RS57840B1 - Humanizovana anti-cd 134 (ox40) antitela i njihove upotrebe - Google Patents
Humanizovana anti-cd 134 (ox40) antitela i njihove upotrebeInfo
- Publication number
- RS57840B1 RS57840B1 RS20181085A RSP20181085A RS57840B1 RS 57840 B1 RS57840 B1 RS 57840B1 RS 20181085 A RS20181085 A RS 20181085A RS P20181085 A RSP20181085 A RS P20181085A RS 57840 B1 RS57840 B1 RS 57840B1
- Authority
- RS
- Serbia
- Prior art keywords
- antibodies
- humanized anti
- humanized
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/74—Inducing cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13159794 | 2013-03-18 | ||
| EP14715138.5A EP2976361B1 (en) | 2013-03-18 | 2014-03-18 | Humanized anti-cd134 (ox40) antibodies and uses thereof |
| PCT/NL2014/050162 WO2014148895A1 (en) | 2013-03-18 | 2014-03-18 | Humanized anti-cd134 (ox40) antibodies and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RS57840B1 true RS57840B1 (sr) | 2018-12-31 |
Family
ID=47891522
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RS20181085A RS57840B1 (sr) | 2013-03-18 | 2014-03-18 | Humanizovana anti-cd 134 (ox40) antitela i njihove upotrebe |
Country Status (33)
| Country | Link |
|---|---|
| US (3) | US9790281B2 (sr) |
| EP (2) | EP3409690A1 (sr) |
| JP (1) | JP2016515544A (sr) |
| KR (1) | KR20160006168A (sr) |
| CN (1) | CN105229032A (sr) |
| AU (2) | AU2014238546C1 (sr) |
| BR (1) | BR112015023862A2 (sr) |
| CA (1) | CA2907436A1 (sr) |
| CL (2) | CL2015002793A1 (sr) |
| CR (1) | CR20150498A (sr) |
| CY (1) | CY1120752T1 (sr) |
| DK (1) | DK2976361T3 (sr) |
| EA (1) | EA201591495A1 (sr) |
| ES (1) | ES2687282T3 (sr) |
| HK (1) | HK1215035A1 (sr) |
| HR (1) | HRP20181478T1 (sr) |
| HU (1) | HUE040234T2 (sr) |
| IL (1) | IL241701A0 (sr) |
| LT (1) | LT2976361T (sr) |
| MD (2) | MD4633B1 (sr) |
| MX (2) | MX2015013288A (sr) |
| NZ (1) | NZ712903A (sr) |
| PE (1) | PE20160690A1 (sr) |
| PH (1) | PH12015502185A1 (sr) |
| PL (1) | PL2976361T3 (sr) |
| PT (1) | PT2976361T (sr) |
| RS (1) | RS57840B1 (sr) |
| SG (2) | SG10201708048XA (sr) |
| SI (1) | SI2976361T1 (sr) |
| SM (1) | SMT201800503T1 (sr) |
| UA (1) | UA119319C2 (sr) |
| WO (1) | WO2014148895A1 (sr) |
| ZA (1) | ZA201507021B (sr) |
Families Citing this family (126)
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| GB201116092D0 (en) * | 2011-09-16 | 2011-11-02 | Bioceros B V | Antibodies and uses thereof |
| US10101337B2 (en) | 2013-03-14 | 2018-10-16 | The Board Of Trustees Of The Leland Stanford Junior University | Methods of detecting donor-specific antibodies and systems for practicing the same |
| KR20160006168A (ko) | 2013-03-18 | 2016-01-18 | 바이오서오엑스 프로덕스 비.브이. | 인간화 항-cd134(ox40) 항체 및 이의 용도 |
| MX2016007965A (es) | 2013-12-17 | 2016-10-28 | Genentech Inc | Terapia de combinacion que comprende agonistas de union a ox40 y antagonistas de union al eje pd-1. |
| JP6588461B2 (ja) | 2014-03-31 | 2019-10-09 | ジェネンテック， インコーポレイテッド | 抗血管新生剤及びｏｘ４０結合アゴニストを含む併用療法 |
| TW201619200A (zh) | 2014-10-10 | 2016-06-01 | 麥迪紐有限責任公司 | 人類化抗－ｏｘ４０抗體及其用途 |
| AU2015343339A1 (en) | 2014-11-03 | 2017-06-15 | Genentech, Inc. | Methods and biomarkers for predicting efficacy and evaluation of an OX40 agonist treatment |
| CA2966523A1 (en) | 2014-11-03 | 2016-05-12 | Genentech, Inc. | Assays for detecting t cell immune subsets and methods of use thereof |
| AU2015343494A1 (en) | 2014-11-06 | 2017-04-27 | Genentech, Inc. | Combination therapy comprising OX40 binding agonists and TIGIT inhibitors |
| BR112017010198A2 (pt) | 2014-11-17 | 2017-12-26 | Genentech Inc | terapia de combinação compreendendo agonistas de ligação a ox40 e antagonistas de ligação ao eixo de pd-1 |
| ES2755527T3 (es) | 2015-01-08 | 2020-04-22 | BioNTech SE | Agentes agonistas de unión al receptor de TNF |
| RS63903B1 (sr) | 2015-03-03 | 2023-02-28 | Kymab Ltd | Antitela, upotrebe i metode |
| AU2016246695A1 (en) | 2015-04-07 | 2017-10-26 | Genentech, Inc. | Antigen binding complex having agonistic activity and methods of use |
| PT3290441T (pt) * | 2015-04-28 | 2019-12-02 | Mitsubishi Tanabe Pharma Corp | Proteína de ligação a rgma e utilização da mesma |
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| JP6797137B2 (ja) * | 2015-05-29 | 2020-12-09 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | Ｏｘ４０に対する抗体およびその使用 |
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| CN115594765A (zh) | 2015-10-02 | 2023-01-13 | 豪夫迈·罗氏有限公司（Ch） | 对共刺激性tnf受体特异性的双特异性抗体 |
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| CN108472382A (zh) | 2015-10-30 | 2018-08-31 | 豪夫迈·罗氏有限公司 | 抗-因子d抗体变体缀合物及其用途 |
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| US10527613B2 (en) * | 2015-11-10 | 2020-01-07 | The Board Of Trustees Of The Leland Stanford Junior University | Biomarker detection methods and systems and kits for practicing same |
| SG10201912984WA (en) | 2015-12-02 | 2020-03-30 | Agenus Inc | Antibodies and methods of use thereof |
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| DE102016105069A1 (de) | 2016-03-18 | 2017-09-21 | Eberhard Karls Universität Tübingen Medizinische Fakultät | Antivirale Immuntherapie durch Membranrezeptorligation |
| US12145993B2 (en) * | 2016-06-08 | 2024-11-19 | Shanghai Jiao Tong University School Of Medicine | Sequence of antibody heavy chain constant region for enhancing agonistic antibody activity |
| BR112018076281A2 (pt) | 2016-06-20 | 2019-03-26 | Kymab Limited | imunocitocina, uso de uma imunocitocina, método, composição farmacêutica, método para tratar uma doença proliferativa em um animal, ácido nucleico, vetor, hospedeiro e anticorpo ou fragmento do mesmo |
| JP2019530434A (ja) | 2016-08-05 | 2019-10-24 | ジェネンテック， インコーポレイテッド | アゴニスト活性を有する多価及び多重エピトープ抗体ならびに使用方法 |
| KR102587941B1 (ko) | 2016-08-12 | 2023-10-11 | 얀센 바이오테크 인코포레이티드 | 향상된 효능작용 및 이펙터 기능을 갖는 조작된 항체 및 다른 Fc-도메인 함유 분자 |
| SG11201900744SA (en) * | 2016-08-12 | 2019-02-27 | Janssen Biotech Inc | Fc engineered anti-tnfr superfamily member antibodies having enhanced agonistic activity and methods of using them |
| TWI788307B (zh) | 2016-10-31 | 2023-01-01 | 美商艾歐凡斯生物治療公司 | 用於擴增腫瘤浸潤性淋巴細胞之工程化人造抗原呈現細胞 |
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| TWI825007B (zh) | 2017-01-20 | 2023-12-11 | 德商海德堡醫藥研究有限責任公司 | 用於cd137＋細胞耗盡（depletion）之組合物及方法 |
| MA47449A (fr) | 2017-02-10 | 2019-12-18 | Genmab Bv | Variants polypeptidiques et ses utilisations |
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| US12024560B2 (en) | 2017-03-28 | 2024-07-02 | Lyvgen Biopharma Holdings Limited | Therapeutic agents and methods for enhancing immune responses in tumor microenvironment |
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- 2014-03-18 ES ES14715138T patent/ES2687282T3/es active Active
- 2014-03-18 PL PL14715138T patent/PL2976361T3/pl unknown
- 2014-03-20 US US14/221,212 patent/US9790281B2/en not_active Expired - Fee Related
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2015
- 2015-09-16 CL CL2015002793A patent/CL2015002793A1/es unknown
- 2015-09-17 IL IL241701A patent/IL241701A0/en unknown
- 2015-09-17 PH PH12015502185A patent/PH12015502185A1/en unknown
- 2015-09-17 MX MX2019004649A patent/MX2019004649A/es unknown
- 2015-09-18 CR CR20150498A patent/CR20150498A/es unknown
- 2015-09-21 ZA ZA2015/07021A patent/ZA201507021B/en unknown
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2016
- 2016-03-14 HK HK16102900.7A patent/HK1215035A1/zh unknown
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2017
- 2017-09-11 US US15/700,986 patent/US10273307B2/en not_active Expired - Fee Related
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2018
- 2018-09-14 CY CY181100953T patent/CY1120752T1/el unknown
- 2018-09-17 HR HRP20181478TT patent/HRP20181478T1/hr unknown
- 2018-12-24 CL CL2018003807A patent/CL2018003807A1/es unknown
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2019
- 2019-01-10 AU AU2019200164A patent/AU2019200164A1/en not_active Abandoned
- 2019-03-13 US US16/351,852 patent/US20190202928A1/en not_active Abandoned
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