01468A patent/ZA200501468B/en unknown
- 2005-02-18 MY MYPI20050621A patent/MY140904A/en unknown
- 2005-02-19 KR KR1020050013860A patent/KR100636499B1/ko active IP Right Grant
- 2005-02-19 EG EG2005020086A patent/EG25619A/xx active
- 2005-02-21 ES ES05290383T patent/ES2336461T3/es not_active Expired - Lifetime
- 2005-02-21 DK DK05290383.8T patent/DK1614687T3/da active
- 2005-02-21 EA EA200500240A patent/EA007743B1/ru unknown
- 2005-02-21 PL PL05290383T patent/PL1614687T3/pl unknown
- 2005-02-21 PT PT05290383T patent/PT1614687E/pt unknown
- 2005-02-21 RS RSP-2010/0006A patent/RS51232B/sr unknown
- 2005-02-21 SI SI200530864T patent/SI1614687T1/sl unknown
- 2005-02-21 AT AT05290383T patent/ATE448221T1/de active
- 2005-02-21 DE DE602005017541T patent/DE602005017541D1/de not_active Expired - Lifetime
- 2005-02-21 WO PCT/FR2005/000396 patent/WO2005111027A1/fr active Application Filing
- 2005-02-21 EP EP05290383A patent/EP1614687B1/fr not_active Expired - Lifetime
- 2005-04-07 MX MXPA05003696A patent/MXPA05003696A/es active IP Right Grant
- 2005-12-22 HK HK05111843A patent/HK1079777A1/xx not_active IP Right Cessation
2009
- 2009-09-25 JP JP2009220529A patent/JP5277130B2/ja not_active Expired - Lifetime
2010
- 2010-01-13 HR HR20100024T patent/HRP20100024T1/hr unknown
- 2010-01-19 CY CY20101100053T patent/CY1109740T1/el unknown

Also Published As

Publication number	Publication date
KR20060042117A (ko)	2006-05-12
NO20050888D0 (no)	2005-02-18
EA007743B1 (ru)	2006-12-29
JP2010047577A (ja)	2010-03-04
CN1683343A (zh)	2005-10-19
AU2005200884B2 (en)	2010-07-15
CY1109740T1 (el)	2014-09-10
US7064200B2 (en)	2006-06-20
EA200500240A1 (ru)	2005-10-27
MXPA05003696A (es)	2006-01-24
MA27598A1 (fr)	2005-11-01
DK1614687T3 (da)	2010-03-29
NO329861B1 (no)	2011-01-17
KR100636499B1 (ko)	2006-10-18
FR2868775A1 (fr)	2005-10-14
JP5277130B2 (ja)	2013-08-28
UA81773C2 (uk)	2008-02-11
EP1614687B1 (fr)	2009-11-11
ES2336461T3 (es)	2010-04-13
CA2496712C (fr)	2010-04-06
JP4515933B2 (ja)	2010-08-04
AU2005200884A1 (en)	2005-10-27
SG116574A1 (en)	2005-11-28
CA2496712A1 (fr)	2005-10-13
HK1079777A1 (en)	2006-04-13
BRPI0500590B1 (pt)	2018-10-09
NO20050888L (no)	2005-10-14
PT1614687E (pt)	2009-12-02
JP2005298478A (ja)	2005-10-27
CN100348585C (zh)	2007-11-14
GEP20074136B (en)	2007-06-25
ATE448221T1 (de)	2009-11-15
BRPI0500590B8 (pt)	2021-05-25
WO2005111027A1 (fr)	2005-11-24
DE602005017541D1 (de)	2009-12-24
NZ538328A (en)	2005-10-28
EP1614687A1 (fr)	2006-01-11
ZA200501468B (en)	2005-11-30
BRPI0500590A (pt)	2005-11-16
RS51232B (sr)	2010-12-31
HRP20100024T1 (hr)	2010-02-28
EG25619A (en)	2012-03-26
US20050228178A1 (en)	2005-10-13
FR2868775B1 (fr)	2008-04-11
PL1614687T3 (pl)	2010-04-30
MY140904A (en)	2010-01-29
AR047707A1 (es)	2006-02-08

Publication	Publication Date	Title
SI1589005T1 (sl)	2007-08-31	Postopek sinteze ivabradina in njegovih farmacevtsko sprejemljivih kislinskih adicijskih soli
SI1598333T1 (sl)	2007-02-28	Postopek za pripravo (1s)-4,5-dimetoksi-1-(metilaminometil)-benzociklobutana in njegovih adicijskih soli, kot tudi uporaba za sintezo ivabradina in njegovih adicijskih soli s farmacevtsko sprejemljivo kislino
MA28626B1 (fr)	2007-06-01	Forme cristalline delta du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
HUP0101336A3 (en)	2003-03-28	Process for the preparation of perindopril and their pharmaceutically acceptable salts
ZA200904316B (en)	2010-05-26	Process for the synthesis of 7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one, and application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
EP1806149A4 (en)	2012-12-05	SOLID MEDICINAL PREPARATION IMPROVED IN TERMS OF SOLUBILITY AND STABILITY AND METHOD FOR PRODUCING SAME
HUE037069T2 (hu)	2018-08-28	Eljárás nagy tisztaságú 2,4'-metiléndifenildiizocianát elõállítására
HK1089187A1 (en)	2006-11-24	Novel method for the synthesis of perindopril and the pharmaceutically acceptable salts thereof
PT1614687E (pt)	2009-12-02	Novo processo de síntese de derivados da 1,3,4,5- tetrahidro-2h-benzazepin-2-ona, e aplicação à síntese da ivabradina e dos seus sais de adição a um ácido aceitáveis do ponto de vista farmacêutico
HUP0401522A2 (en)	2006-04-28	New 4-benzylidene-piperidine derivatives, pharmaceutical compositions containing the same and process for their preparation
ZA200704246B (en)	2009-09-30	Solid medicinal preparation improved in solubility and stability and process for producing the same
HK1096409A1 (en)	2007-06-01	Novel method for the synthesis of perindopril and the pharmaceutically acceptable salts thereof
EP1731139A4 (en)	2008-12-03	PHARMACEUTICAL PREPARATION OF THE S / O TYPE AND MANUFACTURING METHOD THEREFOR
HK1096408A1 (en)	2007-06-01	Novel method for the synthesis of perindopril and the pharmaceutically acceptable salts thereof
PL1589014T3 (pl)	2008-01-31	Sposób syntezy pochodnych 1,3-dihydro-2H-3-benzazepin-2-onu i jego zastosowanie do wytwarzania iwabradyny i jej dopuszczalnych farmaceutycznie soli
PT1753720E (pt)	2014-08-04	Processo para a preparação de perindopril e sais do mesmo
HK1096407A1 (en)	2007-06-01	Novel method for the synthesis of perindopril and the pharmaceutically acceptable salts thereof
HK1096406A1 (en)	2007-06-01	Novel method for the synthesis of perindopril and the pharmaceutically acceptable salts thereof
SI1403275T1 (sl)	2006-02-28	Nov postopek sinteze perindoprila in njegovih farmacevtsko sprejemljivih soli
HK1078878A1 (en)	2006-03-24	Process for the preparation of delta(15-16)-17-ketsteroids and use thereof in the synthesis of pharmacologically active compounds (15-16)-17-
IL175282A0 (en)	2006-09-05	Preparation of pharmaceutical salts of [1,4]-bipiperidine
SG117528A1 (en)	2005-12-29	New process for the synthesis of (1S)-4,5-dimethoxy-1-(methylaminomethyl)-benzocyclobutane and addition salts thereof, and application in the synthesis of ivabradine and addition salts thereof, with