SE405601B - Forfarande for framstellning av 1-(3-(naft-1-yl-oxi)-2-hydroxipropyl)-piperazinderivat - Google Patents

Forfarande for framstellning av 1-(3-(naft-1-yl-oxi)-2-hydroxipropyl)-piperazinderivat

Info

Publication number: SE405601B
Authority: SE; Sweden
Prior art keywords: hydroxipropyl; naft; oxi; preparing; procedure
Prior art date: 1974-02-23

Application number

SE7501911A

Other languages

English (en)

Other versions

SE7501911L (sv

Inventor

E-C Witte

K Stach

M Thiel

G Sponer

E Roesch

Original Assignee

Boehringer Mannheim Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1974-02-23

Filing date

1975-02-20

Publication date

1978-12-18

1975-02-20 Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh

1975-08-25 Publication of SE7501911L publication Critical patent/SE7501911L/xx

1978-12-18 Publication of SE405601B publication Critical patent/SE405601B/sv

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

SE7501911A 1974-02-23 1975-02-20 Forfarande for framstellning av 1-(3-(naft-1-yl-oxi)-2-hydroxipropyl)-piperazinderivat SE405601B (sv)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE2408804A DE2408804C2 (de)	1974-02-23	1974-02-23	1-(2-Methoxyphenyl)-4-[3-(naphth-1-yl-oxy)-2-hydroxy-propyl]-piperazin, dessen Salze, Verfahren zu ihrer Herstellung sowie Arzneimittel, die diese Verbindungen enthalten

Publications (2)

Publication Number	Publication Date
SE7501911L SE7501911L (sv)	1975-08-25
SE405601B true SE405601B (sv)	1978-12-18

Family

ID=5908286

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SE7501911A SE405601B (sv)	1974-02-23	1975-02-20	Forfarande for framstellning av 1-(3-(naft-1-yl-oxi)-2-hydroxipropyl)-piperazinderivat

Country Status (20)

Country	Link
US (1)	US3997666A (sv)
JP (1)	JPS6029712B2 (sv)
AR (1)	AR206339A1 (sv)
AT (1)	AT340937B (sv)
BE (1)	BE825755A (sv)
CA (1)	CA1039282A (sv)
CH (2)	CH612958A5 (sv)
DE (1)	DE2408804C2 (sv)
DK (1)	DK135124C (sv)
ES (1)	ES434829A1 (sv)
FI (1)	FI59248C (sv)
FR (1)	FR2261770B1 (sv)
GB (1)	GB1445548A (sv)
IE (1)	IE40678B1 (sv)
NL (2)	NL175059B (sv)
PL (1)	PL92131B1 (sv)
SE (1)	SE405601B (sv)
SU (2)	SU549085A3 (sv)
YU (2)	YU37156B (sv)
ZA (1)	ZA751031B (sv)

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FR2387971A1 (fr) *	1977-04-19	1978-11-17	Delalande Sa	Nouvelles trimethoxy cinnamoyles piperazines, leur procede de preparation et leur application en therapeutique
JPS63141967A (ja) *	1986-11-21	1988-06-14	エイ・エッチ・ロビンス・カンパニー・インコーポレーテッド	抗アレルギー薬として有用な１−アリールオキシー４−［（４−アリール）−１−ピペラジニル］−２−ブタノール
US4882330A (en) *	1986-11-21	1989-11-21	A. H. Robins Company, Incorporated	1-aryloxy-4-[((4-aryl)-1-piperazinyl]-2-butanols useful as antiallergy agents
DE3918543A1 (de) *	1989-06-07	1990-12-13	Boehringer Mannheim Gmbh	Verwendung von naftopidil zur therapie der dysurie bei benigner prostata-hypertrophie
DE3918542A1 (de) *	1989-06-07	1990-12-13	Boehringer Mannheim Gmbh	Hydroxylierte 1-phenyl-4-(3-(napthth-1-yl-oxy)-2-hydroxy -propyl)-piperazine, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten
US20050065161A1 (en) *	1996-02-02	2005-03-24	Nitromed, Inc.	Nitrosated and nitrosylated alpha-adrenergic receptor antagonist compounds, compositions and their uses
US20020143007A1 (en) *	1996-02-02	2002-10-03	Garvey David S.	Nitrosated and nitrosylated alpha-adrenergic receptor antagonists, compositions and methods of use
US5932538A (en) *	1996-02-02	1999-08-03	Nitromed, Inc.	Nitrosated and nitrosylated α-adrenergic receptor antagonist compounds, compositions and their uses
KR20000070507A (ko)	1997-01-30	2000-11-25	요시다 쇼지	하이드로퀴논 유도체
NZ510685A (en)	1998-09-30	2003-10-31	Takeda Chemical Industries Ltd	Drugs for improving vesical excretory strength
US20020065286A1 (en) *	2000-08-21	2002-05-30	Davies Michael John	Treatment of wounds
US20020091129A1 (en) *	2000-11-20	2002-07-11	Mitradev Boolell	Treatment of premature ejaculation
US20030229001A1 (en) *	2002-01-31	2003-12-11	Pfizer Inc.	Treatment of male sexual dysfunction
OA12905A (en)	2002-08-19	2006-10-13	Pfizer Prod Inc	Combination therapy for hyperproliferative diseases.
GB0219961D0 (en)	2002-08-28	2002-10-02	Pfizer Ltd	Oxytocin inhibitors
US7323462B2 (en) *	2002-12-10	2008-01-29	Pfizer Inc.	Morpholine dopamine agonists
CA2451267A1 (en) *	2002-12-13	2004-06-13	Warner-Lambert Company Llc	Pharmaceutical uses for alpha2delta ligands
PT1572173E (pt)	2002-12-13	2010-05-10	Warner Lambert Co	Ligando alfa-2-delta para tratar sintomas do tracto urinário inferior
PA8597401A1 (es) *	2003-03-14	2005-05-24	Pfizer	Derivados del acido 3-(1-[3-(1,3-benzotiazol-6-il) propilcarbamoil] cicloalquil) propanoico como inhibidores de nep
US20040220186A1 (en) *	2003-04-30	2004-11-04	Pfizer Inc.	PDE9 inhibitors for treating type 2 diabetes,metabolic syndrome, and cardiovascular disease
EA009646B1 (ru)	2003-05-30	2008-02-28	Рэнбакси Лабораториз Лтд.	Замещённые производные пиррола и их применение в качестве ингибиторов hmg-coa
US20050065158A1 (en) *	2003-07-16	2005-03-24	Pfizer Inc.	Treatment of sexual dysfunction
US7291640B2 (en) *	2003-09-22	2007-11-06	Pfizer Inc.	Substituted triazole derivatives as oxytocin antagonists
ATE412648T1 (de)	2005-03-21	2008-11-15	Pfizer Ltd	Substituierte triazolderivate als oxytocinantagonisten
US20100222365A1 (en) *	2005-08-10	2010-09-02	Pfizer Inc	Substituted triazole deriviatives as oxytocin antagonists
GT200600381A (es)	2005-08-25	2007-03-28		Compuestos organicos
US7741317B2 (en)	2005-10-21	2010-06-22	Bristol-Myers Squibb Company	LXR modulators
EP1948599A1 (en)	2005-11-08	2008-07-30	Ranbaxy Laboratories Limited	Process for (3r, 5r)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4- [(4-hydroxy methyl phenyl amino) carbonyl]-pyrrol-1-yl]-3, 5-dihydroxy-heptanoic acid hemi calcium salt
US7888376B2 (en)	2005-11-23	2011-02-15	Bristol-Myers Squibb Company	Heterocyclic CETP inhibitors
US7919506B2 (en)	2006-03-10	2011-04-05	Pfizer Inc.	Dibenzyl amine compounds and derivatives
US8383660B2 (en)	2006-03-10	2013-02-26	Pfizer Inc.	Dibenzyl amine compounds and derivatives
US8470859B2 (en) *	2006-10-23	2013-06-25	Takeda Pharmaceutical Company Limited	Iminopyridine derivative and use thereof
WO2008070496A2 (en)	2006-12-01	2008-06-12	Bristol-Myers Squibb Company	N- ( (3-benzyl) -2, 2- (bis-phenyl) -propan-1-amine derivatives as cetp inhibitors for the treatment of atherosclerosis and cardiovascular diseases
US20110039892A1 (en)	2008-04-23	2011-02-17	Takeda Pharmaceutical Company Limited	Iminopyridine derivative and use thereof
US8481569B2 (en) *	2008-04-23	2013-07-09	Takeda Pharmaceutical Company Limited	Iminopyridine derivatives and use thereof
CN101671317B (zh) *	2009-10-09	2011-04-27	蚌埠丰原涂山制药有限公司	一种萘哌地尔的制备方法
CN101747293B (zh) *	2009-12-29	2011-12-07	蚌埠丰原涂山制药有限公司	萘哌地尔的制备方法
JP5807423B2 (ja) *	2011-07-21	2015-11-10	大日本印刷株式会社	ナフトピジルの製造方法
CN102816136A (zh) *	2012-09-18	2012-12-12	通化吉通药业有限公司	萘哌地尔制备方法
RU2618628C1 (ru)	2013-04-17	2017-05-05	Пфайзер Инк.	Производные N-пиперидин-3-илбензамида для лечения сердечно-сосудистых заболеваний
US9272980B2 (en)	2014-06-06	2016-03-01	Ktn Biotec, Inc.	Anticancer agent
WO2016055901A1 (en)	2014-10-08	2016-04-14	Pfizer Inc.	Substituted amide compounds
CA3125765A1 (en)	2019-01-18	2020-07-23	Astrazeneca Ab	Pcsk9 inhibitors and methods of use thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA967965A (en) *	1968-12-24	1975-05-20	Hoffmann-La Roche Limited	Aromatic ethers and process for the manufacture thereof
GB1317479A (en) *	1970-11-10	1973-05-16	Pfizer Ltd	1-2-hydroxy-3-phenoxy or phenylthiopropyl-4-phenyl-piperazine derivatives
DE2235597A1 (de) *	1972-07-20	1974-01-31	Boehringer Mannheim Gmbh	1-eckige klammer auf 3-(5,6,7,8tetrahydronaphth-1-yl-oxy) -propyl eckige klammer zu -piperazin-derivate und verfahren zu ihrer herstellung

0
- NL NLAANVRAGE7501877,A patent/NL175059C/xx active
1974
- 1974-02-23 DE DE2408804A patent/DE2408804C2/de not_active Expired
1975
- 1975-01-01 AR AR257639A patent/AR206339A1/es active
- 1975-01-28 US US05/544,719 patent/US3997666A/en not_active Expired - Lifetime
- 1975-02-12 CA CA219,883A patent/CA1039282A/en not_active Expired
- 1975-02-17 GB GB656975A patent/GB1445548A/en not_active Expired
- 1975-02-18 ES ES434829A patent/ES434829A1/es not_active Expired
- 1975-02-18 YU YU0382/75A patent/YU37156B/xx unknown
- 1975-02-18 NL NLAANVRAGE7501877,A patent/NL175059B/xx not_active IP Right Cessation
- 1975-02-18 DK DK58175A patent/DK135124C/da not_active IP Right Cessation
- 1975-02-18 FI FI750449A patent/FI59248C/fi not_active IP Right Cessation
- 1975-02-19 ZA ZA00751031A patent/ZA751031B/xx unknown
- 1975-02-20 JP JP50021386A patent/JPS6029712B2/ja not_active Expired
- 1975-02-20 BE BE153540A patent/BE825755A/xx not_active IP Right Cessation
- 1975-02-20 SE SE7501911A patent/SE405601B/sv not_active IP Right Cessation
- 1975-02-21 CH CH1023478A patent/CH612958A5/xx not_active IP Right Cessation
- 1975-02-21 FR FR7505511A patent/FR2261770B1/fr not_active Expired
- 1975-02-21 PL PL1975178230A patent/PL92131B1/pl unknown
- 1975-02-21 CH CH218575A patent/CH609342A5/xx not_active IP Right Cessation
- 1975-02-21 IE IE359/75A patent/IE40678B1/xx unknown
- 1975-02-21 AT AT132375A patent/AT340937B/de not_active IP Right Cessation
- 1975-02-21 SU SU2112509A patent/SU549085A3/ru active
1976
- 1976-01-07 SU SU2308659A patent/SU561514A3/ru active
1981
- 1981-04-21 YU YU1044/81A patent/YU37157B/xx unknown

Also Published As

Publication number	Publication date
FR2261770A1 (sv)	1975-09-19
IE40678B1 (en)	1979-08-01
NL175059C (nl)
FI59248C (fi)	1981-07-10
DE2408804C2 (de)	1983-09-22
DK135124B (da)	1977-03-07
CA1039282A (en)	1978-09-26
ZA751031B (en)	1976-02-25
PL92131B1 (sv)	1977-03-31
YU37157B (en)	1984-08-31
ES434829A1 (es)	1976-12-01
YU37156B (en)	1984-08-31
ATA132375A (de)	1977-05-15
AR206339A1 (es)	1976-07-15
JPS50121286A (sv)	1975-09-23
BE825755A (fr)	1975-08-20
AU7826875A (en)	1976-08-19
GB1445548A (en)	1976-08-11
SU549085A3 (ru)	1977-02-28
AT340937B (de)	1978-01-10
SE7501911L (sv)	1975-08-25
CH609342A5 (sv)	1979-02-28
NL175059B (nl)	1984-04-16
IE40678L (en)	1975-08-23
JPS6029712B2 (ja)	1985-07-12
FI750449A (sv)	1975-08-24
NL7501877A (nl)	1975-08-26
US3997666A (en)	1976-12-14
YU104481A (en)	1983-04-27
YU38275A (en)	1983-04-27
SU561514A3 (ru)	1977-06-05
DK58175A (sv)	1975-10-20
DE2408804A1 (de)	1975-09-04
FI59248B (fi)	1981-03-31
DK135124C (da)	1977-08-15
CH612958A5 (sv)	1979-08-31
FR2261770B1 (sv)	1978-08-04

Publication	Publication Date	Title
SE405601B (sv)	1978-12-18	Forfarande for framstellning av 1-(3-(naft-1-yl-oxi)-2-hydroxipropyl)-piperazinderivat
SE428562B (sv)	1983-07-11	Forfarande for framstellning av purinderivat
SE420199B (sv)	1981-09-21	Forfarande for framstellning av 16-oxiderade prostansyraderivat
SE416299B (sv)	1980-12-15	Forfarande for framstellning av heterocykliska foreningar
SE423633B (sv)	1982-05-17	Forfarande for framstellning av 4-demetoxi-daunomycin
SE420727B (sv)	1981-10-26	Analogiforfarande for framstellning av bispidin- och bispidonderivat
SE431652B (sv)	1984-02-20	Forfarande for framstellning av 7beta-amino-3cefem-3ol-4-karboxylsyraderivat
SE412066B (sv)	1980-02-18	Forfarande for framstellning av famakologiskt verksamma tienodiazinderivat
SE431211B (sv)	1984-01-23	Forfarande for framstellning av n-acylamino-alfa-arylacetamido-cefalosporiner
SE417533B (sv)	1981-03-23	Forfarande for limning av papper
SE7508074L (sv)	1976-01-19	Forfarande for framstellning av stilbenderivat.
SE421612B (sv)	1982-01-18	Forfarande for framstellning av alfa-6-deoxi-5-hydroxitetracyklin
SE422052B (sv)	1982-02-15	Forfarande for framstellning av vissa angivna 1-fenoxi-2-hydroxi-3-aminofenyl-propylderivat
SE418292B (sv)	1981-05-18	Forfarande for framstellning av 5-aryl-2-furamidiner
AR213287A1 (es)	1979-01-15	Procedimiento para preparar derivados de 4-(2-hidroxi-3-aminopropoxi)-indol
SE425739B (sv)	1982-11-01	Forfarande for framstellning av vissa angivna tetrazolyl-bensopyranopyridinderivat
SE422202B (sv)	1982-02-22	Forfarande for framstellning av amidoximderivat
SE422210B (sv)	1982-02-22	Analogiforfarande for framstellning av substituerade indoler
SE414926B (sv)	1980-08-25	Forfarande for framstellning av 1-alkyl-2-(fenoximetyl)-5-nitroimidazoler
SE419543B (sv)	1981-08-10	Forfarande for framstellning av vissa angivna isokinolinderivat
SE415658B (sv)	1980-10-20	Analogiforfarande for framstellning av linnolinderivat
SE404364B (sv)	1978-10-02	Forfarande for framstellning av vissa angivna 5-sulfonylfenyl-tetrazolderivat
SE425784B (sv)	1982-11-08	Analogiforfarande for framstellning av eburnameninderivat
SE405600B (sv)	1978-12-18	Forfarande for framstellning av 1-(3-(naft-1-yl-oxi)-propyl)-piperazinderivat
SE421310B (sv)	1981-12-14	Forfarande for framstellning av substituerade bensoylpyridiner

Legal Events

Date	Code	Title	Description
1995-01-31	NAL	Patent in force	Ref document number: 7501911-7 Format of ref document f/p: F
1995-05-08	NUG	Patent has lapsed	Ref document number: 7501911-7 Format of ref document f/p: F

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1995-01-31

NAL

Patent in force

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1995-05-08

NUG

Patent has lapsed