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PT1753720E - Processo para a preparação de perindopril e sais do mesmo - Google Patents

Processo para a preparação de perindopril e sais do mesmo Download PDF

Info

Publication number
PT1753720E
PT1753720E PT57480485T PT05748048T PT1753720E PT 1753720 E PT1753720 E PT 1753720E PT 57480485 T PT57480485 T PT 57480485T PT 05748048 T PT05748048 T PT 05748048T PT 1753720 E PT1753720 E PT 1753720E
Authority
PT
Portugal
Prior art keywords
perindopril
salts
preparation
Prior art date
Application number
PT57480485T
Other languages
English (en)
Inventor
Marjo Merslavic
Janja Smid
Zdenka Tomsic
Original Assignee
Servier S A Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier S A Lab filed Critical Servier S A Lab
Publication of PT1753720E publication Critical patent/PT1753720E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PT57480485T 2004-05-14 2005-05-10 Processo para a preparação de perindopril e sais do mesmo PT1753720E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SI200400143A SI21800A (sl) 2004-05-14 2004-05-14 Nov postopek sinteze perindoprila
SI200400235A SI21852A (sl) 2004-05-14 2004-08-05 Nov postopek sinteze perindoprila

Publications (1)

Publication Number Publication Date
PT1753720E true PT1753720E (pt) 2014-08-04

Family

ID=34969318

Family Applications (1)

Application Number Title Priority Date Filing Date
PT57480485T PT1753720E (pt) 2004-05-14 2005-05-10 Processo para a preparação de perindopril e sais do mesmo

Country Status (17)

Country Link
US (1) US7674814B2 (pt)
EP (1) EP1753720B1 (pt)
JP (1) JP5032983B2 (pt)
AU (1) AU2005245087B2 (pt)
CA (1) CA2566754C (pt)
CY (1) CY1115222T1 (pt)
DK (1) DK1753720T3 (pt)
EA (1) EA011322B1 (pt)
ES (1) ES2466248T3 (pt)
HR (1) HRP20140487T1 (pt)
NO (1) NO337892B1 (pt)
PL (1) PL1753720T3 (pt)
PT (1) PT1753720E (pt)
SI (3) SI21800A (pt)
UA (1) UA83139C2 (pt)
WO (1) WO2005113500A1 (pt)
ZA (1) ZA200609915B (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4948392B2 (ja) * 2004-03-29 2012-06-06 レ ラボラトア セルビエ 固形薬学的組成物を調製するためのプロセス
US7291745B2 (en) 2005-03-21 2007-11-06 Glenmark Pharmaceuticals Limited Process for the preparation of perindopril
JP2006290825A (ja) * 2005-04-13 2006-10-26 Shiono Chemical Co Ltd アルファ型ペリンドプリルエルブミンの製造法
SI22543A (sl) 2007-06-27 2008-12-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Nove soli perindoprila
WO2016178591A2 (en) 2015-05-05 2016-11-10 Gene Predit, Sa Genetic markers and treatment of male obesity
PH12018502155B1 (en) 2016-04-20 2024-03-27 Servier Lab Pharmaceutical composition comprising a beta blocker, a converting enzyme inhibitor and an antihypertensive or an nsaid
JP7070831B2 (ja) 2018-05-31 2022-05-18 株式会社富士通ゼネラル 天井埋込型空気調和機

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* Cited by examiner, † Cited by third party
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US4508729A (en) * 1979-12-07 1985-04-02 Adir Substituted iminodiacids, their preparation and pharmaceutical compositions containing them
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US4350704A (en) * 1980-10-06 1982-09-21 Warner-Lambert Company Substituted acyl derivatives of octahydro-1H-indole-2-carboxylic acids
US4425355A (en) * 1981-02-17 1984-01-10 Warner-Lambert Company Substituted acyl derivatives of chair form of octahydro-1H-indole-2-carboxylic acids
US4743450A (en) 1987-02-24 1988-05-10 Warner-Lambert Company Stabilized compositions
FR2620699B1 (fr) * 1987-09-17 1990-06-01 Adir Procede de synthese d'alpha amino acides n alkyles et de leurs esters. application a la synthese de carboxyalkyl dipeptides
FR2620709B1 (fr) 1987-09-17 1990-09-07 Adir Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese
FR2620703B1 (fr) 1987-09-17 1991-10-04 Adir Procede de synthese industrielle de l'acide perhydroindole carboxylique - 2(2s, 3as, 7as). application a la synthese de carboxyalkyl dipeptides
FR2620700B1 (fr) 1987-09-17 1990-06-01 Adir Procede de synthese d'alpha amino acides n alkyles et leurs esters. application a la synthese de carboxyalkyl dipeptides
US5258525A (en) * 1991-03-27 1993-11-02 Mcneilab, Inc. Processes for preparing [2S-(2α,3aβ,7aβ)]octahydro-1H-indole-2-carboxylic acid and esters
SI9111842A (sl) * 1991-11-25 1998-04-30 Krka Stabilna formulacija soli enalaprila, postopek za njeno pripravo in njena uporaba
SI9600169A (en) 1996-05-22 1997-12-31 Krka Tovarna Zdravil Process for preparation of compounds with ace inhibitory effect
FR2771010B1 (fr) 1997-11-19 2003-08-15 Adir Utilisation d'une combinaison d'un inhibiteur de l'enzyme de conversion de l'angiotensine et d'un diuretique pour le traitement des desordres microcirculatoires
FR2807037B1 (fr) 2000-03-31 2002-05-10 Adir NOUVEAU PROCEDE DE SYNTHESE DES ESTERS DE LA N-[(s)-1- CARBOXYBUTYL]-(S)-ALANINE ET APPLICATION A LA SYNTHESE DU PERINDOPRIL
FR2807431B1 (fr) 2000-04-06 2002-07-19 Adir Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables
FR2807430B1 (fr) 2000-04-11 2002-05-17 Adir Nouveau procede de synthese des esters de la n-[(s)-1- carboxybutyl]-(s)-alanine et application a la synthese du perindopril
FR2811318B1 (fr) * 2000-07-06 2002-08-23 Adir Nouvelle forme cristalline gamma du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent
FR2811320B1 (fr) 2000-07-06 2002-08-23 Adir Nouvelle forme cristalline alpha du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent
FR2811319B1 (fr) * 2000-07-06 2002-08-23 Adir Nouvelle forme cristalline beta du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent
DE10131217A1 (de) * 2001-06-28 2003-01-09 Solvay Pharm Gmbh 3-Phenyl-3,7-diazabicyclo 3,3,1 nonan-Verbindungen sowie Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
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ATE365714T1 (de) 2002-01-30 2007-07-15 Servier Lab Verfahren zur herstellung von hochreinem perindopril und zwischenverbindungen nützlich in der synthese
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FR2838648B1 (fr) * 2002-04-18 2004-05-21 Servier Lab Nouveau sel de perindopril et les compositions pharmaceutiques qui le contiennent
CA2488498A1 (en) * 2002-06-10 2003-12-18 Elan Pharma International Limited Nanoparticulate polycosanol formulations and novel polycosanol combinations
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EP1338591B1 (fr) 2003-02-28 2005-10-26 Les Laboratoires Servier Nouveau procédé de synthèse de l'acide (2S, 3aS, 7aS)-perhydroindole-2-carboxylique et de ses esters, et application à la synthèse du perindopril
JP4461027B2 (ja) * 2003-02-28 2010-05-12 レ ラボラトワール セルヴィエ ペリンドプリルおよびその塩の製法
DE60300116T2 (de) 2003-03-12 2005-12-22 Les Laboratoires Servier Verfahren zur Synthese von (2S,3aS,7aS)-Perhydroindol-2-carbonsäure und seinen Estern, und Verwendung in der Synthese von Perindopril
SI1367061T1 (sl) * 2003-06-30 2006-04-30 Servier Lab Nov postopek za sintezo perindoprila in njegovih farmacevtsko sprejemljivih soli
US6869963B2 (en) * 2003-07-11 2005-03-22 Sandoz Ag Stable pharmaceutical compositions containing an ACE inhibitor
GB2404336A (en) 2003-07-30 2005-02-02 Cipla Ltd Stabilisation of therapeutic agents using a carbonate salt of an amino acid, preferably in the presence of a saccharide, & pharmaceutical compositions thereof
PT1367062E (pt) * 2003-07-31 2006-12-29 Servier Lab Novo processo de síntese do perindopril e dos seus sais aceitáveis do ponto de vista farmacêutico
SI1367063T1 (sl) * 2003-07-31 2006-10-31 Servier Lab Nov postopek sinteze perindoprila in njegovih farmacevtsko sprejemljivih soli
DK1362845T3 (da) 2003-09-01 2010-01-18 Servier Lab Ny fremgangsmåde til fremstilling af estere af N-((S)-1-carboxybutyl)-(S)-alanin og deres anvendelse ved fremstilling af perindopril
PT1403278E (pt) 2003-09-30 2005-09-30 Servier Lab Processo de sintese da n-((s)-1-carbetoxibutil)-(s)-alanina e aplicacao a sintese do perindopril
ATE315046T1 (de) 2003-09-30 2006-02-15 Servier Lab Verfahren zur herstellung von n-((s)-1- (etoxycarbonyl)butyl)-(s)-alanin und verwendung in der synthese von perindopril
GB2394660A (en) 2003-12-17 2004-05-05 Niche Generics Ltd Stabilisation of pharmaceutical compositions comprising ACE inhibitor by absence of acidic excipients having large specific surface area, eg silicon dioxide
JP4948392B2 (ja) * 2004-03-29 2012-06-06 レ ラボラトア セルビエ 固形薬学的組成物を調製するためのプロセス

Also Published As

Publication number Publication date
ZA200609915B (en) 2008-05-28
SI21852A (sl) 2006-02-28
AU2005245087A1 (en) 2005-12-01
CA2566754A1 (en) 2005-12-01
CA2566754C (en) 2012-09-18
NO20065695L (no) 2006-12-11
CY1115222T1 (el) 2017-01-04
DK1753720T3 (da) 2014-06-30
SI21800A (sl) 2005-12-31
US20080051584A1 (en) 2008-02-28
UA83139C2 (uk) 2008-06-10
HRP20140487T1 (hr) 2014-07-04
WO2005113500A1 (en) 2005-12-01
JP2007537189A (ja) 2007-12-20
EP1753720B1 (en) 2014-05-07
JP5032983B2 (ja) 2012-09-26
EA011322B1 (ru) 2009-02-27
EP1753720A1 (en) 2007-02-21
SI1753720T1 (sl) 2014-08-29
NO337892B1 (no) 2016-07-04
AU2005245087B2 (en) 2010-12-16
EA200602117A1 (ru) 2007-04-27
PL1753720T3 (pl) 2014-09-30
ES2466248T3 (es) 2014-06-09
US7674814B2 (en) 2010-03-09

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