[go: up one dir, main page]

SE336130B - - Google Patents

Info

Publication number
SE336130B
SE336130B SE12607/65A SE1260765A SE336130B SE 336130 B SE336130 B SE 336130B SE 12607/65 A SE12607/65 A SE 12607/65A SE 1260765 A SE1260765 A SE 1260765A SE 336130 B SE336130 B SE 336130B
Authority
SE
Sweden
Prior art keywords
steroid
oxo
cyano
moiety
hydroxy
Prior art date
Application number
SE12607/65A
Inventor
R Clinton
A Manson
Original Assignee
Sterling Drug Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sterling Drug Inc filed Critical Sterling Drug Inc
Publication of SE336130B publication Critical patent/SE336130B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)

Abstract

The invention comprises a 2-cyano-3-oxo steroid, the steroid moiety of which contains 18 to 23 carbon atoms exclusive of ester radicals, and salts thereof derived from strong inorganic bases, and the preparation thereof by treating steroido [2-3-d] isoxazoles with a strong inorganic base (an alkali metal alkoxide may also be used) to form a salt of the 2-cyano-3-oxo steroid and, if desired, converting the salt to the free 2-cyano-3-oxo steroid by acidification. The steroid moiety may be a member of the androstane, etiocholane or pregnane series and may contain one or more double bonds especially at the 4,5- and/or 6,7-positions. The steroid moiety may be substituted at the 17-position by a hydroxy, acyloxy or oxo substituent, or both a hydroxy and alkyl substituents, or a lower alkenyl, lower alkynyl, acetyl, hydroxyacetyl, 1,2-dihydroxyethyl or 1-hydroxyethyl substituent. The lower alkyl, lower alkenyl and lower alkynyl radicals contain 1 to 4 carbon atoms. The steroid may also be an 18- or 19-nor-steroid.
SE12607/65A 1958-07-23 1965-09-29 SE336130B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US75028958A 1958-07-23 1958-07-23

Publications (1)

Publication Number Publication Date
SE336130B true SE336130B (en) 1971-06-28

Family

ID=25017246

Family Applications (1)

Application Number Title Priority Date Filing Date
SE12607/65A SE336130B (en) 1958-07-23 1965-09-29

Country Status (6)

Country Link
BE (1) BE580902A (en)
CH (2) CH390251A (en)
FR (1) FR591M (en)
GB (2) GB905844A (en)
NL (2) NL241544A (en)
SE (1) SE336130B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3136757A (en) * 1960-07-27 1964-06-09 Serono Ist Farm Method for preparation of (3, 2-c)-isoxazoles
GB8328929D0 (en) * 1983-10-29 1983-11-30 Sterwin Ag Steroid compounds
CA2781771A1 (en) 2009-06-22 2010-12-29 Dmi Acquisition Corp. Pharmaceutical dosage forms and compositions comprising danazol
EP2934546A4 (en) 2012-12-19 2016-06-22 Ampio Pharmaceuticals Inc Method for treatment of diseases
CN104086619B (en) * 2014-06-23 2016-08-24 江苏佳尔科药业集团有限公司 The preparation method of danazol
CN109517027B (en) * 2019-01-23 2020-07-03 江苏联环药业股份有限公司 Preparation method of danazol

Also Published As

Publication number Publication date
NL241544A (en)
BE580902A (en) 1960-01-22
GB905845A (en) 1962-09-12
CH390251A (en) 1965-04-15
CH398573A (en) 1966-03-15
NL104564C (en)
FR591M (en) 1961-06-12
GB905844A (en) 1962-09-12

Similar Documents

Publication Publication Date Title
GB963442A (en) Steroid compounds and the preparation thereof
SE336130B (en)
GB901093A (en) Steroids
GB933154A (en) Improvements in or relating to steroidal lactones
GB1103077A (en) A novel gonane derivative, and processes for its preparation
GB1101116A (en) Steroidal 2ª‡-carboxylic acids and esters
GB1014155A (en) New estrene derivatives and processes for the preparation and use thereof
GB1015014A (en) Novel steroid compounds and processes for their preparation
GB1099007A (en) Novel process for preparing unsaturated steroids
ES319114A1 (en) A procedure for preparing the 21-hydroxy steroids of the pregnan series esterified in the position 21. (Machine-translation by Google Translate, not legally binding)
GB765509A (en) Improvements in or relating to steroids and the preparation thereof
GB1056935A (en) Processes for the preparation of 21,21-bis-hydroxymethyl pregnanes
GB1164644A (en) 2,2-Ethylene-Steroids
GB912962A (en) Steroids and method of producing same
GB1047790A (en) Improvements in or relating to steroid compounds
ES245214A1 (en) Procedure for the preparation of hydrazides n1, n2-disustitute of carboxylic acids (Machine-translation by Google Translate, not legally binding)
GB1003305A (en) Novel steroid compounds and their preparation
GB1123766A (en) 12-oxygenated steroids
GB1019455A (en) í¸-3-keto-androstadiene compounds and process for their manufacture
ES356430A1 (en) A procedure for the preparation of 3-oximes and esters of 3-oxima of 19-nortestosteronas. (Machine-translation by Google Translate, not legally binding)
GB1029438A (en) Process for preparing 6-keto-í¸-19-nor-3-acyloxy steroids
GB854408A (en) New cyclopentanophenanthrene derivatives and process for the production thereof
GB1087646A (en) Novel processes for preparing steroid compounds, and novel steroid compounds thereby prepared
GB989918A (en) Preparation of 11ª‡-hydroxy-í¸-3-keto steroids
GR22382B (en) IMPROVEMENTS IN OR RELATING TO METHODS OF MAKING NEW STEROID COMPOUNDS.