SE449489B - Beta-laktam foreningar med antibakteriell och beta-laktam inhiberande aktivitet - Google Patents

Beta-laktam foreningar med antibakteriell och beta-laktam inhiberande aktivitet

Info

Publication number: SE449489B
Authority: SE; Sweden
Prior art keywords: methyl; hydroxyethyl; compound; nitrobenzyloxycarbonyloxyethyl; penem
Prior art date: 1979-02-24

Application number

SE8001424A

Other languages

English (en)

Swedish (sv)

Other versions

SE8001424L (sv

Inventor

M Foglio

G Franceschi

C Scarafile

F Arcamone

A Sanfilippo

Original Assignee

Erba Farmitalia

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1979-02-24

Filing date

1980-02-22

Publication date

1987-05-04

1980-02-22 Application filed by Erba Farmitalia filed Critical Erba Farmitalia

1980-08-25 Publication of SE8001424L publication Critical patent/SE8001424L/xx

1987-05-04 Publication of SE449489B publication Critical patent/SE449489B/sv

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
- C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/568—Four-membered rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Cephalosporin Compounds (AREA)

SE8001424A 1979-02-24 1980-02-22 Beta-laktam foreningar med antibakteriell och beta-laktam inhiberande aktivitet SE449489B (sv)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB7906634		1979-02-24
GB7932591		1979-09-20

Publications (2)

Publication Number	Publication Date
SE8001424L SE8001424L (sv)	1980-08-25
SE449489B true SE449489B (sv)	1987-05-04

Family

ID=26270697

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SE8001424A SE449489B (sv)	1979-02-24	1980-02-22	Beta-laktam foreningar med antibakteriell och beta-laktam inhiberande aktivitet

Country Status (24)

Country	Link
AT (1)	AT368506B (fi)
AU (1)	AU535080B2 (fi)
CA (2)	CA1154010A (fi)
CH (2)	CH654831A5 (fi)
CS (1)	CS226010B2 (fi)
DE (1)	DE3006273A1 (fi)
DK (1)	DK159448C (fi)
ES (2)	ES8200685A1 (fi)
FI (1)	FI75163C (fi)
FR (1)	FR2449690B1 (fi)
GB (1)	GB2043639B (fi)
GR (1)	GR73623B (fi)
HK (1)	HK74487A (fi)
HU (1)	HU182664B (fi)
IE (1)	IE49407B1 (fi)
IT (1)	IT1193922B (fi)
LU (1)	LU82192A1 (fi)
NL (1)	NL192265C (fi)
NO (1)	NO161000C (fi)
NZ (1)	NZ192949A (fi)
PT (1)	PT70849A (fi)
SE (1)	SE449489B (fi)
UA (1)	UA6041A1 (fi)
YU (1)	YU42964B (fi)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5625110A (en) *	1978-12-18	1981-03-10	Bristol Myers Co	Antibacterial
DE3121510A1 (de) *	1980-07-04	1982-06-16	Farmitalia Carlo Erba S.p.A., 20159 Milano	6-alkyl-2-subst.-peneme und verfahren zu ihrer herstellung
JPS588084A (ja) *	1981-07-08	1983-01-18	Takeda Chem Ind Ltd	（６ｒ）−置換−（５ｒ）−ペネム−３−カルボン酸誘導体およびその製造法
EP0180252B1 (en) *	1981-07-15	1989-04-26	Sumitomo Pharmaceuticals Company, Limited	Process of preparing azetidinone compounds
SU1389680A3 (ru) *	1981-12-11	1988-04-15	Фармиталия Карло Эрба С.П.А. (Фирма)	Способ получени оптически активных пенемов или их солей с щелочными металлами
NO831160L (no) *	1982-04-08	1983-10-10	Erba Farmitalia	Fremstilling av substituerte penem-derivater
PH21930A (en) *	1982-11-16	1988-04-08	Ciba Geigy Ag	6-hydroxy-lower alkylpenem compounds,pharmaceutical composition containing same and method of use thereof
EP0112283B1 (de) *	1982-11-16	1987-08-12	Ciba-Geigy Ag	Heterocyclylthioverbindungen, Verfahren zu ihrer Herstellung, pharmazeutische Präparate, welche diese Verbindungen enthalten, und Verwendung von letzteren
GB8300295D0 (en) *	1983-01-06	1983-02-09	Erba Farmitalia	Penem esters
JPS59152387A (ja) *	1983-02-10	1984-08-31	Shionogi & Co Ltd	新規ペネム化合物
GB8321677D0 (en) *	1983-08-11	1983-09-14	Erba Farmitalia	Preparation of penems
US4656165A (en) *	1983-09-02	1987-04-07	Ciba-Geigy Corporation	Aminomethyl penem compounds
US4711886A (en) *	1984-07-02	1987-12-08	Merck & Co., Inc.	β-lactam derivatives as anti-inflammatory and antidegenerative agents
US4761408A (en) *	1984-11-02	1988-08-02	Ciba-Geigy Corporation	Crystalline aminomethyl compound
DE3882730D1 (de) *	1987-02-11	1993-09-09	Ciba Geigy Ag	Bicyclische beta-lactam-carbonsaeuren.
US5364768A (en) *	1987-07-07	1994-11-15	Farmitalia Carlo Erba S.R.L.	Process for the preparation of penems
GB2206578B (en) *	1987-07-07	1991-07-03	Erba Carlo Spa	Process for the preparation of penems
IT1286558B1 (it) *	1996-02-27	1998-07-15	Menarini Farma Ind	Processo per la preparazione di 2-alogenometil-penems e loro uso per la preparazione di penems antibatterici
DE69805975T2 (de)	1997-12-29	2002-12-19	Research Corp. Technologies, Inc.	2-beta-substituierte-6-alkylidenpenizillansäure-derivate als beta-laktamase inhibitoren
US6407091B1 (en)	1999-04-15	2002-06-18	Research Corporation Technologies, Inc.	β-lactamase inhibiting compounds
US6720445B2 (en)	2000-12-21	2004-04-13	Beacon Laboratories, Inc.	Acetyloxymethyl esters and methods for using the same
DE60214740T2 (de)	2001-07-24	2007-10-04	Southern Methodist University Foundation for Research, Dallas	3-substituierte 7-alkylidene-3-cephem-4-carbonsäuren als beta-lactamase inhibitoren
US7022691B2 (en)	2002-04-04	2006-04-04	John D. Buynak	Inhibitors of serine and metallo-β-lactamases

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
LU77306A1 (fi) *	1977-05-09	1979-01-18
AU3796278A (en) *	1977-07-13	1980-01-17	Glaxo Group Ltd	Penams and azetidinones
US4168314A (en) *	1977-11-17	1979-09-18	Merck & Co., Inc.	6-(1'-Hydroxyethyl)-2-aminoethylthio-pen-2-em-3-carboxylic acid
US4155912A (en) *	1977-12-14	1979-05-22	Bristol-Myers Company	2-Methylpenem-3-carboxylic acid antibiotics
EP0003415A3 (en) *	1978-01-20	1979-08-22	Glaxo Group Limited	Beta-lactam compounds, processes for their preparation,compositions containing them and intermediates of use in their preparation
EP0042026B1 (de) *	1978-02-02	1986-01-08	Ciba-Geigy Ag	3,4-Disubstituierte Azetidin-2-onverbindungen und Verfahren zu ihrer Herstellung
EP0010358A1 (en) *	1978-09-20	1980-04-30	Glaxo Group Limited	Beta-lactam compounds, processes for their preparation, compositions containing them, intermediates of use in their preparation and methods for the production thereof
JPS5625110A (en) *	1978-12-18	1981-03-10	Bristol Myers Co	Antibacterial
EP0013067A1 (en) *	1978-12-22	1980-07-09	Beecham Group Plc	Bicyclic beta-lactam antibacterial agents, their use in pharmaceutical compositions, processes for their preparation and intermediates for use in such processes

1980
- 1980-02-19 FI FI800493A patent/FI75163C/fi not_active IP Right Cessation
- 1980-02-19 GR GR61228A patent/GR73623B/el unknown
- 1980-02-19 GB GB8005476A patent/GB2043639B/en not_active Expired
- 1980-02-19 IT IT20021/80A patent/IT1193922B/it active
- 1980-02-19 AU AU55670/80A patent/AU535080B2/en not_active Ceased
- 1980-02-19 NL NL8001012A patent/NL192265C/nl not_active IP Right Cessation
- 1980-02-19 AT AT0091980A patent/AT368506B/de not_active IP Right Cessation
- 1980-02-20 DE DE19803006273 patent/DE3006273A1/de active Granted
- 1980-02-20 CA CA000346011A patent/CA1154010A/en not_active Expired
- 1980-02-20 PT PT70849A patent/PT70849A/pt not_active IP Right Cessation
- 1980-02-20 IE IE338/80A patent/IE49407B1/en not_active IP Right Cessation
- 1980-02-20 YU YU461/80A patent/YU42964B/xx unknown
- 1980-02-21 CH CH2794/84A patent/CH654831A5/de not_active IP Right Cessation
- 1980-02-21 CH CH1400/80A patent/CH651570A5/de not_active IP Right Cessation
- 1980-02-22 SE SE8001424A patent/SE449489B/sv not_active IP Right Cessation
- 1980-02-22 CS CS801241A patent/CS226010B2/cs unknown
- 1980-02-22 LU LU82192A patent/LU82192A1/fr unknown
- 1980-02-22 NZ NZ192949A patent/NZ192949A/en unknown
- 1980-02-22 NO NO800501A patent/NO161000C/no unknown
- 1980-02-22 FR FR8003938A patent/FR2449690B1/fr not_active Expired
- 1980-02-22 DK DK077580A patent/DK159448C/da not_active IP Right Cessation
- 1980-02-22 HU HU80420A patent/HU182664B/hu not_active IP Right Cessation
- 1980-02-22 UA UA2886007A patent/UA6041A1/uk unknown
- 1980-02-23 ES ES488886A patent/ES8200685A1/es not_active Expired
- 1980-10-16 ES ES495977A patent/ES8107224A1/es not_active Expired
1986
- 1986-01-14 CA CA000499579A patent/CA1212665B/en not_active Expired
1987
- 1987-10-15 HK HK744/87A patent/HK74487A/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
FR2449690A1 (fr)	1980-09-19
CS226010B2 (en)	1984-03-19
ES495977A0 (es)	1981-10-01
IT1193922B (it)	1988-08-31
CH651570A5 (de)	1985-09-30
IT8020021A0 (it)	1980-02-19
DK159448C (da)	1991-03-04
NZ192949A (en)	1984-03-16
DE3006273A1 (de)	1980-09-04
AU535080B2 (en)	1984-03-01
IE800338L (en)	1980-08-24
ATA91980A (de)	1982-02-15
FI75163B (fi)	1988-01-29
CH654831A5 (de)	1986-03-14
FI75163C (fi)	1988-05-09
GB2043639A (en)	1980-10-08
SE8001424L (sv)	1980-08-25
PT70849A (en)	1980-03-01
YU42964B (en)	1989-02-28
FI800493A (fi)	1980-08-25
ES8107224A1 (es)	1981-10-01
HU182664B (en)	1984-02-28
FR2449690B1 (fr)	1986-06-13
GB2043639B (en)	1983-07-20
AU5567080A (en)	1980-09-11
NL192265B (nl)	1996-12-02
IT8020021A1 (it)	1981-08-19
LU82192A1 (fr)	1980-06-06
DK77580A (da)	1980-08-25
AT368506B (de)	1982-10-25
NO161000B (no)	1989-03-13
HK74487A (en)	1987-10-23
NO161000C (no)	1989-06-21
ES488886A0 (es)	1981-11-16
IE49407B1 (en)	1985-10-02
NL192265C (nl)	1997-04-03
UA6041A1 (uk)	1994-12-29
NL8001012A (nl)	1980-08-26
GR73623B (fi)	1984-03-26
YU46180A (en)	1983-02-28
DK159448B (da)	1990-10-15
CA1212665B (en)	1986-10-14
NO800501L (no)	1980-08-25
CA1154010A (en)	1983-09-20
ES8200685A1 (es)	1981-11-16

Publication	Publication Date	Title
SE449489B (sv)	1987-05-04	Beta-laktam foreningar med antibakteriell och beta-laktam inhiberande aktivitet
FI83521C (fi)	1991-07-25	Foerfarande foer framstaellning av penemer.
US4482565A (en)	1984-11-13	β-Lactam-containing antibacterial agents and β-lactamase inhibitors
JPH0314037B2 (fi)	1991-02-25
HU189559B (en)	1986-07-28	Process for preparing 2-penem compounds
US4446146A (en)	1984-05-01	β-Lactam containing compounds, their preparation and use
US4584133A (en)	1986-04-22	Process for the production of penems
US4182711A (en)	1980-01-08	Antibacterial agents of the β-lactam type
US4155912A (en)	1979-05-22	2-Methylpenem-3-carboxylic acid antibiotics
US4237051A (en)	1980-12-02	Stereospecific production of 6- or 7-carbon-substituted-β-lactams
US4267177A (en)	1981-05-12	β-Lactam anti-bacterials, compositions containing them, a process for their preparation, and methods of use thereof
FI95256B (fi)	1995-09-29	Menetelmä terapeuttisesti käyttökelpoisten 2-substituoitujen alkyyli-3-karboksikarbapeneemien valmistamiseksi
US4347355A (en)	1982-08-31	Inhibitors of transpeptidase
US4713450A (en)	1987-12-15	2-thiacephems and (5R) penems derivatives
US4341706A (en)	1982-07-27	Process for the preparation of carbapenem antibiotics
FI89490B (fi)	1993-06-30	Foerfarande foer framstaellning av 2-metoximetyl-penemderivat
JPS6254427B2 (fi)	1987-11-14
SE462492B (sv)	1990-07-02	6-('-fluoretyl)- och 6-(l'-fluor-l'-metyl-etyl)-karbapenemer foerfarande foer framstaellning daerav och deras anvaendning som kemoterapeutika
US4558042A (en)	1985-12-10	β-Lactam-containing antibacterial agents and β-lactamase inhibitors
NO860975L (no)	1985-12-30	Mellomprodukt for fremstilling av terapeutisk virksomme 7-okso-4-tia-1-azabicyklo(3,2,0)hept-2-en derivater.
EP0517065A1 (de)	1992-12-09	Tetrazyklische beta-Lactam Antibiotika und Verfahren zur ihrer Darstellung
Branch et al.	1979	Synthesis of some 1-oxa-1-dethiacephalosporins
HU198725B (en)	1989-11-28	Process for producing new penem derivatives
JPH04364183A (ja)	1992-12-16	フルオロアルキル化カルバペネム中間体
US4192801A (en)	1980-03-11	Novel phosphorane intermediates for use in preparing penem antibiotics

Legal Events

Date	Code	Title	Description
1995-01-31	NAL	Patent in force	Ref document number: 8001424-4 Format of ref document f/p: F
2000-05-02	NUG	Patent has lapsed	Ref document number: 8001424-4 Format of ref document f/p: F

Date

Code

Title

Description

1995-01-31

NAL

Patent in force

Ref document number: 8001424-4

Format of ref document f/p: F

2000-05-02

NUG

Patent has lapsed