DK135124B - Analogifremgangsmade til fremstilling af 1-(3-(naphth-1-yl-oxy)-2-hydroxypropyl)-)-piperazinderivater eller syreadditionssalte heraf - Google Patents

Analogifremgangsmade til fremstilling af 1-(3-(naphth-1-yl-oxy)-2-hydroxypropyl)-)-piperazinderivater eller syreadditionssalte heraf

Info

Publication number: DK135124B
Authority: DK; Denmark
Prior art keywords: naphth; oxy; hydroxypropyl; preparation; acid addition
Prior art date: 1974-02-23

Application number

DK58175AA

Other languages

English (en)

Other versions

DK58175A (da

DK135124C (da

Inventor

E-C Witte

K Stach

M Thiel

G Sponer

E Roesch

Original Assignee

Boehringer Mannheim Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1974-02-23

Filing date

1975-02-18

Publication date

1977-03-07

1975-02-18 Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh

1975-10-20 Publication of DK58175A publication Critical patent/DK58175A/da

1977-03-07 Publication of DK135124B publication Critical patent/DK135124B/da

1977-08-15 Application granted granted Critical

1977-08-15 Publication of DK135124C publication Critical patent/DK135124C/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DK58175A 1974-02-23 1975-02-18 Analogifremgangsmade til fremstilling af 1-(3-(naphth-1-yl-oxy)-2-hydroxypropyl)-piperazinderivater eller syreadditionssalte heraf DK135124C (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE2408804A DE2408804C2 (de)	1974-02-23	1974-02-23	1-(2-Methoxyphenyl)-4-[3-(naphth-1-yl-oxy)-2-hydroxy-propyl]-piperazin, dessen Salze, Verfahren zu ihrer Herstellung sowie Arzneimittel, die diese Verbindungen enthalten

Publications (3)

Publication Number	Publication Date
DK58175A DK58175A (da)	1975-10-20
DK135124B true DK135124B (da)	1977-03-07
DK135124C DK135124C (da)	1977-08-15

Family

ID=5908286

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK58175A DK135124C (da)	1974-02-23	1975-02-18	Analogifremgangsmade til fremstilling af 1-(3-(naphth-1-yl-oxy)-2-hydroxypropyl)-piperazinderivater eller syreadditionssalte heraf

Country Status (20)

Country	Link
US (1)	US3997666A (da)
JP (1)	JPS6029712B2 (da)
AR (1)	AR206339A1 (da)
AT (1)	AT340937B (da)
BE (1)	BE825755A (da)
CA (1)	CA1039282A (da)
CH (2)	CH612958A5 (da)
DE (1)	DE2408804C2 (da)
DK (1)	DK135124C (da)
ES (1)	ES434829A1 (da)
FI (1)	FI59248C (da)
FR (1)	FR2261770B1 (da)
GB (1)	GB1445548A (da)
IE (1)	IE40678B1 (da)
NL (2)	NL175059B (da)
PL (1)	PL92131B1 (da)
SE (1)	SE405601B (da)
SU (2)	SU549085A3 (da)
YU (2)	YU37156B (da)
ZA (1)	ZA751031B (da)

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FR2387971A1 (fr) *	1977-04-19	1978-11-17	Delalande Sa	Nouvelles trimethoxy cinnamoyles piperazines, leur procede de preparation et leur application en therapeutique
JPS63141967A (ja) *	1986-11-21	1988-06-14	エイ・エッチ・ロビンス・カンパニー・インコーポレーテッド	抗アレルギー薬として有用な１−アリールオキシー４−［（４−アリール）−１−ピペラジニル］−２−ブタノール
US4882330A (en) *	1986-11-21	1989-11-21	A. H. Robins Company, Incorporated	1-aryloxy-4-[((4-aryl)-1-piperazinyl]-2-butanols useful as antiallergy agents
DE3918543A1 (de) *	1989-06-07	1990-12-13	Boehringer Mannheim Gmbh	Verwendung von naftopidil zur therapie der dysurie bei benigner prostata-hypertrophie
DE3918542A1 (de) *	1989-06-07	1990-12-13	Boehringer Mannheim Gmbh	Hydroxylierte 1-phenyl-4-(3-(napthth-1-yl-oxy)-2-hydroxy -propyl)-piperazine, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten
US20050065161A1 (en) *	1996-02-02	2005-03-24	Nitromed, Inc.	Nitrosated and nitrosylated alpha-adrenergic receptor antagonist compounds, compositions and their uses
US20020143007A1 (en) *	1996-02-02	2002-10-03	Garvey David S.	Nitrosated and nitrosylated alpha-adrenergic receptor antagonists, compositions and methods of use
US5932538A (en) *	1996-02-02	1999-08-03	Nitromed, Inc.	Nitrosated and nitrosylated α-adrenergic receptor antagonist compounds, compositions and their uses
KR20000070507A (ko)	1997-01-30	2000-11-25	요시다 쇼지	하이드로퀴논 유도체
NZ510685A (en)	1998-09-30	2003-10-31	Takeda Chemical Industries Ltd	Drugs for improving vesical excretory strength
US20020065286A1 (en) *	2000-08-21	2002-05-30	Davies Michael John	Treatment of wounds
US20020091129A1 (en) *	2000-11-20	2002-07-11	Mitradev Boolell	Treatment of premature ejaculation
US20030229001A1 (en) *	2002-01-31	2003-12-11	Pfizer Inc.	Treatment of male sexual dysfunction
OA12905A (en)	2002-08-19	2006-10-13	Pfizer Prod Inc	Combination therapy for hyperproliferative diseases.
GB0219961D0 (en)	2002-08-28	2002-10-02	Pfizer Ltd	Oxytocin inhibitors
US7323462B2 (en) *	2002-12-10	2008-01-29	Pfizer Inc.	Morpholine dopamine agonists
CA2451267A1 (en) *	2002-12-13	2004-06-13	Warner-Lambert Company Llc	Pharmaceutical uses for alpha2delta ligands
PT1572173E (pt)	2002-12-13	2010-05-10	Warner Lambert Co	Ligando alfa-2-delta para tratar sintomas do tracto urinário inferior
PA8597401A1 (es) *	2003-03-14	2005-05-24	Pfizer	Derivados del acido 3-(1-[3-(1,3-benzotiazol-6-il) propilcarbamoil] cicloalquil) propanoico como inhibidores de nep
US20040220186A1 (en) *	2003-04-30	2004-11-04	Pfizer Inc.	PDE9 inhibitors for treating type 2 diabetes,metabolic syndrome, and cardiovascular disease
EA009646B1 (ru)	2003-05-30	2008-02-28	Рэнбакси Лабораториз Лтд.	Замещённые производные пиррола и их применение в качестве ингибиторов hmg-coa
US20050065158A1 (en) *	2003-07-16	2005-03-24	Pfizer Inc.	Treatment of sexual dysfunction
US7291640B2 (en) *	2003-09-22	2007-11-06	Pfizer Inc.	Substituted triazole derivatives as oxytocin antagonists
ATE412648T1 (de)	2005-03-21	2008-11-15	Pfizer Ltd	Substituierte triazolderivate als oxytocinantagonisten
US20100222365A1 (en) *	2005-08-10	2010-09-02	Pfizer Inc	Substituted triazole deriviatives as oxytocin antagonists
GT200600381A (es)	2005-08-25	2007-03-28		Compuestos organicos
US7741317B2 (en)	2005-10-21	2010-06-22	Bristol-Myers Squibb Company	LXR modulators
EP1948599A1 (en)	2005-11-08	2008-07-30	Ranbaxy Laboratories Limited	Process for (3r, 5r)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4- [(4-hydroxy methyl phenyl amino) carbonyl]-pyrrol-1-yl]-3, 5-dihydroxy-heptanoic acid hemi calcium salt
US7888376B2 (en)	2005-11-23	2011-02-15	Bristol-Myers Squibb Company	Heterocyclic CETP inhibitors
US7919506B2 (en)	2006-03-10	2011-04-05	Pfizer Inc.	Dibenzyl amine compounds and derivatives
US8383660B2 (en)	2006-03-10	2013-02-26	Pfizer Inc.	Dibenzyl amine compounds and derivatives
US8470859B2 (en) *	2006-10-23	2013-06-25	Takeda Pharmaceutical Company Limited	Iminopyridine derivative and use thereof
WO2008070496A2 (en)	2006-12-01	2008-06-12	Bristol-Myers Squibb Company	N- ( (3-benzyl) -2, 2- (bis-phenyl) -propan-1-amine derivatives as cetp inhibitors for the treatment of atherosclerosis and cardiovascular diseases
US20110039892A1 (en)	2008-04-23	2011-02-17	Takeda Pharmaceutical Company Limited	Iminopyridine derivative and use thereof
US8481569B2 (en) *	2008-04-23	2013-07-09	Takeda Pharmaceutical Company Limited	Iminopyridine derivatives and use thereof
CN101671317B (zh) *	2009-10-09	2011-04-27	蚌埠丰原涂山制药有限公司	一种萘哌地尔的制备方法
CN101747293B (zh) *	2009-12-29	2011-12-07	蚌埠丰原涂山制药有限公司	萘哌地尔的制备方法
JP5807423B2 (ja) *	2011-07-21	2015-11-10	大日本印刷株式会社	ナフトピジルの製造方法
CN102816136A (zh) *	2012-09-18	2012-12-12	通化吉通药业有限公司	萘哌地尔制备方法
RU2618628C1 (ru)	2013-04-17	2017-05-05	Пфайзер Инк.	Производные N-пиперидин-3-илбензамида для лечения сердечно-сосудистых заболеваний
US9272980B2 (en)	2014-06-06	2016-03-01	Ktn Biotec, Inc.	Anticancer agent
WO2016055901A1 (en)	2014-10-08	2016-04-14	Pfizer Inc.	Substituted amide compounds
CA3125765A1 (en)	2019-01-18	2020-07-23	Astrazeneca Ab	Pcsk9 inhibitors and methods of use thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA967965A (en) *	1968-12-24	1975-05-20	Hoffmann-La Roche Limited	Aromatic ethers and process for the manufacture thereof
GB1317479A (en) *	1970-11-10	1973-05-16	Pfizer Ltd	1-2-hydroxy-3-phenoxy or phenylthiopropyl-4-phenyl-piperazine derivatives
DE2235597A1 (de) *	1972-07-20	1974-01-31	Boehringer Mannheim Gmbh	1-eckige klammer auf 3-(5,6,7,8tetrahydronaphth-1-yl-oxy) -propyl eckige klammer zu -piperazin-derivate und verfahren zu ihrer herstellung

0
- NL NLAANVRAGE7501877,A patent/NL175059C/xx active
1974
- 1974-02-23 DE DE2408804A patent/DE2408804C2/de not_active Expired
1975
- 1975-01-01 AR AR257639A patent/AR206339A1/es active
- 1975-01-28 US US05/544,719 patent/US3997666A/en not_active Expired - Lifetime
- 1975-02-12 CA CA219,883A patent/CA1039282A/en not_active Expired
- 1975-02-17 GB GB656975A patent/GB1445548A/en not_active Expired
- 1975-02-18 ES ES434829A patent/ES434829A1/es not_active Expired
- 1975-02-18 YU YU0382/75A patent/YU37156B/xx unknown
- 1975-02-18 NL NLAANVRAGE7501877,A patent/NL175059B/xx not_active IP Right Cessation
- 1975-02-18 DK DK58175A patent/DK135124C/da not_active IP Right Cessation
- 1975-02-18 FI FI750449A patent/FI59248C/fi not_active IP Right Cessation
- 1975-02-19 ZA ZA00751031A patent/ZA751031B/xx unknown
- 1975-02-20 JP JP50021386A patent/JPS6029712B2/ja not_active Expired
- 1975-02-20 BE BE153540A patent/BE825755A/xx not_active IP Right Cessation
- 1975-02-20 SE SE7501911A patent/SE405601B/xx not_active IP Right Cessation
- 1975-02-21 CH CH1023478A patent/CH612958A5/xx not_active IP Right Cessation
- 1975-02-21 FR FR7505511A patent/FR2261770B1/fr not_active Expired
- 1975-02-21 PL PL1975178230A patent/PL92131B1/pl unknown
- 1975-02-21 CH CH218575A patent/CH609342A5/xx not_active IP Right Cessation
- 1975-02-21 IE IE359/75A patent/IE40678B1/xx unknown
- 1975-02-21 AT AT132375A patent/AT340937B/de not_active IP Right Cessation
- 1975-02-21 SU SU2112509A patent/SU549085A3/ru active
1976
- 1976-01-07 SU SU2308659A patent/SU561514A3/ru active
1981
- 1981-04-21 YU YU1044/81A patent/YU37157B/xx unknown

Also Published As

Publication number	Publication date
FR2261770A1 (da)	1975-09-19
IE40678B1 (en)	1979-08-01
NL175059C (nl)
FI59248C (fi)	1981-07-10
DE2408804C2 (de)	1983-09-22
CA1039282A (en)	1978-09-26
ZA751031B (en)	1976-02-25
PL92131B1 (da)	1977-03-31
YU37157B (en)	1984-08-31
ES434829A1 (es)	1976-12-01
YU37156B (en)	1984-08-31
ATA132375A (de)	1977-05-15
AR206339A1 (es)	1976-07-15
JPS50121286A (da)	1975-09-23
BE825755A (fr)	1975-08-20
AU7826875A (en)	1976-08-19
GB1445548A (en)	1976-08-11
SU549085A3 (ru)	1977-02-28
AT340937B (de)	1978-01-10
SE7501911L (da)	1975-08-25
CH609342A5 (da)	1979-02-28
NL175059B (nl)	1984-04-16
IE40678L (en)	1975-08-23
JPS6029712B2 (ja)	1985-07-12
FI750449A (da)	1975-08-24
NL7501877A (nl)	1975-08-26
US3997666A (en)	1976-12-14
YU104481A (en)	1983-04-27
YU38275A (en)	1983-04-27
SU561514A3 (ru)	1977-06-05
DK58175A (da)	1975-10-20
DE2408804A1 (de)	1975-09-04
FI59248B (fi)	1981-03-31
SE405601B (sv)	1978-12-18
DK135124C (da)	1977-08-15
CH612958A5 (da)	1979-08-31
FR2261770B1 (da)	1978-08-04

Publication	Publication Date	Title
DK135124B (da)	1977-03-07	Analogifremgangsmade til fremstilling af 1-(3-(naphth-1-yl-oxy)-2-hydroxypropyl)-)-piperazinderivater eller syreadditionssalte heraf
DK56077A (da)	1977-08-12	Fremgangsmade til fremstilling af 3-quinolincarboxylsyrederivater eller additionssalte deraf
DK143275C (da)	1982-01-18	Analogifremgangsmaade til fremstilling af 1-(3-dimethylaminopropyl)-phthalanderivater eller syreadditionssalte deraf
DK178379A (da)	1979-11-04	Fremgangsmaade til fremstilling af n-substituerede moranolinderivater eller syreadditionssalte deraf
DK137188C (da)	1978-07-03	Analogifremgangsmaade til fremstilling af 2-tetrahydrofurfuryl-6,7-benzomorphaner eller syreadditionssalte heraf
DK139387C (da)	1979-07-23	Analogifremgangsmaade til fremstilling af apovincaminsyrederivater eller syreadditionssalte deraf
DK138992C (da)	1979-04-30	Analogifremgangsmaade til fremstilling af 5,9beta-disubstituerede 2-tetrahydrofurfuryl-6,7-benzomorphaner eller syreadditionssalte heraf
DK138656C (da)	1979-04-02	Analogifremgangsmaade til fremstilling af erythromycinderivater eller syreadditionssalte deraf
DK135842C (da)	1977-11-28	Analogifremgangsmade til fremstilling af 7-methoxy-6-thiatetracycliner eller syreadditionssalte deraf
DK149230C (da)	1986-08-11	Analogifremgangsmaade til fremstilling af 5-benzoyl-6-hydroxy-indan-1-carboxylsyrederivater eller farmaceutisk acceptable salte deraf
DK441875A (da)	1976-04-02	Fremgangsmade til fremstilling af 2-phenyliminoimidazolidiner eller syreadditionssalte deraf
DK591975A (da)	1976-07-01	Fremgangsmade til fremstilling af phenyleddikesyrederivater
DK139724C (da)	1979-09-17	Analogifremgangsmaade til fremstilling af pyridobenzodiazepinoner eller salte heraf
DK140695B (da)	1979-10-29	Analogifremgangsmaade til fremstilling af 2,4-diamo-6,7-dimethoxyquinazolinderivater eller syreadditionssalte heraf
DK137677C (da)	1978-09-25	Analogifremgangsmaade til fremstilling af basisk substitueredexanthinderivater eller syreadditionssalte heraf
DK338376A (da)	1977-01-29	Fremgangsmade til fremstilling af aminobenzocycloheptenderivater eller additionssalte deraf
DK386876A (da)	1977-02-28	Fremgangsmade til fremstilling af n-tetrahydrofurfuryl-noroxymorphoner eller syreadditionssalte deraf
DK139522C (da)	1979-08-20	Analogifremgangsmaade til fremstilling af 9-iminoalkylamino-erythromyciner eller syreadditionssalte deraf
DK131778C (da)	1976-02-02	Fremgangsmade til fremstilling af substituerede 3-hydroksymetylisokinolinderivater eller syreadditionssalte heraf
DK137606C (da)	1978-09-18	Analogifremgangsmaade til fremstilling af substituerede 2-phenylamino-imidazoliner-(2) eller syreadditionssalte deraf
DK139517C (da)	1979-08-20	Analogifremgangsmaade til fremstilling af substituerede thiazol-2-carboxamider eller syreadditionssalte deraf
DK131857C (da)	1976-02-16	Analogifremgangsmade til fremstilling af 4-hydroxymethyl-1-phthalazonderivater eller syreadditionssalte deraf
DK532176A (da)	1977-05-27	Fremgangsmade til fremstilling af tetradydropyridin-og piperidinderivater eller syreadditionssalte deraf
DK136646B (da)	1977-11-07	Analogifremgangsmade til fremstilling af basisk substituerede 2-carbalkoxyamino-benzimidazolyl-5(6)-phenylethere og -ketoner eller syreadditionssalte deraf
DK135125C (da)	1977-08-15	Analogifremgangsmade til fremstilling af 1-(3-(naphth-1-yl-oxy)-propyl)-piperazinderivater eller deres syreadditionssalte

Legal Events

Date	Code	Title	Description
1995-04-03	PUP	Patent expired