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SG10201913656TA - Cells expressing chimeric activating receptors and chimeric stimulating receptors and uses thereof - Google Patents

Cells expressing chimeric activating receptors and chimeric stimulating receptors and uses thereof

Info

Publication number
SG10201913656TA
SG10201913656TA SG10201913656TA SG10201913656TA SG10201913656TA SG 10201913656T A SG10201913656T A SG 10201913656TA SG 10201913656T A SG10201913656T A SG 10201913656TA SG 10201913656T A SG10201913656T A SG 10201913656TA SG 10201913656T A SG10201913656T A SG 10201913656TA
Authority
SG
Singapore
Prior art keywords
receptors
chimeric
cells expressing
stimulating
activating
Prior art date
Application number
SG10201913656TA
Inventor
Hong Liu
Pengbo Zhang
Lucas Horan
Yiyang Xu
Binnaz K Staley
Lianxing Liu
Hongruo Yun
Original Assignee
Eureka Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eureka Therapeutics Inc filed Critical Eureka Therapeutics Inc
Publication of SG10201913656TA publication Critical patent/SG10201913656TA/en

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    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P35/00Antineoplastic agents
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    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14Blood; Artificial blood
    • A61K35/17Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61K40/10Cellular immunotherapy characterised by the cell type used
    • A61K40/11T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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    • C07K16/283Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
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    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C12N5/06Animal cells or tissues; Human cells or tissues
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SG10201913656TA 2017-04-26 2018-04-24 Cells expressing chimeric activating receptors and chimeric stimulating receptors and uses thereof SG10201913656TA (en)

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US201762490576P 2017-04-26 2017-04-26
US201762490580P 2017-04-26 2017-04-26
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SG10201913656TA SG10201913656TA (en) 2017-04-26 2018-04-24 Cells expressing chimeric activating receptors and chimeric stimulating receptors and uses thereof
SG11201909571S SG11201909571SA (en) 2017-04-26 2018-04-24 Cells expressing chimeric activating receptors and chimeric stimulating receptors and uses thereof
SG11201909541W SG11201909541WA (en) 2017-04-26 2018-04-24 Chimeric antibody/t-cell receptor constructs and uses thereof
SG10201913579WA SG10201913579WA (en) 2017-04-26 2018-04-24 Chimeric antibody/t-cell receptor constructs and uses thereof
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SG11201909541W SG11201909541WA (en) 2017-04-26 2018-04-24 Chimeric antibody/t-cell receptor constructs and uses thereof
SG10201913579WA SG10201913579WA (en) 2017-04-26 2018-04-24 Chimeric antibody/t-cell receptor constructs and uses thereof
SG10201913655UA SG10201913655UA (en) 2017-04-26 2018-04-24 Cells expressing chimeric activating receptors and chimeric stimulating receptors and uses thereof

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US (5) US20210093666A1 (en)
EP (2) EP3615567A4 (en)
JP (4) JP2020517287A (en)
KR (3) KR102762834B1 (en)
CN (2) CN110662547A (en)
AU (3) AU2018258046C1 (en)
CA (2) CA3059753A1 (en)
IL (4) IL270136B2 (en)
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SG (5) SG10201913656TA (en)
TW (4) TW201902936A (en)
WO (3) WO2018200583A1 (en)

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SG10201914069SA (en) 2015-05-18 2020-03-30 Tcr2 Therapeutics Inc Compositions and methods for tcr reprogramming using fusion proteins
CN109715668A (en) 2016-08-02 2019-05-03 T细胞受体治疗公司 For using fusion protein to carry out the composition and method of TCR reprogramming
EP3848392A1 (en) 2016-10-07 2021-07-14 TCR2 Therapeutics Inc. Compositions and methods for tcr reprogramming using fusion proteins
CA3044593A1 (en) 2016-11-22 2018-05-31 TCR2 Therapeutics Inc. Compositions and methods for tcr reprogramming using fusion proteins
SG10201913656TA (en) 2017-04-26 2020-03-30 Eureka Therapeutics Inc Cells expressing chimeric activating receptors and chimeric stimulating receptors and uses thereof
SG11202009525VA (en) 2018-03-30 2020-10-29 Eureka Therapeutics Inc Constructs targeting cd22 and uses thereof
CN112469440B (en) 2018-06-18 2024-09-06 优瑞科生物技术公司 Constructs targeting prostate-specific membrane antigen (PSMA) and uses thereof
JP2021530503A (en) * 2018-07-26 2021-11-11 ティーシーアール2 セラピューティクス インク. Compositions and Methods for Reprogramming TCRs Using Target-Specific Fusion Proteins
EP3670530A1 (en) * 2018-12-18 2020-06-24 Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft Cd22-specific t cell receptors and adoptive t cell therapy for treatment of b cell malignancies
CN111100199B (en) * 2018-12-29 2021-02-12 北京百普赛斯生物科技股份有限公司 Fluorescein labeled protein tetramer and preparation method and application thereof
CN113164626A (en) * 2019-01-14 2021-07-23 南京传奇生物科技有限公司 Chimeric receptor polypeptides and uses thereof
TWI754211B (en) * 2019-01-28 2022-02-01 大陸商上海藥明生物技術有限公司 Novel bispecific cd3/cd20 polypeptide complexes
CN113490689B (en) * 2019-02-01 2024-06-04 恺兴生命科技(上海)有限公司 TCR fusion proteins and cells expressing TCR fusion proteins
JP2022541332A (en) * 2019-07-26 2022-09-22 ヤンセン バイオテツク,インコーポレーテツド Proteins containing kallikrein-related peptidase 2 antigen-binding domains and uses thereof
EP4114861A4 (en) * 2020-03-02 2024-05-08 The Regents Of The University Of California Chimeric antigen receptors and related methods and compositions for the treatment of cancer
CN116194130A (en) * 2020-03-16 2023-05-30 南加利福尼亚大学 Novel antigen-binding domains and synthetic antigen receptors comprising these antigen-binding domains
JP2023518293A (en) 2020-03-20 2023-04-28 ライル・イミュノファーマ,インコーポレイテッド A novel recombinant cell surface marker
CA3173480A1 (en) * 2020-03-31 2021-10-07 Kathleen Boyle Modified b cells and methods of use thereof
EP4127188A4 (en) 2020-03-31 2024-08-21 Walking Fish Therapeutics MODIFIED B CELLS AND METHODS OF USE THEREOF
CN112830973B (en) * 2020-04-08 2022-11-01 苏州克睿基因生物科技有限公司 Chimeric polypeptides and uses thereof
BR112022021551A2 (en) 2020-04-28 2023-01-03 Lyell Immunopharma Inc METHODS TO CULTIVATE CELLS
WO2021223707A1 (en) * 2020-05-07 2021-11-11 华夏英泰(北京)生物技术有限公司 Improved chimera consisting of t-cell receptor and co-stimulatory molecules
KR20230058013A (en) * 2020-05-25 2023-05-02 브리스타 이뮤노테크 리미티드 Enhanced synthetic T cell receptor and antigen receptor
CN116348485A (en) 2020-07-17 2023-06-27 英研生物(英国)有限公司 Receptors that provide targeted co-stimulation for adoptive cell therapy
CN116761815A (en) * 2020-07-29 2023-09-15 优瑞科生物技术公司 T cells and chimeric stimulatory receptors and their applications
WO2022164959A1 (en) 2021-01-27 2022-08-04 Lyell Immunopharma, Inc. Improved immune cell therapy
AU2022227686A1 (en) 2021-02-25 2023-07-27 Lyell Immunopharma, Inc. Ror1 targeting chimeric antigen receptor
CN114957481A (en) * 2021-02-25 2022-08-30 华夏英泰(北京)生物技术有限公司 Dual-target STAR for CD19 and CD22
EP4298208A1 (en) 2021-02-25 2024-01-03 Lyell Immunopharma, Inc. Methods for culturing cells
JP2024510900A (en) 2021-02-25 2024-03-12 ライエル・イミュノファーマ・インコーポレイテッド Codon-optimized nucleotide sequence encoding AP-1 transcription factor
EP4347826A1 (en) 2021-06-02 2024-04-10 Lyell Immunopharma, Inc. Nr4a3-deficient immune cells and uses thereof
US11945876B2 (en) 2021-06-16 2024-04-02 Instil Bio (Uk) Limited Receptors providing targeted costimulation for adoptive cell therapy
WO2023288278A1 (en) 2021-07-16 2023-01-19 Instil Bio (Uk) Limited Chimeric molecules providing targeted costimulation for adoptive cell therapy
EP4377336A4 (en) * 2021-07-29 2025-07-16 Nantcell Inc MODIFIED T-CELL RECEPTORS FOR THE PREVENTION AND TREATMENT OF VIRUS INFECTIONS AND CANCER
EP4419544A1 (en) 2021-10-21 2024-08-28 Lyell Immunopharma, Inc. Enhanced immune cell therapy
US20230181644A1 (en) 2021-10-28 2023-06-15 Lyell Immunopharma, Inc. Methods of generating cells
EP4423145A1 (en) 2021-10-28 2024-09-04 Lyell Immunopharma, Inc. Methods for culturing cells expressing ror1-binding protein
KR20240112376A (en) 2021-10-28 2024-07-18 라이엘 이뮤노파마, 인크. Method for culturing cells expressing c-Jun
WO2023133540A1 (en) 2022-01-07 2023-07-13 Lyell Immunopharma, Inc. Il-12 affinity variants
CN114591443A (en) * 2022-03-07 2022-06-07 皖南医学院第一附属医院(皖南医学院弋矶山医院) A scTv-based chimeric receptor CSR and its application
EP4519304A1 (en) 2022-05-02 2025-03-12 The United States of America, as represented by The Secretary, Department of Health and Human Services Compositions targeting gpc2 and gpc3 and their use for treating solid tumors
JP2025516823A (en) 2022-05-19 2025-05-30 ライエル・イミュノファーマ・インコーポレイテッド Polynucleotides targeting NR4A3 and uses thereof
CN119790063A (en) 2022-07-22 2025-04-08 莱尔免疫制药股份有限公司 Immune cell therapy
WO2024064952A1 (en) 2022-09-23 2024-03-28 Lyell Immunopharma, Inc. Methods for culturing nr4a-deficient cells overexpressing c-jun
WO2024064958A1 (en) 2022-09-23 2024-03-28 Lyell Immunopharma, Inc. Methods for culturing nr4a-deficient cells
WO2024077174A1 (en) 2022-10-05 2024-04-11 Lyell Immunopharma, Inc. Methods for culturing nr4a-deficient cells
WO2024102954A1 (en) 2022-11-10 2024-05-16 Massachusetts Institute Of Technology Activation induced clipping system (aics)
WO2024148369A1 (en) 2023-01-07 2024-07-11 Lyell Immunopharma, Inc. Targeted il-12 affinity variants
WO2024182539A1 (en) 2023-02-28 2024-09-06 Lyell Immunopharma, Inc. Methods of culturing reprogrammed cells
WO2025006797A1 (en) 2023-06-27 2025-01-02 Lyell Immunopharma, Inc. Il-12 stability variants
WO2025024559A1 (en) 2023-07-24 2025-01-30 Strand Therapeutics Inc. Rna-based synthetic circuit for producing engineered immune cells for an extracorporeal cell therapy
EP4520346A1 (en) 2023-09-06 2025-03-12 Gyncentrum Sp. z o.o. Cells, methods and systems for use in the treatment of a cancer with dual-car-t
WO2025217398A1 (en) 2024-04-10 2025-10-16 Lyell Immunopharma, Inc. Methods for culturing cells with improved culture medium
WO2026006604A1 (en) 2024-06-26 2026-01-02 Lyell Immunopharma, Inc. Feeder cell replacement

Family Cites Families (149)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3753357A (en) 1970-12-14 1973-08-21 Ovitron Res Corp Method and apparatus for the preservation of cells and tissues
US4199022A (en) 1978-12-08 1980-04-22 The United States Of America As Represented By The Department Of Energy Method of freezing living cells and tissues with improved subsequent survival
US4559298A (en) 1982-11-23 1985-12-17 American National Red Cross Cryopreservation of biological materials in a non-frozen or vitreous state
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5567610A (en) 1986-09-04 1996-10-22 Bioinvent International Ab Method of producing human monoclonal antibodies and kit therefor
IL86278A (en) * 1988-05-04 2003-06-24 Yeda Res & Dev Endowing cells with antibody specificity using chimeric t cell receptor
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
US5858358A (en) 1992-04-07 1999-01-12 The United States Of America As Represented By The Secretary Of The Navy Methods for selectively stimulating proliferation of T cells
US6905680B2 (en) 1988-11-23 2005-06-14 Genetics Institute, Inc. Methods of treating HIV infected subjects
US6352694B1 (en) 1994-06-03 2002-03-05 Genetics Institute, Inc. Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells
US6534055B1 (en) 1988-11-23 2003-03-18 Genetics Institute, Inc. Methods for selectively stimulating proliferation of T cells
US5175384A (en) 1988-12-05 1992-12-29 Genpharm International Transgenic mice depleted in mature t-cells and methods for making transgenic mice
US5703055A (en) 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
US5399346A (en) 1989-06-14 1995-03-21 The United States Of America As Represented By The Department Of Health And Human Services Gene therapy
US5585362A (en) 1989-08-22 1996-12-17 The Regents Of The University Of Michigan Adenovirus vectors for gene therapy
US5229275A (en) 1990-04-26 1993-07-20 Akzo N.V. In-vitro method for producing antigen-specific human monoclonal antibodies
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
JP2938569B2 (en) 1990-08-29 1999-08-23 ジェンファーム インターナショナル,インコーポレイティド Method for producing xenogeneic immunoglobulin and transgenic mouse
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
DE69129154T2 (en) 1990-12-03 1998-08-20 Genentech, Inc., South San Francisco, Calif. METHOD FOR ENRICHING PROTEIN VARIANTS WITH CHANGED BINDING PROPERTIES
IL104570A0 (en) 1992-03-18 1993-05-13 Yeda Res & Dev Chimeric genes and cells transformed therewith
US5350674A (en) 1992-09-04 1994-09-27 Becton, Dickinson And Company Intrinsic factor - horse peroxidase conjugates and a method for increasing the stability thereof
GB9221657D0 (en) * 1992-10-15 1992-11-25 Scotgen Ltd Recombinant bispecific antibodies
US5585358A (en) 1993-07-06 1996-12-17 Yissum Research Development Corporation Of The Hebrew University Of Jerusalem Derivatives of valproic acid amides and 2-valproenoic acid amides, method of making and use thereof as anticonvulsant agents
US7175843B2 (en) 1994-06-03 2007-02-13 Genetics Institute, Llc Methods for selectively stimulating proliferation of T cells
US7067318B2 (en) 1995-06-07 2006-06-27 The Regents Of The University Of Michigan Methods for transfecting T cells
US6692964B1 (en) 1995-05-04 2004-02-17 The United States Of America As Represented By The Secretary Of The Navy Methods for transfecting T cells
AU6353596A (en) 1995-06-30 1997-02-05 Kobenhavns Universitet Recombinant antibodies from a phage display library, directed against a peptide-mhc complex
DE19544393A1 (en) 1995-11-15 1997-05-22 Hoechst Schering Agrevo Gmbh Synergistic herbicidal mixtures
WO2001029058A1 (en) 1999-10-15 2001-04-26 University Of Massachusetts Rna interference pathway genes as tools for targeted genetic interference
US6326193B1 (en) 1999-11-05 2001-12-04 Cambria Biosciences, Llc Insect control agent
AU784983B2 (en) 1999-12-15 2006-08-17 Genentech Inc. Shotgun scanning, a combinatorial method for mapping functional protein epitopes
US6867041B2 (en) 2000-02-24 2005-03-15 Xcyte Therapies, Inc. Simultaneous stimulation and concentration of cells
US7572631B2 (en) 2000-02-24 2009-08-11 Invitrogen Corporation Activation and expansion of T cells
US6797514B2 (en) 2000-02-24 2004-09-28 Xcyte Therapies, Inc. Simultaneous stimulation and concentration of cells
ES2302726T3 (en) 2000-02-24 2008-08-01 Invitrogen Corporation STIMULATION AND SIMULTANEOUS CONCENTRATION OF CELLS.
DK2857516T3 (en) 2000-04-11 2017-08-07 Genentech Inc Multivalent antibodies and uses thereof
WO2001096584A2 (en) 2000-06-12 2001-12-20 Akkadix Corporation Materials and methods for the control of nematodes
CA2425862C (en) 2000-11-07 2013-01-22 City Of Hope Cd19-specific redirected immune cells
CA2467633C (en) 2001-12-03 2012-03-27 Abgenix, Inc. Antibody categorization based on binding characteristics
US6992176B2 (en) 2002-02-13 2006-01-31 Technion Research & Development Foundation Ltd. Antibody having a T-cell receptor-like specificity, yet higher affinity, and the use of same in the detection and treatment of cancer, viral infection and autoimmune disease
US7446190B2 (en) 2002-05-28 2008-11-04 Sloan-Kettering Institute For Cancer Research Nucleic acids encoding chimeric T cell receptors
CA2488441C (en) 2002-06-03 2015-01-27 Genentech, Inc. Synthetic antibody phage libraries
EP1585767A2 (en) 2003-01-16 2005-10-19 Genentech, Inc. Synthetic antibody phage libraries
AU2004242845B2 (en) 2003-05-31 2011-06-02 Amgen Research (Munich) Gmbh Human-anti-human CD3 binding molecules
US7785903B2 (en) 2004-04-09 2010-08-31 Genentech, Inc. Variable domain library and uses
US20060034850A1 (en) 2004-05-27 2006-02-16 Weidanz Jon A Antibodies as T cell receptor mimics, methods of production and uses thereof
WO2006106905A1 (en) 2005-03-31 2006-10-12 Chugai Seiyaku Kabushiki Kaisha Process for production of polypeptide by regulation of assembly
KR20080032097A (en) 2005-06-20 2008-04-14 메다렉스, 인코포레이티드 CD19 antibody and uses thereof
US7612181B2 (en) 2005-08-19 2009-11-03 Abbott Laboratories Dual variable domain immunoglobulin and uses thereof
CN101316610A (en) 2005-09-22 2008-12-03 艾润·R·科恩 Immunogenic fragments of T cell receptor constant regions and peptides derived therefrom
EP1957531B1 (en) 2005-11-07 2016-04-13 Genentech, Inc. Binding polypeptides with diversified and consensus vh/vl hypervariable sequences
US20070237764A1 (en) 2005-12-02 2007-10-11 Genentech, Inc. Binding polypeptides with restricted diversity sequences
NZ572248A (en) 2006-04-28 2011-08-26 Delenex Therapeutics Ag Antibodies binding to the extracellular domain of the receptor tyrosine kinase alk
CA2651174A1 (en) 2006-05-03 2007-11-15 Government Of The United States Of America, Represented By The Secretary , Department Of Health And Human Services Chimeric t cell receptors and related materials and methods of use
AR060871A1 (en) 2006-05-09 2008-07-16 Genentech Inc UNION OF POLYPEPTIDES WITH OPTIMIZED SUPERCONTIGES
EP2026837A4 (en) 2006-06-01 2010-06-02 Receptor Logic Inc Antibodies as t cell receptor mimics, methods of production and uses thereof
EP2066349B1 (en) 2006-09-08 2012-03-28 MedImmune, LLC Humanized anti-cd19 antibodies and their use in treatment of tumors, transplantation and autoimmune diseases
CA2685675C (en) 2007-05-01 2016-02-16 Research Development Foundation Immunoglobulin fc libraries
CL2008001334A1 (en) 2007-05-08 2008-09-22 Genentech Inc ANTI-MUC16 ANTIBODY DESIGNED WITH CISTEINE; CONJUGADO THAT UNDERSTANDS IT; METHOD OF PRODUCTION; PHARMACEUTICAL FORMULATION THAT UNDERSTANDS IT; AND ITS USE TO TREAT CANCER.
CN100592373C (en) 2007-05-25 2010-02-24 群康科技(深圳)有限公司 Liquid crystal display panel driving device and driving method thereof
EA020327B1 (en) 2008-06-25 2014-10-30 Атеникс Корпорейшн Toxin genes and methods for their use
TWI580431B (en) 2008-08-19 2017-05-01 腫瘤療法 科學股份有限公司 HIG2 and URLC10 epitope peptides and vaccines containing the peptides
PE20100362A1 (en) 2008-10-30 2010-05-27 Irm Llc PURINE DERIVATIVES THAT EXPAND HEMATOPOYETIC STEM CELLS
WO2010059543A1 (en) 2008-11-20 2010-05-27 Merck Sharp & Dohme Corp. Generation and characterization of anti-notch antibodies for therapeutic and diagnostic use
US20100153133A1 (en) 2008-12-16 2010-06-17 International Business Machines Corporation Generating Never-Event Cohorts from Patient Care Data
US20110311517A1 (en) 2009-02-10 2011-12-22 Shenogen Pharma Group, Ltd. Antibodies and methods for treating estrogen receptor-associated diseases
EP2258719A1 (en) 2009-05-19 2010-12-08 Max-Delbrück-Centrum für Molekulare Medizin (MDC) Multiple target T cell receptor
CA2767767A1 (en) 2009-07-30 2011-02-03 Helmholtz-Zentrum Fuer Infektionsforschung Gmbh Compositions for generating an antigen specific immune response
CN102666576A (en) 2009-10-22 2012-09-12 里卡多·J·莫罗 Peptides that bind to alpha-fetoprotein (AFP) receptor and uses thereof
US9273283B2 (en) 2009-10-29 2016-03-01 The Trustees Of Dartmouth College Method of producing T cell receptor-deficient T cells expressing a chimeric receptor
PT2552959T (en) 2010-03-26 2017-04-21 Memorial Sloan Kettering Cancer Center MUC16 ANTIBODIES AND METHODS OF USE
WO2012050374A2 (en) 2010-10-13 2012-04-19 Innocell, Inc. Immunotherapy for solid tumors
EP2694553B1 (en) 2011-04-01 2017-10-11 Memorial Sloan-Kettering Cancer Center T cell receptor-like antibodies specific for a wt1 peptide presented by hla-a2
US10239952B2 (en) 2011-04-01 2019-03-26 Memorial Sloan Kettering Cancer Center Anti-WT1/HLA bi-specific antibody
US20130280220A1 (en) * 2012-04-20 2013-10-24 Nabil Ahmed Chimeric antigen receptor for bispecific activation and targeting of t lymphocytes
JP6286757B2 (en) 2012-04-23 2018-03-07 ジーンフロンティア株式会社 Anti-human CD69 antibody and pharmaceutical use thereof
CN103319595B (en) 2012-07-04 2016-12-28 中国药科大学 Anti-human AFP single-chain antibody and the preparation method and application of fused antigen peptide
WO2014011988A2 (en) 2012-07-13 2014-01-16 The Trustees Of The University Of Pennsylvania Enhancing activity of car t cells by co-introducing a bispecific antibody
US20150183877A1 (en) 2012-07-18 2015-07-02 Eli Lilly And Company Multi-Specific IgG-(Fab)2 Constructs Containing T-Cell Receptor Constant Domains
BR112015004522A2 (en) 2012-09-04 2017-11-21 Cellectis multi-chain chimeric antigen receptor and uses of these
NZ746914A (en) 2012-10-02 2020-03-27 Memorial Sloan Kettering Cancer Center Compositions and methods for immunotherapy
CN102993305B (en) 2012-11-16 2015-05-13 上海赛伦生物技术有限公司 Humanized anti-human epidemic growth factor receptor (EGFR) antibody as well as encoding gene and application thereof
HK1216153A1 (en) 2012-12-13 2016-10-21 University Of Virginia Patent Foundation Target peptides for ovarian cancer therapy and diagnostics
CN104968491A (en) 2013-02-06 2015-10-07 旭硝子株式会社 Transparent surface material and display device using same
CN103965362B (en) 2013-02-06 2019-02-01 上海细胞治疗集团有限公司 A kind of chimeric chemokine receptor for making T cell tend to tumor locus
WO2014134165A1 (en) 2013-02-26 2014-09-04 Memorial Sloan-Kettering Cancer Center Compositions and methods for immunotherapy
DK2970371T3 (en) 2013-03-14 2019-09-30 Agrivida Inc Use of dimerization domains for temperature regulation of enzyme activity
US9657105B2 (en) 2013-03-15 2017-05-23 City Of Hope CD123-specific chimeric antigen receptor redirected T cells and methods of their use
AU2014235968B2 (en) 2013-03-21 2018-05-24 Ospedale San Raffaele Srl Targeted disruption of T cell receptor genes using engineered zinc finger protein nucleases
KR101536668B1 (en) 2013-06-18 2015-07-15 사회복지법인 삼성생명공익재단 Antibodies cross-reactive to Human and Mouse c-Met and Uses thereof
GB201313377D0 (en) 2013-07-26 2013-09-11 Adaptimmune Ltd T cell receptors
EP3925618A1 (en) 2013-07-29 2021-12-22 2seventy bio, Inc. Multipartite signaling proteins and uses thereof
WO2015063069A1 (en) 2013-10-28 2015-05-07 Benjamin Felder Chimeric antigen receptors with antigen binding domains derived from gamma delta t cell receptors
EP3066130B1 (en) 2013-11-07 2019-05-15 Memorial Sloan-Kettering Cancer Center Anti-wt1/hla bi-specific antibody
CA2934033A1 (en) 2013-11-07 2015-05-14 Memorial Sloan-Kettering Cancer Center Fc-enhanced anti-wt1/hla antibody
AU2015222065B2 (en) * 2014-02-28 2021-05-20 IGI Therapeutics SA Expression constructs and methods for selecting host cells expressing polypeptides
CN104087592B (en) 2014-05-13 2016-01-27 天津医科大学总医院 AFP 158-166specificity TCR gene and transgenic T cells thereof and in-vitro multiplication method and purposes
RU2745705C2 (en) 2014-09-15 2021-03-30 МОЛМЕД СпА Chimeric antigen receptors
WO2016071343A1 (en) * 2014-11-03 2016-05-12 Immures S.R.L. T cell receptors
MY192062A (en) 2014-12-05 2022-07-25 Memorial Sloan Kettering Cancer Center Chimeric antigen receptors targeting fc receptor-like 5 and uses thereof
SG10201901707QA (en) 2014-12-05 2019-03-28 Memorial Sloan Kettering Cancer Center Antibodies targeting b-cell maturation antigen and methods of use
CA2969870A1 (en) 2014-12-05 2016-06-09 Memorial Sloan-Kettering Cancer Center Chimeric antigen receptors targeting b-cell maturation antigen and uses thereof
HUE057777T2 (en) 2014-12-05 2022-06-28 Memorial Sloan Kettering Cancer Center Chimeric antigen receptors targeting g-protein coupled receptor and uses thereof
WO2016090329A2 (en) 2014-12-05 2016-06-09 Memorial Sloan-Kettering Cancer Center Antibodies targeting g-protein coupled receptor and methods of use
WO2016142768A1 (en) 2015-03-10 2016-09-15 Eureka Therapeutics, Inc. Ror2 antibody
CN107667120B (en) 2015-03-17 2022-03-08 纪念斯隆-凯特林癌症中心 anti-MUC 16 antibodies and uses thereof
US10738116B2 (en) * 2015-03-19 2020-08-11 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Dual specific anti-CD22-anti-CD19 chimeric antigen receptors
WO2016154047A2 (en) 2015-03-20 2016-09-29 Memorial Sloan-Kettering Cancer Center Monoclonal antigen-binding proteins to intracellular oncogene products
WO2016161390A1 (en) 2015-04-03 2016-10-06 Eureka Therapeutics, Inc. Constructs targeting afp peptide/mhc complexes and uses thereof
JP2018516879A (en) 2015-05-08 2018-06-28 ユーリカ セラピューティックス, インコーポレイテッド Constructs targeting the HPV16-E7 peptide / MHC complex and uses thereof
SG10201914069SA (en) 2015-05-18 2020-03-30 Tcr2 Therapeutics Inc Compositions and methods for tcr reprogramming using fusion proteins
WO2016187220A2 (en) 2015-05-18 2016-11-24 Five Prime Therapeutics, Inc. Anti-ror1 antibodies
US20180147271A1 (en) 2015-05-18 2018-05-31 Bluebird Bio, Inc. Anti-ror1 chimeric antigen receptors
WO2016191246A2 (en) 2015-05-22 2016-12-01 Memorial Sloan-Kettering Cancer Center T cell receptor-like antibodies specific for a prame peptide
NL2014935B1 (en) 2015-06-08 2017-02-03 Applied Immune Tech Ltd T cell receptor like antibodies having fine specificity.
AU2016274767B2 (en) 2015-06-09 2022-05-19 Eureka Therapeutics, Inc. T cell receptor-like antibody agents specific for EBV latent membrane protein 2A peptide presented by human HLA
CN117387731A (en) 2015-06-12 2024-01-12 美蓓亚三美株式会社 Load detector and load detection system
TWI773647B (en) 2015-06-23 2022-08-11 史隆凱特林紀念癌症中心 Novel pd-1 immune modulating agents
EP3313873A4 (en) 2015-06-24 2019-04-24 Eureka Therapeutics, Inc. CONSTRUCTS TARGETING NY-ESO-1 / MHC PEPTIDE COMPLEXES AND USES THEREOF
WO2017004252A1 (en) 2015-06-30 2017-01-05 The Arizona Board Of Regents On Behalf Of The University Of Arizona Redirected cells with mhc chimeric receptors and methods of use in immunotherapy
US20200087400A1 (en) 2015-07-22 2020-03-19 Eureka Therapeutics, Inc. Constructs targeting psa peptide/mhc complexes and uses thereof
WO2017027392A1 (en) * 2015-08-07 2017-02-16 Novartis Ag Treatment of cancer using chimeric cd3 receptor proteins
CN105384825B (en) * 2015-08-11 2018-06-01 南京传奇生物科技有限公司 A kind of bispecific chimeric antigen receptor and its application based on single domain antibody
EP3347375B1 (en) 2015-09-10 2020-12-23 The United States of America, as represented by The Secretary, Department of Health and Human Services Anti-cd276 chimeric antigen receptors
MY201101A (en) 2015-09-17 2024-02-05 Novartis Ag Car t cell therapies with enhanced efficacy
CA3001910A1 (en) 2015-10-13 2017-04-20 Eureka Therapeutics, Inc. Antibody agents specific for human cd19 and uses thereof
SG10201913245UA (en) * 2015-10-23 2020-02-27 Eureka Therapeutics Inc Antibody/t-cell receptor chimeric constructs and uses thereof
CN105331585A (en) * 2015-11-13 2016-02-17 科济生物医药(上海)有限公司 Chimeric antigen receptor-modified immunologic effector cell with PD-L1 blocking agent
EP3383913A4 (en) 2015-12-04 2019-10-30 Memorial Sloan-Kettering Cancer Center ANTIBODIES TARGETING FC 5 RECEPTOR TYPE PROTEIN AND METHODS OF USE
CA3004491A1 (en) 2016-01-08 2017-07-13 The Regents Of The University Of California Conditionally active heterodimeric polypeptides and methods of use thereof
CN109069627A (en) 2016-01-14 2018-12-21 纪念斯隆-凯特琳癌症中心 To the T cell receptor sample antibody of the derivative peptide specific of FOXP3
CN109715668A (en) 2016-08-02 2019-05-03 T细胞受体治疗公司 For using fusion protein to carry out the composition and method of TCR reprogramming
WO2018057967A2 (en) 2016-09-23 2018-03-29 Eureka Therapeutics, Inc. Constructs targeting hiv peptide/mhc complexes and uses thereof
EP3848392A1 (en) 2016-10-07 2021-07-14 TCR2 Therapeutics Inc. Compositions and methods for tcr reprogramming using fusion proteins
CA3044593A1 (en) 2016-11-22 2018-05-31 TCR2 Therapeutics Inc. Compositions and methods for tcr reprogramming using fusion proteins
WO2018119298A1 (en) 2016-12-21 2018-06-28 TCR2 Therapeutics Inc. Engineered t cells for the treatment of cancer
WO2018148454A1 (en) 2017-02-09 2018-08-16 The Regents Of The University Of California Chimeric t cell antigen receptors and methods of use thereof
SG10201913582XA (en) 2017-04-26 2020-02-27 Eureka Therapeutics Inc Constructs specifically recognizing glypican 3 and uses thereof
SG10201913656TA (en) 2017-04-26 2020-03-30 Eureka Therapeutics Inc Cells expressing chimeric activating receptors and chimeric stimulating receptors and uses thereof
WO2018232020A1 (en) 2017-06-13 2018-12-20 TCR2 Therapeutics Inc. Compositions and methods for tcr reprogramming using fusion proteins
SG11202009525VA (en) 2018-03-30 2020-10-29 Eureka Therapeutics Inc Constructs targeting cd22 and uses thereof
CN112469440B (en) 2018-06-18 2024-09-06 优瑞科生物技术公司 Constructs targeting prostate-specific membrane antigen (PSMA) and uses thereof
KR20210101235A (en) 2018-11-16 2021-08-18 메모리얼 슬로안 케터링 캔서 센터 Antibodies to mucin-16 and methods of use thereof
EP3966248A4 (en) 2019-05-08 2023-04-12 Memorial Sloan Kettering Cancer Center HUMANIZED ANTIBODIES TO MUCIN-16 AND METHODS OF USE THEREOF
CA3148646A1 (en) 2019-07-24 2021-01-28 Eureka Therapeutics, Inc. Cells expressing chimeric antigen receptors and chimeric stimulating receptors and uses thereof
CN116761815A (en) 2020-07-29 2023-09-15 优瑞科生物技术公司 T cells and chimeric stimulatory receptors and their applications

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