PT95902A - Processo para a preparacao de derivados de piridazina uteis como ligandos dos receptores colinergicos - Google Patents

Processo para a preparacao de derivados de piridazina uteis como ligandos dos receptores colinergicos

Info

Publication number: PT95902A
Authority: PT; Portugal
Prior art keywords: lygands; uteric; colinergic; receptors; preparation
Prior art date: 1989-11-17

Application number

PT95902A

Other languages

English (en)

Other versions

PT95902B (pt

Inventor

Robert Boigegrain

Roger Brodin

Jean Paul Kan

Dominique Olliero

Camille Georges Wermuth

Original Assignee

Sanofi Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-11-17

Filing date

1990-11-15

Publication date

1991-09-13

1989-11-17 Priority claimed from FR8915137A external-priority patent/FR2654727B1/fr

1990-11-15 Application filed by Sanofi Sa filed Critical Sanofi Sa

1991-09-13 Publication of PT95902A publication Critical patent/PT95902A/pt

1998-01-30 Publication of PT95902B publication Critical patent/PT95902B/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/14—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/20—Nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Veterinary Medicine (AREA)
Biomedical Technology (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Hospice & Palliative Care (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Psychiatry (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

PT95902A 1989-11-17 1990-11-15 Processo para a preparacao de derivados de piridazina uteis como ligandos dos receptores colinergicos PT95902B (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR8915137A FR2654727B1 (fr)	1989-11-17	1989-11-17	Derives de la pyridazine, procede de preparation et compositions pharmaceutiques en contenant.
FR909007533A FR2663326B2 (fr)	1989-11-17	1990-06-15	Derives de la pyridazine, procede de preparation et compositions pharmaceutiques en contenant.

Publications (2)

Publication Number	Publication Date
PT95902A true PT95902A (pt)	1991-09-13
PT95902B PT95902B (pt)	1998-01-30

Family

ID=26227673

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT95902A PT95902B (pt)	1989-11-17	1990-11-15	Processo para a preparacao de derivados de piridazina uteis como ligandos dos receptores colinergicos

Country Status (21)

Country	Link
EP (1)	EP0429344B1 (pt)
JP (1)	JPH03170465A (pt)
KR (1)	KR0164599B1 (pt)
AR (1)	AR247557A1 (pt)
AT (1)	ATE143010T1 (pt)
AU (1)	AU639043B2 (pt)
CA (1)	CA2030133A1 (pt)
DE (1)	DE69028602T2 (pt)
DK (1)	DK0429344T3 (pt)
ES (1)	ES2094146T3 (pt)
FI (1)	FI101881B (pt)
FR (1)	FR2663326B2 (pt)
GR (1)	GR3021933T3 (pt)
HK (1)	HK1000597A1 (pt)
HU (2)	HU207852B (pt)
IE (1)	IE75697B1 (pt)
IL (1)	IL96384A (pt)
LV (1)	LV11972B (pt)
NO (1)	NO178967C (pt)
NZ (1)	NZ236107A (pt)
PT (1)	PT95902B (pt)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2665442B1 (fr) *	1990-07-31	1992-12-04	Sanofi Sa	Derives d'alkyl-6 pyridazine, procede de preparation et compositions pharmaceutiques en contenant.
FR2676444B1 (fr) *	1991-05-16	1995-03-10	Sanofi Elf	Nouveaux derives d'amino-3 pyridazines actifs sur le systeme nerveux central, procede de preparation et compositions pharmaceutiques en contenant.
KR100443893B1 (ko) *	1996-01-15	2004-10-15	얀센 파마슈티카 엔.브이.	혈관형성억제제피리다진아민
WO1999032448A1 (en) *	1997-12-19	1999-07-01	Amgen Inc.	Substituted pyridine and pyridazine compounds and their pharmaceutical use
US6528529B1 (en)	1998-03-31	2003-03-04	Acadia Pharmaceuticals Inc.	Compounds with activity on muscarinic receptors
CA2442004A1 (en)	2001-03-23	2002-10-03	David J. Kyle	Microbial feeds for aquaculture and agriculture
EP2258359A3 (en)	2005-08-26	2011-04-06	Braincells, Inc.	Neurogenesis by muscarinic receptor modulation with sabcomelin
EP1928437A2 (en)	2005-08-26	2008-06-11	Braincells, Inc.	Neurogenesis by muscarinic receptor modulation
RU2416609C2 (ru)	2005-12-07	2011-04-20	Сумитомо Кемикал Компани, Лимитед	Соединение пиридазина и его применение
FR2904314A1 (fr) *	2006-07-26	2008-02-01	Centre Nat Rech Scient	Composes pyridaziniques et pyrroliques lineaires, procedes d'obtention et applications
AR081626A1 (es) *	2010-04-23	2012-10-10	Cytokinetics Inc	Compuestos amino-piridazinicos, composiciones farmaceuticas que los contienen y uso de los mismos para tratar trastornos musculares cardiacos y esqueleticos
EP2560488B1 (en)	2010-04-23	2015-10-28	Cytokinetics, Inc.	Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use
AR081331A1 (es)	2010-04-23	2012-08-08	Cytokinetics Inc	Amino- pirimidinas composiciones de las mismas y metodos para el uso de los mismos
AR119731A1 (es)	2019-05-17	2022-01-05	Novartis Ag	Inhibidores del inflamasoma nlrp3
US20230107277A1 (en) *	2020-03-27	2023-04-06	Astellas Pharma Inc.	Substituted pyridazine compound
EP4289823A4 (en) *	2021-02-08	2025-02-26	Medshine Discovery Inc	SUBSTITUTED PYRIDAZINE PHENOL DERIVATIVES

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2510998B1 (fr) *	1981-08-07	1986-01-10	Sanofi Sa	Nouveaux derives amines de la pyridazine, leur procede de preparation et les medicaments, a action desinhibitrice, qui en comportent
FR2540113A1 (fr) *	1983-01-27	1984-08-03	Sanofi Sa	Acides derives de la pyridazine actifs sur le systeme nerveux central
DE3629929A1 (de) *	1986-09-03	1988-03-10	Thomae Gmbh Dr K	Neue sulfonamido-aethylverbindungen, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
FR2642648B1 (fr) *	1989-02-07	1991-06-21	Sanofi Sa	Utilisation de derives d'alkyl-5 pyridazine comme medicaments actifs sur le systeme cholinergique
PT93060B (pt) *	1989-02-07	1995-12-29	Sanofi Sa	Processo para a obtencao de derivados de piridazina e de composicoes farmaceuticas que os contem

1990
- 1990-06-15 FR FR909007533A patent/FR2663326B2/fr not_active Expired - Lifetime
- 1990-11-15 PT PT95902A patent/PT95902B/pt not_active IP Right Cessation
- 1990-11-15 FI FI905663A patent/FI101881B/fi not_active IP Right Cessation
- 1990-11-16 ES ES90403239T patent/ES2094146T3/es not_active Expired - Lifetime
- 1990-11-16 DE DE69028602T patent/DE69028602T2/de not_active Expired - Fee Related
- 1990-11-16 NZ NZ236107A patent/NZ236107A/en unknown
- 1990-11-16 IE IE414590A patent/IE75697B1/en not_active IP Right Cessation
- 1990-11-16 JP JP2312597A patent/JPH03170465A/ja active Pending
- 1990-11-16 AU AU66672/90A patent/AU639043B2/en not_active Ceased
- 1990-11-16 NO NO904984A patent/NO178967C/no unknown
- 1990-11-16 HU HU907178A patent/HU207852B/hu not_active IP Right Cessation
- 1990-11-16 DK DK90403239.8T patent/DK0429344T3/da active
- 1990-11-16 EP EP90403239A patent/EP0429344B1/fr not_active Expired - Lifetime
- 1990-11-16 AT AT90403239T patent/ATE143010T1/de not_active IP Right Cessation
- 1990-11-16 CA CA002030133A patent/CA2030133A1/en active Granted
- 1990-11-16 AR AR90318401A patent/AR247557A1/es active
- 1990-11-17 KR KR1019900018663A patent/KR0164599B1/ko not_active IP Right Cessation
- 1990-11-18 IL IL9638490A patent/IL96384A/en not_active IP Right Cessation
1995
- 1995-06-27 HU HU95P/P00450P patent/HU211351A9/hu unknown
1996
- 1996-12-06 GR GR960403344T patent/GR3021933T3/el unknown
1997
- 1997-09-10 LV LVP-97-165A patent/LV11972B/lv unknown
- 1997-11-10 HK HK97102147A patent/HK1000597A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
NZ236107A (en)	1992-10-28
IE75697B1 (en)	1997-09-10
FI101881B1 (fi)	1998-09-15
DE69028602D1 (de)	1996-10-24
PT95902B (pt)	1998-01-30
KR0164599B1 (ko)	1999-01-15
HU211351A9 (en)	1995-11-28
DE69028602T2 (de)	1997-04-03
CA2030133A1 (en)	1991-05-18
ES2094146T3 (es)	1997-01-16
NO904984L (no)	1991-05-21
EP0429344B1 (fr)	1996-09-18
HK1000597A1 (en)	1998-04-09
LV11972B (lv)	1998-04-20
DK0429344T3 (pt)	1997-03-03
ATE143010T1 (de)	1996-10-15
NO904984D0 (no)	1990-11-16
FR2663326A2 (fr)	1991-12-20
LV11972A (lv)	1998-02-20
IE904145A1 (en)	1991-05-22
GR3021933T3 (en)	1997-03-31
FI101881B (fi)	1998-09-15
FR2663326B2 (fr)	1992-10-16
FI905663A0 (fi)	1990-11-15
HU907178D0 (en)	1991-05-28
AU6667290A (en)	1991-05-23
AU639043B2 (en)	1993-07-15
HUT56078A (en)	1991-07-29
IL96384A0 (en)	1991-08-16
IL96384A (en)	1995-10-31
JPH03170465A (ja)	1991-07-24
NO178967C (no)	1996-07-10
NO178967B (no)	1996-04-01
KR910009672A (ko)	1991-06-28
FI905663A (fi)	1991-05-18
AR247557A1 (es)	1995-01-31
EP0429344A1 (fr)	1991-05-29
CA2030133C (pt)	1991-05-18
HU207852B (en)	1993-06-28

Publication	Publication Date	Title
PT93785A (pt)	1990-11-20	Processo para a preparacao de derivados de 3-substituido-2-oxindole
PT93516A (pt)	1990-11-07	Processo para a preparacao de derivados de2-anilino-pirimidina uteis para controlar pragas
PT90119A (pt)	1989-11-10	Processo para a preparacao de um adocante
PT83389B (pt)	1989-05-12	Processo para a preparacao de derivados de sulfonilureia uteis como agentes anti-tumurais
PT91188A (pt)	1990-02-08	Processo para a preparacao de derivados de furano
PT84561B (pt)	1989-11-10	Processo aperfeicoado para a preparacao de derivados macrolidos
PT94045A (pt)	1991-01-08	Processo para a preparacao de derivados de 2-piperidino-1-alcanol uteis como agentes anti-isquemicos
PT89205A (pt)	1989-12-29	Processo para a preparacao de derivados de indano
PT95902A (pt)	1991-09-13	Processo para a preparacao de derivados de piridazina uteis como ligandos dos receptores colinergicos
PT91895A (pt)	1990-04-30	Processo para a preparacao de 9h-purinas substituidas
PT92786A (pt)	1990-07-31	Processo para a preparacao de compostos de tiazol
PT89922A (pt)	1989-11-10	Processo para a preparacao de derivados da tiazolidenodiona
PT90914A (pt)	1989-12-29	Processo para a preparacao de derivados de benzazepinae benzotiazapina
PT89545A (pt)	1989-10-04	Processo para a preparacao de derivados da isoquinolinona
BR8702112A (pt)	1988-02-09	Processo para a preparacao de um derivado de pirazol pirimidina
PT93629A (pt)	1990-11-20	Processo para a preparacao de derivados de tieno-triazolo-diazepina
PT88181A (pt)	1989-06-30	Processo para a preparacao de derivados aralquilaminoalcoxifenilo
BR9001503A (pt)	1991-04-16	Processo para a preparacao de alquil-halogenossilanos
PT92365A (pt)	1990-05-31	Processo para a preparacao de (s)-alfa-etil-2-oxo-1-pirrolidinoacetamida
PT89775A (pt)	1989-10-04	Processo para a preparacao de derivados de isoquinolina
PT91027A (pt)	1990-02-08	Processo para a preparacao de derivados peptidicos
PT92539A (pt)	1990-06-29	Processo para a preparacao de derivados de anfotericina b
PT94008A (pt)	1991-01-08	Processo para a preparacao de novos derivados de tieno-triazolo-diazepina
PT93033A (pt)	1990-11-07	Processo para a preparacao de derivados de guanidina
PT92808A (pt)	1990-07-31	Processo para a preparacao de novos derivados de tetralina

Legal Events

Date	Code	Title	Description
1991-09-13	BB1A	Laying open of patent application	Effective date: 19910405
1998-01-30	FG3A	Patent granted, date of granting	Effective date: 19971008
1998-02-27	TE3A	Change of address (patent)
2000-08-31	MM3A	Annulment or lapse	Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 20000430