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Application filed by Mark Dr EisenbergfiledCriticalMark Dr Eisenberg
Priority to MYPI9101945priorityCriticalpatent/MY131052A/en
Publication of MY131052ApublicationCriticalpatent/MY131052A/en
Micro-Organisms Or Cultivation Processes Thereof
(AREA)
Abstract
A COMPOSITE LIVING SKIN EQUIVALENT IS DESCRIBED COMPRISING AN EPIDERMAL LAYER OF CULTURED KERATINOCYTE CELLS, A LAYER OF NON-POROUS COLLAGEN, AND DERMAL LAYER OF CULTURED FIBROBLAST CELLS IN A POROUS CROSS-LINKED COLLAGEN SPONGE MATRIX. PREFERABLY THE NON-POROUS COLLAGEN IS TYPE 1, TYPE 3 OR MIXTURES OF TYPES 1 AND 3 BOVINE COLLAGEN, WHICH HAS BEEN PEPSIN TREATED. A PROCESS FOR PREPARING THE SKIN EQUIVALENT IS DESCRIBED, AS WELL AS A TEST KIT FOR IN VITRO TESTING OF THE SKIN EQUIVALENT. THE SKIN EQUIVALENT HAS USE FOR SKIN GRAFTING AS WELL AS IN VITRO TESTING OF THE EFFECTS OF VARIOUS SUBSTANCES ON SKIN.(FIG 1)
MYPI91019451991-10-221991-10-22Composite living skin equivalents
MY131052A
(en)
Biocompatible perforated membranes,processes for their use as a support in the in vitro growth of epithelial cells,the artificial skin obtained in this manner,and its use in skin grafts
Development of an artificial skin by means of keratinocyte culture on a base of fibrin and human fibroblasts, and method for preparing this skin for transplantation