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SG54120A1 - Hypoglycemic agent - Google Patents

Hypoglycemic agent

Info

Publication number
SG54120A1
SG54120A1 SG1996000975A SG1996000975A SG54120A1 SG 54120 A1 SG54120 A1 SG 54120A1 SG 1996000975 A SG1996000975 A SG 1996000975A SG 1996000975 A SG1996000975 A SG 1996000975A SG 54120 A1 SG54120 A1 SG 54120A1
Authority
SG
Singapore
Prior art keywords
group
hydrogen atom
hypoglycemic agent
formula
acyl group
Prior art date
Application number
SG1996000975A
Other languages
English (en)
Inventor
Kenji Arakawa
Kenji Tsujihara
Masanori Inamasu
Mitsuya Hongu
Nobuyuki Funami
Original Assignee
Tanabe Seiyaku Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co filed Critical Tanabe Seiyaku Co
Publication of SG54120A1 publication Critical patent/SG54120A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SG1996000975A 1992-11-12 1993-11-12 Hypoglycemic agent SG54120A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP30148592 1992-11-12
JP2877093 1993-02-18
JP3598893 1993-02-25

Publications (1)

Publication Number Publication Date
SG54120A1 true SG54120A1 (en) 1998-11-16

Family

ID=27286314

Family Applications (1)

Application Number Title Priority Date Filing Date
SG1996000975A SG54120A1 (en) 1992-11-12 1993-11-12 Hypoglycemic agent

Country Status (12)

Country Link
US (1) US5424406A (fr)
EP (1) EP0598359B1 (fr)
KR (1) KR100211438B1 (fr)
AT (1) ATE193828T1 (fr)
CA (1) CA2102591C (fr)
DE (1) DE69328856T2 (fr)
DK (1) DK0598359T3 (fr)
ES (1) ES2149186T3 (fr)
GR (1) GR3033594T3 (fr)
PT (1) PT598359E (fr)
SG (1) SG54120A1 (fr)
TW (1) TW283643B (fr)

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US5731292A (en) * 1992-11-12 1998-03-24 Tanabe Seiyaku Co., Ltd. Dihydrochalcone derivatives which are hypoglycemic agents
US5555329A (en) 1993-11-05 1996-09-10 Alliesignal Inc. Light directing optical structure
US5830873A (en) * 1994-05-11 1998-11-03 Tanabe Seiyaku Co., Ltd. Propiophenone derivative and a process for preparing the same
JP3059088B2 (ja) * 1995-11-07 2000-07-04 田辺製薬株式会社 プロピオフェノン誘導体およびその製法
EP0850948B1 (fr) * 1996-12-26 2002-04-24 Tanabe Seiyaku Co., Ltd. Dérivés de propiophénone et un procédé pour leur préparation
FR2765801B1 (fr) * 1997-07-08 2003-04-11 Oreal Utilisation de monoesters d'arbutine comme agent depigmentant
WO2001015706A1 (fr) 1999-08-27 2001-03-08 Ehrenkranz Joel R L Technique d'utilisation de derives de dihydrochalcone destinee a bloquer le transfert de glucose
PH12000002657B1 (en) * 1999-10-12 2006-02-21 Bristol Myers Squibb Co C-aryl glucoside SGLT2 inhibitors
US6515117B2 (en) 1999-10-12 2003-02-04 Bristol-Myers Squibb Company C-aryl glucoside SGLT2 inhibitors and method
US6555519B2 (en) * 2000-03-30 2003-04-29 Bristol-Myers Squibb Company O-glucosylated benzamide SGLT2 inhibitors and method
US6683056B2 (en) 2000-03-30 2004-01-27 Bristol-Myers Squibb Company O-aryl glucoside SGLT2 inhibitors and method
AU9025701A (en) * 2000-09-29 2002-04-15 Kissei Pharmaceutical Glucopyranosyloxybenzylbenzene derivatives and medicinal compositions containingthe same
WO2002044192A1 (fr) * 2000-11-30 2002-06-06 Kissei Pharmaceutical Co., Ltd. Derives de glucopyranosyloxybenzylbenzene, compositions medicinales contenant ces derives et produits intermediaires obtenus lors de l'elaboration de ces compositions
JP4035052B2 (ja) * 2000-12-28 2008-01-16 キッセイ薬品工業株式会社 グルコピラノシルオキシピラゾール誘導体及びその医薬用途
TWI255817B (en) * 2001-02-14 2006-06-01 Kissei Pharmaceutical Glucopyranosyloxybenzylbenzene derivatives and medicinal use thereof
WO2002068439A1 (fr) * 2001-02-26 2002-09-06 Kissei Pharmaceutical Co., Ltd. Derives de glycopyranosyloxypyrazole et utilisation medicinale de ceux-ci
ES2350084T3 (es) * 2001-02-27 2011-01-18 Kissei Pharmaceutical Co., Ltd. Derivados de glucopiranosiloxipirazol y uso médico de los mismos.
US6936590B2 (en) 2001-03-13 2005-08-30 Bristol Myers Squibb Company C-aryl glucoside SGLT2 inhibitors and method
EP1392326B1 (fr) * 2001-04-04 2009-09-09 Ortho-McNeil-Janssen Pharmaceuticals, Inc. Polytherapie comprenant des inhibiteurs de reabsorption du glucose et des modulateurs du recepteur x du retinoide
CA2442917C (fr) 2001-04-04 2011-02-01 Ortho-Mcneil Pharmaceutical, Inc. Polytherapie comprenant des inhibiteurs de reabsorption du glucose et des modulateurs ppar
TW200504021A (en) 2003-01-24 2005-02-01 Bristol Myers Squibb Co Substituted anilide ligands for the thyroid receptor
JP4130466B2 (ja) * 2003-08-01 2008-08-06 田辺三菱製薬株式会社 新規化合物
TW200521131A (en) * 2003-08-01 2005-07-01 Janssen Pharmaceutica Nv Substituted fused heterocyclic c-glycosides
US8785403B2 (en) 2003-08-01 2014-07-22 Mitsubishi Tanabe Pharma Corporation Glucopyranoside compound
RS20060320A (en) * 2003-08-01 2008-08-07 Janssen Pharmaceutica N.V., Substituted indazole-o-glucosides
US7094764B2 (en) * 2003-08-01 2006-08-22 Janssen Pharmaceutica N.V. Substituted benzimidazole-, Benztriazole-, and benzimidazolone-O-glucosides
US7129220B2 (en) * 2003-08-01 2006-10-31 Janssen Pharmaceutica N.V Substituted indole-O-glucosides
TW200606129A (en) 2004-07-26 2006-02-16 Chugai Pharmaceutical Co Ltd Novel cyclohexane derivative, its prodrug, its salt and diabetic therapeutic agent containing the same
TW200637869A (en) * 2005-01-28 2006-11-01 Chugai Pharmaceutical Co Ltd The spiroketal derivatives and the use as therapeutical agent for diabetes of the same
AR053329A1 (es) * 2005-01-31 2007-05-02 Tanabe Seiyaku Co Derivados de indol utiles como inhibidores de los transportadores de glucosa dependientes del sodio (sglt)
MY147375A (en) * 2005-01-31 2012-11-30 Mitsubishi Tanabe Pharma Corp Indole derivatives
TWI418556B (zh) * 2006-07-27 2013-12-11 Mitsubishi Tanabe Pharma Corp 吲哚衍生物
UY30730A1 (es) * 2006-12-04 2008-07-03 Mitsubishi Tanabe Pharma Corp Forma cristalina del hemihidrato de 1-(b (beta)-d-glucopiranosil) -4-metil-3-[5-(4-fluorofenil) -2-tienilmetil]benceno
JP5298025B2 (ja) * 2006-12-04 2013-09-25 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 抗糖尿病薬としてのチエニル含有グリコピラノシル誘導体
NO2200606T3 (fr) 2007-09-10 2018-03-24
CL2008003653A1 (es) 2008-01-17 2010-03-05 Mitsubishi Tanabe Pharma Corp Uso de un inhibidor de sglt derivado de glucopiranosilo y un inhibidor de dppiv seleccionado para tratar la diabetes; y composicion farmaceutica.
ES2526930T3 (es) 2008-05-22 2015-01-16 Astrazeneca Ab Método para el tratamiento de la hiperuricemia empleando un inhibidor de SGLT2 y composición que contiene el mismo
US9056850B2 (en) * 2008-10-17 2015-06-16 Janssen Pharmaceutica N.V. Process for the preparation of compounds useful as inhibitors of SGLT
US20110009347A1 (en) * 2009-07-08 2011-01-13 Yin Liang Combination therapy for the treatment of diabetes
CA2767258C (fr) 2009-07-10 2016-09-13 Janssen Pharmaceutica Nv Procede de cristallisation pour obtenir du 1-(?-d-glucopyranosyle)-4-methyl-3-[5-(4-fluorophenyle)-2-thienylmethyle] benzene
BR112012008939B1 (pt) * 2009-10-14 2021-06-22 Janssen Pharmaceutica Nv Processo para a preparação de compostos úteis como inibidores de sglt2
MX339570B (es) 2010-05-11 2016-05-31 Janssen Pharmaceutica Nv Formulaciones farmaceuticas que comprenden derivados de 1-(beta-d-glucopiranosil)-2-tienil-metilbenceno como inhibidores de transportadores de glucosa dependientes de sodio.
DK2697218T3 (en) 2011-04-13 2016-07-25 Janssen Pharmaceutica Nv PROCESS FOR THE PREPARATION OF COMPOUNDS useful as inhibitors of SGLT2
US9035044B2 (en) 2011-05-09 2015-05-19 Janssen Pharmaceutica Nv L-proline and citric acid co-crystals of (2S, 3R, 4R, 5S,6R)-2-(3-((5-(4-fluorophenyl)thiopen-2-yl)methyl)4-methylphenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
US9545610B2 (en) 2013-03-04 2017-01-17 Nova Chemicals (International) S.A. Complex comprising oxidative dehydrogenation unit
US20160033480A1 (en) * 2013-12-16 2016-02-04 Amy Huimeei Lo Immunovir and Components, Immunovir A, B, C, D Utility and Useful Processes
CN104193786A (zh) * 2014-08-05 2014-12-10 张家港威胜生物医药有限公司 一种新橙皮苷二氢查尔酮的合成方法
CN104447907A (zh) * 2015-01-14 2015-03-25 佛山市赛维斯医药科技有限公司 含硝基联苯双葡萄糖苷结构化合物、其制备方法和用途
CN104447905A (zh) * 2015-01-14 2015-03-25 佛山市赛维斯医药科技有限公司 一种含硝基苯和双o-葡萄糖苷衍生物、其制备方法和用途
CN104478969A (zh) * 2015-01-14 2015-04-01 佛山市赛维斯医药科技有限公司 含烷氧苯基噻唑基的o-半乳糖苷衍生物、其制备方法和用途
CN104478962A (zh) * 2015-01-15 2015-04-01 佛山市赛维斯医药科技有限公司 一类卤代苯基s-葡萄糖苷衍生物、其制备方法和用途
US20170071970A1 (en) 2015-09-15 2017-03-16 Janssen Pharmaceutica Nv Co-therapy comprising canagliflozin and phentermine for the treatment of obesity and obesity related disorders
KR101998087B1 (ko) * 2018-02-19 2019-07-09 충북대학교 산학협력단 토종다래 유래 신규 화합물 및 이의 용도
CA3105626A1 (fr) 2018-07-19 2020-01-23 Astrazeneca Ab Methodes de traitement de hfpef au moyen de dapagliflozine et compositions comprenant celle-ci
CN110078774A (zh) * 2019-04-25 2019-08-02 北京理工亘舒科技有限公司 一种非葡萄糖碳苷二氢查尔酮及其制备方法
TW202220672A (zh) 2020-07-27 2022-06-01 瑞典商阿斯特捷利康公司 用達格列淨治療慢性腎臟病之方法
AU2022251165A1 (en) 2021-04-01 2023-11-09 Astrazeneca Uk Limited Systems and methods for managing prediabetes with a gliflozin sodium-glucose cotransport 2 inhibitor pharmaceutical composition
CN118510504A (zh) 2022-01-26 2024-08-16 阿斯利康(瑞典)有限公司 用于在治疗糖尿病前期或降低发展2型糖尿病的风险中使用的达格列净

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Also Published As

Publication number Publication date
DK0598359T3 (da) 2000-07-31
PT598359E (pt) 2000-09-29
DE69328856T2 (de) 2000-12-07
ES2149186T3 (es) 2000-11-01
US5424406A (en) 1995-06-13
ATE193828T1 (de) 2000-06-15
KR940010997A (ko) 1994-06-20
EP0598359B1 (fr) 2000-06-14
TW283643B (fr) 1996-08-21
CA2102591A1 (fr) 1994-05-13
DE69328856D1 (de) 2000-07-20
EP0598359A1 (fr) 1994-05-25
GR3033594T3 (en) 2000-09-29
KR100211438B1 (ko) 1999-08-02
CA2102591C (fr) 2000-12-26

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