PT906122E - Ligantes activados e metodos para os produzir e purificar - Google Patents
Ligantes activados e metodos para os produzir e purificarInfo
- Publication number
- PT906122E PT906122E PT96944251T PT96944251T PT906122E PT 906122 E PT906122 E PT 906122E PT 96944251 T PT96944251 T PT 96944251T PT 96944251 T PT96944251 T PT 96944251T PT 906122 E PT906122 E PT 906122E
- Authority
- PT
- Portugal
- Prior art keywords
- purifying
- pegs
- ligants
- activated
- producing
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Saccharide Compounds (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Separation Of Suspended Particles By Flocculating Agents (AREA)
- Road Signs Or Road Markings (AREA)
- Thermistors And Varistors (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/611,918 US5747639A (en) | 1996-03-06 | 1996-03-06 | Use of hydrophobic interaction chromatography to purify polyethylene glycols |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT906122E true PT906122E (pt) | 2003-12-31 |
Family
ID=24450930
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT96944251T PT906122E (pt) | 1996-03-06 | 1996-12-06 | Ligantes activados e metodos para os produzir e purificar |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US5747639A (pt) |
| EP (1) | EP0906122B1 (pt) |
| JP (1) | JP2000506851A (pt) |
| AT (1) | ATE249244T1 (pt) |
| AU (1) | AU720399B2 (pt) |
| CA (1) | CA2248006C (pt) |
| DE (1) | DE69629949T2 (pt) |
| DK (1) | DK0906122T3 (pt) |
| ES (1) | ES2206616T3 (pt) |
| PT (1) | PT906122E (pt) |
| WO (1) | WO1997032607A2 (pt) |
Families Citing this family (74)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6552170B1 (en) | 1990-04-06 | 2003-04-22 | Amgen Inc. | PEGylation reagents and compounds formed therewith |
| US5932462A (en) | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
| US5747639A (en) * | 1996-03-06 | 1998-05-05 | Amgen Boulder Inc. | Use of hydrophobic interaction chromatography to purify polyethylene glycols |
| TW555765B (en) | 1996-07-09 | 2003-10-01 | Amgen Inc | Low molecular weight soluble tumor necrosis factor type-I and type-II proteins |
| DK0942740T3 (da) | 1996-12-06 | 2003-12-15 | Amgen Inc | Kombinationsterapi under anvendelse af et TFN-bindende protein til behandling af TFN-medierede sygdomme |
| AU725133B2 (en) * | 1997-01-15 | 2000-10-05 | Polaris Group | Modified tumor necrosis factor |
| US7642323B2 (en) | 1997-11-06 | 2010-01-05 | Nektar Therapeutics | Heterobifunctional poly(ethylene glycol) derivatives and methods for their preparation |
| US6448369B1 (en) | 1997-11-06 | 2002-09-10 | Shearwater Corporation | Heterobifunctional poly(ethylene glycol) derivatives and methods for their preparation |
| CZ299164B6 (cs) | 1998-10-16 | 2008-05-07 | Biogen Idec Ma Inc. | Farmaceutická kompozice obsahující glykosylovaný interferon-beta-1a navázaný na polymer |
| SK287491B6 (sk) * | 1998-10-16 | 2010-11-08 | Biogen Idec Ma Inc. | Fúzne proteíny interferónu- beta-1a a ich použitie |
| US6660843B1 (en) * | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
| US6924264B1 (en) | 1999-04-30 | 2005-08-02 | Amylin Pharmaceuticals, Inc. | Modified exendins and exendin agonists |
| EP1250154B1 (en) | 2000-01-10 | 2009-07-01 | Maxygen Holdings Ltd | G-csf conjugates |
| CA2739933A1 (en) | 2000-02-11 | 2001-08-16 | Bayer Healthcare Llc | Factor vii or viia-like molecules |
| DK1411970T3 (da) * | 2000-12-06 | 2007-06-04 | Applied Research Systems | Anvendelse af SARP-1 til behandling og/eller forebyggelse af sclerodermia |
| JP2004534523A (ja) | 2001-02-27 | 2004-11-18 | マキシゲン・エイピーエス | 新規なインターフェロンβ様分子 |
| JP2005508365A (ja) * | 2001-10-29 | 2005-03-31 | ネクター セラピューティックス エイエル，コーポレイション | プロテインキナーゼｃインヒビターのポリマー結合体 |
| EP3025726B1 (en) | 2002-01-18 | 2019-11-20 | Biogen MA Inc. | Polyalkylene polymer compounds and uses thereof |
| KR101186140B1 (ko) | 2002-06-21 | 2012-09-27 | 노보 노르디스크 헬스 케어 악티엔게젤샤프트 | 페길화된 인자 ｖｉｉ 글리코형태 |
| US8129330B2 (en) * | 2002-09-30 | 2012-03-06 | Mountain View Pharmaceuticals, Inc. | Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof |
| EA008866B1 (ru) * | 2002-12-26 | 2007-08-31 | Маунтин Вью Фамэсьютикэлс, Инк. | ПОЛИМЕРНЫЙ КОНЪЮГАТ МОДИФИКАЦИЙ ИНТЕРФЕРОНА-β, ФАРМАЦЕВТИЧЕСКИЕ ПРОДУКТЫ НА ЕГО ОСНОВЕ И СПОСОБ ИХ ПОЛУЧЕНИЯ |
| RS20050501A (en) * | 2002-12-26 | 2007-08-03 | Mountain View Pharmaceuticals Inc., | Polymer conjugates of cytokines,chemokines,growth factors, polypeptide hormones and antagonists thereof with preserved receptor-binding activity |
| CN1867581B (zh) | 2003-10-10 | 2012-02-01 | 诺沃挪第克公司 | Il-21衍生物 |
| EP2633866A3 (en) | 2003-10-17 | 2013-12-18 | Novo Nordisk A/S | Combination therapy |
| GB2426521A (en) | 2004-02-02 | 2006-11-29 | Ambrx Inc | Modified human four helical bundle polypeptides and their uses |
| CN102532321B (zh) | 2004-06-18 | 2018-10-12 | Ambrx公司 | 新颖抗原结合多肽和其用途 |
| CA2569381A1 (en) | 2004-07-21 | 2006-08-31 | Ambrx, Inc. | Biosynthetic polypeptides utilizing non-naturally encoded amino acids |
| US8080391B2 (en) | 2004-12-22 | 2011-12-20 | Ambrx, Inc. | Process of producing non-naturally encoded amino acid containing high conjugated to a water soluble polymer |
| KR101252835B1 (ko) | 2004-12-22 | 2013-04-10 | 암브룩스, 인코포레이티드 | 아미노아실-ｔＲＮＡ 합성효소의 조성물 및 그것의 용도 |
| US7939496B2 (en) | 2004-12-22 | 2011-05-10 | Ambrx, Inc. | Modified human growth horomone polypeptides and their uses |
| AU2005322019B2 (en) | 2004-12-22 | 2010-08-26 | Ambrx, Inc. | Formulations of human growth hormone comprising a non-naturally encoded amino acid |
| KR20080026135A (ko) | 2005-06-03 | 2008-03-24 | 암브룩스, 인코포레이티드 | 개선된 인간 인터페론 분자 및 이의 용도 |
| WO2006134173A2 (en) | 2005-06-17 | 2006-12-21 | Novo Nordisk Health Care Ag | Selective reduction and derivatization of engineered proteins comprising at least one non-native cysteine |
| NZ565294A (en) | 2005-08-18 | 2010-06-25 | Ambrx Inc | Compositions of tRNA and uses thereof |
| WO2007059312A2 (en) | 2005-11-16 | 2007-05-24 | Ambrx, Inc. | Methods and compositions comprising non-natural amino acids |
| KR20090042755A (ko) | 2006-02-28 | 2009-04-30 | 닥터 레디즈 레버러토리즈 (이유) 리미티드 | 폴리에틸렌 글리콜 카보네이트의 제조방법 |
| WO2007135182A2 (en) | 2006-05-24 | 2007-11-29 | Novo Nordisk Health Care Ag | Factor ix analogues having prolonged in vivo half life |
| AU2007292892B9 (en) | 2006-09-08 | 2013-02-28 | Ambrx, Inc. | Hybrid suppressor tRNA for vertebrate cells |
| EP2615108B1 (en) | 2006-09-08 | 2016-10-26 | Ambrx, Inc. | Modified human plasma polypeptide or fc scaffolds and thier uses |
| ES2465473T3 (es) | 2006-09-08 | 2014-06-05 | Ambrx, Inc. | Transcripción de arnt supresor en células de vertebrado |
| US8222039B2 (en) * | 2007-02-22 | 2012-07-17 | Biovectra Inc. | Process for purification of water soluble polymers |
| KR20140012199A (ko) | 2007-03-30 | 2014-01-29 | 암브룩스, 인코포레이티드 | 변형된 ｆｇｆ-21 폴리펩티드 및 그 용도 |
| CA2685596A1 (en) | 2007-05-02 | 2008-11-13 | Ambrx, Inc. | Modified interferon beta polypeptides and their uses |
| DK2217265T3 (en) | 2007-11-20 | 2017-07-03 | Ambrx Inc | Modified insulin polypeptides and their use |
| CN103694337B (zh) | 2008-02-08 | 2016-03-02 | Ambrx公司 | 经修饰瘦素多肽和其用途 |
| WO2010011735A2 (en) | 2008-07-23 | 2010-01-28 | Ambrx, Inc. | Modified bovine g-csf polypeptides and their uses |
| AU2009296267B2 (en) | 2008-09-26 | 2013-10-31 | Ambrx, Inc. | Non-natural amino acid replication-dependent microorganisms and vaccines |
| JP5694171B2 (ja) | 2008-09-26 | 2015-04-01 | アンブルックス, インコーポレイテッドAmbrx, Inc. | 修飾されている動物のエリスロポエチンポリペプチドおよびそれらの使用 |
| JP2013515080A (ja) | 2009-12-21 | 2013-05-02 | アンブルックス，インコーポレイテッド | 修飾されているウシのソマトトロピンポリペプチドおよびそれらの使用 |
| EA201290542A1 (ru) | 2009-12-21 | 2013-07-30 | Амбркс, Инк. | Модифицированные свиные соматотропиновые полипептиды и их применение |
| EP3815708A1 (en) | 2010-03-05 | 2021-05-05 | Omeros Corporation | Chimeric inhibitor molecules of complement activation |
| US20120135912A1 (en) | 2010-05-10 | 2012-05-31 | Perseid Therapeutics Llc | Polypeptide inhibitors of vla4 |
| ES2972902T3 (es) | 2010-08-17 | 2024-06-17 | Ambrx Inc | Polipéptidos de relaxina modificados y sus usos |
| US9567386B2 (en) | 2010-08-17 | 2017-02-14 | Ambrx, Inc. | Therapeutic uses of modified relaxin polypeptides |
| TWI480288B (zh) | 2010-09-23 | 2015-04-11 | Lilly Co Eli | 牛顆粒細胞群落刺激因子及其變體之調配物 |
| CN103930440A (zh) | 2011-07-01 | 2014-07-16 | 拜耳知识产权有限责任公司 | 松弛素融合多肽及其用途 |
| HUE043552T2 (hu) | 2012-06-08 | 2019-09-30 | Sutro Biopharma Inc | Antitestek, amelyek tartalmaznak helyspecifikus nem természetes aminosav maradékokat, eljárások elõállításukra és eljárások használatukra |
| EP3135690A1 (en) | 2012-06-26 | 2017-03-01 | Sutro Biopharma, Inc. | Modified fc proteins comprising site-specific non-natural amino acid residues, conjugates of the same, methods of their preparation and methods of their use |
| US9395468B2 (en) | 2012-08-27 | 2016-07-19 | Ocular Dynamics, Llc | Contact lens with a hydrophilic layer |
| ES2907763T3 (es) | 2012-08-31 | 2022-04-26 | Sutro Biopharma Inc | Aminoácidos modificados que comprenden un grupo azido |
| JP2016518311A (ja) * | 2013-03-08 | 2016-06-23 | ユニヴァーシティー オブ サザン カリフォルニア | ビニルスルホン系１８ｆ標識化組成物ならびにその方法およびその使用 |
| WO2015006555A2 (en) | 2013-07-10 | 2015-01-15 | Sutro Biopharma, Inc. | Antibodies comprising multiple site-specific non-natural amino acid residues, methods of their preparation and methods of their use |
| US9840493B2 (en) | 2013-10-11 | 2017-12-12 | Sutro Biopharma, Inc. | Modified amino acids comprising tetrazine functional groups, methods of preparation, and methods of their use |
| TWI654440B (zh) | 2013-11-15 | 2019-03-21 | 美商實體科學公司 | 具有親水層的隱形眼鏡 |
| MX2017004947A (es) | 2014-10-24 | 2017-06-29 | Bristol Myers Squibb Co | Polipeptidos del factor de crecimiento de fibroblastos 2 (fgf-21) modificados y usos de los mismos. |
| WO2016094533A1 (en) | 2014-12-09 | 2016-06-16 | Ocular Dynamics, Llc | Medical device coating with a biocompatible layer |
| ES2963839T3 (es) | 2017-02-08 | 2024-04-02 | Bristol Myers Squibb Co | Polipéptidos de relaxina modificados que comprenden un potenciador farmacocinético y usos de los mismos |
| US12049485B2 (en) | 2018-09-11 | 2024-07-30 | Ambrx, Inc. | Interleukin-2 polypeptide conjugates and their uses |
| WO2020082057A1 (en) | 2018-10-19 | 2020-04-23 | Ambrx, Inc. | Interleukin-10 polypeptide conjugates, dimers thereof, and their uses |
| WO2020168017A1 (en) | 2019-02-12 | 2020-08-20 | Ambrx, Inc. | Compositions containing, methods and uses of antibody-tlr agonist conjugates |
| EP4028159A1 (en) | 2019-09-10 | 2022-07-20 | Pierce Biotechnology, Inc. | Sample preparation compositions, devices, systems and methods |
| CA3174114A1 (en) | 2020-03-11 | 2021-09-16 | Ambrx, Inc. | Interleukin-2 polypeptide conjugates and methods of use thereof |
| JP2023538071A (ja) | 2020-08-20 | 2023-09-06 | アンブルックス，インコーポレイテッド | 抗体－ｔｌｒアゴニストコンジュゲート、その方法及び使用 |
| KR20240004342A (ko) | 2021-04-03 | 2024-01-11 | 암브룩스, 인코포레이티드 | 항-her2 항체-약물 접합체 및 이의 용도 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1989004203A1 (en) * | 1987-11-10 | 1989-05-18 | North Carolina State University | Chromatography apparatus and method and material for making the same |
| US5094960A (en) * | 1988-10-07 | 1992-03-10 | New York Blood Center, Inc. | Removal of process chemicals from labile biological mixtures by hydrophobic interaction chromatography |
| US5349052A (en) * | 1988-10-20 | 1994-09-20 | Royal Free Hospital School Of Medicine | Process for fractionating polyethylene glycol (PEG)-protein adducts and an adduct for PEG and granulocyte-macrophage colony stimulating factor |
| US5645717A (en) * | 1989-01-13 | 1997-07-08 | Bio-Rad Laboratories, Inc. | Hydrophobic polymers from water-soluble monomers and their use as chromatography media |
| IL95031A (en) * | 1989-07-18 | 2007-03-08 | Amgen Inc | A method of producing a recombinant human necrotic factor absorber |
| US6552170B1 (en) * | 1990-04-06 | 2003-04-22 | Amgen Inc. | PEGylation reagents and compounds formed therewith |
| SG89295A1 (en) * | 1991-03-15 | 2002-06-18 | Amgen Inc | Pegylation of polypeptides |
| WO1993001498A1 (en) * | 1991-07-04 | 1993-01-21 | Immunodex K/S | Water-soluble, polymer-based reagents and conjugates comprising moieties derived from divinyl sulfone |
| US5424063A (en) * | 1992-01-09 | 1995-06-13 | The Dow Chemical Company | Narrow poly- and mono-dispersed anionic oligomers, and their uses, formulations and process |
| ZA933926B (en) * | 1992-06-17 | 1994-01-03 | Amgen Inc | Polyoxymethylene-oxyethylene copolymers in conjuction with blomolecules |
| EP0622394A1 (en) * | 1993-04-30 | 1994-11-02 | S.A. Laboratoires S.M.B. | Reversible modification of sulfur-containing molecules with polyalkylene glycol derivatives and their use |
| ATE171276T1 (de) * | 1993-07-16 | 1998-10-15 | Merck Patent Gmbh | Trennmaterialien für die hydrophobe chromatographie |
| US5446090A (en) * | 1993-11-12 | 1995-08-29 | Shearwater Polymers, Inc. | Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules |
| US5476643A (en) * | 1993-11-19 | 1995-12-19 | Bernel Chemical Co. | Method of dispersing micronized TIo2, ZnO and other pigments |
| DE19517848A1 (de) * | 1995-05-16 | 1996-11-21 | Merck Patent Gmbh | Fluorhaltige Benzoylguanidine |
| US5747639A (en) * | 1996-03-06 | 1998-05-05 | Amgen Boulder Inc. | Use of hydrophobic interaction chromatography to purify polyethylene glycols |
-
1996
- 1996-03-06 US US08/611,918 patent/US5747639A/en not_active Expired - Lifetime
- 1996-12-06 EP EP96944251A patent/EP0906122B1/en not_active Expired - Lifetime
- 1996-12-06 JP JP9531747A patent/JP2000506851A/ja active Pending
- 1996-12-06 AU AU14108/97A patent/AU720399B2/en not_active Ceased
- 1996-12-06 WO PCT/US1996/019459 patent/WO1997032607A2/en active IP Right Grant
- 1996-12-06 ES ES96944251T patent/ES2206616T3/es not_active Expired - Lifetime
- 1996-12-06 AT AT96944251T patent/ATE249244T1/de not_active IP Right Cessation
- 1996-12-06 CA CA002248006A patent/CA2248006C/en not_active Expired - Fee Related
- 1996-12-06 PT PT96944251T patent/PT906122E/pt unknown
- 1996-12-06 DE DE69629949T patent/DE69629949T2/de not_active Expired - Fee Related
- 1996-12-06 DK DK96944251T patent/DK0906122T3/da active
-
1997
- 1997-09-18 US US08/936,478 patent/US5935564A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US5747639A (en) | 1998-05-05 |
| EP0906122A2 (en) | 1999-04-07 |
| EP0906122B1 (en) | 2003-09-10 |
| US5935564A (en) | 1999-08-10 |
| ES2206616T3 (es) | 2004-05-16 |
| WO1997032607A3 (en) | 1997-11-13 |
| DE69629949D1 (de) | 2003-10-16 |
| CA2248006C (en) | 2002-05-28 |
| DK0906122T3 (da) | 2004-01-19 |
| ATE249244T1 (de) | 2003-09-15 |
| CA2248006A1 (en) | 1997-09-12 |
| JP2000506851A (ja) | 2000-06-06 |
| DE69629949T2 (de) | 2004-07-22 |
| AU720399B2 (en) | 2000-06-01 |
| AU1410897A (en) | 1997-09-22 |
| WO1997032607A2 (en) | 1997-09-12 |
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