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RS20080002A - N-phenyl-2-pyrimidine-amine derivatives and process for the preparation thereof - Google Patents

N-phenyl-2-pyrimidine-amine derivatives and process for the preparation thereof

Info

Publication number
RS20080002A
RS20080002A RSP-2008/0002A RSP20080002A RS20080002A RS 20080002 A RS20080002 A RS 20080002A RS P20080002 A RSP20080002 A RS P20080002A RS 20080002 A RS20080002 A RS 20080002A
Authority
RS
Serbia
Prior art keywords
cancer
pyrimidine
phenyl
compound
relates
Prior art date
Application number
RSP-2008/0002A
Other languages
English (en)
Inventor
Dong-Yeon Kim
Dae-Jin Cho
Gong-Yeal Lee
Hong-Youb Kim
Seok-Hun Woo
Yong-Seok Kim
Sun-Ahe Lee
Byoung-Cheol Han
Original Assignee
Il-Yang Pharm. Co.Ltd.,
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Il-Yang Pharm. Co.Ltd., filed Critical Il-Yang Pharm. Co.Ltd.,
Publication of RS20080002A publication Critical patent/RS20080002A/sr
Publication of RS53379B publication Critical patent/RS53379B/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Photoreceptors In Electrophotography (AREA)

Abstract

Predstavljeni pronalazak se odnosi na novi derivat N-fenil-2-pirimidin-amina predstavljen prethodnom formulom (1) i njegovu so koji pokazuju bolji efekat na kancer kod tolpokrvnih životinja, kao što su rak pluća, rak želudca, rak debelog creva, rak pankreasa, hepatom, rak prostate, rak dojke, hronična ili akutna leukemija, hematološki malignitet, encefalofima, rak bešike, rak rektuma, rak grlića materice, limfom, itd. Predstavljeni pronalazak se takođe odnosi na postupak za pripremu jedinjenja, i na farmaceutsku kompoziciju za tretman prethodno navedenih različitih bolesti, koja sadrži efikasnu količinu jedinjenja kao aktivni sastojak zajedno sa farmaceutski prihvatljivim inertnim nosačima: gde su Rl do R8 kao što je određeno u prethodnom tekstu.
RS20080002A 2005-08-05 2005-09-07 Derivati n-fenil-2-pirimidin-amina i postupak za njihovo pripremanje RS53379B (sr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020050071656A KR100674813B1 (ko) 2005-08-05 2005-08-05 Ｎ-페닐-2-피리미딘-아민 유도체 및 그의 제조방법
PCT/KR2005/002962 WO2007018325A1 (en) 2005-08-05 2005-09-07 N-phenyl-2-pyrimidine-amine derivatives and process for the preparation thereof

Publications (2)

Publication Number Publication Date
RS20080002A true RS20080002A (en) 2009-07-15
RS53379B RS53379B (sr) 2014-10-31

Family

ID=37727490

Family Applications (1)

Application Number Title Priority Date Filing Date
RS20080002A RS53379B (sr) 2005-08-05 2005-09-07 Derivati n-fenil-2-pirimidin-amina i postupak za njihovo pripremanje

Country Status (16)

Country Link
US (1) US7501424B2 (sr)
EP (1) EP1922309B1 (sr)
JP (1) JP5094721B2 (sr)
KR (1) KR100674813B1 (sr)
CN (1) CN101155786B (sr)
AU (1) AU2005335298C1 (sr)
CA (1) CA2617991C (sr)
DK (1) DK1922309T3 (sr)
EA (1) EA015103B1 (sr)
ES (1) ES2493627T3 (sr)
MX (1) MX2008001221A (sr)
NZ (1) NZ564908A (sr)
PL (1) PL1922309T3 (sr)
PT (1) PT1922309E (sr)
RS (1) RS53379B (sr)
WO (1) WO2007018325A1 (sr)

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KR100654039B1 (ko) 2005-11-14 2006-12-05 에스케이 텔레콤주식회사 무선 인터넷에서 서비스 서버의 인증방법 및 이를 이용한결제방법
EP2684874B1 (en) 2006-10-23 2017-05-17 Cephalon, Inc. Fused bicyclic derivatives of 2,4-diaminopyrimidine as alk and C-met inhibitors
KR20120049397A (ko) * 2006-11-03 2012-05-16 노파르티스 아게 단백질 키나제 억제제로서의 화합물 및 조성물
BRPI0811516A2 (pt) * 2007-05-04 2014-11-18 Irm Llc Compostos e composições como inibidores de c-kit e pdgfr cinase
CA2686378C (en) * 2007-05-04 2012-07-24 Irm Llc Pyrimidine derivatives and compositions as c-kit and pdgfr kinase inhibitors
TWI433677B (zh) 2007-06-04 2014-04-11 Avila Therapeutics Inc 雜環化合物及其用途
ATE520682T1 (de) 2007-08-22 2011-09-15 Irm Llc 2-heteroarylaminopyrimidinderivate als kinaseinhibitoren
US20100016590A1 (en) * 2008-07-17 2010-01-21 Teva Pharmaceutical Industries Ltd. Nilotinib intermediates and preparation thereof
KR20100021321A (ko) * 2008-08-14 2010-02-24 일양약품주식회사 Ν-페닐-2-피리미딘-아민 유도체의 제조방법
TW201022240A (en) 2008-11-05 2010-06-16 Teva Pharma Nilotinib HCl crystalline forms
WO2010060074A1 (en) * 2008-11-24 2010-05-27 Teva Pharmaceutical Industries Ltd. Preparation of nilotinib and intermediates thereof
WO2011144742A1 (en) 2010-05-21 2011-11-24 Chemilia Ab Novel pyrimidine derivatives
ES2587864T3 (es) 2011-03-24 2016-10-27 Noviga Research Ab Derivados de pirimidina
KR101369584B1 (ko) 2011-04-19 2014-03-06 일양약품주식회사 페닐-이속사졸 유도체 및 그의 제조방법
RU2486180C1 (ru) * 2011-11-02 2013-06-27 Общество с ограниченной ответственностью "ТехноХим" (ООО "ТехноХим") Способ получения 2-ариламино-4-гетарилпиримидинов
KR101956586B1 (ko) * 2012-03-27 2019-03-11 일양약품주식회사 약제학적 조성물 및 이의 제조방법
JP5910311B2 (ja) * 2012-05-23 2016-04-27 ニプロ株式会社 医薬錠剤およびその製造方法
CN104940748A (zh) * 2015-06-09 2015-09-30 林正兴 一种治疗胃癌的药物组合物
US11091466B2 (en) 2017-03-17 2021-08-17 Cardio Therapeutics Pty Ltd Heterocyclic inhibitors of PCSK9
CN107056713A (zh) * 2017-05-18 2017-08-18 厦门大学 4‑((4‑取代芳基‑2‑嘧啶基)氨基)苯甲酰肼衍生物及其制备方法和应用
CN111039932B (zh) * 2019-12-13 2023-09-12 安徽峆一药业股份有限公司 一种拉多替尼的高收率合成方法

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CO4940418A1 (es) 1997-07-18 2000-07-24 Novartis Ag Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso
US6368651B1 (en) * 1999-05-13 2002-04-09 The Nutrasweet Company Use of additives to modify the taste characteristics of N-neohexyl-α-aspartyl-L-phenylalanine methyl ester
BR0014454A (pt) * 1999-10-04 2002-08-20 Composição edulcorante com um alto grau de edulcoração, edulcorante, alimento e bebida, ou um outro produto edulcorado, processos para conferir um sabor doce, e para corrigir um sabor, modificador de sabor, e, alimento e bebida, um medicamento etc. com sabor amargo aperfeiçoado
GB0021726D0 (en) * 2000-09-05 2000-10-18 Astrazeneca Ab Chemical compounds
GB0022438D0 (en) * 2000-09-13 2000-11-01 Novartis Ag Organic Compounds
PT1330452E (pt) * 2000-09-20 2009-01-22 Ortho Mcneil Pharm Inc Derivados de pirazina como moduladores de tirosina-cinases
US7129242B2 (en) * 2000-12-06 2006-10-31 Signal Pharmaceuticals, Llc Anilinopyrimidine derivatives as JNK pathway inhibitors and compositions and methods related thereto
EP1392684B1 (en) * 2001-06-01 2006-09-13 Vertex Pharmaceuticals Incorporated Thiazole compounds useful as inhibitors of protein kinases
WO2003011836A1 (en) * 2001-08-01 2003-02-13 Merck & Co., Inc. Tyrosine kinase inhibitors
BRPI0312288B8 (pt) * 2002-06-28 2021-05-25 Nippon Shinyaku Co Ltd derivados de amidas
GB0215676D0 (en) * 2002-07-05 2002-08-14 Novartis Ag Organic compounds
US20040235834A1 (en) * 2003-03-25 2004-11-25 Farmer Luc J. Thiazoles useful as inhibitors of protein kinases
JP2006522125A (ja) * 2003-03-25 2006-09-28 バーテックス　ファーマシューティカルズ　インコーポレイテッド プロテインキナーゼのインヒビターとして有用なチアゾール
AU2003232650A1 (en) 2003-05-06 2004-11-26 Il Yang Pharm Co., Ltd. N-phenyl-2-pyrimidine-amine derivatives and process for the preparation thereof
CA2529090A1 (en) * 2003-06-13 2004-12-23 Novartis Ag 2-aminopyrimidine derivatives as raf kinase inhibitors
WO2005063720A1 (ja) * 2003-12-25 2005-07-14 Nippon Shinyaku Co., Ltd. アミド誘導体及び医薬
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WO2005113550A1 (ja) * 2004-05-20 2005-12-01 Mitsubishi Pharma Corporation アミノピリミジン誘導体及びその医薬としての用途

Also Published As

Publication number Publication date
CN101155786B (zh) 2012-08-29
EA200800516A1 (ru) 2008-08-29
ES2493627T3 (es) 2014-09-12
US7501424B2 (en) 2009-03-10
JP2009503060A (ja) 2009-01-29
EP1922309B1 (en) 2014-05-21
RS53379B (sr) 2014-10-31
AU2005335298C1 (en) 2010-11-25
PL1922309T3 (pl) 2014-11-28
EA015103B1 (ru) 2011-06-30
DK1922309T3 (da) 2014-08-25
US20080096899A1 (en) 2008-04-24
CA2617991A1 (en) 2007-02-15
WO2007018325A1 (en) 2007-02-15
NZ564908A (en) 2011-02-25
PT1922309E (pt) 2014-09-02
EP1922309A4 (en) 2009-10-14
CN101155786A (zh) 2008-04-02
KR100674813B1 (ko) 2007-01-29
CA2617991C (en) 2011-08-09
AU2005335298A1 (en) 2007-02-15
EP1922309A1 (en) 2008-05-21
MX2008001221A (es) 2009-02-24
JP5094721B2 (ja) 2012-12-12
AU2005335298B2 (en) 2010-05-27

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