SE466259B - Protein d - ett igd-bindande protein fraan haemophilus influenzae, samt anvaendning av detta foer analys, vacciner och uppreningsaendamaal - Google Patents

Protein d - ett igd-bindande protein fraan haemophilus influenzae, samt anvaendning av detta foer analys, vacciner och uppreningsaendamaal

Info

Publication number: SE466259B
Authority: SE; Sweden
Prior art keywords: protein; igd; variants; molecular weight; influenzae
Prior art date: 1990-05-31

Application number

SE9001949A

Other languages

English (en)

Swedish (sv)

Other versions

SE9001949L (sv

SE9001949D0 (sv

Inventor

Arne Forsgren

Original Assignee

Arne Forsgren

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-05-31

Filing date

1990-05-31

Publication date

1992-01-20

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=20379641&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SE466259(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1990-05-31 Publication of SE9001949D0 publication Critical patent/SE9001949D0/xx

1990-05-31 Priority to SE9001949A priority Critical patent/SE466259B/sv

1990-05-31 Application filed by Arne Forsgren filed Critical Arne Forsgren

1991-02-21 Priority to AU75593/91A priority patent/AU650011B2/en

1991-02-21 Priority to DE122009000059C priority patent/DE122009000059I1/de

1991-02-21 Priority to EP91907067A priority patent/EP0594610B1/en

1991-02-21 Priority to PCT/SE1991/000129 priority patent/WO1991018926A1/en

1991-02-21 Priority to DE200912000060 priority patent/DE122009000060I1/de

1991-02-21 Priority to AT91907067T priority patent/ATE170531T1/de

1991-02-21 Priority to DE69130116T priority patent/DE69130116T2/de

1991-02-21 Priority to DK91907067T priority patent/DK0594610T3/da

1991-02-21 Priority to JP3506522A priority patent/JP3066072B2/ja

1991-02-21 Priority to ES91907067T priority patent/ES2119776T3/es

1991-02-21 Priority to CA002083172A priority patent/CA2083172C/en

1991-12-01 Publication of SE9001949L publication Critical patent/SE9001949L/

1992-01-20 Publication of SE466259B publication Critical patent/SE466259B/sv

1992-11-24 Priority to NO924507A priority patent/NO309721B1/no

1992-11-30 Priority to FI925460A priority patent/FI109029B/fi

1996-11-12 Priority to US08/747,381 priority patent/US5989828A/en

1997-09-25 Priority to US08/936,912 priority patent/US5888517A/en

1997-11-05 Priority to US08/968,885 priority patent/US5858677A/en

1997-11-13 Priority to US08/969,761 priority patent/US6025484A/en

1999-01-06 Priority to US09/225,443 priority patent/US6139846A/en

2000-06-30 Priority to US09/607,933 priority patent/US7115271B1/en

2000-07-20 Priority to NO20003716A priority patent/NO322330B1/no

2006-09-15 Priority to US11/521,598 priority patent/US7666621B2/en

2008-10-02 Priority to US12/285,368 priority patent/USRE41277E1/en

2009-09-24 Priority to LU91609C priority patent/LU91609I2/fr

2009-09-24 Priority to NO2009022C priority patent/NO2009022I1/no

2009-09-24 Priority to NO2009021C priority patent/NO2009021I1/no

2009-09-24 Priority to LU91610C priority patent/LU91610I2/fr

2009-09-24 Priority to NL300409C priority patent/NL300409I2/nl

2009-09-24 Priority to NL300410C priority patent/NL300410I1/nl

2010-01-29 Priority to US12/696,733 priority patent/US20100209905A1/en

Links

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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/102—Pasteurellales, e.g. Actinobacillus, Pasteurella; Haemophilus
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/285—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pasteurellaceae (F), e.g. Haemophilus influenza
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
- C07K16/1242—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Pasteurellaceae (F), e.g. Haemophilus influenza
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/705—Fusion polypeptide containing domain for protein-protein interaction containing a protein-A fusion
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/11—Automated chemical analysis
- Y10T436/115831—Condition or time responsive
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Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Communicable Diseases (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Immunology (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Gastroenterology & Hepatology (AREA)
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Mycology (AREA)
Epidemiology (AREA)
Pulmonology (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

SE9001949A 1990-05-31 1990-05-31 Protein d - ett igd-bindande protein fraan haemophilus influenzae, samt anvaendning av detta foer analys, vacciner och uppreningsaendamaal SE466259B (sv)

Priority Applications (30)

Application Number	Priority Date	Filing Date	Title
SE9001949A SE466259B (sv)	1990-05-31	1990-05-31	Protein d - ett igd-bindande protein fraan haemophilus influenzae, samt anvaendning av detta foer analys, vacciner och uppreningsaendamaal
ES91907067T ES2119776T3 (es)	1990-05-31	1991-02-21	Proteina d- una proteina que une igd de haemophilus influenzae.
CA002083172A CA2083172C (en)	1990-05-31	1991-02-21	Protein d - an igd-binding protein of haemophilus influenzae
DE69130116T DE69130116T2 (de)	1990-05-31	1991-02-21	Protein d- ein igd-bindendes protein von haemophilus influenzae
DK91907067T DK0594610T3 (da)	1990-05-31	1991-02-21	Protein D - et lgD-bindende protein fra Haemophilus influenzae
EP91907067A EP0594610B1 (en)	1990-05-31	1991-02-21	PROTEIN D - AN IgD-BINDING PROTEIN OF HAEMOPHILUS INFLUENZAE
PCT/SE1991/000129 WO1991018926A1 (en)	1990-05-31	1991-02-21	PROTEIN D - AN IgD-BINDING PROTEIN OF HAEMOPHILUS INFLUENZAE
DE200912000060 DE122009000060I1 (de)	1990-05-31	1991-02-21	Protein D-ein IGD-Bindendes protein von haemophilus influenzae.
AT91907067T ATE170531T1 (de)	1990-05-31	1991-02-21	Protein d- ein igd-bindendes protein von haemophilus influenzae
AU75593/91A AU650011B2 (en)	1990-05-31	1991-02-21	Protein D - an IgD-binding protein of haemophilus influenzae
DE122009000059C DE122009000059I1 (de)	1990-05-31	1991-02-21	Protein d- ein igd-bindendes protein von haemophilus influenzae
JP3506522A JP3066072B2 (ja)	1990-05-31	1991-02-21	タンパク質Ｄ―インフルエンザ菌のＩｇＤ結合タンパク質
NO924507A NO309721B1 (no)	1990-05-31	1992-11-24	Fremgangsmåte for fremstilling av et terapeutisk aktivt protein D fra Haemophilus influenzae, DNA-sekvens, rekombinant DNA- molekyl, samt ikke-human vertscelle som er i stand til å produsere et protein av Haemophilus influenzae eller beslektede H
FI925460A FI109029B (fi)	1990-05-31	1992-11-30	Menetelmä Haemophilus influenzaen tai siihen liittyvissä Haemophiluslajien kannoissa esiintyvän pintaproteiinin valmistamiseksi
US08/747,381 US5989828A (en)	1990-05-31	1996-11-12	Protein D-an IgD binding protein of Haemophilus influenzae
US08/936,912 US5888517A (en)	1990-05-31	1997-09-25	Protein D-an IgD-binding protein of Haemophilus influenzae
US08/968,885 US5858677A (en)	1990-05-31	1997-11-05	Protein D--an IgD-binding protein of haemophilus influenzae
US08/969,761 US6025484A (en)	1990-05-31	1997-11-13	Protein D--an IgD-binding protein ofhaemophilus influenzae
US09/225,443 US6139846A (en)	1990-05-31	1999-01-06	Protein D- an IGD-binding protein of haemophilus influenzae
US09/607,933 US7115271B1 (en)	1990-05-31	2000-06-30	Protein D—an IgD-binding protein of Haemophilus influenzae
NO20003716A NO322330B1 (no)	1990-05-31	2000-07-20	Protein D fra Haemophilus influenzae eller beslektede Haemophilus-arter for anvendelse in vitro, et renset antistoff som binder proteinet, samt anvendelser derav.
US11/521,598 US7666621B2 (en)	1990-05-31	2006-09-15	Methods of producing recombinant protein D
US12/285,368 USRE41277E1 (en)	1990-05-31	2008-10-02	Protein D—an IGD binding protein of Haemophilus influenzae
NL300410C NL300410I1 (nl)	1990-05-31	2009-09-24	Proteïne D - een IgD-bindend eiwit van Haemophilusinfluenzae
NL300409C NL300409I2 (nl)	1990-05-31	2009-09-24	Proteïne D - een IgD-bindend eiwit van Haemophilusinfluenzae
LU91610C LU91610I2 (fr)	1990-05-31	2009-09-24	Protéine D et ses dérivés pharmaceutiquement acceptables (SYNFLORIX - Vaccin pneumococcique polysaccharidique conjugé (adsorbé)
LU91609C LU91609I2 (fr)	1990-05-31	2009-09-24	Sérotype pneumococcique polysaccharidique 1,4,5,6B,7F,9V,14 et 23F conjugé aux protéines D (dérivé du non-typable Haemophilus influenzae); Sérotype pneumococcique polysaccaridique 18C conjugé au transporteur anatoxine tétanique protéines; Sérotype pneumococcique polysaccharidique 19F conjugé au transporteur anatoxine diphtérique protéines (SYNFLORIX - Vaccin pneumococcique polysaccharidique conjugé (adsorbé)
NO2009021C NO2009021I1 (no)	1990-05-31	2009-09-24	Protein D
NO2009022C NO2009022I1 (no)	1990-05-31	2009-09-24	Protein-D ; Se annet dokument (det siste)
US12/696,733 US20100209905A1 (en)	1990-05-31	2010-01-29	Protein d - an igd-binding protein of haemophilus influenzae

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
SE9001949A SE466259B (sv)	1990-05-31	1990-05-31	Protein d - ett igd-bindande protein fraan haemophilus influenzae, samt anvaendning av detta foer analys, vacciner och uppreningsaendamaal

Publications (3)

Publication Number	Publication Date
SE9001949D0 SE9001949D0 (sv)	1990-05-31
SE9001949L SE9001949L (sv)	1991-12-01
SE466259B true SE466259B (sv)	1992-01-20

Family

ID=20379641

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SE9001949A SE466259B (sv)	1990-05-31	1990-05-31	Protein d - ett igd-bindande protein fraan haemophilus influenzae, samt anvaendning av detta foer analys, vacciner och uppreningsaendamaal

Country Status (15)

Country	Link
US (9)	US5989828A (no)
EP (1)	EP0594610B1 (no)
JP (1)	JP3066072B2 (no)
AT (1)	ATE170531T1 (no)
AU (1)	AU650011B2 (no)
CA (1)	CA2083172C (no)
DE (3)	DE69130116T2 (no)
DK (1)	DK0594610T3 (no)
ES (1)	ES2119776T3 (no)
FI (1)	FI109029B (no)
LU (2)	LU91609I2 (no)
NL (2)	NL300409I2 (no)
NO (4)	NO309721B1 (no)
SE (1)	SE466259B (no)
WO (1)	WO1991018926A1 (no)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
USRE41277E1 (en)	1990-05-31	2010-04-27	Arne Forsgren	Protein D—an IGD binding protein of Haemophilus influenzae

Families Citing this family (293)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE9201331D0 (sv) *	1992-04-28	1992-04-28	Hightech Receptor C O Active	Protein l och hybridproteiner daerav
US6153406A (en) *	1993-07-23	2000-11-28	North American Vaccine, Inc.	Method for the high level expression, purification and refolding of the outer membrane protein P2 from Haemophilus influenzae type B
US6001564A (en) *	1994-09-12	1999-12-14	Infectio Diagnostic, Inc.	Species specific and universal DNA probes and amplification primers to rapidly detect and identify common bacterial pathogens and associated antibiotic resistance genes from clinical specimens for routine diagnosis in microbiology laboratories
US20020055101A1 (en)	1995-09-11	2002-05-09	Michel G. Bergeron	Specific and universal probes and amplification primers to rapidly detect and identify common bacterial pathogens and antibiotic resistance genes from clinical specimens for routine diagnosis in microbiology laboratories
WO1996032963A1 (en) *	1995-04-17	1996-10-24	Henry M. Jackson Foundation For The Advancement Of Military Medicine	Induction and enhancement of the immune response to polysaccharides with bacterial lipoproteins
US5994066A (en) *	1995-09-11	1999-11-30	Infectio Diagnostic, Inc.	Species-specific and universal DNA probes and amplification primers to rapidly detect and identify common bacterial pathogens and associated antibiotic resistance genes from clinical specimens for routine diagnosis in microbiology laboratories
US20030049636A1 (en)	1999-05-03	2003-03-13	Bergeron Michel G.	Species-specific, genus-specific and universal DNA probes and amplification primers to rapidly detect and identify common bacterial and fungal pathogens and associated antibiotic resistance genes from clinical specimens for diagnosis in microbiology laboratories
US20100267012A1 (en)	1997-11-04	2010-10-21	Bergeron Michel G	Highly conserved genes and their use to generate probes and primers for detection of microorganisms
US20050033022A1 (en) *	1997-09-26	2005-02-10	Smithkline Beecham Biologicals Sa	Fusion proteins comprising HIV-1 Tat and/or Nef proteins
GB9727262D0 (en) *	1997-12-24	1998-02-25	Smithkline Beecham Biolog	Vaccine
CA2319309C (en) *	1998-02-05	2010-08-10	Smithkline Beecham Biologicals S.A.	Tumor-associated antigen derivatives from the mage family, and nucleic acid sequences encoding them, used for the preparation of fusion proteins and of compositions for vaccination
US6482597B1 (en)	1999-12-17	2002-11-19	Corixa Corporation	Compounds and methods for therapy and diagnosis of lung cancer
US6960570B2 (en)	1998-03-18	2005-11-01	Corixa Corporation	Compositions and methods for the therapy and diagnosis of lung cancer
US6312695B1 (en)	1998-03-18	2001-11-06	Corixa Corporation	Compounds and methods for therapy of lung cancer
US6821518B1 (en)	1998-03-18	2004-11-23	Corixa Corporation	Compounds and methods for therapy and diagnosis of lung cancer
US7049063B2 (en)	1998-03-18	2006-05-23	Corixa Corporation	Methods for diagnosis of lung cancer
US6426072B1 (en)	2000-08-02	2002-07-30	Corixa Corporation	Compositions and methods for the therapy and diagnosis of lung cancer
US7579160B2 (en)	1998-03-18	2009-08-25	Corixa Corporation	Methods for the detection of cervical cancer
US6531315B1 (en)	1998-03-18	2003-03-11	Corixa Corporation	Compositions and methods for the therapy and diagnosis of lung cancer
US6706262B1 (en)	1998-03-18	2004-03-16	Corixa Corporation	Compounds and methods for therapy and diagnosis of lung cancer
US6696247B2 (en)	1998-03-18	2004-02-24	Corixa Corporation	Compounds and methods for therapy and diagnosis of lung cancer
US6660838B1 (en)	1998-03-18	2003-12-09	Corixa Corporation	Compounds and methods for therapy and diagnosis of lung cancer
US7258860B2 (en)	1998-03-18	2007-08-21	Corixa Corporation	Compositions and methods for the therapy and diagnosis of lung cancer
US6737514B1 (en)	1998-12-22	2004-05-18	Corixa Corporation	Compositions and methods for the therapy and diagnosis of lung cancer
US20020147143A1 (en)	1998-03-18	2002-10-10	Corixa Corporation	Compositions and methods for the therapy and diagnosis of lung cancer
US6518256B1 (en)	1998-03-18	2003-02-11	Corixa Corporation	Compounds and methods for therapy and diagnosis of lung cancer
US6342231B1 (en)	1998-07-01	2002-01-29	Akzo Nobel N.V.	Haemophilus parasuis vaccine and diagnostic
KR20010085348A (ko)	1998-08-07	2001-09-07	추후보정	면역능을 갖는 헤르페스 심플렉스 바이러스 항원 및 이를이용하는 방법
US20030235557A1 (en)	1998-09-30	2003-12-25	Corixa Corporation	Compositions and methods for WT1 specific immunotherapy
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US7198920B1 (en)	1999-01-29	2007-04-03	Corika Corporation	HER-2/neu fusion proteins
CA2363118A1 (en) *	1999-02-25	2000-08-31	Smithkline Beecham Biologicals S.A.	Immunogens comprising a peptide and a carrier derived from h.influenzae protein d
DE122009000054I1 (de)	1999-03-19	2009-12-31	Glaxosmithkline Biolog Sa	Impfstoff gegen bakterielle antigene
GB9909077D0 (en)	1999-04-20	1999-06-16	Smithkline Beecham Biolog	Novel compositions
BR0009505A (pt)	1999-04-02	2002-06-11	Corixa Corp	Compostos e processos para terapia e diagnóstico de câncer de pulmão
US20040040205A1 (en) *	2002-04-25	2004-03-04	Weder Donald E.	Wrapper with decorative extension and method
AU7636000A (en)	1999-09-28	2001-04-30	Infectio Diagnostic (I.D.I.) Inc.	Highly conserved genes and their use to generate species- specific, genus-specific, family-specific, group-specific and universal nucleic acid probes and amplification primers to rapidly detect and identify algal, archaeal, bacterial fungal and parasitical microorganisms from clinical specimens for diagnosis
SI1265915T1 (sl)	2000-02-23	2011-02-28	Glaxosmithkline Biolog Sa	Nove spojine
US20040002068A1 (en)	2000-03-01	2004-01-01	Corixa Corporation	Compositions and methods for the detection, diagnosis and therapy of hematological malignancies
ATE389020T1 (de)	2000-04-21	2008-03-15	Corixa Corp	Verbindungen und verfahren zur behandlung und diagnose von chlamydia-infektionen
JP5139618B2 (ja)	2000-06-20	2013-02-06	コリクサコーポレイション	Ｍｙｃｏｂａｃｔｅｒｉｕｍｔｕｂｅｒｃｕｌｏｓｉｓの融合タンパク質
WO2002000174A2 (en)	2000-06-28	2002-01-03	Corixa Corporation	Compositions and methods for the therapy and diagnosis of lung cancer
CN1449293B (zh)	2000-06-29	2012-08-22	史密丝克莱恩比彻姆生物有限公司	多价疫苗组合物
GB0108364D0 (en)	2001-04-03	2001-05-23	Glaxosmithkline Biolog Sa	Vaccine composition
US7713544B2 (en) *	2000-07-28	2010-05-11	Emory University	Biological component comprising artificial membrane
US7229623B1 (en)	2000-08-03	2007-06-12	Corixa Corporation	Her-2/neu fusion proteins
GB0022742D0 (en)	2000-09-15	2000-11-01	Smithkline Beecham Biolog	Vaccine
GB0025171D0 (en) *	2000-10-13	2000-11-29	Smithkline Beecham Biolog	Novel compounds
US20050019340A1 (en)	2000-10-18	2005-01-27	Nathalie Garcon	Vaccines
GB0025998D0 (en) *	2000-10-24	2000-12-13	Smithkline Beecham Biolog	Novel compounds
US7082569B2 (en)	2001-01-17	2006-07-25	Outlooksoft Corporation	Systems and methods providing dynamic spreadsheet functionality
AU2002304681A1 (en) *	2001-04-30	2002-11-11	Glaxosmithkline Biologicals S.A.	Haemophilus influenzae antigens
WO2002089747A2 (en)	2001-05-09	2002-11-14	Corixa Corporation	Compositions and methods for the therapy and diagnosis of prostate cancer
JP2003047482A (ja) *	2001-05-22	2003-02-18	Pfizer Prod Inc	非アナフィラキシー誘発性ＩｇＥワクチン
MXPA04005382A (es) *	2001-11-07	2005-02-24	Mannkind Corp	Vectores de expresion que codifican epitopes de antigenos asociados al objetivo y metodos para su diseno.
CA2476755C (en)	2001-12-17	2014-08-26	Corixa Corporation	Compositions and methods for the therapy and diagnosis of inflammatory bowel disease
CA2492598C (en)	2002-07-18	2013-12-17	University Of Washington	Rapid, efficient purification of hsv-specific t-lymphocytes and hsv antigens identified via same
EP1549338B1 (en)	2002-10-11	2010-12-22	Novartis Vaccines and Diagnostics S.r.l.	Polypeptide-vaccines for broad protection against hypervirulent meningococcal lineages
GB0227346D0 (en)	2002-11-22	2002-12-31	Chiron Spa	741
US7960522B2 (en)	2003-01-06	2011-06-14	Corixa Corporation	Certain aminoalkyl glucosaminide phosphate compounds and their use
RU2389732C2 (ru)	2003-01-06	2010-05-20	Корикса Корпорейшн	Некоторые аминоалкилглюкозаминидфосфатные производные и их применение
ES2383175T3 (es)	2003-01-30	2012-06-18	Novartis Ag	Vacunas inyectables contra múltiples serogrupos de meningococos
GB0313916D0 (en)	2003-06-16	2003-07-23	Glaxosmithkline Biolog Sa	Vaccine composition
GB0321615D0 (en)	2003-09-15	2003-10-15	Glaxo Group Ltd	Improvements in vaccination
PL1670506T3 (pl)	2003-10-02	2013-04-30	Novartis Ag	Płynne szczepionki przeciw wielu grupom serologicznym meningokoków
GB0323103D0 (en)	2003-10-02	2003-11-05	Chiron Srl	De-acetylated saccharides
JP2005112827A (ja) *	2003-10-10	2005-04-28	National Institute Of Advanced Industrial & Technology	抗体アフィニティ担体
GB0406013D0 (en)	2004-03-17	2004-04-21	Chiron Srl	Analysis of saccharide vaccines without interference
GB0409745D0 (en)	2004-04-30	2004-06-09	Chiron Srl	Compositions including unconjugated carrier proteins
GB0411387D0 (en)	2004-05-21	2004-06-23	Chiron Srl	Analysis of saccharide length
GB0413868D0 (en)	2004-06-21	2004-07-21	Chiron Srl	Dimensional anlaysis of saccharide conjugates
EP2261672B1 (en)	2004-07-14	2014-09-03	The Regents of The University of California	Biomarkers for early detection of ovarian cancer
EP2181714A3 (en)	2004-09-22	2010-06-23	GlaxoSmithKline Biologicals S.A.	Immunogenic composition for use in vaccination against staphylococcei
GB0424092D0 (en)	2004-10-29	2004-12-01	Chiron Srl	Immunogenic bacterial vesicles with outer membrane proteins
GB0502096D0 (en)	2005-02-01	2005-03-09	Chiron Srl	Purification of streptococcal capsular polysaccharide
GB0502095D0 (en)	2005-02-01	2005-03-09	Chiron Srl	Conjugation of streptococcal capsular saccharides
SG160329A1 (en)	2005-02-18	2010-04-29	Novartis Vaccines & Diagnostic	Proteins and nucleic acids from meningitis/sepsis-associated escherichia coli
WO2006091517A2 (en)	2005-02-18	2006-08-31	Novartis Vaccines And Diagnostics Inc.	Immunogens from uropathogenic escherichia coli
GB0505518D0 (en)	2005-03-17	2005-04-27	Chiron Srl	Combination vaccines with whole cell pertussis antigen
SG158145A1 (en)	2005-03-31	2010-01-29	Glaxosmithkline Biolog Sa	Vaccines against chlamydial infection
DK1868645T3 (da)	2005-04-08	2012-04-10	Wyeth Llc	Multivalent pneumokok-sakkarid-protein-konjugat-sammensætning
EP1871411A4 (en)	2005-04-18	2010-07-21	Novartis Vaccines & Diagnostic	EXPRESSION OF HEPATITIS B VIRUS SURFACE ANTIGEN FOR VACCINE MANUFACTURE
SI1877426T1 (sl)	2005-04-29	2012-06-29	Glaxosmithkline Biolog Sa	Postopek za preprečevanje ali zdravljenje infekcije z M. tuberculosis
BRPI0612655B1 (pt)	2005-06-27	2021-06-15	Pfizer Ireland Pharmaceuticals	Composição imunogênica
AU2006286228A1 (en)	2005-09-01	2007-03-08	Novartis Vaccines And Diagnostics Gmbh & Co Kg	Multiple vaccination including serogroup C meningococcus
GB0522765D0 (en)	2005-11-08	2005-12-14	Chiron Srl	Combination vaccine manufacture
GB0524066D0 (en)	2005-11-25	2006-01-04	Chiron Srl	741 ii
TWI457133B (zh)	2005-12-13	2014-10-21	Glaxosmithkline Biolog Sa	新穎組合物
KR101441368B1 (ko)	2005-12-22	2014-09-24	글락소스미스클라인 바이오로지칼즈 에스.에이.	폐렴구균 다당류 컨쥬게이트 백신
GB0607088D0 (en)	2006-04-07	2006-05-17	Glaxosmithkline Biolog Sa	Vaccine
US9259463B2 (en)	2006-01-16	2016-02-16	The United States Of America, As Represented By The Secretary, Department Of Health & Human Services	Chlamydia vaccine
ZA200805602B (en)	2006-01-17	2009-12-30	Arne Forsgren	A novel surface exposed haemophilus influenzae protein (protein E; pE)
US7868139B2 (en)	2006-01-24	2011-01-11	Uab Research Foundation	Compositions and methods for the identification and treatment of immune-mediated inflammatory diseases
PL2004225T3 (pl)	2006-03-22	2012-09-28	Novartis Ag	Schematy immunizacji koniugatami meningokokowymi
GB0605757D0 (en)	2006-03-22	2006-05-03	Chiron Srl	Separation of conjugated and unconjugated components
SG170090A1 (en)	2006-03-30	2011-04-29	Glaxosmithkline Biolog Sa	Immunogenic composition
EP2390366A1 (en)	2006-06-02	2011-11-30	GlaxoSmithKline Biologicals S.A.	Method for identifying whether a patient will be responder or not to immunotherapy based on the differential expression of the TRAT1 gene
GB0612854D0 (en)	2006-06-28	2006-08-09	Novartis Ag	Saccharide analysis
CA2659552A1 (en)	2006-08-16	2008-02-21	Novartis Ag	Immunogens from uropathogenic escherichia coli
US8956625B2 (en)	2006-09-07	2015-02-17	Glaxosmithkline Biologicals, S.A.	Inactivated polio vaccines
US8309096B2 (en)	2007-01-15	2012-11-13	Glaxosmithkline Biologicals S.A.	Fusion protein
EP2114993B1 (en) *	2007-01-15	2012-08-29	GlaxoSmithKline Biologicals SA	Vaccine
JP5378350B2 (ja)	2007-04-04	2013-12-25	インフェクティアスディジーズリサーチインスティチュート	結核菌（Ｍｙｃｏｂａｃｔｅｒｉｕｍｔｕｂｅｒｃｕｌｏｓｉｓ）ポリペプチドおよびその融合物を含む免疫原性組成物
JP2010525035A (ja)	2007-05-02	2010-07-22	グラクソスミスクラインバイオロジカルズソシエテアノニム	ワクチン
EA018201B1 (ru)	2007-05-24	2013-06-28	Глаксосмитклайн Байолоджикалс С.А.	Лиофилизированная антигенная композиция
DK2167121T3 (en)	2007-06-26	2015-11-23	Glaxosmithkline Biolog Sa	A vaccine comprising Streptococcus pneumoniae kapselpolysaccharidkonjugater
DK2170384T3 (en)	2007-07-02	2016-07-25	Etubics Corp	METHODS AND COMPOSITIONS FOR THE PRODUCTION OF AN adenovirus vector for use in higher vaccination
GB0713880D0 (en)	2007-07-17	2007-08-29	Novartis Ag	Conjugate purification
GB0714963D0 (en)	2007-08-01	2007-09-12	Novartis Ag	Compositions comprising antigens
NZ583796A (en)	2007-09-17	2011-12-22	Oncomethylome Sciences Sa	Improved detection of mage-a expression
BR122016015627A2 (pt)	2007-10-19	2018-10-30	Novartis Ag	kit, composição antigênica liofilizada e método para preparação de uma composição imunogênica
GB0818453D0 (en)	2008-10-08	2008-11-12	Novartis Ag	Fermentation processes for cultivating streptococci and purification processes for obtaining cps therefrom
CA2716212A1 (en)	2008-02-21	2009-08-27	Novartis Ag	Meningococcal fhbp polypeptides
JP2012502898A (ja) *	2008-09-17	2012-02-02	ハンター・イミュノロジー・リミテッド	分類不能（ｎｏｎ−ｔｙｐｅａｂｌｅ）インフルエンザ菌（Ｈａｅｍｏｐｈｉｌｕｓｉｎｆｌｕｅｎｚａｅ）ワクチンおよびその使用
US20110163528A1 (en) *	2008-09-19	2011-07-07	Felix Schoeller Jr. Foto-Und Spezialpapiere Gmbh & Co. Kg	Recording Material for Laser Printing Process
CA2739581A1 (en)	2008-10-06	2010-04-15	University Of Chicago	Compositions and methods related to bacterial eap, emp, and/or adsa proteins
ES2586308T3 (es)	2008-10-27	2016-10-13	Glaxosmithkline Biologicals Sa	Procedimiento de purificación de un hidrato de carbono de Streptococcus del grupo A
EP2865389A1 (en)	2008-12-09	2015-04-29	Pfizer Vaccines LLC	IgE CH3 peptide vaccine
GB0822633D0 (en)	2008-12-11	2009-01-21	Novartis Ag	Formulation
GB0822634D0 (en)	2008-12-11	2009-01-21	Novartis Ag	Meningitis vaccines
WO2010070453A2 (en)	2008-12-17	2010-06-24	Novartis Ag	Meningococcal vaccines including hemoglobin receptor
US7876118B2 (en)	2009-02-05	2011-01-25	Advantest Corporation	Test equipment
CN102575284A (zh)	2009-03-17	2012-07-11	MDx健康公司	改进的基因表达检测
CN102438649A (zh)	2009-03-24	2012-05-02	诺华有限公司	脑膜炎球菌h因子结合蛋白和肺炎球菌结合糖的组合物
NZ595234A (en)	2009-03-24	2013-12-20	Novartis Ag	Adjuvanting meningococcal factor h binding protein
SG174968A1 (en)	2009-04-03	2011-11-28	Univ Chicago	Compositions and methods related to protein a (spa) variants
CA2758490C (en)	2009-04-14	2023-05-02	Novartis Ag	Compositions for immunising against staphylococcus aureus
ES2552153T3 (es)	2009-04-30	2015-11-26	Coley Pharmaceutical Group, Inc.	Vacuna neumocócica y usos de la misma
US8668911B2 (en)	2009-05-14	2014-03-11	The Regents Of The University Of Michigan	Streptococcus vaccine compositions and methods of using the same
RU2518291C2 (ru)	2009-07-30	2014-06-10	Пфайзер Вэксинс ЭлЭлСи	Антигенные tau-пептиды и их применения
GB0913680D0 (en)	2009-08-05	2009-09-16	Glaxosmithkline Biolog Sa	Immunogenic composition
GB0913681D0 (en)	2009-08-05	2009-09-16	Glaxosmithkline Biolog Sa	Immunogenic composition
EP3017828A1 (en)	2009-08-27	2016-05-11	GlaxoSmithKline Biologicals SA	Hybrid polypeptides including meningococcal fhbp sequences
PE20161560A1 (es)	2009-09-03	2017-01-11	Pfizer Vaccines Llc	Vacuna de pcsk9
EP2475385A1 (en)	2009-09-10	2012-07-18	Novartis AG	Combination vaccines against respiratory tract diseases
GB0917457D0 (en)	2009-10-06	2009-11-18	Glaxosmithkline Biolog Sa	Method
EP2483390A2 (en)	2009-09-30	2012-08-08	Novartis AG	Expression of meningococcal fhbp polypeptides
RU2603267C2 (ru)	2009-09-30	2016-11-27	Новартис Аг	Конъюгация капсульных полисахаридов staphylococcus aureus типа 5 и типа 8
CN102917730A (zh)	2009-10-27	2013-02-06	诺华有限公司	修饰的脑膜炎球菌fHBP多肽
CA2779578A1 (en)	2009-10-30	2011-05-05	Novartis Ag	Purification of staphylococcus aureus type 5 and type 8 capsular saccharides
GB0919690D0 (en)	2009-11-10	2009-12-23	Guy S And St Thomas S Nhs Foun	compositions for immunising against staphylococcus aureus
WO2011092253A1 (en)	2010-01-27	2011-08-04	Glaxosmithkline Biologicals S.A.	Modified tuberculosis antigens
GB201003333D0 (en)	2010-02-26	2010-04-14	Novartis Ag	Immunogenic proteins and compositions
GB201003922D0 (en)	2010-03-09	2010-04-21	Glaxosmithkline Biolog Sa	Conjugation process
GB201005625D0 (en)	2010-04-01	2010-05-19	Novartis Ag	Immunogenic proteins and compositions
US8808699B2 (en)	2010-04-05	2014-08-19	The University Of Chicago	Compositions and methods related to protein A (SpA) antibodies as an enhancer of immune response
CA2800774A1 (en)	2010-06-07	2011-12-15	Pfizer Vaccines Llc	Ige ch3 peptide vaccine
CA2803239A1 (en)	2010-06-25	2011-12-29	Novartis Ag	Combinations of meningococcal factor h binding proteins
SG186290A1 (en)	2010-07-02	2013-01-30	Univ Chicago	Compositions and methods related to protein a (spa) variants
EP2614074A1 (en)	2010-09-09	2013-07-17	The University of Chicago	Methods and compositions involving protective staphylococcal antigens
GB201101665D0 (en)	2011-01-31	2011-03-16	Novartis Ag	Immunogenic compositions
WO2012057904A1 (en)	2010-10-27	2012-05-03	Infectious Disease Research Institute	Mycobacterium tuberculosis antigens and combinations thereof having high seroreactivity
EA201390676A1 (ru)	2010-11-08	2013-11-29	Инфекшес Дизиз Рисерч Инститьют	Вакцины, содержащие полипептиды неспецифической нуклеозидгидролазы и стерол 24-c-метилтрансферазы (smt), для лечения и диагностики лейшманиоза
WO2012072769A1 (en)	2010-12-01	2012-06-07	Novartis Ag	Pneumococcal rrgb epitopes and clade combinations
US20130315959A1 (en)	2010-12-24	2013-11-28	Novartis Ag	Compounds
CA2822953C (en)	2011-01-26	2022-02-08	The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services	Selective detection of haemophilus influenzae
US10286056B2 (en)	2011-01-27	2019-05-14	Glaxosmithkline Biologicals S.A.	Adjuvant nanoemulsions with crystallisation inhibitors
CA2828844C (en)	2011-03-02	2020-07-14	Novartis Ag	Combination vaccines with lower doses of antigen and/or adjuvant
WO2012131504A1 (en)	2011-03-02	2012-10-04	Pfizer Inc.	Pcsk9 vaccine
GB201103836D0 (en)	2011-03-07	2011-04-20	Glaxosmithkline Biolog Sa	Conjugation process
EP2688590B1 (en)	2011-03-24	2020-02-12	GlaxoSmithKline Biologicals SA	Adjuvant nanoemulsions with phospholipids
GB201105981D0 (en)	2011-04-08	2011-05-18	Glaxosmithkline Biolog Sa	Novel process
TW201302779A (zh)	2011-04-13	2013-01-16	Glaxosmithkline Biolog Sa	融合蛋白質及組合疫苗
WO2012170356A1 (en)	2011-06-04	2012-12-13	Rochester General Hospital Research Institute	Compositions and methods related to p6 of haemophilus influenzae
US9149541B2 (en)	2011-07-08	2015-10-06	Novartis Ag	Tyrosine ligation process
JP2014529338A (ja)	2011-07-22	2014-11-06	グラクソスミスクラインバイオロジカルズソシエテアノニム	Ｐｒａｍｅの精製
CA2846865A1 (en)	2011-08-29	2013-03-07	The Regents Of The University Of California	Use of hdl-related molecules to treat and prevent proinflammatory conditions
GB201114923D0 (en)	2011-08-30	2011-10-12	Novartis Ag	Immunogenic proteins and compositions
GB201114919D0 (en)	2011-08-30	2011-10-12	Glaxosmithkline Biolog Sa	Method
RU2636350C2 (ru)	2011-11-07	2017-11-22	Новартис Аг	МОЛЕКУЛА, СОДЕРЖАЩАЯ SPR0096 и SPR2021
GB2495341B (en)	2011-11-11	2013-09-18	Novartis Ag	Fermentation methods and their products
EP2592137A1 (en)	2011-11-11	2013-05-15	Novartis AG	Fermentation media free of animal-derived components for production of diphtheria toxoids suitable for human vaccine use
DE102011118371B4 (de)	2011-11-11	2014-02-13	Novartis Ag	Zur Impfung von Menschen geeignete Zusammensetzung, die ein Diphtherie-Toxoid umfasst, sowie Verfahren zu deren Herstellung
DE102011122891B4 (de)	2011-11-11	2014-12-24	Novartis Ag	Fermentationsmedium, das frei von tierischen Bestandteilen ist, zur Herstellung von Diphtherie-Toxoiden zur Verwendung bei der Impfung von Menschen
GB201121301D0 (en)	2011-12-12	2012-01-25	Novartis Ag	Method
JP2015505309A (ja)	2011-12-29	2015-02-19	ノバルティスアーゲー	髄膜炎菌ｈ因子結合タンパク質のアジュバントされた組み合わせ
CN104519910B (zh)	2012-03-07	2017-05-03	诺华股份有限公司	肺炎链球菌抗原的含佐剂制剂
EP2822584A1 (en)	2012-03-08	2015-01-14	Novartis AG	Combination vaccines with tlr4 agonists
SA115360586B1 (ar)	2012-03-09	2017-04-12	فايزر انك	تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها
HRP20201127T1 (hr)	2012-04-26	2020-11-27	University Of Chicago	Antigeni stafilokokne koagulaze i metode primjene istih
SG11201407440WA (en)	2012-05-22	2014-12-30	Novartis Ag	Meningococcus serogroup x conjugate
EP2666785A1 (en)	2012-05-23	2013-11-27	Affiris AG	Complement component C5a-based vaccine
HRP20240164T1 (hr)	2012-08-03	2024-04-12	Access To Advanced Health Institute	Pripravci i postupci za liječenje aktivne tuberkulozne infekcije mikobakterijama
US9605276B2 (en)	2012-08-24	2017-03-28	Etubics Corporation	Replication defective adenovirus vector in vaccination
EP2703483A1 (en)	2012-08-29	2014-03-05	Affiris AG	PCSK9 peptide vaccine
CA2882619A1 (en)	2012-09-06	2014-03-13	Novartis Ag	Combination vaccines with serogroup b meningococcus and d/t/p
KR20150073943A (ko)	2012-10-03	2015-07-01	글락소스미스클라인 바이오로지칼즈 에스.에이.	면역원성 조성물
CN104918634A (zh)	2012-10-12	2015-09-16	葛兰素史密丝克莱恩生物有限公司	用于组合疫苗的非交联无细胞百日咳抗原
EP2925355B1 (en)	2012-11-30	2017-11-15	GlaxoSmithKline Biologicals S.A.	Pseudomonas antigens and antigen combinations
ES2670863T3 (es)	2013-02-01	2018-06-01	Glaxosmithkline Biologicals Sa	Administración intradérmica de composiciones inmunológicas que comprenden agonistas del receptor de tipo Toll
WO2014160987A2 (en)	2013-03-28	2014-10-02	Infectious Disease Research Institute	Vaccines comprising leishmania polypeptides for the treatment and diagnosis of leishmaniasis
GB201310008D0 (en)	2013-06-05	2013-07-17	Glaxosmithkline Biolog Sa	Immunogenic composition for use in therapy
CA2923129C (en)	2013-09-08	2020-06-09	Pfizer Inc.	Neisseria meningitidis compositions and methods thereof
US11708411B2 (en)	2013-12-20	2023-07-25	Wake Forest University Health Sciences	Methods and compositions for increasing protective antibody levels induced by pneumococcal polysaccharide vaccines
CN112336854B (zh)	2014-01-21	2024-11-26	辉瑞大药厂	肺炎链球菌荚膜多糖及其缀合物
US11160855B2 (en)	2014-01-21	2021-11-02	Pfizer Inc.	Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof
CN110859957B (zh)	2014-01-21	2024-04-12	辉瑞公司	包含缀合荚膜糖抗原的免疫原性组合物及其用途
CN120718167A (zh)	2014-01-21	2025-09-30	辉瑞大药厂	肺炎链球菌荚膜多糖及其缀合物
EP3443983B1 (en)	2014-02-14	2022-07-20	Pfizer Inc.	Immunogenic glycoprotein conjugates
TW201620927A (zh)	2014-02-24	2016-06-16	葛蘭素史密斯克藍生物品公司	Ｕｓｐａ２蛋白質構築體及其用途
RS61246B1 (sr)	2014-02-28	2021-01-29	Glaxosmithkline Biologicals Sa	Modifikovani meningokokni fhbp polipeptidi
US20170281744A1 (en)	2014-12-10	2017-10-05	Glaxosmithkline Biologicals Sa	Method of treatment
EP3034516A1 (en)	2014-12-19	2016-06-22	Novartis AG	Purification of streptococcal capsular polysaccharide
PL3244917T3 (pl)	2015-01-15	2023-07-17	Pfizer Inc.	Kompozycje immunogenne do zastosowania w szczepionkach przeciwko pneumokokom
US20180071380A1 (en)	2015-03-20	2018-03-15	The Regents Of The University Of Michigan	Immunogenic compositions for use in vaccination against bordetella
KR20210027523A (ko)	2015-07-21	2021-03-10	화이자 인코포레이티드	접합된 캡슐형 사카라이드 항원을 포함하는 면역원성 조성물, 그를 포함하는 키트 및 그의 용도
GB201518684D0 (en)	2015-10-21	2015-12-02	Glaxosmithkline Biolog Sa	Vaccine
JP6884145B2 (ja)	2015-11-20	2021-06-09	ファイザー・インク	肺炎連鎖球菌ワクチンにおいて用いるための免疫原性組成物
RU2021109510A (ru)	2015-12-04	2021-04-16	Дана-Фарбер Кэнсер Инститьют, Инк.	Вакцинация с использованием альфа 3 домена mica/b для лечения рака
EP3439704A1 (en)	2016-04-05	2019-02-13	GSK Vaccines S.r.l.	Immunogenic compositions
US20200148729A1 (en)	2016-05-21	2020-05-14	Infectious Disease Research Institute	Compositions and Methods for Treating Secondary Tuberculosis and Nontuberculosis Mycobacterium Infections
US11191822B2 (en)	2016-06-22	2021-12-07	MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V.	Pneumococcal polysaccharide-protein conjugate composition
EP3269385A1 (en)	2016-07-12	2018-01-17	Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.	Pneumococcal polysaccharide-protein conjugate composition
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US20210108002A1 (en)	2016-12-06	2021-04-15	Glaxosmithkline Biologicals Sa	Purification Process For Capsular Polysaccharide
GB201621686D0 (en)	2016-12-20	2017-02-01	Glaxosmithkline Biologicals Sa	Novel methods for inducing an immune response
AU2018208844B2 (en)	2017-01-20	2021-02-25	Pfizer Inc.	Immunogenic compositions for use in pneumococcal vaccines
US10183070B2 (en)	2017-01-31	2019-01-22	Pfizer Inc.	Neisseria meningitidis compositions and methods thereof
US20200222550A1 (en)	2017-01-31	2020-07-16	Merck Sharp & Dohme Corp.	Methods for production of capsular polysaccharide protein conjugates from streptococcus pneumoniae serotype 19f
CN110225764A (zh)	2017-01-31	2019-09-10	默沙东公司	制备多糖-蛋白缀合物的方法
DK3585803T3 (da)	2017-02-24	2025-12-15	Merck Sharp & Dohme Llc	Formuleringer af pneumokokkal konjugatvaccine
EP3600391A1 (en) *	2017-03-31	2020-02-05	GlaxoSmithKline Intellectual Property Development Limited	Immunogenic composition, use and method of treatment
WO2018178265A1 (en)	2017-03-31	2018-10-04	Glaxosmithkline Intellectual Property Development Limited	Immunogenic composition, use and method of treatment
US12016919B2 (en)	2017-05-30	2024-06-25	Glaxosmithkline Biologicals Sa	Methods for manufacturing an adjuvant
JP2020530478A (ja)	2017-08-14	2020-10-22	グラクソスミスクラインバイオロジカルズソシエテアノニム	免疫応答を強化する方法
HRP20241185T1 (hr)	2017-09-07	2024-11-22	Merck Sharp & Dohme Llc	Pneumokokni polisaharidi i njihova primjena u imunogenim konjugatima polisaharid-proteinski nosač
MX2020005481A (es)	2017-12-01	2020-12-07	Glaxosmithkline Biologicals Sa	Purificacion de saponina.
SG11202005255PA (en)	2017-12-06	2020-07-29	Merck Sharp & Dohme	Compositions comprising streptococcus pneumoniae polysaccharide-protein conjugates and methods of use thereof
WO2020016322A1 (en)	2018-07-19	2020-01-23	Glaxosmithkline Biologicals Sa	Processes for preparing dried polysaccharides
MX2021001479A (es)	2018-08-07	2021-04-28	Glaxosmithkline Biologicals Sa	Novedosos procesos y vacunas.
EP3607967A1 (en)	2018-08-09	2020-02-12	GlaxoSmithKline Biologicals S.A.	Modified meningococcal fhbp polypeptides
US11260119B2 (en)	2018-08-24	2022-03-01	Pfizer Inc.	Escherichia coli compositions and methods thereof
EP3886901A1 (en)	2018-11-29	2021-10-06	GlaxoSmithKline Biologicals S.A.	Methods for manufacturing an adjuvant
WO2020121159A1 (en)	2018-12-12	2020-06-18	Pfizer Inc.	Immunogenic multiple hetero-antigen polysaccharide-protein conjugates and uses thereof
CN113227125A (zh)	2018-12-12	2021-08-06	葛兰素史密丝克莱恩生物有限公司	用于o-连接的糖基化的修饰的载体蛋白
JOP20210148A1 (ar)	2018-12-19	2023-01-30	Merck Sharp & Dohme	تركيبات تشتمل على متقارنات بولي سكاريد-بروتين للمكورات العقدية الرئوية وطرق استخدامها
CA3129425A1 (en)	2019-02-11	2020-08-20	Pfizer Inc.	Neisseria meningitidis compositions and methods thereof
JP7239509B6 (ja)	2019-02-22	2023-03-28	ファイザー・インク	細菌多糖類を精製するための方法
WO2020208502A1 (en)	2019-04-10	2020-10-15	Pfizer Inc.	Immunogenic compositions comprising conjugated capsular saccharide antigens, kits comprising the same and uses thereof
US20220221455A1 (en)	2019-04-18	2022-07-14	Glaxosmithkline Biologicals Sa	Antigen binding proteins and assays
MX2021013736A (es)	2019-05-10	2021-12-10	Glaxosmithkline Biologicals Sa	Produccion de conjugados.
KR20220025724A (ko)	2019-05-14	2022-03-03	더 유니버서티 오브 시카고	스타필로코커스 단백질 Ａ(ＳｐＡ) 변이체를 포함하는 방법 및 조성물
WO2020245207A1 (en)	2019-06-05	2020-12-10	Glaxosmithkline Biologicals Sa	Saponin purification
CA3148824A1 (en)	2019-07-31	2021-02-04	Sanofi Pasteur Inc.	Multivalent pneumococcal polysaccharide-protein conjugate compositions and methods of using the same
EP4010014A1 (en)	2019-08-05	2022-06-15	GlaxoSmithKline Biologicals S.A.	Immunogenic composition
BR112021026775A2 (pt)	2019-08-05	2022-05-10	Glaxosmithkline Biologicals Sa	Processo para preparar uma composição que compreende um polipeptídeo de proteína d
WO2021059181A1 (en)	2019-09-27	2021-04-01	Pfizer Inc.	Neisseria meningitidis compositions and methods thereof
WO2021084429A1 (en)	2019-11-01	2021-05-06	Pfizer Inc.	Escherichia coli compositions and methods thereof
US12533418B2 (en)	2019-11-22	2026-01-27	Glaxosmithkline Biologicals Sa	Dosage and administration of a bacterial saccharide glycoconjugate vaccine
WO2021165847A1 (en)	2020-02-21	2021-08-26	Pfizer Inc.	Purification of saccharides
BR112022014555A2 (pt)	2020-02-23	2022-09-20	Pfizer	Composições de escherichia coli e métodos das mesmas.
EP4165064A2 (en)	2020-06-12	2023-04-19	GlaxoSmithKline Biologicals S.A.	Dock tag system
GB202013262D0 (en)	2020-08-25	2020-10-07	Glaxosmithkline Biologicals Sa	Vaccine Composition
EP4232593A1 (en)	2020-10-22	2023-08-30	Pfizer Inc.	Methods for purifying bacterial polysaccharides
WO2022090893A2 (en)	2020-10-27	2022-05-05	Pfizer Inc.	Escherichia coli compositions and methods thereof
US12138302B2 (en)	2020-10-27	2024-11-12	Pfizer Inc.	Escherichia coli compositions and methods thereof
CN116744965A (zh)	2020-11-04	2023-09-12	辉瑞大药厂	用于肺炎球菌疫苗的免疫原性组合物
EP4243863A2 (en)	2020-11-10	2023-09-20	Pfizer Inc.	Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof
US12357681B2 (en)	2020-12-23	2025-07-15	Pfizer Inc.	E. coli FimH mutants and uses thereof
TW202245835A (zh)	2021-02-04	2022-12-01	美商默沙東有限責任公司	用於肺炎球菌結合物疫苗之奈米乳化液佐劑組合物
WO2022175423A1 (en)	2021-02-22	2022-08-25	Glaxosmithkline Biologicals Sa	Immunogenic composition, use and methods
JP2024517780A (ja)	2021-05-03	2024-04-23	ファイザー・インク	細菌およびベータコロナウイルス感染症に対するワクチン接種
WO2022234416A1 (en)	2021-05-03	2022-11-10	Pfizer Inc.	Vaccination against pneumoccocal and covid-19 infections
AU2022281543A1 (en)	2021-05-28	2023-11-23	Pfizer Inc.	Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof
TW202306969A (zh)	2021-05-28	2023-02-16	美商輝瑞大藥廠	包含結合之莢膜醣抗原的免疫原組合物及其用途
US12036276B2 (en)	2021-09-09	2024-07-16	Affinivax, Inc.	Multivalent pneumococcal vaccines
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WO2023161817A1 (en)	2022-02-25	2023-08-31	Pfizer Inc.	Methods for incorporating azido groups in bacterial capsular polysaccharides
EP4522208A1 (en)	2022-05-11	2025-03-19	Pfizer Inc.	Process for producing of vaccine formulations with preservatives
GB202208089D0 (en)	2022-06-01	2022-07-13	Glaxosmithkline Biologicals Sa	Immunogenic composition
GB202208093D0 (en)	2022-06-01	2022-07-13	Glaxosmithkline Biologicals Sa	Immunogenic composition
WO2024017827A1 (en)	2022-07-19	2024-01-25	Glaxosmithkline Biologicals Sa	Continuous process for vaccine production
WO2024084397A1 (en)	2022-10-19	2024-04-25	Pfizer Inc.	Vaccination against pneumoccocal and covid-19 infections
WO2024110827A1 (en)	2022-11-21	2024-05-30	Pfizer Inc.	Methods for preparing conjugated capsular saccharide antigens and uses thereof
KR20250107930A (ko)	2022-11-22	2025-07-14	화이자 인코포레이티드	접합된 피막 사카라이드 항원을 포함하는 면역원성 조성물 및 그의 용도
EP4626405A1 (en)	2022-12-01	2025-10-08	Pfizer Inc.	Pneumococcal conjugate vaccine formulations
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AU2024255922A1 (en)	2023-04-14	2025-10-30	Pfizer Inc.	Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof
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WO2025133971A1 (en)	2023-12-23	2025-06-26	Pfizer Inc.	Improved methods for producing bacterial capsular saccharide glycoconjugates
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WO2025191415A1 (en)	2024-03-11	2025-09-18	Pfizer Inc.	Immunogenic compositions comprising conjugated escherichia coli saccharides and uses thereof
WO2025193903A1 (en)	2024-03-15	2025-09-18	Affinivax, Inc.	Pneumococcal polysaccharide compositions and uses thereof
WO2025219908A2 (en)	2024-04-19	2025-10-23	Pfizer Inc.	Media and fermentation methods for polysaccharide production in bacterial cell culture
WO2025219904A1 (en)	2024-04-19	2025-10-23	Pfizer Inc.	Improved methods for producing glycoconjugates by reductive amination in aprotic solvent
WO2025242657A1 (en)	2024-05-21	2025-11-27	Shape Biopharmaceuticals Ag	Lipopeptide building blocks and aggregates

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3800798A (en) *	1972-07-11	1974-04-02	A Winkler	Hydrophobic catheter construction
DE2322533C2 (de) *	1972-11-06	1986-08-28	Pharmacia AB, Uppsala	Verfahren zum Binden von Immunoglobulin und Hilfsmittel zur Durchführung des Verfahrens
SE451596B (sv) *	1983-06-22	1987-10-19	Excorim Kb	Forfarande for utvinning av protein g
SE459503B (sv) *	1985-05-03	1989-07-10	Excorim Kommanditbolag	Hybrid-dna-molekyl innefattande dna-sekvens som kodar foer protein g samt foerfarande foer framstaellning av protein g
SE459662B (sv) *	1986-03-21	1989-07-24	Pharmacia Ab	Hybrid-dna-molekyl som kodar foer ett protein med samma igg specificitet som protein g, plasmid innehaallande densamma samt foerfarande foer framstaellning av proteinet
US5173294A (en) *	1986-11-18	1992-12-22	Research Foundation Of State University Of New York	Dna probe for the identification of haemophilus influenzae
AU623353B2 (en) *	1987-12-10	1992-05-14	Board Of Regents, The University Of Texas System	Methods and compositions for the production of haemophilus influenzae type b major outer membrane protein antigens
DE68915046T2 (de) *	1988-04-19	1994-12-08	American Cyanamid Co	Haemophilus influenzae Typ B Polysaccharid-Aussermembranprotein-Konjugat als Impfstoff.
USRE37919E1 (en)	1989-05-12	2002-12-03	The General Hospital Corporation	Recombinant DNA method for production of parathyroid hormone
SE466259B (sv) *	1990-05-31	1992-01-20	Arne Forsgren	Protein d - ett igd-bindande protein fraan haemophilus influenzae, samt anvaendning av detta foer analys, vacciner och uppreningsaendamaal
US6680057B1 (en)	1995-03-23	2004-01-20	Immunex Corporation	Methods of treating autoimmune disease by administering interleukin-17 receptor

1990
- 1990-05-31 SE SE9001949A patent/SE466259B/sv not_active IP Right Cessation
1991
- 1991-02-21 AT AT91907067T patent/ATE170531T1/de active
- 1991-02-21 DE DE69130116T patent/DE69130116T2/de not_active Expired - Lifetime
- 1991-02-21 JP JP3506522A patent/JP3066072B2/ja not_active Expired - Lifetime
- 1991-02-21 DE DE200912000060 patent/DE122009000060I1/de active Pending
- 1991-02-21 DK DK91907067T patent/DK0594610T3/da active
- 1991-02-21 AU AU75593/91A patent/AU650011B2/en not_active Expired
- 1991-02-21 WO PCT/SE1991/000129 patent/WO1991018926A1/en not_active Ceased
- 1991-02-21 CA CA002083172A patent/CA2083172C/en not_active Expired - Lifetime
- 1991-02-21 DE DE122009000059C patent/DE122009000059I1/de active Pending
- 1991-02-21 ES ES91907067T patent/ES2119776T3/es not_active Expired - Lifetime
- 1991-02-21 EP EP91907067A patent/EP0594610B1/en not_active Expired - Lifetime
1992
- 1992-11-24 NO NO924507A patent/NO309721B1/no not_active IP Right Cessation
- 1992-11-30 FI FI925460A patent/FI109029B/fi active Protection Beyond IP Right Term
1996
- 1996-11-12 US US08/747,381 patent/US5989828A/en not_active Expired - Fee Related
1997
- 1997-09-25 US US08/936,912 patent/US5888517A/en not_active Expired - Fee Related
- 1997-11-05 US US08/968,885 patent/US5858677A/en not_active Expired - Lifetime
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1999
- 1999-01-06 US US09/225,443 patent/US6139846A/en not_active Expired - Fee Related
2000
- 2000-06-30 US US09/607,933 patent/US7115271B1/en not_active Ceased
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2006
- 2006-09-15 US US11/521,598 patent/US7666621B2/en not_active Expired - Fee Related
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2009
- 2009-09-24 NL NL300409C patent/NL300409I2/nl unknown
- 2009-09-24 LU LU91609C patent/LU91609I2/fr unknown
- 2009-09-24 NO NO2009021C patent/NO2009021I1/no not_active Application Discontinuation
- 2009-09-24 NL NL300410C patent/NL300410I1/nl unknown
- 2009-09-24 LU LU91610C patent/LU91610I2/fr unknown
- 2009-09-24 NO NO2009022C patent/NO2009022I1/no not_active Application Discontinuation
2010
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
USRE41277E1 (en)	1990-05-31	2010-04-27	Arne Forsgren	Protein D—an IGD binding protein of Haemophilus influenzae

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US5989828A (en)	1999-11-23
NO309721B1 (no)	2001-03-19
US20070071774A1 (en)	2007-03-29
LU91609I2 (fr)	2009-11-24
DE122009000060I1 (de)	2011-12-01
DE122009000059I1 (de)	2010-04-29
NO322330B1 (no)	2006-09-18
US7115271B1 (en)	2006-10-03
JPH05507465A (ja)	1993-10-28
NO20003716D0 (no)	2000-07-20
LU91610I2 (fr)	2009-11-24
AU650011B2 (en)	1994-06-09
NO20003716L (no)	1992-11-30
NO924507L (no)	1992-11-30
FI109029B (fi)	2002-05-15
US6025484A (en)	2000-02-15
ATE170531T1 (de)	1998-09-15
US20100209905A1 (en)	2010-08-19
CA2083172A1 (en)	1991-12-01
US5858677A (en)	1999-01-12
SE9001949L (sv)	1991-12-01
USRE41277E1 (en)	2010-04-27
SE9001949D0 (sv)	1990-05-31
AU7559391A (en)	1991-12-31
CA2083172C (en)	2002-07-02
US6139846A (en)	2000-10-31
FI925460A0 (fi)	1992-11-30
EP0594610B1 (en)	1998-09-02
NO2009022I1 (no)	2009-10-12
DE69130116D1 (de)	1998-10-08
NL300409I2 (nl)	2010-03-01
JP3066072B2 (ja)	2000-07-17
ES2119776T3 (es)	1998-10-16
NO924507D0 (no)	1992-11-24
US7666621B2 (en)	2010-02-23
EP0594610A1 (en)	1994-05-04
DK0594610T3 (da)	1998-11-02
WO1991018926A1 (en)	1991-12-12
DE69130116T2 (de)	1999-02-18
NL300410I1 (nl)	2009-12-01
NO2009021I1 (no)	2009-10-12
US5888517A (en)	1999-03-30
NL300409I1 (nl)	2009-12-01
FI925460L (fi)	1992-11-30

Publication	Publication Date	Title
SE466259B (sv)	1992-01-20	Protein d - ett igd-bindande protein fraan haemophilus influenzae, samt anvaendning av detta foer analys, vacciner och uppreningsaendamaal
Barenkamp et al.	1996	Identification of a second family of high‐molecular‐weight adhesion proteins expressed by non‐typable Haemophilus influenzae
Gray-Owen et al.	1995	Identification and characterization of genes encoding the human transferrin-binding proteins from Haemophilus influenzae
US5173294A (en)	1992-12-22	Dna probe for the identification of haemophilus influenzae
Janson et al.	1991	Protein D, an immunoglobulin D-binding protein of Haemophilus influenzae: cloning, nucleotide sequence, and expression in Escherichia coli
Deich et al.	1988	Cloning of genes encoding a 15,000-dalton peptidoglycan-associated outer membrane lipoprotein and an antigenically related 15,000-dalton protein from Haemophilus influenzae
Everett et al.	1991	Sequence analysis and lipid modification of the cysteine-rich envelope proteins of Chlamydia psittaci 6BC
Janson et al.	1992	Protein D, the immunoglobulin D-binding protein of Haemophilus influenzae, is a lipoprotein
EP0771213B1 (en)	2007-01-03	Haemophilus influenzae adherence and penetration proteins
JP3023089B2 (ja)	2000-03-21	インフルエンザ菌用ワクチンおよび診断法
Akkoyunlu et al.	1996	Biological activity of serum antibodies to a nonacylated form of lipoprotein D of Haemophilus influenzae
EP0617128A1 (en)	1994-09-28	Recombinant vaccine for porcine pleuropneumonia
Schouls et al.	1991	Characterization of the 35-kilodalton Treponema pallidum subsp. pallidum recombinant lipoprotein TmpC and antibody response to lipidated and nonlipidated T. pallidum antigens
EP0389925A1 (en)	1990-10-03	A method for purifying an outer membrane protein of Haemophilus influenzae
USRE37768E1 (en)	2002-06-25	DNA encoding the 15 kD outer membrane protein of Haemophilus influenzae
US5300632A (en)	1994-04-05	Method for purifying an outer membrane protein of Haemophilus influenzae
US6323005B1 (en)	2001-11-27	Transferrin-binding protein 1 (TBP1) gene of Actinobacillus pleuropneumoniae, its use to prepare products for the utilization in vaccines for pleuropneumonia and as diagnostic reagents
Wieles et al.	1995	Molecular characterization and T-cell-stimulatory capacity of Mycobacterium leprae antigen T5
JP2002512528A (ja)	2002-04-23	ストレプトコッカスイクイの保護ｍ−様タンパク質をコードする化合物及びその検定

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SE466259B - Protein d - ett igd-bindande protein fraan haemophilus influenzae, samt anvaendning av detta foer analys, vacciner och uppreningsaendamaal - Google Patents

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