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RS50589B - 2-(1h-indolilsulfanil)-benzil amin derivati kao ssri - Google Patents

2-(1h-indolilsulfanil)-benzil amin derivati kao ssri

Info

Publication number
RS50589B
RS50589B RSP-2008/0315A RSP20080315A RS50589B RS 50589 B RS50589 B RS 50589B RS P20080315 A RSP20080315 A RS P20080315A RS 50589 B RS50589 B RS 50589B
Authority
RS
Serbia
Prior art keywords
indolylsulfanyl
ssri
comme
benzyl amine
benzyl
Prior art date
Application number
RSP-2008/0315A
Other languages
English (en)
Inventor
Jan Kehler
Karsten Juhl
Jimmy Sejberg
Morten Bang Norgaard
Original Assignee
H. Lundbeck A/S.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H. Lundbeck A/S. filed Critical H. Lundbeck A/S.
Publication of RS50589B publication Critical patent/RS50589B/sr

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/06—Anti-spasmodics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
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  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Anesthesiology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Jedinjenje op[te formule I:, naznačeno time, što je atom sumpora zakačen za indol putem bilo kog ugljenika u prstenu indola i gde- R1-R2 su nezavisno odabrani od vodonika, C1-6-alk(en/in)il, C3.8-cikloalk(en)il i C3-8-cikloalk(en)il-C1-6-alk(en/in)il ili R1 i R2 zajedno sa azotom formiraju 4-7 člani prsten koji sadrži nijednu ili jednu dvogubu vezu, opciono navedeni prsten dodatno navedenom azotu sadrži još jedan heteroatom odabran od azota, kiseonika i sumpora; - R3-R12 su nezavisno odabrani od vodonika, halogena, cijano, nitro, C1-6-alk(en/in)il, C3-8-cikloalk(en)il, C3-8-cikloalk(en)il-C1-6-alk(en/in)il, amino, C1-6-alk(en/in)ilamino, di-(C1-6-alk(en/in)il)amino, C1-6-alk(en/in)ilkarbonil, aminokarbonil, C1-6-alk(en/in)ilaminokarbonil, di-(C1-6-alk(en/in)il)aminokarbonil, hidroksi, C1-6-alk(en/in)iloksi, C1-6-alk(en/in)iltio, halo-C1-6-alk(en/in)il i C1-6-alk(en/in)ilsulfonil;- Pod uslovom daje R10 odabran od haiogena, cijano, C1-6-alk(en/in)il, hidroksil, C1-6-alk(en/in)iloksi i haloC1-6-alk(en/in)il; i- R13 je odabran od vodonika i C1-6-alkila; kao slobodna baza ili njena so; pod uslovima da:- kada je atom sumpora zakačen putem atoma br. 2 indola onda R7 ne postoji;- kada je atom sumpora zakačen putem atoma br. 3 indola onda R12 ne postoji;- kada je atom sumpora zakačen putem atoma br. 4 indola onda R8 ne postoji;- kada je atom sumpora zakačen putem atoma br. 5 indola onda R9 ne postoji;- kada je atom sumpora zakačen putem atoma br. 7 indola onda R11 ne postoji.Prijava sadrži još 16 patentnih zahteva.
RSP-2008/0315A 2003-12-23 2004-12-21 2-(1h-indolilsulfanil)-benzil amin derivati kao ssri RS50589B (sr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US53259303P 2003-12-23 2003-12-23
DKPA200301923 2003-12-23
PCT/DK2004/000894 WO2005061455A1 (en) 2003-12-23 2004-12-21 2-(1h-indolylsulfanyl)-benzyl amine derivatives as ssri

Publications (1)

Publication Number Publication Date
RS50589B true RS50589B (sr) 2010-05-07

Family

ID=34712442

Family Applications (1)

Application Number Title Priority Date Filing Date
RSP-2008/0315A RS50589B (sr) 2003-12-23 2004-12-21 2-(1h-indolilsulfanil)-benzil amin derivati kao ssri

Country Status (18)

Country Link
US (4) US7563908B2 (sr)
EP (1) EP1701940B1 (sr)
JP (3) JP4090491B2 (sr)
AT (1) ATE396970T1 (sr)
AU (1) AU2004303461B2 (sr)
BR (1) BRPI0417858B1 (sr)
CY (2) CY1108230T1 (sr)
DE (1) DE602004014190D1 (sr)
DK (1) DK1701940T3 (sr)
ES (1) ES2303960T3 (sr)
HR (2) HRP20080274T3 (sr)
IL (1) IL176111A (sr)
MX (1) MXPA06007172A (sr)
PL (1) PL1701940T3 (sr)
PT (1) PT1701940E (sr)
RS (1) RS50589B (sr)
SI (1) SI1701940T1 (sr)
WO (1) WO2005061455A1 (sr)

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AU2004303461A1 (en) 2005-07-07
IL176111A0 (en) 2006-10-05
CY1111733T1 (el) 2015-10-07
JP2008110984A (ja) 2008-05-15
WO2005061455A1 (en) 2005-07-07
EP1701940B1 (en) 2008-05-28
US20080214645A1 (en) 2008-09-04
BRPI0417858A (pt) 2007-04-27
MXPA06007172A (es) 2006-08-23
US7737171B2 (en) 2010-06-15
HRP20080274T3 (en) 2008-12-31
US20080214644A1 (en) 2008-09-04
ES2303960T3 (es) 2008-09-01
DE602004014190D1 (de) 2008-07-10
US7652150B2 (en) 2010-01-26
US20080176922A1 (en) 2008-07-24
PT1701940E (pt) 2008-07-30
US7737170B2 (en) 2010-06-15
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AU2004303461B2 (en) 2011-04-28
JP2007515436A (ja) 2007-06-14
EP1701940A1 (en) 2006-09-20
SI1701940T1 (sl) 2008-10-31
JP4091648B2 (ja) 2008-05-28
US7563908B2 (en) 2009-07-21
JP4090491B2 (ja) 2008-05-28
HRP20110400T1 (hr) 2011-06-30
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ATE396970T1 (de) 2008-06-15
IL176111A (en) 2011-10-31

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