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SI0960109T1 - Process to prepare tolterodine - Google Patents

Process to prepare tolterodine

Info

Publication number
SI0960109T1
SI0960109T1 SI9730426T SI9730426T SI0960109T1 SI 0960109 T1 SI0960109 T1 SI 0960109T1 SI 9730426 T SI9730426 T SI 9730426T SI 9730426 T SI9730426 T SI 9730426T SI 0960109 T1 SI0960109 T1 SI 0960109T1
Authority
SI
Slovenia
Prior art keywords
tolterodine
prepare
prepare tolterodine
benzopyran
dihydro
Prior art date
Application number
SI9730426T
Other languages
English (en)
Slovenian (sl)
Inventor
James R. Gage
John E. Cabaj
Original Assignee
Pharmacia & Upjohn Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Company filed Critical Pharmacia & Upjohn Company
Publication of SI0960109T1 publication Critical patent/SI0960109T1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/20—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 hydrogenated in the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/48—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups
    • C07C215/54—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Pyrane Compounds (AREA)
  • Optical Integrated Circuits (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SI9730426T 1996-12-31 1997-12-18 Process to prepare tolterodine SI0960109T1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3396196P 1996-12-31 1996-12-31
EP97954678A EP0960109B1 (en) 1996-12-31 1997-12-18 Process to prepare tolterodine
PCT/US1997/022521 WO1998029402A1 (en) 1996-12-31 1997-12-18 Process to prepare tolterodine

Publications (1)

Publication Number Publication Date
SI0960109T1 true SI0960109T1 (en) 2003-04-30

Family

ID=21873473

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9730426T SI0960109T1 (en) 1996-12-31 1997-12-18 Process to prepare tolterodine

Country Status (22)

Country Link
US (1) US5922914A (fi)
EP (1) EP0960109B1 (fi)
JP (1) JP4199310B2 (fi)
KR (2) KR20000057548A (fi)
CN (1) CN1151141C (fi)
AT (1) ATE226949T1 (fi)
AU (1) AU717985B2 (fi)
CA (1) CA2273789C (fi)
CZ (1) CZ295477B6 (fi)
DE (1) DE69716767T2 (fi)
DK (1) DK0960109T3 (fi)
ES (1) ES2186018T3 (fi)
FI (1) FI991477A0 (fi)
HU (1) HUP0000527A3 (fi)
NO (1) NO317158B1 (fi)
NZ (1) NZ336533A (fi)
PL (1) PL191603B1 (fi)
PT (1) PT960109E (fi)
RU (1) RU2176246C2 (fi)
SI (1) SI0960109T1 (fi)
SK (1) SK283591B6 (fi)
WO (1) WO1998029402A1 (fi)

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US6566537B2 (en) 1999-12-30 2003-05-20 Pharmacia Ab Process and intermediates
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PE20020547A1 (es) 2000-10-24 2002-06-12 Upjohn Co Uso de la tolterodina en tratamientos del asma
US20030027856A1 (en) * 2001-06-29 2003-02-06 Aberg A.K. Gunnar Tolterodine metabolites
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US7005449B2 (en) 2002-04-23 2006-02-28 Pharmacia & Upjohn Company Tolterodine salts
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WO2004014853A1 (en) 2002-07-31 2004-02-19 Ranbaxy Laboratories Limited 3,6-disubstituted azabicyclo [3.1.0]hexane derivatives useful as muscarinic receptor antagonists
EP1545508A4 (en) 2002-08-09 2009-11-25 Ranbaxy Lab Ltd 3,6-DISUBSTITUTED AZABICYCLO ¬3.1.0 HEXANE DERIVATIVES AS USEFUL AS MUSCARINIC RECEPTOR AGONISTS
US7288562B2 (en) 2002-08-23 2007-10-30 Ranbaxy Laboratories Limited Fluoro and sulphonylamino containing 3,6-disubstituted azabicyclo (3.1.0) hexane derivatives as muscarinic receptor antagonists
AU2003265680A1 (en) * 2002-08-28 2004-03-19 Pharmacia Corporation Oral liquid tolterodine composition
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AU2002347553A1 (en) 2002-12-23 2004-07-14 Ranbaxy Laboratories Limited Flavaxate derivatives as muscarinic receptor antagonists
US7465751B2 (en) 2002-12-23 2008-12-16 Ranbaxy Laboratories Limited 1-substituted-3-pyrrolidine derivatives as muscarinic receptor antagonists
US7488748B2 (en) 2003-01-28 2009-02-10 Ranbaxy Laboratories Limited 3,6-Disubstituted azabicyclo hexane derivatives as muscarinic receptor antagonists
EP1603862A1 (en) * 2003-03-06 2005-12-14 Ranbaxy Laboratories Limited 3,3-diarylpropylamine derivatives and processes for isolation thereof
US7393874B2 (en) * 2003-04-08 2008-07-01 Hetero Drugs Limited Polymorphs of tolterodine tartrate
DE10315917A1 (de) * 2003-04-08 2004-11-18 Schwarz Pharma Ag Hochreine Basen von 3,3-Diphenylpropylaminmonoestern
AU2003214520A1 (en) 2003-04-09 2004-11-01 Ranbaxy Laboratories Limited Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists
WO2004089363A1 (en) 2003-04-10 2004-10-21 Ranbaxy Laboratories Limited Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists
EP1615887A1 (en) 2003-04-10 2006-01-18 Ranbaxy Laboratories, Ltd. Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists
AU2004228452A1 (en) 2003-04-11 2004-10-21 Ranbaxy Laboratories Limited Azabicyclo derivatives as muscarinic receptor antagonists
ITMI20031354A1 (it) * 2003-07-02 2005-01-03 Istituto Di Chimica Biomolecolare D El Cnr Sezione Sintesis enantioselettiva di composti enantiomericamente arricchiti.
ES2235648B1 (es) * 2003-12-22 2006-11-01 Ragactives, S.L. Procedimiento para la obtencion de tolterodina.
KR101154023B1 (ko) * 2003-12-24 2012-06-07 씨아이피엘에이 엘티디. 톨테로딘, 그 조성물 및 용도, 그리고 그 제조방법
EP1629834A1 (en) 2004-08-27 2006-03-01 KRKA, D.D., Novo Mesto Sustained release pharmaceutical composition of tolterodine
ITMI20041920A1 (it) * 2004-10-11 2005-01-11 Chemi Spa Processo per la preparazione di n, n-diisopropil-3-2-idrossi-5-metilfenil-3-fenil-propabammina
US7355077B2 (en) * 2004-10-28 2008-04-08 Dr. Reddy's Laboratories Limited Process for preparing tolterodine
JP4513535B2 (ja) * 2004-12-03 2010-07-28 住友化学株式会社 トルテロジンの製造方法
CA2590555A1 (en) * 2005-01-10 2006-07-13 Teva Pharmaceutical Industries Ltd. Substantially pure tolterodine tartrate and process for preparing thereof
US7528267B2 (en) 2005-08-01 2009-05-05 Girindus America, Inc. Method for enantioselective hydrogenation of chromenes
ES2268987B1 (es) * 2005-08-05 2008-02-01 Ragactives, S.L. Procedimiento para la obtencion de 3,3-difenilpropilaminas.
WO2007039918A1 (en) * 2005-10-06 2007-04-12 Natco Pharma Limited Novel process for the preparation of tolterodine
US20090221664A1 (en) 2005-10-19 2009-09-03 Abhijit Ray Pharmaceutical compositions of muscarinic receptor antagonists
KR100686351B1 (ko) * 2006-01-12 2007-02-22 주식회사 카이로제닉스 톨테로딘 라세미체의 제조방법
ITMI20060110A1 (it) * 2006-01-24 2007-07-25 Dipharma Spa Procedimento per la purificazione di tolterodina
DK2029567T3 (da) 2006-05-24 2010-11-29 Pfizer Ltd Fremgangsmåde til frembringelse af benzopyran-2-ol-derivater
US7268257B1 (en) 2006-05-31 2007-09-11 Sumitomo Chemical Company, Limited Process for producing tolterodine
CZ302585B6 (cs) * 2007-02-26 2011-07-20 Zentiva, A. S. Krystalická sul 2-[(1R)-3-[bis(1-methylethyl)amino]-1-fenylpropyl]-4-methylfenolu s kyselinou (2R,3R)-2,3-dihydroxybutandiovou
US8486452B2 (en) * 2007-07-20 2013-07-16 Mylan Pharmaceuticals Inc. Stabilized tolterodine tartrate formulations
WO2009019599A2 (en) 2007-08-08 2009-02-12 Themis Laboratories Private Limited Extended release compositions comprising tolterodine
KR101188333B1 (ko) * 2008-02-20 2012-10-09 에스케이케미칼주식회사 안정성이 우수하고 경피제로 유용한 톨테로딘 결정성산부가염
US20090214665A1 (en) * 2008-02-26 2009-08-27 Lai Felix S Controlled Release Muscarinic Receptor Antagonist Formulation
ITMI20082055A1 (it) * 2008-11-19 2009-02-18 Dipharma Francis Srl Procedimento per la preparazione di (r)-tolterodina base libera
WO2010092500A2 (en) 2009-02-12 2010-08-19 Alembic Limited A process for the preparation of tolterodine tartrate
WO2010094292A1 (en) * 2009-02-17 2010-08-26 Pharmathen S.A. Improved process for the preparation of (r)-2-(3-diisopropylamino)-1-phenylpropyl)-4methylphenol and salts thereof
ES2604705T3 (es) 2010-03-31 2017-03-08 Ono Pharmaceutical Co., Ltd. Agente preventivo y/o remedio para el síndrome mano-pie
WO2012098044A1 (en) 2011-01-17 2012-07-26 Cambrex Profarmaco Milano S.R.L. Process for the preparation of n,n-diisopropyl-3-(2-hydroxy-5-methylphenyl)- 3-phenyl propylamine and its salts starting from a novel intermediate
EP2476665A1 (en) 2011-01-17 2012-07-18 Cambrex Profarmaco Milano S.r.l. Process for the preparation of N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)- 3-phenyl propylamine and its salts starting from a novel intermediate
CN102516098B (zh) * 2011-12-09 2014-06-18 北京联本医药化学技术有限公司 酒石酸托特罗定制备方法
CN103044274B (zh) * 2012-11-29 2014-10-22 珠海保税区丽珠合成制药有限公司 一种无溶剂合成酒石酸托特罗定的方法
GB201402556D0 (en) 2014-02-13 2014-04-02 Crystec Ltd Improvements relating to inhalable particles
CN110229072B (zh) * 2019-06-25 2022-04-08 中国药科大学 一种托特罗定及其对映体的合成方法

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Also Published As

Publication number Publication date
HUP0000527A2 (hu) 2001-11-28
NZ336533A (en) 2000-05-26
SK81599A3 (en) 1999-12-10
AU5956998A (en) 1998-07-31
HUP0000527A3 (en) 2001-12-28
AU717985B2 (en) 2000-04-06
KR100463614B1 (ko) 2004-12-29
KR20000069771A (ko) 2000-11-25
ES2186018T3 (es) 2003-05-01
JP2001507691A (ja) 2001-06-12
EP0960109B1 (en) 2002-10-30
CN1151141C (zh) 2004-05-26
DK0960109T3 (da) 2002-11-25
RU2176246C2 (ru) 2001-11-27
FI991477A7 (fi) 1999-06-29
NO317158B1 (no) 2004-08-30
SK283591B6 (sk) 2003-10-07
CN1238768A (zh) 1999-12-15
DE69716767D1 (de) 2002-12-05
FI991477L (fi) 1999-06-29
US5922914A (en) 1999-07-13
NO993247L (no) 1999-08-09
ATE226949T1 (de) 2002-11-15
NO993247D0 (no) 1999-06-29
CA2273789C (en) 2006-06-06
HK1023566A1 (en) 2000-09-15
EP0960109A1 (en) 1999-12-01
CZ227299A3 (cs) 1999-11-17
FI991477A0 (fi) 1999-06-29
CZ295477B6 (cs) 2005-08-17
CA2273789A1 (en) 1998-07-09
KR20000057548A (ko) 2000-09-25
PL334375A1 (en) 2000-02-28
WO1998029402A1 (en) 1998-07-09
JP4199310B2 (ja) 2008-12-17
PL191603B1 (pl) 2006-06-30
DE69716767T2 (de) 2003-06-12
PT960109E (pt) 2003-03-31

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