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RU2003104284A - Фармацевтическое средство, содержащее ингибитор rho-киназы - Google Patents

Фармацевтическое средство, содержащее ингибитор rho-киназы Download PDF

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RU2003104284A
RU2003104284A RU2003104284/15A RU2003104284A RU2003104284A RU 2003104284 A RU2003104284 A RU 2003104284A RU 2003104284/15 A RU2003104284/15 A RU 2003104284/15A RU 2003104284 A RU2003104284 A RU 2003104284A RU 2003104284 A RU2003104284 A RU 2003104284A
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hydrogen
alkyl
isomer
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Масайоси УЕХАТА (JP)
Масайоси УЕХАТА
Такаси ОНО (JP)
Такаси ОНО
Кейдзи ЯМАГАМИ (JP)
Кейдзи ЯМАГАМИ
Хироюки САТОХ (JP)
Хироюки САТОХ
Тосио КАВАХАРА (JP)
Тосио КАВАХАРА
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Мицубиси Фарма Корпорейшн (Jp)
Мицубиси Фарма Корпорейшн
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Claims (9)

1. Противовоспалительный агент, включающий амидное производное формулы (I)
Figure 00000001
где Ra - группа формулы
Figure 00000002
Figure 00000003
Figure 00000004
в формулах (а) и (b) R обозначает водород, алкил или циклоалкил, циклоал-килалкил, фенил или аралкил, которые необязательно имеют заместитель в кольце, или группу формулы
Figure 00000005
где R6 обозначает водород, алкил или формулу –NR8R9,
где R8 и R9 одинаковы или различны, и каждый обозначает водород, алкил, аралкил или фенил;
R7 обозначает водород, алкил, аралкил, фенил, нитро или циано, или R6 и R7 в сочетании создают группу, образующую гетероцикл, необязательно имеющий в кольце атом кислорода, атом серы или необязательно замещенный атом азота;
R1 обозначает водород, алкил или циклоалкил, циклоалкилалкил, фенил или аралкил, которые необязательно имеют заместитель в кольце, или R и R1 в сочетании образуют вместе с соседним атомом азота группу, образующую гетероцикл, необязательно имеющий в кольце атом кислорода, атом серы или необязательно замещенный атом азота;
R2 обозначает водород или алкил;
R3 и R4 одинаковы или различны, и каждый обозначает водород, алкил, аралкил, галоген, нитро, амино, алкиламино, ациламино, гидрокси, алкокси, аралкилокси, циано, ацил, меркапто, алкилтио, аралкилтио, карбокси, алкоксикарбонил, карбамоил, алкилкарбамоил или азид;
А обозначает группу формулы
Figure 00000006
где R10 и R11 одинаковы или различны, и каждый обозначает водород, алкил, галогеналкил, аралкил, гидроксиалкил, карбокси или алкоксикарбонил, или R10 и R11 создают группу, которая образует циклоалкил в сочетании;
l, m и n обозначают каждый 0 или целое число 1-3,
в формуле (с) L обозначает водород, алкил, аминоалкил, моно- или диалкиламиноалкил, тетрагидрофурфурил, карбамоилалкил, фталимидоалкил, амидино или группу формулы
Figure 00000007
Figure 00000008
Figure 00000009
Figure 00000010
где В обозначает водород, алкил, алкокси, аралкил, аралкилокси, аминоалкил, гидроксиалкил, алканоилоксиалкил, алкоксикарбонилалкил, α-аминобензил, фурил, пиридил, фенил, фениламино, стирил или имидазопиридил,
Q1 обозначает водород, галоген, гидрокси, аралкилокси или тиенилметил;
W обозначает алкилен;
Q2 обозначает водород, галоген, гидрокси или аралкилокси;
X обозначает алкилен;
Q3 обозначает водород, галоген, гидрокси, алкокси, нитро, амино, 2,3-дигидрофурил или 5-метил-3-оксо-2,3,4,5-тетрагидропиридазин-6-ил;
Y обозначает ординарную связь, алкилен или алкенилен;
в формуле (с) пунктирная линия обозначает ординарную связь или двойную связь;
R5 обозначает водород, гидрокси, алкокси, алкоксикарбонилокси, алканоилокси или аралкилоксикарбонилокси;
Rb обозначает водород, алкил, аралкил, аминоалкил или моно- или диалкиламиноалкил;
Rc обозначает необязательно замещенный гетероцикл, содержащий азот,
или его изомер и/или его фармацевтически приемлемую кислотно-аддитивную соль.
2. Иммунодепрессант, включающий соединение формулы (I), определенное в п.1, его изомер и/или его фармацевтически приемлемую кислотно-аддитивную соль.
3. Терапевтический агент от аутоиммунного заболевания, включающий соединение формулы (I), определенное в п.1, его изомер и/или его фармацевтически приемлемую кислотно-аддитивную соль.
4. Лекарственное средство против СПИДа, включающее соединение формулы (I), определенное в п.1, его изомер и/или его фармацевтически приемлемую кислотно-аддитивную соль.
5. Лекарственное средство, улучшающее мозговую функцию, включающее соединение формулы (I), определенное в п.1, его изомер и/или его фармацевтически приемлемую кислотно-аддитивную соль.
6. Профилактический агент для предотвращения позднего выкидыша, включающий соединение формулы (I), определенное в п.1, его изомер и/или его фармацевтически приемлемую кислотно-аддитивную соль.
7. Противозачаточное средство, включающее соединение формулы (I), определенное в п.1, его изомер и/или его фармацевтически приемлемую кислотно-аддитивную соль.
8. Профилактический агент против инфекции пищеварительного тракта, включающий соединение формулы (I), определенное в п.1, его изомер и/или его фармацевтически приемлемую кислотно-аддитивную соль.
9. Диагностическое средство заболевания, обусловленного Rho-киназой, включающее соединение формулы (I), определенное в п.1, его изомер и/или его фармацевтически приемлемую кислотно-аддитивную соль.
RU2003104284/15A 1996-08-12 2003-02-12 Фармацевтическое средство, содержащее ингибитор rho-киназы RU2003104284A (ru)

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RU2003103606/15A RU2003103606A (ru) 1996-08-12 2003-02-06 Фармацевтическое средство, содержащее ингибитор rho-киназы
RU2003104284/15A RU2003104284A (ru) 1996-08-12 2003-02-12 Фармацевтическое средство, содержащее ингибитор rho-киназы

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8357693B2 (en) 2005-03-25 2013-01-22 Surface Logix, Inc. Pharmacokinetically improved compounds

Families Citing this family (200)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2286834T5 (es) * 1996-08-12 2011-01-31 Mitsubishi Tanabe Pharma Corporation Medicamentos que comprenden un inhibidor de la rho quinasa.
WO1999054306A1 (fr) * 1997-03-10 1999-10-28 Hiroyoshi Hidaka Derives isoquinolinesulfonamide et medicaments integrant ces derives comme principe actif
US20080233098A1 (en) * 1997-10-31 2008-09-25 Mckerracher Lisa RHO Family Antagonists and Their Use to Block Inhibition of Neurite Outgrowth
ATE527993T1 (de) * 1998-08-17 2011-10-15 Senju Pharma Co Verbindung zur vorbeugung und behandlung von augen-asthenopie und pseudomyopie
US7169783B2 (en) * 1998-11-02 2007-01-30 Universite De Montreal (+)-Trans-4-(1-aminoethyl)-1-(4-pyridycarbamoyl)-cyclohexane and method for promoting neural growth in the central nervous system and in a patient at a site of neuronal lesion
WO2000057913A1 (fr) * 1999-03-25 2000-10-05 Welfide Corporation Prophylaxies/remedes pour la pneumonie interstitielle et la fibrose pulmonaire
WO2000057914A1 (fr) * 1999-03-25 2000-10-05 Santen Pharmaceutical Co., Ltd. Agents permettant d'abaisser la tension oculaire
WO2000064477A1 (fr) * 1999-04-22 2000-11-02 Mitsubishi Pharma Corporation Compositions preventives/ traitements contre l'angiostenose
KR100812972B1 (ko) * 1999-04-27 2008-03-13 미쯔비시 웰 파마 가부시키가이샤 간질환 예방/치료제
AU5250400A (en) * 1999-06-18 2001-01-09 Mitsubishi Pharma Corporation Osteogenesis promoters
JP2001081031A (ja) * 1999-08-30 2001-03-27 Schering Ag 溶解性および経口吸収性を改善したベンズアミド誘導体含有製剤
WO2001017562A1 (en) * 1999-09-02 2001-03-15 Yamanouchi Pharmaceutical Co., Ltd. Osteogenesis promoting agents
WO2001022997A1 (fr) * 1999-09-29 2001-04-05 Mitsubishi Pharma Corporation Analgesiques
US7217722B2 (en) 2000-02-01 2007-05-15 Kirin Beer Kabushiki Kaisha Nitrogen-containing compounds having kinase inhibitory activity and drugs containing the same
DK1270570T3 (da) 2000-03-16 2006-10-02 Mitsubishi Pharma Corp Amidforbindelser og anvendelse deraf
JP4776138B2 (ja) * 2000-03-31 2011-09-21 田辺三菱製薬株式会社 腎臓疾患予防・治療剤
CN100548375C (zh) 2000-06-23 2009-10-14 田边三菱制药株式会社 抗肿瘤作用增效剂
BR0114020A (pt) * 2000-09-20 2003-07-22 Merck Patent Gmbh 4-amino-quinazolinas
CN1474816A (zh) * 2000-09-20 2004-02-11 Ĭ��ר���ɷ����޹�˾ 4-氨基-喹唑啉
JP4582561B2 (ja) * 2000-10-23 2010-11-17 旭化成ファーマ株式会社 移植による血管病変の発生抑制剤
JP2002139493A (ja) * 2000-11-01 2002-05-17 Sumitomo Pharmaceut Co Ltd 新規なハイスループット・スクリーニング方法
CA2325842C (en) * 2000-11-02 2007-08-07 Lisa Mckerracher Methods for making and delivering rho-antagonist tissue adhesive formulations to the injured mammalian central and peripheral nervous systems and uses thereof
US20020177207A1 (en) * 2001-03-14 2002-11-28 Myriad Genetics, Incorporated Tsg101-interacting proteins and use thereof
US20020132832A1 (en) * 2001-01-05 2002-09-19 Mills Thomas M. Treatment of erectile dysfunction
JP2002226375A (ja) * 2001-01-31 2002-08-14 Asahi Kasei Corp 線維化予防、治療剤
WO2002069904A2 (en) * 2001-03-02 2002-09-12 Medimmune, Inc. Cd2 antagonists for treatment of autoimmune or inflammatory disease
DE60211317T2 (de) * 2001-03-23 2007-04-12 Bayer Corp. Rho-kinase inhibitoren
ES2280517T3 (es) * 2001-03-23 2007-09-16 Bayer Pharmaceuticals Corporation Inhibidor de rho-cinasa.
CA2707827A1 (en) 2001-04-11 2002-10-24 Senju Pharmaceutical Co., Ltd. Visual function disorder improving agents containing rho kinase inhibitors
US7442686B2 (en) 2001-04-12 2008-10-28 Bioaxone Therapeutique Inc. Treatment of macular degeneration with ADP-ribosyl transferase fusion protein therapeutic compositions
EP1403255A4 (en) * 2001-06-12 2005-04-06 Sumitomo Pharma RHO KINASE INHIBITORS
JP5042419B2 (ja) * 2001-08-15 2012-10-03 旭化成ファーマ株式会社 骨形成促進剤および骨形成促進組成物
US7829566B2 (en) * 2001-09-17 2010-11-09 Werner Mederski 4-amino-quinazolines
DE10153605A1 (de) * 2001-11-02 2003-05-28 Morphochem Ag Komb Chemie Verwendung von Inhibitoren der Rho-Kinasen zur Stimulation des Nervenwachstums, zur Inhibition der Narbengewebsbildung und/oder Reduktion eines Sekundärschadens
JP4525964B2 (ja) * 2001-11-30 2010-08-18 旭化成ファーマ株式会社 肺高血圧症予防治療剤
FR2833840B1 (fr) * 2001-12-21 2010-06-18 Rytek Methodes et compositions pour le traitement de pathologies respiratoires
ES2305435T3 (es) * 2002-01-10 2008-11-01 Bayer Healthcare Ag Inhibidores de la rho-quinasa.
DE60318177T2 (de) * 2002-01-23 2008-10-09 Bayer Pharmaceuticals Corp., West Haven Rho-kinase inhibitoren
US6924290B2 (en) * 2002-01-23 2005-08-02 Bayer Pharmaceuticals Corporation Rho-kinase inhibitors
GB0206860D0 (en) * 2002-03-22 2002-05-01 Glaxo Group Ltd Compounds
US7645878B2 (en) * 2002-03-22 2010-01-12 Bayer Healthcare Llc Process for preparing quinazoline Rho-kinase inhibitors and intermediates thereof
AU2003220935A1 (en) * 2002-04-03 2003-10-13 Sumitomo Pharmaceuticals Company, Limited. Benzamide derivatives
US7425618B2 (en) 2002-06-14 2008-09-16 Medimmune, Inc. Stabilized anti-respiratory syncytial virus (RSV) antibody formulations
US7132100B2 (en) 2002-06-14 2006-11-07 Medimmune, Inc. Stabilized liquid anti-RSV antibody formulations
US20040028716A1 (en) * 2002-06-14 2004-02-12 Marks Andrew R. Use of Y-27632 as an agent to prevent restenosis after coronary artery angioplasty/stent implantation
AU2003281152A1 (en) * 2002-07-12 2004-02-02 Yihai Cao A method for inhibiting vascular permeability and tissue edema
CA2493230A1 (en) * 2002-07-22 2004-01-29 Asahi Kasei Pharma Corporation 5-substituted isoquinoline derivative
US7094789B2 (en) 2002-07-22 2006-08-22 Asahi Kasei Pharma Corporation 5-substituted isoquinoline derivatives
DE10233737A1 (de) * 2002-07-24 2004-02-05 Morphochem Aktiengesellschaft für kombinatorische Chemie Verwendung von Modulatoren des Signaltransduktionswegs über die Proteinkinase Fyn zur Behandlung von Tumorerkrankungen
WO2004016739A2 (en) * 2002-08-01 2004-02-26 Caritas St. Elizabeth's Medical Center Of Boston, Inc. Cell modulation using a cytoskeletal protein
CA2496797C (en) * 2002-08-29 2012-01-10 Santen Pharmaceutical Co., Ltd. Therapeutic agent for glaucoma comprising rho kinase inhibitor and prostaglandin
CA2400996A1 (en) * 2002-09-03 2004-03-03 Lisa Mckerracher 1,4-substituted cyclohexane derivatives
JPWO2004024717A1 (ja) * 2002-09-12 2006-01-05 麒麟麦酒株式会社 キナーゼ阻害活性を有するイソキノリン誘導体およびそれを含む医薬
US20050215601A1 (en) * 2002-09-25 2005-09-29 Santen Pharmaceutical Co., Ltd. Therapeutic agent for rheumatic disease comprising benzamide derivative as active ingredient
US7563810B2 (en) 2002-11-06 2009-07-21 Celgene Corporation Methods of using 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myeloproliferative diseases
US8034831B2 (en) * 2002-11-06 2011-10-11 Celgene Corporation Methods for the treatment and management of myeloproliferative diseases using 4-(amino)-2-(2,6-Dioxo(3-piperidyl)-isoindoline-1,3-dione in combination with other therapies
EP1568382B1 (en) * 2002-11-18 2013-11-06 Santen Pharmaceutical Co., Ltd. REMEDY FOR GLAUCOMA COMPRISING Rho KINASE INHIBITOR AND beta-BLOCKER
AU2004221792C1 (en) * 2003-03-18 2009-09-24 Medvet Science Pty. Ltd. A method of modulating smooth muscle cell functioning by modulating sphingosine kinase mediated signalling
AU2003901270A0 (en) * 2003-03-18 2003-04-03 Medvet Science Pty. Ltd. A method of modulating muscle cell functioning
GB2400316A (en) * 2003-04-10 2004-10-13 Richard Markoll Electromagnetic stimulation in patients with osteoporosis
EP1613273B1 (en) 2003-04-11 2012-06-13 MedImmune, LLC Recombinant il-9 antibodies and uses thereof
WO2004091662A1 (ja) 2003-04-18 2004-10-28 Senju Pharmaceutical Co. Ltd. 角膜知覚回復剤
WO2004105757A2 (en) * 2003-05-29 2004-12-09 Schering Aktiengesellschaft Use of rho-kinase inhibitors in the treatment of aneurysm and cardiac hypertrophy
US20110098232A1 (en) * 2003-05-30 2011-04-28 Zeilig Charles E Methods For The Selective Treatment Of Tumors By Calcium-Mediated Induction Of Apoptosis
US7160894B2 (en) 2003-06-06 2007-01-09 Asahi Kasei Pharma Corporation Tricyclic compound
WO2004108142A2 (en) * 2003-06-06 2004-12-16 The University Of Manchester Inhibitors of tip-1 for treatment tissue damage
EP1656156A2 (en) * 2003-08-13 2006-05-17 Children's Hospital Medical Center Mobilization of hematopoietic cells
US20050069553A1 (en) * 2003-08-13 2005-03-31 Yi Zheng Chimeric peptides for the regulation of GTPases
US20060228350A1 (en) * 2003-08-18 2006-10-12 Medimmune, Inc. Framework-shuffling of antibodies
US20050048617A1 (en) 2003-08-18 2005-03-03 Medimmune, Inc. Humanization of antibodies
US7371850B1 (en) 2003-08-20 2008-05-13 Myriad Genetics, Inc. Method and composition for reducing expression of ROCK-II
EP2468729B1 (en) 2003-10-15 2013-12-25 Ube Industries, Ltd. Novel indazole derivative
US20050238666A1 (en) * 2003-12-05 2005-10-27 Williams David A Methods of enhancing stem cell engraftment
SI1696920T1 (sl) 2003-12-19 2015-02-27 Plexxikon Inc. Spojine in postopki za razvoj modulatorjev ret
WO2005063249A1 (en) * 2003-12-22 2005-07-14 Alcon, Inc. Agents for treatment of diabetic retinopathy and drusen formation in macular degeneration
EP1696958B1 (en) * 2003-12-22 2007-03-28 Alcon, Inc. Agents for treatment of glaucomatous retinopathy and optic neuropathy
TW200526224A (en) * 2003-12-22 2005-08-16 Alcon Inc Short form c-Maf transcription factor antagonists for treatment of glaucoma
CA2556589A1 (en) * 2004-02-24 2005-09-01 Bioaxone Therapeutique Inc. 4-substituted piperidine derivatives
WO2005094824A1 (en) * 2004-03-25 2005-10-13 East Carolina University Methods of enhancing cancer therapy by protecting nerve cells
US20060115870A1 (en) * 2004-03-30 2006-06-01 Alcon, Inc. High throughput assay for human Rho kinase activity
WO2005102345A1 (en) * 2004-03-30 2005-11-03 Alcon, Inc. Use of rho kinase inhibitors in the treatment of hearing loss, tinnitus and improving body balance
US20080096238A1 (en) * 2004-03-30 2008-04-24 Alcon, Inc. High throughput assay for human rho kinase activity with enhanced signal-to-noise ratio
ES2671522T3 (es) 2004-04-02 2018-06-06 The Regents Of The University Of California Métodos y composiciones para tratar y prevenir una enfermedad asociada con la integrina alfa V beta 5
JP4932480B2 (ja) * 2004-06-03 2012-05-16 千寿製薬株式会社 アミド化合物を含有する角膜知覚回復剤
AU2005299355A1 (en) 2004-10-27 2006-05-04 Medimmune, Llc Modulation of antibody specificity by tailoring the affinity to cognate antigens
FR2879100B1 (fr) 2004-12-09 2007-07-06 Lionel Bueno Compositions pour le traitement des pathologies oculaires de surface et de la retine
AR054416A1 (es) * 2004-12-22 2007-06-27 Incyte Corp Pirrolo [2,3-b]piridin-4-il-aminas y pirrolo [2,3-b]pirimidin-4-il-aminas como inhibidores de las quinasas janus. composiciones farmaceuticas.
WO2006071548A2 (en) * 2004-12-27 2006-07-06 Alcon, Inc. Aminopyrazine analogs for treating glaucoma and other rho kinase-mediated diseases
EP1854484A4 (en) * 2005-02-16 2010-02-10 Astellas Pharma Inc REMEDY FOR PAIN CONTAINING INHIBITOR OF RHO-KINASE PROTEIN
CA2602035C (en) 2005-03-18 2015-06-16 Medimmune, Inc. Framework-shuffling of antibodies
JP2008546805A (ja) 2005-06-23 2008-12-25 メディミューン，エルエルシー 最適な凝集および断片化プロフィールを有する抗体製剤
AU2006264043B2 (en) 2005-06-28 2012-04-26 Sanofi-Aventis Isoquinoline derivatives as inhibitors of Rho-kinase
SI1912949T1 (sl) 2005-07-26 2011-12-30 Sanofi Sa Cikloheksilamin izokinolonski derivati kot inhibitorji Rho-kinaze
NI200800025A (es) 2005-07-26 2009-03-03 Derivados de isoquinolona sustituidos con piperidinilo en calidad de inhibidores de rho-quinasa
EP2258359A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis by muscarinic receptor modulation with sabcomelin
EP1928437A2 (en) 2005-08-26 2008-06-11 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
EP1932841B1 (en) 2005-08-30 2014-01-01 Asahi Kasei Pharma Corporation Sulfonamide compound
KR20080040027A (ko) 2005-09-02 2008-05-07 아스테라스 세이야쿠 가부시키가이샤 Ｒｏｃｋ 억제제로서 아미드 유도체
JP2009512711A (ja) 2005-10-21 2009-03-26 ブレインセルス，インコーポレイティド Ｐｄｅ阻害による神経新生の調節
JP4832051B2 (ja) * 2005-10-21 2011-12-07 学校法人順天堂 半月体形成性腎病変治療剤
US7893050B2 (en) 2005-10-26 2011-02-22 Asahi Kasei Pharma Corporation Fasudil in combination therapies for the treatment of pulmonary arterial hypertension
AU2006308889A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. GABA receptor mediated modulation of neurogenesis
US7655662B2 (en) * 2005-12-22 2010-02-02 Alcon Research, Ltd. (Indazol-5-yl)-pyrazines and (1,3-dihydro-indol-2-one)-pyrazines for treating glaucoma and controlling intraocular pressure
US7867999B1 (en) 2005-12-22 2011-01-11 Alcon Research, Ltd. Hydroxyamino- and amino-substituted pyridine analogs for treating rho kinase-mediated diseases and conditions
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
MX2008014320A (es) 2006-05-09 2009-03-25 Braincells Inc Neurogenesis mediada por el receptor de 5-hidroxitriptamina.
EP2021000A2 (en) 2006-05-09 2009-02-11 Braincells, Inc. Neurogenesis by modulating angiotensin
RU2008152065A (ru) 2006-06-08 2010-07-20 Убе Индастриз, Лтд (Jp) Новое производное имидазола со спироциклической структурой в боковой цепи
KR20090057223A (ko) * 2006-07-31 2009-06-04 센주 세이야꾸 가부시키가이샤 아미드 화합물을 함유하는 수성 액제
WO2008022182A1 (en) * 2006-08-16 2008-02-21 The Uab Research Foundation Methods for promoting coupling between bone formation and resorption
MX2009002151A (es) 2006-08-28 2009-07-03 Kirin Pharma Kk Anticuerpos monoclonales humanos especificos para light humano antagonistas.
GB0617222D0 (en) * 2006-08-31 2006-10-11 Vereniging Het Nl Kanker I Antibiotics
MX2009002496A (es) 2006-09-08 2009-07-10 Braincells Inc Combinaciones que contienen un derivado de 4-acilaminopiridina.
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
US20090036465A1 (en) * 2006-10-18 2009-02-05 United Therapeutics Corporation Combination therapy for pulmonary arterial hypertension
WO2008063888A2 (en) 2006-11-22 2008-05-29 Plexxikon, Inc. Compounds modulating c-fms and/or c-kit activity and uses therefor
WO2008079945A2 (en) * 2006-12-20 2008-07-03 University Of South Florida Rock inhibitors and uses thereof
AR064420A1 (es) * 2006-12-21 2009-04-01 Alcon Mfg Ltd Composiciones farmaceuticas oftalmicas que comprenden una cantidad efectiva de analogos de 6-aminoimidazo[1,2b]piridazinas, utiles para el tratamiento del glaucoma y/o controlar la presion intraocular normal o elevada(iop).
EP2114920A1 (en) 2006-12-27 2009-11-11 Sanofi-Aventis Substituted isoquinoline and isoquinolinone derivatives
NZ577984A (en) 2006-12-27 2011-03-31 Sanofi Aventis Cycloalkylamine substituted isoquinoline and isoquinolinone derivatives
WO2008077551A1 (en) 2006-12-27 2008-07-03 Sanofi-Aventis Cycloalkylamine substituted isoquinolone derivatives
AU2007338406B2 (en) 2006-12-27 2012-08-09 Sanofi-Aventis Substituted isoquinoline and isoquinolinone derivatives as inhibitors of Rho-kinase
EP2132194B1 (en) 2006-12-27 2011-03-16 Sanofi-Aventis Substituted isoquinolines and their use as rho-kinase inhibitors
MY151953A (en) 2006-12-27 2014-07-31 Sanofi Aventis Cycloalkylamine substituted isoquinoline derivatives
US7892830B2 (en) * 2007-01-17 2011-02-22 Wisconsin Alumni Research Foundation Clonal culture of human pluripotent stem cells
WO2008105058A1 (ja) 2007-02-27 2008-09-04 Asahi Kasei Pharma Corporation スルホンアミド化合物
JP5313125B2 (ja) 2007-02-28 2013-10-09 旭化成ファーマ株式会社 スルホンアミド誘導体
KR101566171B1 (ko) 2007-03-09 2015-11-06 삼성전자 주식회사 디지털 저작권 관리 방법 및 장치
CA2682170A1 (en) 2007-03-30 2008-10-09 Medimmune, Llc Antibodies with decreased deamidation profiles
WO2008134828A2 (en) 2007-05-04 2008-11-13 Katholieke Universiteit Leuven Tissue degeneration protection
CN101730690B (zh) 2007-07-02 2013-01-16 旭化成制药株式会社 磺酰胺化合物及其结晶
JP2010533729A (ja) 2007-07-17 2010-10-28 プレキシコン，インコーポレーテッド キナーゼ調節のための化合物と方法、及びそのための適応
EP2193806B1 (en) 2007-08-29 2017-12-06 Senju Pharmaceutical Co., Ltd. Agent for promoting corneal endothelial cell adhesion
KR20110014183A (ko) * 2008-05-12 2011-02-10 엠네스틱스, 인코포레이티드 학습 및 기억을 개선시키기 위한 화합물
AU2009262509B2 (en) 2008-06-24 2014-01-30 Sanofi Bi-and polycyclic substituted isoquinoline and isoquinoline derivatives as Rho kinase inhibitors
SI2313374T1 (sl) 2008-06-24 2013-12-31 Sanofi 6-substituirani izokinolini in izokinolinoni
EP2303846B1 (en) 2008-06-24 2015-04-29 Sanofi Substituted isoquinolines and isoquinolinones as rho kinase inhibitors
EP2319539A4 (en) 2008-07-24 2012-03-28 Univ Osaka PROPHYLACTIC OR THERAPEUTIC AGENT AGAINST AXIAL MYOPIA
BRPI0918045A2 (pt) * 2008-09-18 2015-12-01 Astellas Pharma Inc compostos de carboxamida heterocíclicos
EP2177218A1 (en) 2008-10-15 2010-04-21 Medizinische Universität Wien Regenerative therapy
EP2177510A1 (en) 2008-10-17 2010-04-21 Universität des Saarlandes Allosteric protein kinase modulators
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
NZ594398A (en) 2009-04-03 2014-03-28 Plexxikon Inc Propane-1-sulfonic acid (3-[5-(4-chloro-phenyl)-1h-pyrrol [2, 3-b] pyridine-3-carbonyl]-2,4-difluoro-phenyl} -amide compositions and uses thereof
US8329724B2 (en) 2009-08-03 2012-12-11 Hoffmann-La Roche Inc. Process for the manufacture of pharmaceutically active compounds
WO2011021221A2 (en) 2009-08-17 2011-02-24 Reliance Life Sciences Pvt. Ltd. Compositions for spinal cord injury
ES2638464T3 (es) 2009-10-16 2017-10-20 The Scripps Research Institute Inducción de células pluripotentes
NZ629615A (en) 2009-11-06 2016-01-29 Plexxikon Inc Compounds and methods for kinase modulation, and indications therefor
CN102188697B (zh) * 2010-03-03 2014-11-05 中国医学科学院药物研究所 重组人Rho激酶在制备药物中的应用
US9782454B2 (en) 2010-04-22 2017-10-10 Longevity Biotech, Inc. Highly active polypeptides and methods of making and using the same
JP6182456B2 (ja) 2010-12-22 2017-08-23 フェイト セラピューティクス，インコーポレイテッド 単細胞選別のための細胞培養プラットホームおよびｉＰＳＣの再プログラミングの増強
DK2668210T3 (da) 2011-01-26 2020-08-24 Celldex Therapeutics Inc Anti-kit antistoffer og anvendelser deraf
BR112013020041B1 (pt) 2011-02-07 2021-11-23 Plexxikon, Inc Compostos e composições para a modulação de quinases e uso dos mesmos
AR085279A1 (es) 2011-02-21 2013-09-18 Plexxikon Inc Formas solidas de {3-[5-(4-cloro-fenil)-1h-pirrolo[2,3-b]piridina-3-carbonil]-2,4-difluor-fenil}-amida del acido propano-1-sulfonico
EP2628482A1 (en) 2012-02-17 2013-08-21 Academisch Medisch Centrum Rho kinase inhiitors for use in the treatment of neuroblastoma
WO2013167475A1 (en) * 2012-05-08 2013-11-14 Syddansk Universitet Anabolic compounds for treating and preventing bone loss diseases
US9150570B2 (en) 2012-05-31 2015-10-06 Plexxikon Inc. Synthesis of heterocyclic compounds
DK3381943T3 (da) 2012-07-25 2022-05-16 Celldex Therapeutics Inc Anti-kit-antistoffer og anvendelser deraf
JP2015533832A (ja) 2012-10-09 2015-11-26 アイジェニカ バイオセラピューティクス インコーポレイテッド 抗Ｃ１６ｏｒｆ５４抗体およびその使用方法
US9789164B2 (en) 2013-03-15 2017-10-17 Longevity Biotech, Inc. Peptides comprising non-natural amino acids and methods of making and using the same
EP2990040B1 (en) 2013-04-24 2019-12-04 Kyushu University, National University Corporation Therapeutic agent for eyeground disease
WO2014177699A1 (en) * 2013-05-03 2014-11-06 INSERM (Institut National de la Santé et de la Recherche Médicale) Rhoa (rock) inhibitors for the treatment of enflammatory bowel disease
EP3003390B1 (en) 2013-06-06 2021-07-07 Pierre Fabre Médicament Anti-c10orf54 antibodies and uses thereof
CN112695039A (zh) 2013-08-26 2021-04-23 生物技术研发公司 编码抗唾液酸化路易斯a抗原的人抗体的核酸
CN106414721A (zh) 2014-03-04 2017-02-15 菲特治疗公司 改良的重编程方法和细胞培养平台
GB201403775D0 (en) 2014-03-04 2014-04-16 Kymab Ltd Antibodies, uses & methods
JP6626461B2 (ja) 2014-06-04 2019-12-25 バイオエヌテック リサーチ アンド デベロップメント， インコーポレイテッド ガングリオシドｇｄ２に対するヒトモノクローナル抗体
MX2017000181A (es) 2014-06-27 2017-05-01 Univ California Celulas madre limbales de mamifero cultivadas, metodos para generarlas y sus usos.
KR102693806B1 (ko) 2014-12-11 2024-08-09 피에르 파브르 메디카먼트 항-c10orf54 항체들 및 그들의 용도들
US10857157B2 (en) 2015-01-26 2020-12-08 BioAxone BioSciences, Inc. Treatment of cerebral cavernous malformations and cerebral aneurysms with rho kinase inhibitors
US10149856B2 (en) 2015-01-26 2018-12-11 BioAxone BioSciences, Inc. Treatment of cerebral cavernous malformations and cerebral aneurysms with rho kinase inhibitors
US10106525B2 (en) 2015-01-26 2018-10-23 BioAxone BioSciences, Inc. Rho kinase inhibitor BA-1049 (R) and active metabolites thereof
EP3256164B1 (en) 2015-02-09 2020-03-25 Memorial Sloan Kettering Cancer Center Multi-specific antibodies with affinity for human a33 antigen and dota metal complex
DE112016001013T5 (de) 2015-03-03 2017-12-21 Kymab Limited Antikörper, verwendungen und verfahren
US10167253B2 (en) 2015-06-24 2019-01-01 Nitto Denko Corporation Ionizable compounds and compositions and uses thereof
US12048761B2 (en) 2015-10-13 2024-07-30 Inserm (Institut National De La Santé Et De La Recherche Medicale) Methods and pharmaceutical compositions for the treatment of retinal capillary non-perfusion
EP4088719A1 (en) 2015-10-13 2022-11-16 Institut National de la Santé et de la Recherche Médicale (INSERM) Methods and pharmaceutical compositions for the treatment of retinal capillary non-perfusion
CA3001917A1 (en) 2015-10-16 2017-04-20 Fate Therapeutics, Inc. Platform for the induction & maintenance of ground state pluripotency
CN108925136B (zh) 2015-12-02 2022-02-01 斯特赛恩斯公司 特异于糖基化的btla（b和t淋巴细胞衰减因子）的抗体
JP7090545B2 (ja) 2015-12-02 2022-06-24 ストキューブ アンド シーオー．， インコーポレイテッド Ｂｔｎ１ａ１に免疫特異的に結合する抗体及び分子並びにそれらの治療的使用
EP3534947A1 (en) 2016-11-03 2019-09-11 Kymab Limited Antibodies, combinations comprising antibodies, biomarkers, uses & methods
US11198680B2 (en) 2016-12-21 2021-12-14 BioAxone BioSciences, Inc. Rho kinase inhibitor BA-1049 (R) and active metabolites thereof
AU2018277545A1 (en) 2017-05-31 2019-12-19 Stcube & Co., Inc. Methods of treating cancer using antibodies and molecules that immunospecifically bind to BTN1A1
JP7369038B2 (ja) 2017-05-31 2023-10-25 ストキューブ アンド シーオー．， インコーポレイテッド Ｂｔｎ１ａ１に免疫特異的に結合する抗体及び分子並びにその治療的使用
KR20200026209A (ko) 2017-06-06 2020-03-10 주식회사 에스티큐브앤컴퍼니 Btn1a1 또는 btn1a1-리간드에 결합하는 항체 및 분자를 사용하여 암을 치료하는 방법
WO2019014322A1 (en) * 2017-07-11 2019-01-17 BioAxone BioSciences, Inc. KINASE INHIBITORS FOR THE TREATMENT OF DISEASES
JP7256796B2 (ja) 2017-10-13 2023-04-12 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｔｈｏｍｓｅｎ－ｎｏｕｖｅｌｌｅ（ｔｎ）抗原に対するヒト抗体
ES2972934T3 (es) 2017-12-21 2024-06-17 Santen Pharmaceutical Co Ltd Combinación de sepetaprost y ripasudil para su uso en la profilaxis o tratamiento del glaucoma o hipertensión ocular
CN118994395A (zh) 2018-07-20 2024-11-22 皮埃尔法布雷医药公司 Vista受体
WO2020047229A1 (en) 2018-08-29 2020-03-05 University Of Massachusetts Inhibition of protein kinases to treat friedreich ataxia
UY38427A (es) 2018-10-26 2020-05-29 Novartis Ag Métodos y composiciones para terapia con células oculares
CN111116555B (zh) * 2018-10-30 2023-06-02 北京盈科瑞创新药物研究有限公司 一种Rho激酶抑制剂及其制备方法和应用
WO2020193802A1 (en) 2019-03-28 2020-10-01 Fundación De La Comunidad Valenciana Centro De Investigación Príncipe Felipe Polymeric conjugates and uses thereof
EP4142879A1 (en) 2020-04-27 2023-03-08 Novartis AG Methods and compositions for ocular cell therapy
CN111707831A (zh) * 2020-07-16 2020-09-25 首都医科大学附属北京朝阳医院 Rock激酶活性在辅助诊断sle以及评价sle病情中的应用
MX2023008141A (es) 2021-01-11 2023-10-20 Incyte Corp Terapia combinada que comprende el inhibidor de la vía de proteínas tirosina cinasas de janus cinasas (jak) y el inhibidor de la proteína cinasa asociada a rho (rock).
CN113262226B (zh) * 2021-04-19 2023-05-16 杭州市第一人民医院 利舒地尔在制备细菌感染治疗药物中的应用
WO2023069949A1 (en) 2021-10-18 2023-04-27 Evia Life Sciences Inc. Compositions and methods of use thereof for treating liver fibrosis
KR20240093785A (ko) 2021-10-22 2024-06-24 에비아 라이프 사이언시스 인코포레이션 세포외 소포의 제조 방법, 이의 조성물 및 사용 방법
WO2023122213A1 (en) 2021-12-22 2023-06-29 Byomass Inc. Targeting gdf15-gfral pathway cross-reference to related applications
WO2023147107A1 (en) 2022-01-31 2023-08-03 Byomass Inc. Myeloproliferative conditions

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57200366A (en) * 1981-06-01 1982-12-08 Asahi Chem Ind Co Ltd Isoquinoline compound
US4456757A (en) † 1981-03-20 1984-06-26 Asahi Kasei Kogyo Kabushiki Kaisha Isoquinolinesulfonyl derivatives and process for the preparation thereof
JPH0227992B2 (ja) 1982-01-14 1990-06-20 Asahi Kasei Kogyo Kk Isokinorinsuruhonirukagobutsu
JPS58121278A (ja) 1982-01-12 1983-07-19 Asahi Chem Ind Co Ltd イソキノリンスルホン酸アミド誘導体
JPS5993054A (ja) 1982-11-18 1984-05-29 Asahi Chem Ind Co Ltd イソキノリンスルホン酸アミド誘導体
JPS6081168A (ja) 1983-10-13 1985-05-09 Asahi Chem Ind Co Ltd アミジン誘導体
US4678783B1 (en) 1983-11-04 1995-04-04 Asahi Chemical Ind Substituted isoquinolinesulfonyl compounds
JPS61227581A (ja) * 1985-04-02 1986-10-09 Asahi Chem Ind Co Ltd 血管拡張剤
JPS61152658A (ja) 1984-12-27 1986-07-11 Asahi Chem Ind Co Ltd 置換されたイソキノリンスルホンアミド誘導体
DE3583287D1 (de) * 1984-12-27 1991-07-25 Asahi Chemical Ind Substituierte isochinolinsulfonyl-verbindungen.
JPH0680054B2 (ja) * 1985-06-19 1994-10-12 吉富製薬株式会社 ピペリジン誘導体
JPH062741B2 (ja) 1985-10-29 1994-01-12 旭化成工業株式会社 ２級のイソキノリンスルホンアミド誘導体
JP2770497B2 (ja) * 1988-11-24 1998-07-02 吉富製薬株式会社 トランス―４―アミノ（アルキル）―１―ピリジルカルバモイルシクロヘキサン化合物およびその医薬用途
WO1990005723A1 (en) † 1988-11-24 1990-05-31 Yoshitomi Pharmaceutical Industries, Ltd. Trans-4-amino(alkyl)-1-pyridylcarbamoyl-cyclohexane compounds and their medicinal use
JP2720348B2 (ja) * 1989-03-30 1998-03-04 旭化成工業株式会社 脳細胞機能障害改善剤
JP3408546B2 (ja) * 1991-02-19 2003-05-19 旭化成株式会社 抗喘息剤
JP2864489B2 (ja) * 1991-02-27 1999-03-03 吉富製薬株式会社 喘息治療剤
DE69231297T2 (de) 1991-09-06 2000-11-23 Yoshitomi Pharmaceutical Industries, Ltd. 4-amino(alkyl)cyclohexan-1-carboxamidverbindungen und ihre verwendung
JP3275389B2 (ja) * 1991-09-06 2002-04-15 三菱ウェルファーマ株式会社 ４−アミノ（アルキル）シクロヘキサン−１−カルボン酸アミド化合物
JPH05273821A (ja) 1992-03-24 1993-10-22 Nippon Steel Corp 静電画像形成装置
JP3265695B2 (ja) * 1992-05-12 2002-03-11 三菱ウェルファーマ株式会社 ４−置換アミノ（アルキル）シクロヘキサン−１−カルボン酸アミド化合物
JP2893029B2 (ja) * 1992-08-10 1999-05-17 旭化成工業株式会社 心臓保護剤
JPH0680569A (ja) * 1992-09-03 1994-03-22 Asahi Chem Ind Co Ltd 血小板凝集阻害剤
JP3218356B2 (ja) 1993-03-31 2001-10-15 ヤンマー農機株式会社 管理機
JPH06289679A (ja) * 1993-04-01 1994-10-18 Hitachi Metals Ltd 画像形成方法
JP3464012B2 (ja) * 1993-04-05 2003-11-05 旭化成株式会社 精神症候治療剤
DE4323295C1 (de) * 1993-07-12 1995-02-09 Manfred R Dr Hamm Dosiervorrichtung
JPH0741424A (ja) * 1993-07-28 1995-02-10 Asahi Chem Ind Co Ltd 抗炎症剤
JPH07277979A (ja) * 1994-04-12 1995-10-24 Asahi Chem Ind Co Ltd 過粘性症候群治療または予防剤
EP1195372A1 (en) † 1994-04-18 2002-04-10 Mitsubishi Pharma Corporation N-heterocyclic substituted benzamide derivatives with antihypertensive activity
ES2286834T5 (es) * 1996-08-12 2011-01-31 Mitsubishi Tanabe Pharma Corporation Medicamentos que comprenden un inhibidor de la rho quinasa.

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8357693B2 (en) 2005-03-25 2013-01-22 Surface Logix, Inc. Pharmacokinetically improved compounds
US8916576B2 (en) 2005-03-25 2014-12-23 Surface Logix, Inc. Pharmacokinetically improved compounds
US9440961B2 (en) 2005-03-25 2016-09-13 Surface Logix, Inc. Rho-kinase inhibitors and method of preparation
US10570123B2 (en) 2005-03-25 2020-02-25 Surface Logix, Llc Pharmacokinetically improved compounds

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