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RU2350327C2 - Составы, вызывающие потерю веса - Google Patents

Составы, вызывающие потерю веса Download PDF

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Publication number
RU2350327C2
RU2350327C2 RU2005132453/15A RU2005132453A RU2350327C2 RU 2350327 C2 RU2350327 C2 RU 2350327C2 RU 2005132453/15 A RU2005132453/15 A RU 2005132453/15A RU 2005132453 A RU2005132453 A RU 2005132453A RU 2350327 C2 RU2350327 C2 RU 2350327C2
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compound
bupropion
naltrexone
amount
weight loss
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RU2005132453/15A
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RU2005132453A (ru
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Экард ВЕБЕР (US)
Экард Вебер
Майкл Александр КОВЛИ (US)
Майкл Александр КОВЛИ
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Ориксиджен Серапьютикс, Инкорпорэйтд
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Magnetic Ceramics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Compositions Of Oxide Ceramics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Dental Preparations (AREA)

Abstract

Настоящее изобретение относится к области лекарственных средств, в частности к составу для снижения веса, содержащему в синергетически эффективных количествах опиоидный антагонист налтрексон и бупропион. Кроме того, описывается способ снижения веса при введении: налтрексона и бупропиона или флуоксетина; или налмефена и флувоксамина. Также изобретение относится к применению указанных сочетаний для приготовления лекарственного средства для снижения веса. Технический результат - синергетический эффект указанных сочетаний. 4 н. и 14 з.п. ф-лы, 3 табл.

Description

Текст описания приведен в факсимильном виде.
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Claims (18)

1. Состав для снижения веса, содержащий в синергетически эффективных количествах первое соединение и второе соединение, где первое соединение является опиоидным антагонистом, представляющим собой налтрексон, а второе соединение является бупропионом.
2. Состав по п.1, в котором указанный бупропион представляет собой Бупропион-SR.
3. Состав по п.1, в котором указанный состав представляет собой единичную стандартную пероральную лекарственную форму.
4. Состав по любому из пп.1-3, в котором количество указанного бупропиона составляет от 30 до 500 мг.
5. Состав по любому из п.1 или 3, в котором количество указанного налтрексона составляет от 5 до 50 мг.
6. Способ снижения веса, включающий введение человеку, нуждающемуся в таком введении, в синергетически эффективном количестве налтрексона и бупропиона или флуоксетина
или налмефена и флувоксамина.
7. Способ по п.6, в котором вышеуказанный человек имеет индекс массы тела выше, чем 25.
8. Способ по п.6, в котором указанные соединения вводятся одновременно.
9. Способ по п.6, в котором первое соединение применяется перед вторым или первое соединение применяется после второго соединения.
10. Способ по п.6, в котором упомянутый человек не страдает депрессией, синдромом Прадера-Вилли или перееданием.
11. Способ по любому из пп.6-10, в котором количество указанного бупропиона составляет от 30 до 500 мг.
12. Способ по любому из пп.6-10, в котором количество указанного налтрексона составляет от 5 до 50 мг.
13. Применение первого соединения и второго соединения в синергетически эффективных количествах для приготовления лекарства, вызывающего потерю веса, при этом первое соединение представляет собой налтрексон, а второе соединение представляет собой бупропион или флуоксентин, или первое соединение представляет собой налмефен, а второе соединение представляет собой флувоксамин.
14. Применение по п.13, в котором количество указанного бупропиона составляет от 30 до 500 мг.
15. Применение по п.13, в котором количество указанного налтрексона составляет от 5 до 50 мг.
16. Применение сочетания в синергетически эффективных количествах налтрексона и бупропиона для приготовления лекарства, вызывающего потерю веса.
17. Применение по п.16, в котором количество указанного налтрексона составляет от 5 до 50 мг.
18. Применение по п.16, в котором количество указанного бупропиона составляет от 30 до 500 мг.
RU2005132453/15A 2003-04-29 2004-04-21 Составы, вызывающие потерю веса RU2350327C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46683803P 2003-04-29 2003-04-29
US60/466,838 2003-04-29

Publications (2)

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RU2350327C2 true RU2350327C2 (ru) 2009-03-27

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Country Status (21)

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US (10) US7375111B2 (ru)
EP (3) EP2316456B1 (ru)
JP (1) JP4343948B2 (ru)
KR (1) KR101167579B1 (ru)
CN (1) CN1784221B (ru)
AT (1) ATE388698T1 (ru)
AU (2) AU2004233846B2 (ru)
CA (1) CA2522708C (ru)
DE (1) DE602004012403T2 (ru)
DK (2) DK2316456T3 (ru)
ES (3) ES2303085T3 (ru)
HK (2) HK1088850A1 (ru)
HU (2) HUE034290T2 (ru)
IL (3) IL171519A (ru)
MX (1) MXPA05011557A (ru)
PL (2) PL1617832T3 (ru)
PT (2) PT1617832E (ru)
RU (1) RU2350327C2 (ru)
SI (1) SI2316456T1 (ru)
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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2616496C2 (ru) * 2010-01-11 2017-04-17 Ориксиджен Терапьютикс, Инк. Способы проведения терапии потери веса у пациентов с доминирующей депрессией (варианты)
RU2640561C2 (ru) * 2010-12-03 2018-01-09 Орексиджен Терапьютикс, Инк. Повышение биодоступности лекарственных средств при терапии налтрексоном
RU2664442C2 (ru) * 2012-05-24 2018-08-17 Найя Метаболик, Инк. Способ снижения веса
US10172837B2 (en) 2007-01-25 2019-01-08 NAIA Metabolic, Inc. Insulin sensitisers and methods of treatment
RU2781141C2 (ru) * 2010-12-03 2022-10-06 Орексиджен Терапьютикс, Инк. Повышение биодоступности лекарственных средств при терапии налтрексоном

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