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SG11201600060VA - Orthogonal cas9 proteins for rna-guided gene regulation and editing - Google Patents

Orthogonal cas9 proteins for rna-guided gene regulation and editing

Info

Publication number
SG11201600060VA
SG11201600060VA SG11201600060VA SG11201600060VA SG11201600060VA SG 11201600060V A SG11201600060V A SG 11201600060VA SG 11201600060V A SG11201600060V A SG 11201600060VA SG 11201600060V A SG11201600060V A SG 11201600060VA SG 11201600060V A SG11201600060V A SG 11201600060VA
Authority
SG
Singapore
Prior art keywords
editing
rna
gene regulation
cas9 proteins
guided gene
Prior art date
Application number
SG11201600060VA
Inventor
George M Church
Kevin Esvelt
Prashant Mali
Original Assignee
Harvard College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard College filed Critical Harvard College
Publication of SG11201600060VA publication Critical patent/SG11201600060VA/en

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • C12N2310/00—Structure or type of the nucleic acid
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  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
SG11201600060VA 2013-07-10 2014-07-08 Orthogonal cas9 proteins for rna-guided gene regulation and editing SG11201600060VA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361844844P 2013-07-10 2013-07-10
PCT/US2014/045700 WO2015006294A2 (en) 2013-07-10 2014-07-08 Orthogonal cas9 proteins for rna-guided gene regulation and editing

Publications (1)

Publication Number Publication Date
SG11201600060VA true SG11201600060VA (en) 2016-02-26

Family

ID=52280701

Family Applications (3)

Application Number Title Priority Date Filing Date
SG11201600060VA SG11201600060VA (en) 2013-07-10 2014-07-08 Orthogonal cas9 proteins for rna-guided gene regulation and editing
SG10201800213VA SG10201800213VA (en) 2013-07-10 2014-07-08 Orthogonal cas9 proteins for rna-guided gene regulation and editing
SG10201913015XA SG10201913015XA (en) 2013-07-10 2014-07-08 Orthogonal cas9 proteins for rna-guided gene regulation and editing

Family Applications After (2)

Application Number Title Priority Date Filing Date
SG10201800213VA SG10201800213VA (en) 2013-07-10 2014-07-08 Orthogonal cas9 proteins for rna-guided gene regulation and editing
SG10201913015XA SG10201913015XA (en) 2013-07-10 2014-07-08 Orthogonal cas9 proteins for rna-guided gene regulation and editing

Country Status (12)

Country Link
US (4) US10329587B2 (en)
EP (2) EP3019204B1 (en)
JP (3) JP6718813B2 (en)
KR (2) KR102481330B1 (en)
CN (2) CN105517579B (en)
AU (4) AU2014287397B2 (en)
BR (1) BR112016000571B1 (en)
CA (2) CA3218040A1 (en)
IL (3) IL282489B (en)
RU (3) RU2704981C2 (en)
SG (3) SG11201600060VA (en)
WO (1) WO2015006294A2 (en)

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