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BR0317591A - Composto, sal ou pró-medicamento farmaceuticamente aceitáveis, composição farmacêutica, e, métodos para tratar uma doença ou condição, para modular a função de crth2 e/ou um ou mais outros receptores de pgd2 em uma célula e para modular crth2 e/ou um ou mais outros receptores de pgd2 - Google Patents

Composto, sal ou pró-medicamento farmaceuticamente aceitáveis, composição farmacêutica, e, métodos para tratar uma doença ou condição, para modular a função de crth2 e/ou um ou mais outros receptores de pgd2 em uma célula e para modular crth2 e/ou um ou mais outros receptores de pgd2

Info

Publication number
BR0317591A
BR0317591A BR0317591-0A BR0317591A BR0317591A BR 0317591 A BR0317591 A BR 0317591A BR 0317591 A BR0317591 A BR 0317591A BR 0317591 A BR0317591 A BR 0317591A
Authority
BR
Brazil
Prior art keywords
crth2
modulating
methods
function
pgd2 receptors
Prior art date
Application number
BR0317591-0A
Other languages
English (en)
Inventor
Zice Fu
Xi Alan Huang
Jiwen Liu
Julio C Medina
Michael J Schmitt
H Lucy Tang
Yingcai Wang
Qingge Xu
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of BR0317591A publication Critical patent/BR0317591A/pt

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    • C07C205/35—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C205/36—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system
    • C07C205/37—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
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    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

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Abstract

"COMPOSTO, SAL OU PRó-MEDICAMENTO FARMACEUTICAMENTE ACEITáVEIS, COMPOSIçãO FARMACêUTICA, E, MéTODOS PARA TRATAR UMA DOENçA OU CONDIçãO, PARA MODULAR A FUNçãO DE CRTH2 E/OU UM OU MAIS OUTROS RECEPTORES DE PGD2 EM UMA CéLULA E PARA MODULAR CRTH2 E/OU UM OU MAIS OUTROS RECEPTORES DE PGD2" Compostos, composições farmacêuticas e métodos são fornecidos que são úteis no tratamento de doenças e condições inflamatórias e imuno-relacionadas. Em particular, a invenção fornece compostos que modulam a função e/ou expressão de proteínas envolvidas em doenças atópicas, condições inflamatórias e câncer. Os compostos objetos são derivados do ácido carboxílico.
BR0317591-0A 2002-12-20 2003-12-19 Composto, sal ou pró-medicamento farmaceuticamente aceitáveis, composição farmacêutica, e, métodos para tratar uma doença ou condição, para modular a função de crth2 e/ou um ou mais outros receptores de pgd2 em uma célula e para modular crth2 e/ou um ou mais outros receptores de pgd2 BR0317591A (pt)

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US43536602P 2002-12-20 2002-12-20
PCT/US2003/040617 WO2004058164A2 (en) 2002-12-20 2003-12-19 Asthma and allergic inflammation modulators

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