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EA200500240A1 - Новый способ синтеза соединений 1,3,4,5-тетрагидро-2h-3-бензазепин-2-она и применение при синтезе ивабрадина и его солей присоединения с фармацевтически приемлемой кислотой - Google Patents

Новый способ синтеза соединений 1,3,4,5-тетрагидро-2h-3-бензазепин-2-она и применение при синтезе ивабрадина и его солей присоединения с фармацевтически приемлемой кислотой

Info

Publication number
EA200500240A1
EA200500240A1 EA200500240A EA200500240A EA200500240A1 EA 200500240 A1 EA200500240 A1 EA 200500240A1 EA 200500240 A EA200500240 A EA 200500240A EA 200500240 A EA200500240 A EA 200500240A EA 200500240 A1 EA200500240 A1 EA 200500240A1
Authority
EA
Eurasian Patent Office
Prior art keywords
synthesis
ivabradine
compounds
application
salts
Prior art date
Application number
EA200500240A
Other languages
English (en)
Other versions
EA007743B1 (ru
Inventor
Жан-Мишель Лерести
Жан-Пьер Лекув
Жан-Клод Суви
Даньель Бриго
Original Assignee
Ле Лаборатуар Сервье
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ле Лаборатуар Сервье filed Critical Ле Лаборатуар Сервье
Publication of EA200500240A1 publication Critical patent/EA200500240A1/ru
Publication of EA007743B1 publication Critical patent/EA007743B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Способ синтеза соединений формулы (I)в которой Rи R, которые могут быть одинаковыми или разными, каждый представляет собой линейную или разветвленную (C-C)алкоксигруппу или образуют вместе с атомом углерода, к которому они присоединены, 1,3-диоксановое, 1,3-диоксолановое или 1,3-диоксепановое кольцо. Применение при синтезе ивабрадина, его солей присоединения с фармацевтически приемлемой кислотой и гидратов.
EA200500240A 2004-04-13 2005-02-21 Способ получения производных 1,3,4,5-тетрагидро-2н-3-бензазепин-2-она EA007743B1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0403828A FR2868775B1 (fr) 2004-04-13 2004-04-13 Nouveau procede de synthese de derives de la 1,3,4,5- tetrahydro-2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable

Publications (2)

Publication Number Publication Date
EA200500240A1 true EA200500240A1 (ru) 2005-10-27
EA007743B1 EA007743B1 (ru) 2006-12-29

Family

ID=34941961

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200500240A EA007743B1 (ru) 2004-04-13 2005-02-21 Способ получения производных 1,3,4,5-тетрагидро-2н-3-бензазепин-2-она

Country Status (33)

Country Link
US (1) US7064200B2 (ru)
EP (1) EP1614687B1 (ru)
JP (2) JP4515933B2 (ru)
KR (1) KR100636499B1 (ru)
CN (1) CN100348585C (ru)
AR (1) AR047707A1 (ru)
AT (1) ATE448221T1 (ru)
AU (1) AU2005200884B2 (ru)
BR (1) BRPI0500590B8 (ru)
CA (1) CA2496712C (ru)
CY (1) CY1109740T1 (ru)
DE (1) DE602005017541D1 (ru)
DK (1) DK1614687T3 (ru)
EA (1) EA007743B1 (ru)
EG (1) EG25619A (ru)
ES (1) ES2336461T3 (ru)
FR (1) FR2868775B1 (ru)
GE (1) GEP20074136B (ru)
HK (1) HK1079777A1 (ru)
HR (1) HRP20100024T1 (ru)
MA (1) MA27598A1 (ru)
MX (1) MXPA05003696A (ru)
MY (1) MY140904A (ru)
NO (1) NO329861B1 (ru)
NZ (1) NZ538328A (ru)
PL (1) PL1614687T3 (ru)
PT (1) PT1614687E (ru)
RS (1) RS51232B (ru)
SG (1) SG116574A1 (ru)
SI (1) SI1614687T1 (ru)
UA (1) UA81773C2 (ru)
WO (1) WO2005111027A1 (ru)
ZA (1) ZA200501468B (ru)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2868777B1 (fr) * 2004-04-13 2006-05-26 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2868775B1 (fr) * 2004-04-13 2008-04-11 Servier Lab Nouveau procede de synthese de derives de la 1,3,4,5- tetrahydro-2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
GT200500185A (es) * 2004-08-09 2006-04-10 Moduladores del receptor de progesterona que comprenden derivados de pirrol-oxindol y sus usos
EP2471780B1 (en) 2007-05-30 2014-11-26 Ind-Swift Laboratories Limited Crystalline Ivabradine Oxalate Salts and Polymorphs Thereof
ES2402765T3 (es) 2008-12-22 2013-05-08 Krka, D.D., Novo Mesto Procedimiento de preparación de ivabradina
FR2940287B1 (fr) * 2008-12-24 2010-12-24 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable.
WO2011098582A2 (en) 2010-02-12 2011-08-18 Krka, D.D., Novo Mesto Novel forms of ivabradine hydrochloride
FR2956401B1 (fr) * 2010-02-17 2012-02-03 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2971507B1 (fr) * 2011-02-14 2013-01-18 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2984320B1 (fr) * 2011-12-20 2013-11-29 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2993561B1 (fr) * 2012-07-17 2014-10-31 Servier Lab Procede de synthese enzymatique de la (7s)-1-(3,4-dimethoxy bicyclo[4.2.0]octa-1,3,5-triene 7-yl) n-methyl methanamine, et application a la synthese de l'ivabradine et de ses sels
FR3003859B1 (fr) * 2013-03-26 2015-03-13 Servier Lab "procede de synthese de derives de la 7,8-dimethoxy-1,3-dihydro-2h-3-benzazepin-2-one et application a la synthese de l'ivabradine"

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3119874A1 (de) * 1981-05-19 1982-12-09 Dr. Karl Thomae Gmbh, 7950 Biberach "benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel"
DE3418270A1 (de) * 1984-05-17 1985-11-21 Dr. Karl Thomae Gmbh, 7950 Biberach Neue aminotetralinderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
EP0204349A3 (de) * 1985-06-01 1990-01-03 Dr. Karl Thomae GmbH Neue heteroaromatische Aminderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
DE3519735A1 (de) * 1985-06-01 1986-12-04 Dr. Karl Thomae Gmbh, 7950 Biberach Neue heteroaromatische aminderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
FR2681862B1 (fr) * 1991-09-27 1993-11-12 Adir Cie Nouvelles (benzocycloalkyl)alkylamines, leur procede de preparation, et les compositions pharmaceutiques qui les contiennent.
FR2868777B1 (fr) * 2004-04-13 2006-05-26 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2868775B1 (fr) * 2004-04-13 2008-04-11 Servier Lab Nouveau procede de synthese de derives de la 1,3,4,5- tetrahydro-2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable

Also Published As

Publication number Publication date
KR20060042117A (ko) 2006-05-12
NO20050888D0 (no) 2005-02-18
EA007743B1 (ru) 2006-12-29
JP2010047577A (ja) 2010-03-04
CN1683343A (zh) 2005-10-19
AU2005200884B2 (en) 2010-07-15
CY1109740T1 (el) 2014-09-10
US7064200B2 (en) 2006-06-20
MXPA05003696A (es) 2006-01-24
MA27598A1 (fr) 2005-11-01
DK1614687T3 (da) 2010-03-29
NO329861B1 (no) 2011-01-17
KR100636499B1 (ko) 2006-10-18
FR2868775A1 (fr) 2005-10-14
JP5277130B2 (ja) 2013-08-28
UA81773C2 (ru) 2008-02-11
EP1614687B1 (fr) 2009-11-11
ES2336461T3 (es) 2010-04-13
CA2496712C (fr) 2010-04-06
JP4515933B2 (ja) 2010-08-04
AU2005200884A1 (en) 2005-10-27
SI1614687T1 (sl) 2010-01-29
SG116574A1 (en) 2005-11-28
CA2496712A1 (fr) 2005-10-13
HK1079777A1 (en) 2006-04-13
BRPI0500590B1 (pt) 2018-10-09
NO20050888L (no) 2005-10-14
PT1614687E (pt) 2009-12-02
JP2005298478A (ja) 2005-10-27
CN100348585C (zh) 2007-11-14
GEP20074136B (en) 2007-06-25
ATE448221T1 (de) 2009-11-15
BRPI0500590B8 (pt) 2021-05-25
WO2005111027A1 (fr) 2005-11-24
DE602005017541D1 (de) 2009-12-24
NZ538328A (en) 2005-10-28
EP1614687A1 (fr) 2006-01-11
ZA200501468B (en) 2005-11-30
BRPI0500590A (pt) 2005-11-16
RS51232B (sr) 2010-12-31
HRP20100024T1 (hr) 2010-02-28
EG25619A (en) 2012-03-26
US20050228178A1 (en) 2005-10-13
FR2868775B1 (fr) 2008-04-11
PL1614687T3 (pl) 2010-04-30
MY140904A (en) 2010-01-29
AR047707A1 (es) 2006-02-08

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