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RU92016420A - COMPOSITE EQUIVALENTS OF LIVING SKIN, METHOD FOR ITS OBTAINING, TEST-SET - Google Patents

COMPOSITE EQUIVALENTS OF LIVING SKIN, METHOD FOR ITS OBTAINING, TEST-SET

Info

Publication number
RU92016420A
RU92016420A RU92016420/14A RU92016420A RU92016420A RU 92016420 A RU92016420 A RU 92016420A RU 92016420/14 A RU92016420/14 A RU 92016420/14A RU 92016420 A RU92016420 A RU 92016420A RU 92016420 A RU92016420 A RU 92016420A
Authority
RU
Russia
Prior art keywords
skin
composite
equivalent
equivalents
obtaining
Prior art date
Application number
RU92016420/14A
Other languages
Russian (ru)
Other versions
RU2135191C1 (en
Inventor
Эйсенбер Марк
Original Assignee
Эйсенбер Марк
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эйсенбер Марк filed Critical Эйсенбер Марк
Priority claimed from PCT/AU1991/000160 external-priority patent/WO1991016010A1/en
Publication of RU92016420A publication Critical patent/RU92016420A/en
Application granted granted Critical
Publication of RU2135191C1 publication Critical patent/RU2135191C1/en

Links

Claims (1)

Предложен композиционный эквивалент живой кожи, включающий эпидермальный слой культивированных кератиноцитовых клеток, слой беспористого коллагена и дермальный слой культивированных фибробластовых клеток в сшитой пористой коллагеновой губчатой матрице. Предпочтительно беспористым коллагеном является бычий коллаген типа 1, типа 3 или их смеси, обработанные пепсином. Описаны способ получения эквивалента кожи, а также тест-набор для испытаний in vitro эквивалента кожи. Указанный эквивалент кожи может использоваться для трансплантации кожи, а также для определения in vitro действия, оказываемого на кожу различными веществами.A composite equivalent of living skin is proposed, including an epidermal layer of cultured keratinocyte cells, a layer of non-porous collagen, and a dermal layer of cultured fibroblast cells in a cross-linked porous collagen sponge matrix. Preferably, the non-porous collagen is bovine collagen type 1, type 3, or mixtures thereof treated with pepsin. A method for producing skin equivalent is described, as well as a test kit for in vitro skin equivalent tests. This skin equivalent can be used for skin transplantation, as well as for determining in vitro the effects exerted on the skin by various substances.
RU92016420A 1990-04-24 1991-04-24 Composition equivalent of living skin, method of its preparing, test-set RU2135191C1 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
AU9816 1983-06-15
AU9819 1990-04-24
AUPJ981990 1990-04-24
AUPK430291 1991-01-22
PCT/AU1991/000160 WO1991016010A1 (en) 1990-04-24 1991-04-24 Composite living skin equivalents
AU4302 1992-08-26

Publications (2)

Publication Number Publication Date
RU92016420A true RU92016420A (en) 1995-09-10
RU2135191C1 RU2135191C1 (en) 1999-08-27

Family

ID=25643857

Family Applications (1)

Application Number Title Priority Date Filing Date
RU92016420A RU2135191C1 (en) 1990-04-24 1991-04-24 Composition equivalent of living skin, method of its preparing, test-set

Country Status (15)

Country Link
US (3) US5282859A (en)
EP (1) EP0526550B1 (en)
JP (1) JPH0747043B2 (en)
AT (1) ATE161408T1 (en)
BR (1) BR9106354A (en)
CA (1) CA2080693C (en)
DE (1) DE69128530T2 (en)
DK (1) DK0526550T3 (en)
ES (1) ES2111566T3 (en)
FI (1) FI924773A0 (en)
GR (1) GR3026463T3 (en)
HU (1) HUT63319A (en)
RU (1) RU2135191C1 (en)
TW (1) TW225986B (en)
WO (1) WO1991016010A1 (en)

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