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PT99267A - Processo para a preparacao de novos derivados de mercaptoacetilamida e de composicoes farmaceuticas que os contem - Google Patents

Processo para a preparacao de novos derivados de mercaptoacetilamida e de composicoes farmaceuticas que os contem

Info

Publication number
PT99267A
PT99267A PT99267A PT9926791A PT99267A PT 99267 A PT99267 A PT 99267A PT 99267 A PT99267 A PT 99267A PT 9926791 A PT9926791 A PT 9926791A PT 99267 A PT99267 A PT 99267A
Authority
PT
Portugal
Prior art keywords
mercaptoacetilamide
preparation
pharmaceutical compositions
new derivatives
derivatives
Prior art date
Application number
PT99267A
Other languages
English (en)
Other versions
PT99267B (pt
Inventor
Philippe Bey
Gary Alan Flynn
Alan M Warshawsky
Douglas Wade Beight
Shujaath Mehdi
Eugene Lewis Giroux
Timothy Paul Burkholder
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of PT99267A publication Critical patent/PT99267A/pt
Publication of PT99267B publication Critical patent/PT99267B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Hydrogenated Pyridines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
PT99267A 1990-10-18 1991-10-17 Processo para a preparacao de novos derivados de mercaptoacetilamida e de composicoes farmaceuticas que os contem PT99267B (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60005290A 1990-10-18 1990-10-18
US73549691A 1991-07-25 1991-07-25

Publications (2)

Publication Number Publication Date
PT99267A true PT99267A (pt) 1992-08-31
PT99267B PT99267B (pt) 1999-04-30

Family

ID=27083513

Family Applications (1)

Application Number Title Priority Date Filing Date
PT99267A PT99267B (pt) 1990-10-18 1991-10-17 Processo para a preparacao de novos derivados de mercaptoacetilamida e de composicoes farmaceuticas que os contem

Country Status (18)

Country Link
EP (1) EP0481522B1 (pt)
JP (1) JP3181335B2 (pt)
KR (1) KR100372491B1 (pt)
CN (2) CN1036590C (pt)
AT (1) ATE161536T1 (pt)
AU (1) AU642535B2 (pt)
CA (1) CA2053340C (pt)
DE (1) DE69128516T2 (pt)
DK (1) DK0481522T3 (pt)
ES (1) ES2114870T3 (pt)
FI (2) FI95255C (pt)
GR (1) GR3026222T3 (pt)
HU (1) HU210008B (pt)
IE (1) IE913648A1 (pt)
IL (1) IL99769A (pt)
NO (1) NO180718C (pt)
NZ (1) NZ240230A (pt)
PT (1) PT99267B (pt)

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US5455242A (en) * 1991-09-27 1995-10-03 Merrell Dow Pharmaceuticals Inc. Carboxyalkyl tricyclic derivatives useful as inhibitors of enkephalinase and ace
US5457196A (en) * 1991-09-27 1995-10-10 Merrell Dow Pharmaceuticals Inc. 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE
AU657793B2 (en) * 1991-09-27 1995-03-23 Merrell Pharmaceuticals Inc. Novel 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE
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AU668707B2 (en) * 1992-02-14 1996-05-16 Merrell Pharmaceuticals Inc. Aminoacetylmercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ACE
US5552397A (en) * 1992-05-18 1996-09-03 E. R. Squibb & Sons, Inc. Substituted azepinone dual inhibitors of angiotensin converting enzyme and neutral exdopeptidase
WO1993023403A1 (en) * 1992-05-15 1993-11-25 Merrell Dow Pharmaceuticals Inc. NOVEL MERCAPTOACETYLAMIDO PYRIDAZO[1,2]PYRIDAZINE, PYRAZOLO[1,2]PYRIDAZINE, PYRIDAZO[1,2-a][1,2]DIAZEPINE AND PYRAZOLO[1,2-a][1,2]DIAZEPINE DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE AND ACE
RU2124503C1 (ru) * 1992-05-18 1999-01-10 И.Р.Сквибб энд Санз, Инк. Гетероциклические азотсодержащие производные карбоновой кислоты, способ их получения и фармацевтическая композиция
US5238932A (en) * 1992-05-20 1993-08-24 Merrell Dow Pharmaceuticals Inc. Mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase
US5298492A (en) * 1992-08-04 1994-03-29 Schering Corporation Diamino acid derivatives as antihypertensives
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US5208236A (en) * 1992-09-23 1993-05-04 Schering Corporation N-(acylaminomethyl)glutaryl amino acids and use
US5504080A (en) * 1992-10-28 1996-04-02 Bristol-Myers Squibb Co. Benzo-fused lactams
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US5525723A (en) * 1993-11-18 1996-06-11 Bristol-Myers Squibb Co. Compounds containing a fused multiple ring lactam
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US5530013A (en) * 1994-02-14 1996-06-25 American Home Products Corporation Venlafaxine in the inducement of cognition enhancement
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US5484783A (en) * 1994-03-24 1996-01-16 Merrell Dow Pharmaceuticals Inc. Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide and benzazapine derivatives
DE69514912T2 (de) * 1994-03-24 2000-10-05 Merrell Pharmaceuticals Inc., Cincinnati Hypocholesterolemische, antiatherosklerotische und hypotriglyceridemische verwendung von aminoacetylmercapto derivaten
DK0751774T3 (da) * 1994-03-24 2003-12-08 Merrell Pharma Inc Hypocholesterolæmiske mercaptoacetylamiddisulfid-derivater
US5616775A (en) * 1994-05-05 1997-04-01 Bristol-Myers Squibb Co. Process for preparing homocystein analogs useful as intermediates for compounds containing a fused bicyclic ring
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US5877313A (en) * 1995-05-17 1999-03-02 Bristol-Myers Squibb Benzo-fused azepinone and piperidinone compounds useful in the inhibition of ACE and NEP
US5635504A (en) * 1995-06-07 1997-06-03 Bristol-Myers Squibb Co. Diazepine containing dual action inhibitors
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US7009047B2 (en) 2002-03-19 2006-03-07 Sanofi-Aventis Deutschland Gmbh Ethane-1,2-diaminium bis[(2R)-2-bromo-3-phenylpropanoate], processes for its preparation and its use
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Also Published As

Publication number Publication date
CA2053340A1 (en) 1992-04-19
FI914905A0 (fi) 1991-10-17
CN1058013C (zh) 2000-11-01
JPH04282382A (ja) 1992-10-07
ES2114870T3 (es) 1998-06-16
HU210008B (en) 1995-01-30
CN1166490A (zh) 1997-12-03
CN1061971A (zh) 1992-06-17
NO914092D0 (no) 1991-10-17
NO180718B (no) 1997-02-24
NZ240230A (en) 1993-01-27
NO180718C (no) 1997-06-04
ATE161536T1 (de) 1998-01-15
GR3026222T3 (en) 1998-05-29
AU642535B2 (en) 1993-10-21
FI943363A0 (fi) 1994-07-14
DE69128516D1 (de) 1998-02-05
KR100372491B1 (ko) 2003-05-27
IE913648A1 (en) 1992-04-22
PT99267B (pt) 1999-04-30
NO914092L (no) 1992-04-21
FI943363A (fi) 1994-07-14
IL99769A (en) 1998-12-27
AU8581991A (en) 1992-04-30
JP3181335B2 (ja) 2001-07-03
HUT63419A (en) 1993-08-30
CN1036590C (zh) 1997-12-03
DE69128516T2 (de) 1998-07-23
HU913282D0 (en) 1992-01-28
DK0481522T3 (da) 1998-03-09
EP0481522A1 (en) 1992-04-22
KR920008040A (ko) 1992-05-27
FI96691C (fi) 1996-08-12
CA2053340C (en) 2002-04-02
FI95255B (fi) 1995-09-29
IL99769A0 (en) 1992-08-18
FI914905A (fi) 1992-04-19
EP0481522B1 (en) 1997-12-29
FI95255C (fi) 1996-01-10
FI96691B (fi) 1996-04-30

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