HUP0000527A3 - Process to prepare tolterodine and the intermediate - Google Patents
Process to prepare tolterodine and the intermediateInfo
- Publication number
- HUP0000527A3 HUP0000527A3 HU0000527A HUP0000527A HUP0000527A3 HU P0000527 A3 HUP0000527 A3 HU P0000527A3 HU 0000527 A HU0000527 A HU 0000527A HU P0000527 A HUP0000527 A HU P0000527A HU P0000527 A3 HUP0000527 A3 HU P0000527A3
- Authority
- HU
- Hungary
- Prior art keywords
- tolterodine
- prepare
- prepare tolterodine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
- C07D311/20—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 hydrogenated in the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C215/48—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups
- C07C215/54—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Pyrane Compounds (AREA)
- Optical Integrated Circuits (AREA)
- Saccharide Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3396196P | 1996-12-31 | 1996-12-31 | |
| PCT/US1997/022521 WO1998029402A1 (en) | 1996-12-31 | 1997-12-18 | Process to prepare tolterodine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0000527A2 HUP0000527A2 (hu) | 2001-11-28 |
| HUP0000527A3 true HUP0000527A3 (en) | 2001-12-28 |
Family
ID=21873473
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0000527A HUP0000527A3 (en) | 1996-12-31 | 1997-12-18 | Process to prepare tolterodine and the intermediate |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US5922914A (hu) |
| EP (1) | EP0960109B1 (hu) |
| JP (1) | JP4199310B2 (hu) |
| KR (2) | KR20000057548A (hu) |
| CN (1) | CN1151141C (hu) |
| AT (1) | ATE226949T1 (hu) |
| AU (1) | AU717985B2 (hu) |
| CA (1) | CA2273789C (hu) |
| CZ (1) | CZ295477B6 (hu) |
| DE (1) | DE69716767T2 (hu) |
| DK (1) | DK0960109T3 (hu) |
| ES (1) | ES2186018T3 (hu) |
| FI (1) | FI991477A0 (hu) |
| HU (1) | HUP0000527A3 (hu) |
| NO (1) | NO317158B1 (hu) |
| NZ (1) | NZ336533A (hu) |
| PL (1) | PL191603B1 (hu) |
| PT (1) | PT960109E (hu) |
| RU (1) | RU2176246C2 (hu) |
| SI (1) | SI0960109T1 (hu) |
| SK (1) | SK283591B6 (hu) |
| WO (1) | WO1998029402A1 (hu) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6310103B1 (en) * | 1996-07-19 | 2001-10-30 | Bridge Pharma, Inc. | S(−)-tolterodine in the treatment of urinary and gastrointestinal disorders |
| EP0957073A1 (en) | 1998-05-12 | 1999-11-17 | Schwarz Pharma Ag | Novel derivatives of 3,3-diphenylpropylamines |
| HUP0201623A3 (en) | 1999-07-01 | 2004-12-28 | Upjohn Co | Use of (s,s)reboxetine a selective norepinephrine reuptake inhibitor for the preparation of pharmaceutical compositions treating disorders of the nervous system |
| SE9904850D0 (sv) | 1999-12-30 | 1999-12-30 | Pharmacia & Upjohn Ab | Novel process and intermediates |
| US6566537B2 (en) | 1999-12-30 | 2003-05-20 | Pharmacia Ab | Process and intermediates |
| DE10028443C1 (de) * | 2000-06-14 | 2002-05-29 | Sanol Arznei Schwarz Gmbh | Verfahren zur Herstellung von 3,3-Diarylpropylaminen, (R,S)- und (R)-4-Phenyl-2-chromanon-6-carbonsäure sowie (R)-4-Phenyl-2-chromanon-carbonsäure-cinchonidinsalz und deren Verwendung zur Herstellung eines rechtsdrehenden Hydroxybenzylalkohols und von pharmazeutischen Zusammensetzungen |
| DE10033016A1 (de) * | 2000-07-07 | 2002-01-24 | Sanol Arznei Schwarz Gmbh | Verfahren zur Herstellung von 3,3-Diarylpropylaminen |
| PE20020547A1 (es) | 2000-10-24 | 2002-06-12 | Upjohn Co | Uso de la tolterodina en tratamientos del asma |
| US20030027856A1 (en) * | 2001-06-29 | 2003-02-06 | Aberg A.K. Gunnar | Tolterodine metabolites |
| IN191835B (hu) * | 2001-08-03 | 2004-01-10 | Ranbaxy Lab Ltd | |
| JP3981357B2 (ja) | 2001-10-26 | 2007-09-26 | ファルマシア・アンド・アップジョン・カンパニー・エルエルシー | 第４級アンモニウム化合物および抗ムスカリン剤としてのそれらの使用 |
| US7005449B2 (en) | 2002-04-23 | 2006-02-28 | Pharmacia & Upjohn Company | Tolterodine salts |
| EA200500173A1 (ru) | 2002-07-08 | 2005-08-25 | Рэнбакси Лабораториз Лимитед | Производные 3,6-дизамещенного азабицикло[3.1.0]гексана в качестве антагонистов мускариновых рецепторов |
| WO2004014853A1 (en) | 2002-07-31 | 2004-02-19 | Ranbaxy Laboratories Limited | 3,6-disubstituted azabicyclo [3.1.0]hexane derivatives useful as muscarinic receptor antagonists |
| EP1545508A4 (en) | 2002-08-09 | 2009-11-25 | Ranbaxy Lab Ltd | 3,6-DISUBSTITUTED AZABICYCLO ¬3.1.0 HEXANE DERIVATIVES AS USEFUL AS MUSCARINIC RECEPTOR AGONISTS |
| US7288562B2 (en) | 2002-08-23 | 2007-10-30 | Ranbaxy Laboratories Limited | Fluoro and sulphonylamino containing 3,6-disubstituted azabicyclo (3.1.0) hexane derivatives as muscarinic receptor antagonists |
| AU2003265680A1 (en) * | 2002-08-28 | 2004-03-19 | Pharmacia Corporation | Oral liquid tolterodine composition |
| JP2006518707A (ja) | 2002-12-10 | 2006-08-17 | ランバクシー ラボラトリーズ リミテッド | ムスカリン様受容体アンタゴニストとしての３，６−二置換アザビシクロ［３．１．０］ヘキサン誘導体 |
| AU2002347553A1 (en) | 2002-12-23 | 2004-07-14 | Ranbaxy Laboratories Limited | Flavaxate derivatives as muscarinic receptor antagonists |
| US7465751B2 (en) | 2002-12-23 | 2008-12-16 | Ranbaxy Laboratories Limited | 1-substituted-3-pyrrolidine derivatives as muscarinic receptor antagonists |
| US7488748B2 (en) | 2003-01-28 | 2009-02-10 | Ranbaxy Laboratories Limited | 3,6-Disubstituted azabicyclo hexane derivatives as muscarinic receptor antagonists |
| EP1603862A1 (en) * | 2003-03-06 | 2005-12-14 | Ranbaxy Laboratories Limited | 3,3-diarylpropylamine derivatives and processes for isolation thereof |
| US7393874B2 (en) * | 2003-04-08 | 2008-07-01 | Hetero Drugs Limited | Polymorphs of tolterodine tartrate |
| DE10315917A1 (de) * | 2003-04-08 | 2004-11-18 | Schwarz Pharma Ag | Hochreine Basen von 3,3-Diphenylpropylaminmonoestern |
| AU2003214520A1 (en) | 2003-04-09 | 2004-11-01 | Ranbaxy Laboratories Limited | Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists |
| WO2004089363A1 (en) | 2003-04-10 | 2004-10-21 | Ranbaxy Laboratories Limited | Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists |
| EP1615887A1 (en) | 2003-04-10 | 2006-01-18 | Ranbaxy Laboratories, Ltd. | Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists |
| AU2004228452A1 (en) | 2003-04-11 | 2004-10-21 | Ranbaxy Laboratories Limited | Azabicyclo derivatives as muscarinic receptor antagonists |
| ITMI20031354A1 (it) * | 2003-07-02 | 2005-01-03 | Istituto Di Chimica Biomolecolare D El Cnr Sezione | Sintesis enantioselettiva di composti enantiomericamente arricchiti. |
| ES2235648B1 (es) * | 2003-12-22 | 2006-11-01 | Ragactives, S.L. | Procedimiento para la obtencion de tolterodina. |
| KR101154023B1 (ko) * | 2003-12-24 | 2012-06-07 | 씨아이피엘에이 엘티디. | 톨테로딘, 그 조성물 및 용도, 그리고 그 제조방법 |
| EP1629834A1 (en) | 2004-08-27 | 2006-03-01 | KRKA, D.D., Novo Mesto | Sustained release pharmaceutical composition of tolterodine |
| ITMI20041920A1 (it) * | 2004-10-11 | 2005-01-11 | Chemi Spa | Processo per la preparazione di n, n-diisopropil-3-2-idrossi-5-metilfenil-3-fenil-propabammina |
| US7355077B2 (en) * | 2004-10-28 | 2008-04-08 | Dr. Reddy's Laboratories Limited | Process for preparing tolterodine |
| JP4513535B2 (ja) * | 2004-12-03 | 2010-07-28 | 住友化学株式会社 | トルテロジンの製造方法 |
| CA2590555A1 (en) * | 2005-01-10 | 2006-07-13 | Teva Pharmaceutical Industries Ltd. | Substantially pure tolterodine tartrate and process for preparing thereof |
| US7528267B2 (en) | 2005-08-01 | 2009-05-05 | Girindus America, Inc. | Method for enantioselective hydrogenation of chromenes |
| ES2268987B1 (es) * | 2005-08-05 | 2008-02-01 | Ragactives, S.L. | Procedimiento para la obtencion de 3,3-difenilpropilaminas. |
| WO2007039918A1 (en) * | 2005-10-06 | 2007-04-12 | Natco Pharma Limited | Novel process for the preparation of tolterodine |
| US20090221664A1 (en) | 2005-10-19 | 2009-09-03 | Abhijit Ray | Pharmaceutical compositions of muscarinic receptor antagonists |
| KR100686351B1 (ko) * | 2006-01-12 | 2007-02-22 | 주식회사 카이로제닉스 | 톨테로딘 라세미체의 제조방법 |
| ITMI20060110A1 (it) * | 2006-01-24 | 2007-07-25 | Dipharma Spa | Procedimento per la purificazione di tolterodina |
| DK2029567T3 (da) | 2006-05-24 | 2010-11-29 | Pfizer Ltd | Fremgangsmåde til frembringelse af benzopyran-2-ol-derivater |
| US7268257B1 (en) | 2006-05-31 | 2007-09-11 | Sumitomo Chemical Company, Limited | Process for producing tolterodine |
| CZ302585B6 (cs) * | 2007-02-26 | 2011-07-20 | Zentiva, A. S. | Krystalická sul 2-[(1R)-3-[bis(1-methylethyl)amino]-1-fenylpropyl]-4-methylfenolu s kyselinou (2R,3R)-2,3-dihydroxybutandiovou |
| US8486452B2 (en) * | 2007-07-20 | 2013-07-16 | Mylan Pharmaceuticals Inc. | Stabilized tolterodine tartrate formulations |
| WO2009019599A2 (en) | 2007-08-08 | 2009-02-12 | Themis Laboratories Private Limited | Extended release compositions comprising tolterodine |
| KR101188333B1 (ko) * | 2008-02-20 | 2012-10-09 | 에스케이케미칼주식회사 | 안정성이 우수하고 경피제로 유용한 톨테로딘 결정성산부가염 |
| US20090214665A1 (en) * | 2008-02-26 | 2009-08-27 | Lai Felix S | Controlled Release Muscarinic Receptor Antagonist Formulation |
| ITMI20082055A1 (it) * | 2008-11-19 | 2009-02-18 | Dipharma Francis Srl | Procedimento per la preparazione di (r)-tolterodina base libera |
| WO2010092500A2 (en) | 2009-02-12 | 2010-08-19 | Alembic Limited | A process for the preparation of tolterodine tartrate |
| WO2010094292A1 (en) * | 2009-02-17 | 2010-08-26 | Pharmathen S.A. | Improved process for the preparation of (r)-2-(3-diisopropylamino)-1-phenylpropyl)-4methylphenol and salts thereof |
| ES2604705T3 (es) | 2010-03-31 | 2017-03-08 | Ono Pharmaceutical Co., Ltd. | Agente preventivo y/o remedio para el síndrome mano-pie |
| WO2012098044A1 (en) | 2011-01-17 | 2012-07-26 | Cambrex Profarmaco Milano S.R.L. | Process for the preparation of n,n-diisopropyl-3-(2-hydroxy-5-methylphenyl)- 3-phenyl propylamine and its salts starting from a novel intermediate |
| EP2476665A1 (en) | 2011-01-17 | 2012-07-18 | Cambrex Profarmaco Milano S.r.l. | Process for the preparation of N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)- 3-phenyl propylamine and its salts starting from a novel intermediate |
| CN102516098B (zh) * | 2011-12-09 | 2014-06-18 | 北京联本医药化学技术有限公司 | 酒石酸托特罗定制备方法 |
| CN103044274B (zh) * | 2012-11-29 | 2014-10-22 | 珠海保税区丽珠合成制药有限公司 | 一种无溶剂合成酒石酸托特罗定的方法 |
| GB201402556D0 (en) | 2014-02-13 | 2014-04-02 | Crystec Ltd | Improvements relating to inhalable particles |
| CN110229072B (zh) * | 2019-06-25 | 2022-04-08 | 中国药科大学 | 一种托特罗定及其对映体的合成方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1169945A (en) * | 1966-08-25 | 1969-11-05 | Geistlich Soehne Ag | Pharmaceutical Compositions containing Diphenylalkyl-amine Derivatives |
| US5382600A (en) * | 1988-01-22 | 1995-01-17 | Pharmacia Aktiebolag | 3,3-diphenylpropylamines and pharmaceutical compositions thereof |
| SE8800207D0 (sv) * | 1988-01-22 | 1988-01-22 | Kabivitrum Ab | Nya aminer, deras anvendning och framstellning |
| NO179904C (no) * | 1992-09-04 | 1997-01-08 | Takeda Chemical Industries Ltd | Kondenserte heterocykliske forbindelser og deres anvendelse |
| RU2089539C1 (ru) * | 1994-04-05 | 1997-09-10 | Стерлитамакский нефтехимических завод | Способ получения 2,5-n,n'-(диметиламинометил)-1,4-гидрохинона |
-
1997
- 1997-11-21 KR KR1019990705269A patent/KR20000057548A/ko not_active Withdrawn
- 1997-12-18 NZ NZ336533A patent/NZ336533A/xx not_active IP Right Cessation
- 1997-12-18 PL PL334375A patent/PL191603B1/pl not_active IP Right Cessation
- 1997-12-18 SK SK815-99A patent/SK283591B6/sk not_active IP Right Cessation
- 1997-12-18 CZ CZ19992272A patent/CZ295477B6/cs not_active IP Right Cessation
- 1997-12-18 AT AT97954678T patent/ATE226949T1/de active
- 1997-12-18 CA CA002273789A patent/CA2273789C/en not_active Expired - Fee Related
- 1997-12-18 KR KR10-1999-7005910A patent/KR100463614B1/ko not_active Expired - Fee Related
- 1997-12-18 HU HU0000527A patent/HUP0000527A3/hu unknown
- 1997-12-18 WO PCT/US1997/022521 patent/WO1998029402A1/en active IP Right Grant
- 1997-12-18 PT PT97954678T patent/PT960109E/pt unknown
- 1997-12-18 US US08/993,257 patent/US5922914A/en not_active Expired - Lifetime
- 1997-12-18 CN CNB971801479A patent/CN1151141C/zh not_active Expired - Fee Related
- 1997-12-18 JP JP53003098A patent/JP4199310B2/ja not_active Expired - Fee Related
- 1997-12-18 ES ES97954678T patent/ES2186018T3/es not_active Expired - Lifetime
- 1997-12-18 FI FI991477A patent/FI991477A0/fi unknown
- 1997-12-18 DE DE69716767T patent/DE69716767T2/de not_active Expired - Lifetime
- 1997-12-18 AU AU59569/98A patent/AU717985B2/en not_active Ceased
- 1997-12-18 DK DK97954678T patent/DK0960109T3/da active
- 1997-12-18 RU RU99116356/04A patent/RU2176246C2/ru not_active IP Right Cessation
- 1997-12-18 SI SI9730426T patent/SI0960109T1/xx unknown
- 1997-12-18 EP EP97954678A patent/EP0960109B1/en not_active Expired - Lifetime
-
1999
- 1999-06-29 NO NO19993247A patent/NO317158B1/no not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA9A | Lapse of provisional patent protection due to relinquishment or protection considered relinquished |