RO122912B8 - Procedeu de preparare a unui derivat de 2h-cromen - Google Patents
Procedeu de preparare a unui derivat de 2h-cromenInfo
- Publication number
- RO122912B8 RO122912B8 ROA200700589A RO200700589A RO122912B8 RO 122912 B8 RO122912 B8 RO 122912B8 RO A200700589 A ROA200700589 A RO A200700589A RO 200700589 A RO200700589 A RO 200700589A RO 122912 B8 RO122912 B8 RO 122912B8
- Authority
- RO
- Romania
- Prior art keywords
- formula
- preparing
- compound
- chromene derivative
- chromene
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- KYNSBQPICQTCGU-UHFFFAOYSA-N Benzopyrane Chemical class C1=CC=C2C=CCOC2=C1 KYNSBQPICQTCGU-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- 125000000850 2H-chromenyl group Chemical class O1C(C=CC2=CC=CC=C12)* 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 108010022394 Threonine synthase Proteins 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 238000010511 deprotection reaction Methods 0.000 abstract 1
- 102000004419 dihydrofolate reductase Human genes 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 150000002576 ketones Chemical class 0.000 abstract 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 abstract 1
- 238000007363 ring formation reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Indole Compounds (AREA)
Abstract
Invenţia se referă la un procedeu de preparare a unui derivat de 2H-cromen cu formula I: cu acţiune de inhibare a dihidrofolat reductazei, putând fi utilizat pentru controlul sau prevenirea bolilor infecţioase la mamifere, şi la intermediarii din acest procedeu. Procedeul conform invenţiei constă în reacţia unui compus cu formula 6: în care R reprezintă -C(CH)sau -CH(CH), după protejarea prealabilă a grupei fenol, cu o cetonă cu formula 8: urmată de reducerea compusului obţinut şi, în continuare, de ciclizare, cu obţinerea compusului cu formula 11: din care, după deprotejare, se obţine compusul dorit, cu formula I.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP2005001695 | 2005-02-18 | ||
| PCT/EP2006/001185 WO2006087143A1 (en) | 2005-02-18 | 2006-02-10 | Novel processes for the preparation of a 2h-chromene |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RO122912B1 RO122912B1 (ro) | 2010-04-30 |
| RO122912B8 true RO122912B8 (ro) | 2010-09-30 |
Family
ID=36283919
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ROA200700589A RO122912B8 (ro) | 2005-02-18 | 2006-02-10 | Procedeu de preparare a unui derivat de 2h-cromen |
| ROA200700590A RO122853B1 (ro) | 2005-02-18 | 2006-02-10 | Procedeu de preparare a unui derivat de benzofuran |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ROA200700590A RO122853B1 (ro) | 2005-02-18 | 2006-02-10 | Procedeu de preparare a unui derivat de benzofuran |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US20080221324A1 (ro) |
| EP (3) | EP1856109A1 (ro) |
| JP (2) | JP2009505943A (ro) |
| KR (2) | KR20070106635A (ro) |
| CN (4) | CN101115746A (ro) |
| AU (2) | AU2006215788B2 (ro) |
| BG (2) | BG109938A (ro) |
| BR (2) | BRPI0607797A2 (ro) |
| CA (2) | CA2596668A1 (ro) |
| CZ (2) | CZ2007537A3 (ro) |
| EE (2) | EE200700050A (ro) |
| HU (2) | HUP0700604A3 (ro) |
| IL (2) | IL184405A0 (ro) |
| MX (2) | MX2007009282A (ro) |
| NO (2) | NO20073678L (ro) |
| NZ (1) | NZ556800A (ro) |
| RO (2) | RO122912B8 (ro) |
| RU (2) | RU2007134583A (ro) |
| TR (1) | TR200705187T1 (ro) |
| TW (2) | TW200640914A (ro) |
| WO (2) | WO2006087140A1 (ro) |
| ZA (2) | ZA200706421B (ro) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2007009282A (es) * | 2005-02-18 | 2008-02-19 | Arpida Ag | Nuevos procesos para la preparacion de un 2h-cromeno. |
| AU2008354622A1 (en) * | 2008-04-08 | 2009-10-15 | Acino Pharma Ag | Aqueous pharmaceutical formulation |
| US7947293B2 (en) | 2008-04-08 | 2011-05-24 | Arpida Ag | Aqueous pharmaceutical formulation |
| FR2949465B1 (fr) * | 2009-09-01 | 2011-08-12 | Pf Medicament | Derives chromones, leur procede de preparation et leurs applications therapeutiques |
| CN110606831A (zh) * | 2018-06-14 | 2019-12-24 | 上海度德医药科技有限公司 | 一种Iclaprim的新中间体及其制备方法和应用 |
| CN110818693B (zh) * | 2018-08-07 | 2023-06-02 | 上海度德医药科技有限公司 | 一种艾拉普林甲磺酸盐晶型b及其制备方法 |
| CN109988156B (zh) * | 2019-03-12 | 2021-12-28 | 广东中科药物研究有限公司 | 一种氨基嘧啶化合物 |
| CN110372746A (zh) * | 2019-07-11 | 2019-10-25 | 辽宁石油化工大学 | 一种合成β-胺基膦氧化合物的方法 |
| CN110818694B (zh) * | 2019-11-18 | 2023-04-21 | 上海医药工业研究院有限公司 | 艾拉普林中间体及其应用 |
| CN110724108B (zh) * | 2019-11-18 | 2023-04-28 | 上海医药工业研究院有限公司 | 一种艾拉普林中间体及其制备方法 |
| CN110724135B (zh) * | 2019-11-18 | 2023-04-28 | 上海医药工业研究院有限公司 | 一种艾拉普林中间体及其制备方法 |
| CN110790753B (zh) * | 2019-11-18 | 2023-04-07 | 上海医药工业研究院 | 艾拉普林对甲苯磺酸盐、其制备方法和应用 |
| CN110746361B (zh) * | 2019-11-18 | 2023-04-21 | 上海医药工业研究院有限公司 | 一种艾拉普林中间体及其制备方法 |
| CN110713483B (zh) * | 2019-11-18 | 2023-04-07 | 上海医药工业研究院 | 艾拉普林中间体及艾拉普林的制备方法 |
| CN110642792B (zh) * | 2019-11-18 | 2023-04-21 | 上海医药工业研究院有限公司 | 艾拉普林中间体的制备方法 |
| CN113493461A (zh) * | 2020-04-01 | 2021-10-12 | 上海医药工业研究院 | 一种七元杂环化合物或其盐、其制备方法及应用 |
| CN117700410B (zh) * | 2023-05-20 | 2025-07-04 | 山东康诺生物工程有限公司 | 一种3-(2-氯乙基)-2-甲基-9-羟基-4H-吡啶并[1,2-a]嘧啶-4-酮的制备方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2709634A1 (de) * | 1977-03-05 | 1978-09-07 | Basf Ag | Benzylpyrimidine, verfahren zu ihrer herstellung und diese enthaltende arzneimittel |
| US4438267A (en) * | 1980-11-11 | 1984-03-20 | Daluge Susan M | Monoheteroring compounds and their use |
| BR9611871B1 (pt) * | 1995-12-04 | 2010-11-03 | diaminopirimidinas, compostos intermediários para a sìntese das mesmas, bem como medicamento que as contém. | |
| WO2002010156A1 (en) * | 2000-07-29 | 2002-02-07 | Arpida Ag | Benzofuran derivatives and their use as antibacterial agents |
| US7365205B2 (en) * | 2001-06-20 | 2008-04-29 | Daiichi Sankyo Company, Limited | Diamine derivatives |
| WO2005005418A1 (en) * | 2003-07-11 | 2005-01-20 | Arpida Ag | Benzofuran derivatives and their use in the treatment of microbial infections |
| WO2005014586A1 (en) * | 2003-08-08 | 2005-02-17 | Arpida Ag | Novel process for the preparation of 2h-chromenes |
| MX2007009282A (es) * | 2005-02-18 | 2008-02-19 | Arpida Ag | Nuevos procesos para la preparacion de un 2h-cromeno. |
-
2006
- 2006-02-10 MX MX2007009282A patent/MX2007009282A/es not_active Application Discontinuation
- 2006-02-10 JP JP2007555507A patent/JP2009505943A/ja active Pending
- 2006-02-10 WO PCT/EP2006/001179 patent/WO2006087140A1/en active Application Filing
- 2006-02-10 EE EEP200700050A patent/EE200700050A/xx unknown
- 2006-02-10 CZ CZ20070537A patent/CZ2007537A3/cs unknown
- 2006-02-10 RO ROA200700589A patent/RO122912B8/ro unknown
- 2006-02-10 RU RU2007134583/04A patent/RU2007134583A/ru not_active Application Discontinuation
- 2006-02-10 RO ROA200700590A patent/RO122853B1/ro unknown
- 2006-02-10 US US11/816,150 patent/US20080221324A1/en not_active Abandoned
- 2006-02-10 MX MX2007009283A patent/MX2007009283A/es unknown
- 2006-02-10 US US11/816,157 patent/US20080161561A1/en not_active Abandoned
- 2006-02-10 KR KR1020077021394A patent/KR20070106635A/ko not_active Ceased
- 2006-02-10 CA CA002596668A patent/CA2596668A1/en not_active Abandoned
- 2006-02-10 AU AU2006215788A patent/AU2006215788B2/en not_active Ceased
- 2006-02-10 BR BRPI0607797-8A patent/BRPI0607797A2/pt not_active IP Right Cessation
- 2006-02-10 AU AU2006215785A patent/AU2006215785A1/en not_active Abandoned
- 2006-02-10 EP EP06706809A patent/EP1856109A1/en not_active Withdrawn
- 2006-02-10 BR BRPI0607758-7A patent/BRPI0607758A2/pt not_active IP Right Cessation
- 2006-02-10 EP EP06706815A patent/EP1856106A1/en not_active Withdrawn
- 2006-02-10 RU RU2007134584/04A patent/RU2397980C2/ru not_active IP Right Cessation
- 2006-02-10 WO PCT/EP2006/001185 patent/WO2006087143A1/en active Application Filing
- 2006-02-10 HU HU0700604A patent/HUP0700604A3/hu unknown
- 2006-02-10 CN CNA2006800039630A patent/CN101115746A/zh active Pending
- 2006-02-10 CZ CZ20070536A patent/CZ2007536A3/cs unknown
- 2006-02-10 CN CN2006800039626A patent/CN101115743B/zh not_active Expired - Fee Related
- 2006-02-10 KR KR1020077021395A patent/KR20070106636A/ko not_active Withdrawn
- 2006-02-10 NZ NZ556800A patent/NZ556800A/en not_active IP Right Cessation
- 2006-02-10 CN CN2011100324952A patent/CN102079727A/zh active Pending
- 2006-02-10 EP EP10184131A patent/EP2270003A1/en not_active Withdrawn
- 2006-02-10 EE EEP200700051A patent/EE200700051A/xx unknown
- 2006-02-10 CA CA002596669A patent/CA2596669A1/en not_active Abandoned
- 2006-02-10 HU HU0700605A patent/HUP0700605A3/hu unknown
- 2006-02-10 TR TR2007/05187T patent/TR200705187T1/xx unknown
- 2006-02-10 CN CN2011100324933A patent/CN102140094B/zh not_active Expired - Fee Related
- 2006-02-10 JP JP2007555504A patent/JP2008530156A/ja active Pending
- 2006-02-17 TW TW095105425A patent/TW200640914A/zh unknown
- 2006-02-17 TW TW095105426A patent/TW200640912A/zh unknown
-
2007
- 2007-07-04 IL IL184405A patent/IL184405A0/en unknown
- 2007-07-04 IL IL184404A patent/IL184404A0/en unknown
- 2007-07-17 NO NO20073678A patent/NO20073678L/no not_active Application Discontinuation
- 2007-07-18 NO NO20073701A patent/NO20073701L/no not_active Application Discontinuation
- 2007-08-01 ZA ZA200706421A patent/ZA200706421B/xx unknown
- 2007-08-01 ZA ZA200706422A patent/ZA200706422B/xx unknown
- 2007-08-10 BG BG109938A patent/BG109938A/bg unknown
- 2007-08-10 BG BG109937A patent/BG109937A/bg unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RO122912B8 (ro) | Procedeu de preparare a unui derivat de 2h-cromen | |
| WO2006092213A8 (de) | Pyrazolylcarboxanilide | |
| MXPA04000622A (es) | Pirazolilcarboxanilidas como funguicidas. | |
| RS20060699A (en) | Isoxazolines for controlling inverterbrate pests | |
| WO2007044565A3 (en) | Composition and synthesis of new reagents for inhibition of hiv replication | |
| GEP20105073B (en) | Imidazo- and triazolopyridines as inhibitors of 11-beta hydroxysteroid dehydrogenase type i | |
| WO2007103550A3 (en) | Substituted aminothiazole derivatives with anti-hcv activity | |
| TW200612949A (en) | Pyrimidine derivatives for the treatment of abnormal cell growth | |
| TW200607801A (en) | Pyrimidine derivatives for the treatment of abnormal cell growth | |
| WO2007118198A8 (en) | 2-METHYLENE-1α,25-DIHYDROXY-19,21-DINORVITAMIN D3 ANALOGS AND USES THEREOF | |
| WO2009146218A8 (en) | Compounds including an anti-inflammatory pharmacore and methods of use | |
| WO2007031548A3 (en) | Processes for preparing of glucopyranosyl-substituted (ethynyl-benzyl)-benzene derivatives and intermediates thereof | |
| ZA200406813B (en) | Glytaminyl based DPIV inhibitors | |
| TW200635509A (en) | 5-Alkoxyalkyl-6-alkyl-7-aminoazolopyrimidines, process for their preparation, their use for controlling harmful fungi, and compositions comprising them | |
| WO2006120208A8 (en) | Processes for preparing of glucopyranosyl-substituted benzyl-benzene derivatives and intermediates therein | |
| WO2004029045A3 (en) | Process for preparing quinazoline rho-kinase inhibitors and intermediates thereof | |
| WO2009025839A3 (en) | Phosphodiesterase 10 inhibitors | |
| NZ598165A (en) | Nitroimidazooxazine and nitroimidazooxazole analogues and their uses | |
| WO2005070884A3 (en) | Heterocyclic compounds useful as growth hormone secretagogues | |
| TW200509948A (en) | Prevention of urogenital infections | |
| WO2006093547A3 (en) | Novel lipoxygenase inhibitors | |
| SI1751093T1 (sl) | Substituirani derivati cikloheksilocetne kisline | |
| WO2006129168A3 (en) | Bicyclic derivatives for the treatment of abnormal cell growth | |
| EP1944027A4 (en) | PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OR PREVENTION OF NEPHRITIS AND METHOD OF MANUFACTURE THEREOF | |
| TW200633977A (en) | Novel process for the manufacture of 3-pyrrolidin-2-yl-propionic acid derivatives |