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SE0101765D0 - Novel compounds - Google Patents

Novel compounds

Info

Publication number
SE0101765D0
SE0101765D0 SE0101765A SE0101765A SE0101765D0 SE 0101765 D0 SE0101765 D0 SE 0101765D0 SE 0101765 A SE0101765 A SE 0101765A SE 0101765 A SE0101765 A SE 0101765A SE 0101765 D0 SE0101765 D0 SE 0101765D0
Authority
SE
Sweden
Prior art keywords
sub
sup
ring
phenyl
novel compounds
Prior art date
Application number
SE0101765A
Other languages
English (en)
Swedish (sv)
Inventor
William Brown
Christopher Walpole
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Priority to SE0101765A priority Critical patent/SE0101765D0/xx
Publication of SE0101765D0 publication Critical patent/SE0101765D0/xx
Priority to RU2003131970/04A priority patent/RU2003131970A/ru
Priority to JP2002591485A priority patent/JP2005510457A/ja
Priority to EEP200300540A priority patent/EE200300540A/xx
Priority to BR0209676-5A priority patent/BR0209676A/pt
Priority to MXPA03010439A priority patent/MXPA03010439A/es
Priority to HU0401096A priority patent/HUP0401096A2/hu
Priority to US10/477,821 priority patent/US7074808B2/en
Priority to CZ20033085A priority patent/CZ20033085A3/cs
Priority to IL15870402A priority patent/IL158704A0/xx
Priority to DE60205894T priority patent/DE60205894T2/de
Priority to ARP020101810A priority patent/AR035973A1/es
Priority to PCT/SE2002/000953 priority patent/WO2002094812A1/en
Priority to EP02733710A priority patent/EP1395576B1/en
Priority to SK1395-2003A priority patent/SK13952003A3/sk
Priority to PL02366640A priority patent/PL366640A1/xx
Priority to KR10-2003-7014941A priority patent/KR20040000467A/ko
Priority to AT02733710T priority patent/ATE303379T1/de
Priority to CA002446332A priority patent/CA2446332A1/en
Priority to CNA028101952A priority patent/CN1509282A/zh
Priority to ZA200308633A priority patent/ZA200308633B/en
Priority to BG108326A priority patent/BG108326A/bg
Priority to IS7026A priority patent/IS7026A/is
Priority to CO03100156A priority patent/CO5611136A2/es
Priority to NO20035116A priority patent/NO20035116D0/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Hydrogenated Pyridines (AREA)
SE0101765A 2001-05-18 2001-05-18 Novel compounds SE0101765D0 (sv)

Priority Applications (25)

Application Number Priority Date Filing Date Title
SE0101765A SE0101765D0 (sv) 2001-05-18 2001-05-18 Novel compounds
CNA028101952A CN1509282A (zh) 2001-05-18 2002-05-16 4-(苯基-哌啶-4-基亚基-甲基)-苯甲酰胺衍生物及其在治疗疼痛、焦虑或胃肠疾病中的用途
DE60205894T DE60205894T2 (de) 2001-05-18 2002-05-16 4-(phenyl-piperidin-4-ylidenmethyl)-benzamid-derivate und deren verwendung zur behandlung von schmerzen, angst oder gastrointestinalen störungen
PCT/SE2002/000953 WO2002094812A1 (en) 2001-05-18 2002-05-16 4-(phenyl-piperidin-4-ylidene-methyl)-benzamide derivatives and their use for the treatment of pain, anxiety or gastrointestinal disorders
EEP200300540A EE200300540A (et) 2001-05-18 2002-05-16 4-(fenüülpiperidiin-4-ülideenmetüül)bensamiidi derivaadid, nende valmistamine ja kasutamine valu, ärevuse või seedetrakti häirete ravis
BR0209676-5A BR0209676A (pt) 2001-05-18 2002-05-16 Composto, processo para preparar o mesmo, uso de um composto, composição farmacêutica, e, métodos para o tratamento da dor, de distúrbios gastrintestinais funcionais, e da ansiedade.
MXPA03010439A MXPA03010439A (es) 2001-05-18 2002-05-16 Derivados de 4-(fenil-piperidin-a-iliden-metil)-benzamida y su uso para tratar dolor, ansiedad o trastornos gastrointestinales.
HU0401096A HUP0401096A2 (hu) 2001-05-18 2002-05-16 4-[Fenil-(4-piperidinilidén)-metil]-benzamid-származékok és alkalmazásuk fájdalom, szorongás vagy gasztrointesztinális zavarok kezelésére, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények
US10/477,821 US7074808B2 (en) 2001-05-18 2002-05-16 4-(Phenyl-piperidin-4-ylidene-methyl)-benzamide derivatives and their use for the treatment of pain, anxiety or gastrointestional disorders
CZ20033085A CZ20033085A3 (cs) 2001-05-18 2002-05-16 @}Fenylpiperidin@ylidenmethylB benzamidové deriváty a jejich použití pro ošetřování bolestiŹ úzkosti nebo gastrointestinálních poruch
IL15870402A IL158704A0 (en) 2001-05-18 2002-05-16 4-(phenyl-piperidin-4-ylidene-methyl)-benzamide derivatives and their use for the treatment of pain, anxiety or gastrointestinal disorders
RU2003131970/04A RU2003131970A (ru) 2001-05-18 2002-05-16 Производные 4-(фенил-пиперидин-4-илиден-метил)-бензамида и их применение для лечения боли, тревоги или желудочно-кишечных расстройств
ARP020101810A AR035973A1 (es) 2001-05-18 2002-05-16 Derivados de 4-[1-(3-amino-fenil)-1-(piperidin-4-iliden)-metil]-n,n-dietil-benzamida, procedimiento para su preparacion, empleo de estos compuestos para la fabricacion de medicamentos, composicion farmaceutica e intermediarios
JP2002591485A JP2005510457A (ja) 2001-05-18 2002-05-16 ４−（フェニル−ピペリジン−４−イリデン−メチル）−ベンズアミド誘導体及び疼痛、不安症又は胃腸障害の治療のためのその使用
EP02733710A EP1395576B1 (en) 2001-05-18 2002-05-16 4-(phenyl-piperidin-4-ylidene-methyl)-benzamide derivatives and their use for the treatment of pain, anxiety or gastrointestinal disorders
SK1395-2003A SK13952003A3 (sk) 2001-05-18 2002-05-16 4-(Fenylpiperidín-4-ylidénmetyl)benzamidové deriváty a ich použitie na liečbu bolesti, anxiety alebo gastrointestinálnych porúch
PL02366640A PL366640A1 (en) 2001-05-18 2002-05-16 4-(phenyl-piperidin-4-ylidene-methyl)-benzamide derivatives and their use for the treatment of pain, anxiety or gastrointestinal disorders
KR10-2003-7014941A KR20040000467A (ko) 2001-05-18 2002-05-16 4-(페닐-피페리딘-4-일리덴-메틸)-벤즈아미드 유도체 및통증, 불안증 또는 위장관 장애의 치료를 위한 그의 용도
AT02733710T ATE303379T1 (de) 2001-05-18 2002-05-16 4-(phenyl-piperidin-4-ylidenmethyl)-benzamid- derivate und deren verwendung zur behandlung von schmerzen, angst oder gastrointestinalen störungen
CA002446332A CA2446332A1 (en) 2001-05-18 2002-05-16 4-(phenyl-piperidin-4-ylidene-methyl)-benzamide derivatives and their use for the treatment of pain, anxiety or gastrointestinal disorders
ZA200308633A ZA200308633B (en) 2001-05-18 2003-11-05 4-(phenyl-piperidin-4-ylidene-methyl)-benzamide derivatives and their use for the treatment of pain, anxiety or gastrointestinal disorders.
BG108326A BG108326A (bg) 2001-05-18 2003-11-07 4-(фенил-пиперидин-4-илиден-метил)-бензамидни производни и тяхното използване за лечение на болка, потиснатост или стомашно-чревни разстройства
IS7026A IS7026A (is) 2001-05-18 2003-11-11 4-(fenýl-píperidín-4-ýlíden-metýl)-bensamíðafleiður og notkun þeirra til meðhöndlunar á sársauka, kvíða eða truflunum í maga og þörmum
CO03100156A CO5611136A2 (es) 2001-05-18 2003-11-12 Derivados de 4-(fenil-(piperidin-4-iliden-metil)-benzamida y su uso para el tratramiento del dolor, ansiedad o desordenes gastrointestinales
NO20035116A NO20035116D0 (no) 2001-05-18 2003-11-17 4-(fenylpiperidin-4-yliden-metyl)-benzamidderivater og deres anvendelse forbehandling av smerte, angst eller gastrointestinale forstyrrelser

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE0101765A SE0101765D0 (sv) 2001-05-18 2001-05-18 Novel compounds

Publications (1)

Publication Number Publication Date
SE0101765D0 true SE0101765D0 (sv) 2001-05-18

Family

ID=20284168

Family Applications (1)

Application Number Title Priority Date Filing Date
SE0101765A SE0101765D0 (sv) 2001-05-18 2001-05-18 Novel compounds

Country Status (25)

Country Link
US (1) US7074808B2 (xx)
EP (1) EP1395576B1 (xx)
JP (1) JP2005510457A (xx)
KR (1) KR20040000467A (xx)
CN (1) CN1509282A (xx)
AR (1) AR035973A1 (xx)
AT (1) ATE303379T1 (xx)
BG (1) BG108326A (xx)
BR (1) BR0209676A (xx)
CA (1) CA2446332A1 (xx)
CO (1) CO5611136A2 (xx)
CZ (1) CZ20033085A3 (xx)
DE (1) DE60205894T2 (xx)
EE (1) EE200300540A (xx)
HU (1) HUP0401096A2 (xx)
IL (1) IL158704A0 (xx)
IS (1) IS7026A (xx)
MX (1) MXPA03010439A (xx)
NO (1) NO20035116D0 (xx)
PL (1) PL366640A1 (xx)
RU (1) RU2003131970A (xx)
SE (1) SE0101765D0 (xx)
SK (1) SK13952003A3 (xx)
WO (1) WO2002094812A1 (xx)
ZA (1) ZA200308633B (xx)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2446326C (en) 2001-05-18 2010-12-07 Astrazeneca Ab 4(phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain, anxiety or gastrointestinal disorders
SE0203300D0 (sv) 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
SE0203303D0 (sv) 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
SE0300104D0 (sv) * 2003-01-16 2003-01-16 Astrazeneca Ab Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof
SE0300103D0 (sv) * 2003-01-16 2003-01-16 Astrazeneca Ab Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof
KR20060010811A (ko) * 2003-05-16 2006-02-02 아스트라제네카 아베 디아릴메틸리덴 피페리딘 유도체, 그의 제조 및 그의 용도
SE0301442D0 (sv) * 2003-05-16 2003-05-16 Astrazeneca Ab Diarylmethylidene piperidine derivatives, preparations therof and uses thereof
EA015491B1 (ru) * 2003-06-27 2011-08-30 Янссен Фармацевтика Н.В. ТРИЦИКЛИЧЕСКИЕ δ-ОПИОИДНЫЕ МОДУЛЯТОРЫ
KR101255074B1 (ko) 2003-10-01 2013-04-16 아돌로 코포레이션 스피로시클릭 헤테로시클릭 유도체 및 이의 사용 방법
SE0400025D0 (sv) * 2004-01-09 2004-01-09 Astrazeneca Ab Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof
SE0400027D0 (sv) * 2004-01-09 2004-01-09 Astrazeneca Ab Diarylmethyl piperazine derivatives, preparations thereof and uses thereof
SE0400026D0 (sv) * 2004-01-09 2004-01-09 Astrazeneca Ab Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof
MX2007001240A (es) 2004-08-02 2007-03-23 Astrazeneca Ab Derivados de diarilmetil-piperazina, preparaciones y usos de las mismas.
US7598261B2 (en) 2005-03-31 2009-10-06 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use
EP1991539A4 (en) * 2006-02-28 2010-08-25 Astrazeneca Ab NEW SALTS OF INDIGENOUS DERIVATIVES AND THEIR USE IN MEDICINE
US7576207B2 (en) 2006-04-06 2009-08-18 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use
WO2008033299A2 (en) 2006-09-12 2008-03-20 Adolor Corporation Use of n-containing spirocompounds for the enhancement of cognitive function

Family Cites Families (15)

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Publication number Priority date Publication date Assignee Title
US2898339A (en) * 1957-07-29 1959-08-04 Wm S Merrell Co N-substituted benzhydrol, benzhydryl, and benzhydrylidene piperidine
US4581171A (en) * 1983-07-27 1986-04-08 Janssen Pharmaceutica, N.V. [[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones useful for treating psychotropic disorders
US4816586A (en) * 1987-07-29 1989-03-28 Regents Of The University Of Minnesota Delta opioid receptor antagonists
US5140029A (en) * 1989-01-09 1992-08-18 Janssen Pharmaceutica N.V. 2-aminopyrimidinone derivatives
US4939137A (en) * 1989-06-28 1990-07-03 Ortho Pharmaceutical Corporation Ring-fused thienopyrimidinedione derivatives
US5683998A (en) * 1991-04-23 1997-11-04 Toray Industries, Inc. Tricyclic triazolo derivatives, processes for producing the same and the uses of the same
GB9202238D0 (en) 1992-02-03 1992-03-18 Wellcome Found Compounds
US5574159A (en) * 1992-02-03 1996-11-12 Delta Pharmaceuticals, Inc. Opioid compounds and methods for making therefor
SE9504661D0 (sv) 1995-12-22 1995-12-22 Astra Pharma Inc New compounds
TW548271B (en) 1996-12-20 2003-08-21 Astra Pharma Inc Novel piperidine derivatives having an exocyclic double bond with analgesic effects
AU2009799A (en) 1997-12-24 1999-07-19 Ortho-Mcneil Pharmaceutical, Inc. 4-(aryl(piperidin-4-yl)) aminobenzamides which bind to the delta-opioid receptor
CA2402039A1 (en) * 2000-03-03 2001-09-13 Ortho-Mcneil Pharmaceutical, Inc. 3-(diarylmethylene)-8-azabicyclo[3.2.1]octane derivatives
US6556387B1 (en) * 2000-03-31 2003-04-29 Seagate Technology Llc Controlling mechanical response characteristics of a disc drive actuator by adjusting a fastener engaging the actuator shaft to vary axial force on the bearing assembly
SE0001208D0 (sv) 2000-04-04 2000-04-04 Astrazeneca Canada Inc Novel compounds
SE0001207D0 (sv) * 2000-04-04 2000-04-04 Astrazeneca Canada Inc Novel compounds

Also Published As

Publication number Publication date
KR20040000467A (ko) 2004-01-03
EE200300540A (et) 2004-02-16
SK13952003A3 (sk) 2004-04-06
MXPA03010439A (es) 2004-03-09
RU2003131970A (ru) 2005-05-10
CN1509282A (zh) 2004-06-30
US7074808B2 (en) 2006-07-11
NO20035116D0 (no) 2003-11-17
HUP0401096A2 (hu) 2004-09-28
ZA200308633B (en) 2005-02-07
ATE303379T1 (de) 2005-09-15
PL366640A1 (en) 2005-02-07
IL158704A0 (en) 2004-05-12
US20040142967A1 (en) 2004-07-22
IS7026A (is) 2003-11-11
CA2446332A1 (en) 2002-11-28
DE60205894D1 (de) 2005-10-06
CZ20033085A3 (cs) 2004-05-12
AR035973A1 (es) 2004-07-28
BG108326A (bg) 2004-12-30
EP1395576A1 (en) 2004-03-10
WO2002094812A1 (en) 2002-11-28
JP2005510457A (ja) 2005-04-21
CO5611136A2 (es) 2006-02-28
DE60205894T2 (de) 2006-06-08
BR0209676A (pt) 2004-07-27
EP1395576B1 (en) 2005-08-31

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