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RU2013140115A - METHOD FOR PRODUCING L-AMINO ACIDS USING THE BACTERIA OF THE Enterobacteriaceae FAMILY IN WHICH THE EXPRESSION OF THE znuACB GENERAL CLUSTER IS DISORDERED - Google Patents

METHOD FOR PRODUCING L-AMINO ACIDS USING THE BACTERIA OF THE Enterobacteriaceae FAMILY IN WHICH THE EXPRESSION OF THE znuACB GENERAL CLUSTER IS DISORDERED Download PDF

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RU2013140115A
RU2013140115A RU2013140115/10A RU2013140115A RU2013140115A RU 2013140115 A RU2013140115 A RU 2013140115A RU 2013140115/10 A RU2013140115/10 A RU 2013140115/10A RU 2013140115 A RU2013140115 A RU 2013140115A RU 2013140115 A RU2013140115 A RU 2013140115A
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bacterium
znuacb
genes
gene cluster
bacterium according
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RU2013140115/10A
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Михаил Маркович Гусятинер
Юлия Георгиевна Ростова
Эльвира Борисовна Ворошилова
Михаил Юрьевич Кирюхин
Анастасия Юрьевна Ромкина
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Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО "АГРИ")
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Priority to RU2013140115/10A priority Critical patent/RU2013140115A/en
Priority to PCT/JP2014/072346 priority patent/WO2015030019A1/en
Publication of RU2013140115A publication Critical patent/RU2013140115A/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/10—Citrulline; Arginine; Ornithine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/14—Glutamic acid; Glutamine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/24—Proline; Hydroxyproline; Histidine

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

1. Бактерия-продуцент L-аминокислоты семейства Enterobacteriaceae, отличающаяся тем, что указанная бактерия модифицирована таким образом, что экспрессия, по меньшей мере, одного из генов кластера генов znuACB нарушена.2. Бактерия по п.1, отличающаяся тем, что указанная бактерия принадлежит к роду Escherichia.3. Бактерия по п.2, отличающаяся тем, что указанная бактерия есть Escherichia coli.4. Бактерия по п.1, отличающаяся тем, что указанная бактерия принадлежит к роду Pantoea.5. Бактерия по п.4, отличающаяся тем, что указанная бактерия есть Pantoea ananatis.6. Бактерия по п.1, отличающаяся тем, что указанная экспрессия, по меньшей мере, одного из генов кластера генов znuACB нарушена за счет инактивации, по меньшей мере, одного из генов кластера генов znuACB.7. Бактерия по п.6, отличающаяся тем, что указанный, по меньшей мере, один из генов кластера генов znuACB делегирован.8. Бактерия по п.1, отличающаяся тем, что указанная экспрессия, по меньшей мере, одного из генов кластера генов znuACB нарушена за счет ослабления экспрессии, по меньшей мере, одного из генов кластера генов znuACB.9. Бактерия по п.1, отличающаяся тем, что указанный кластер генов znuACB делегирован.10. Бактерия по п.1 или пп.6-9, отличающаяся тем, что указанные гены кластера генов znuACB выбраны из группы, состоящей из генов znuA, znuB и znuC.11. Бактерия по п.1, отличающаяся тем, что указанная L-аминокислота выбрана из группы, состоящей из L-аланина, L-аргинина, L-аспарагина, L-аспарагиновой кислоты, L-цитруллина, L-цистеина, L-глутаминовой кислоты, L-глутамина, глицина, L-гистидина, L-изолейцина, L-лейцина, L-лизина, L-метионина, L-орнитина, L-фенилаланина, L-пролина, L-серина, L-треонина, L-триптофана, L-тирозина и L-валина.12. Бактерия по п.11, отличающаяся те1. A bacterium producing L-amino acids of the Enterobacteriaceae family, characterized in that said bacterium is modified in such a way that expression of at least one of the genes of the znuACB gene cluster is impaired. The bacterium according to claim 1, characterized in that said bacterium belongs to the genus Escherichia. The bacterium according to claim 2, characterized in that said bacterium is Escherichia coli. 4. The bacterium according to claim 1, characterized in that said bacterium belongs to the genus Pantoea. The bacterium according to claim 4, characterized in that said bacterium is Pantoea ananatis. 6. The bacterium according to claim 1, characterized in that said expression of at least one of the genes of the znuACB gene cluster is violated by inactivation of at least one of the genes of the znuACB gene cluster. The bacterium according to claim 6, characterized in that said at least one of the genes of the znuACB gene cluster is delegated. The bacterium according to claim 1, characterized in that said expression of at least one of the genes of the znuACB gene cluster is impaired by weakening the expression of at least one of the genes of the znuACB gene cluster. The bacterium according to claim 1, characterized in that said znuACB gene cluster is delegated. The bacterium according to claim 1 or claims 6 to 9, characterized in that said genes of the znuACB gene cluster are selected from the group consisting of znuA, znuB and znuC genes. The bacterium according to claim 1, characterized in that said L-amino acid is selected from the group consisting of L-alanine, L-arginine, L-asparagine, L-aspartic acid, L-citrulline, L-cysteine, L-glutamic acid, L-glutamine, glycine, L-histidine, L-isoleucine, L-leucine, L-lysine, L-methionine, L-ornithine, L-phenylalanine, L-proline, L-serine, L-threonine, L-tryptophan, L-tyrosine and L-valine. 12. The bacterium according to claim 11, characterized in

Claims (15)

1. Бактерия-продуцент L-аминокислоты семейства Enterobacteriaceae, отличающаяся тем, что указанная бактерия модифицирована таким образом, что экспрессия, по меньшей мере, одного из генов кластера генов znuACB нарушена.1. A bacterium producing L-amino acids of the Enterobacteriaceae family, characterized in that said bacterium is modified in such a way that expression of at least one of the genes of the znuACB gene cluster is impaired. 2. Бактерия по п.1, отличающаяся тем, что указанная бактерия принадлежит к роду Escherichia.2. The bacterium according to claim 1, characterized in that said bacterium belongs to the genus Escherichia. 3. Бактерия по п.2, отличающаяся тем, что указанная бактерия есть Escherichia coli.3. The bacterium according to claim 2, characterized in that said bacterium is Escherichia coli. 4. Бактерия по п.1, отличающаяся тем, что указанная бактерия принадлежит к роду Pantoea.4. The bacterium according to claim 1, characterized in that said bacterium belongs to the genus Pantoea. 5. Бактерия по п.4, отличающаяся тем, что указанная бактерия есть Pantoea ananatis.5. The bacterium according to claim 4, characterized in that said bacterium is Pantoea ananatis. 6. Бактерия по п.1, отличающаяся тем, что указанная экспрессия, по меньшей мере, одного из генов кластера генов znuACB нарушена за счет инактивации, по меньшей мере, одного из генов кластера генов znuACB.6. The bacterium according to claim 1, characterized in that said expression of at least one of the genes of the znuACB gene cluster is violated by inactivation of at least one of the genes of the znuACB gene cluster. 7. Бактерия по п.6, отличающаяся тем, что указанный, по меньшей мере, один из генов кластера генов znuACB делегирован.7. The bacterium according to claim 6, characterized in that said at least one of the genes of the znuACB gene cluster is delegated. 8. Бактерия по п.1, отличающаяся тем, что указанная экспрессия, по меньшей мере, одного из генов кластера генов znuACB нарушена за счет ослабления экспрессии, по меньшей мере, одного из генов кластера генов znuACB.8. The bacterium according to claim 1, characterized in that said expression of at least one of the genes of the znuACB gene cluster is impaired by weakening the expression of at least one of the genes of the znuACB gene cluster. 9. Бактерия по п.1, отличающаяся тем, что указанный кластер генов znuACB делегирован.9. The bacterium according to claim 1, characterized in that said znuACB gene cluster is delegated. 10. Бактерия по п.1 или пп.6-9, отличающаяся тем, что указанные гены кластера генов znuACB выбраны из группы, состоящей из генов znuA, znuB и znuC.10. The bacterium according to claim 1 or claims 6 to 9, characterized in that said genes of the znuACB gene cluster are selected from the group consisting of znuA, znuB and znuC genes. 11. Бактерия по п.1, отличающаяся тем, что указанная L-аминокислота выбрана из группы, состоящей из L-аланина, L-аргинина, L-аспарагина, L-аспарагиновой кислоты, L-цитруллина, L-цистеина, L-глутаминовой кислоты, L-глутамина, глицина, L-гистидина, L-изолейцина, L-лейцина, L-лизина, L-метионина, L-орнитина, L-фенилаланина, L-пролина, L-серина, L-треонина, L-триптофана, L-тирозина и L-валина.11. The bacterium according to claim 1, characterized in that said L-amino acid is selected from the group consisting of L-alanine, L-arginine, L-asparagine, L-aspartic acid, L-citrulline, L-cysteine, L-glutamic acids, L-glutamine, glycine, L-histidine, L-isoleucine, L-leucine, L-lysine, L-methionine, L-ornithine, L-phenylalanine, L-proline, L-serine, L-threonine, L- tryptophan, L-tyrosine and L-valine. 12. Бактерия по п.11, отличающаяся тем, что указанная L-аминокислота принадлежит к семейству глутамата и выбрана из группы, состоящей из L-аргинина, L-цитруллина, L-глутаминовой кислоты, L-глутамина, L-орнитина и L-пролина.12. The bacterium according to claim 11, characterized in that said L-amino acid belongs to the glutamate family and is selected from the group consisting of L-arginine, L-citrulline, L-glutamic acid, L-glutamine, L-ornithine and L- proline. 13. Способ получения L-аминокислоты или ее соли, включающий:13. A method of obtaining an L-amino acid or its salt, comprising: (i) выращивание бактерии по любому из пп.1-12 в питательной среде;(i) growing bacteria according to any one of claims 1 to 12 in a nutrient medium; (ii) накопление указанной L-аминокислоты или ее соли в бактерии или культуральной жидкости, или в бактерии и культуральной жидкости; и, если необходимо,(ii) the accumulation of the specified L-amino acid or its salt in bacteria or culture fluid, or in bacteria and culture fluid; and if necessary (iii) выделение L-аминокислоты или ее соли из бактерии или культуральной жидкости, или из бактерии и культуральной жидкости.(iii) isolating an L-amino acid or its salt from a bacterium or culture fluid, or from a bacterium and culture fluid. 14. Способ по п.13, отличающийся тем, что указанная L-аминокислота выбрана из группы, состоящей из L-аланина, L-аргинина, L-аспарагина, L-аспарагиновой кислоты, L-цитруллина, L-цистеина, L-глутаминовой кислоты, L-глутамина, глицина, L-гистидина, L-изолейцина, L-лейцина, L-лизина, L-метионина, L-орнитина, L-фенилаланина, L-пролина, L-серина, L-треонина, L-триптофана, L-тирозина и L-валина.14. The method according to item 13, wherein said L-amino acid is selected from the group consisting of L-alanine, L-arginine, L-asparagine, L-aspartic acid, L-citrulline, L-cysteine, L-glutamic acids, L-glutamine, glycine, L-histidine, L-isoleucine, L-leucine, L-lysine, L-methionine, L-ornithine, L-phenylalanine, L-proline, L-serine, L-threonine, L- tryptophan, L-tyrosine and L-valine. 15. Способ по п.14, отличающийся тем, что указанная L-аминокислота принадлежит к семейству глутамата и выбрана из группы, состоящей из L-аргинина, L-цитруллина, L-глутаминовой кислоты, L-глутамина, L-орнитина и L-пролина. 15. The method according to 14, characterized in that said L-amino acid belongs to the glutamate family and is selected from the group consisting of L-arginine, L-citrulline, L-glutamic acid, L-glutamine, L-ornithine and L- proline.
RU2013140115/10A 2013-08-30 2013-08-30 METHOD FOR PRODUCING L-AMINO ACIDS USING THE BACTERIA OF THE Enterobacteriaceae FAMILY IN WHICH THE EXPRESSION OF THE znuACB GENERAL CLUSTER IS DISORDERED RU2013140115A (en)

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RU2013140115/10A RU2013140115A (en) 2013-08-30 2013-08-30 METHOD FOR PRODUCING L-AMINO ACIDS USING THE BACTERIA OF THE Enterobacteriaceae FAMILY IN WHICH THE EXPRESSION OF THE znuACB GENERAL CLUSTER IS DISORDERED
PCT/JP2014/072346 WO2015030019A1 (en) 2013-08-30 2014-08-20 A METHOD FOR PRODUCING AN L-AMINO ACID USING A BACTERIUM OF THE FAMILY ENTEROBACTERIACEAE HAVING ATTENUATED EXPRESSION OF THE znuACB GENE CLUSTER

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RU2013140115/10A RU2013140115A (en) 2013-08-30 2013-08-30 METHOD FOR PRODUCING L-AMINO ACIDS USING THE BACTERIA OF THE Enterobacteriaceae FAMILY IN WHICH THE EXPRESSION OF THE znuACB GENERAL CLUSTER IS DISORDERED

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