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PT837848E - 4-aril-1-fenilalquil-1,2,3,6-tetra-hidropiridinas tendo actividade neurotrofica e neuroprotectora - Google Patents

4-aril-1-fenilalquil-1,2,3,6-tetra-hidropiridinas tendo actividade neurotrofica e neuroprotectora

Info

Publication number
PT837848E
PT837848E PT96924023T PT96924023T PT837848E PT 837848 E PT837848 E PT 837848E PT 96924023 T PT96924023 T PT 96924023T PT 96924023 T PT96924023 T PT 96924023T PT 837848 E PT837848 E PT 837848E
Authority
PT
Portugal
Prior art keywords
alkyl
aryl
phenylalquil
tetrahydropyridines
neurotrophic
Prior art date
Application number
PT96924023T
Other languages
English (en)
Inventor
Umberto Guzzi
Domenico Badone
Marco Baroni
Rosanna Cardamone
Jacqueline Fournier
Allessandra Ielmini
Original Assignee
Sanofi Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo filed Critical Sanofi Synthelabo
Publication of PT837848E publication Critical patent/PT837848E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
PT96924023T 1995-06-28 1996-06-26 4-aril-1-fenilalquil-1,2,3,6-tetra-hidropiridinas tendo actividade neurotrofica e neuroprotectora PT837848E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9507760A FR2736053B1 (fr) 1995-06-28 1995-06-28 Nouvelles 1-phenylalkyl-1,2,3,6-tetrahydropyridines

Publications (1)

Publication Number Publication Date
PT837848E true PT837848E (pt) 2002-12-31

Family

ID=9480466

Family Applications (1)

Application Number Title Priority Date Filing Date
PT96924023T PT837848E (pt) 1995-06-28 1996-06-26 4-aril-1-fenilalquil-1,2,3,6-tetra-hidropiridinas tendo actividade neurotrofica e neuroprotectora

Country Status (30)

Country Link
US (1) US5981754A (pt)
EP (2) EP1216996A3 (pt)
JP (2) JP3147906B2 (pt)
KR (1) KR100460581B1 (pt)
CN (1) CN1153765C (pt)
AT (1) ATE223897T1 (pt)
AU (1) AU715090B2 (pt)
BR (1) BR9608662A (pt)
CA (1) CA2225746C (pt)
CY (1) CY2312B1 (pt)
CZ (1) CZ291075B6 (pt)
DE (1) DE69623631T2 (pt)
DK (1) DK0837848T3 (pt)
EE (1) EE03870B1 (pt)
ES (1) ES2183965T3 (pt)
FR (1) FR2736053B1 (pt)
HK (1) HK1014952A1 (pt)
HU (1) HUP9900055A3 (pt)
IL (1) IL122159A (pt)
IS (1) IS1999B (pt)
NO (1) NO310144B1 (pt)
NZ (1) NZ312723A (pt)
PL (2) PL187087B1 (pt)
PT (1) PT837848E (pt)
RU (1) RU2163237C2 (pt)
SK (2) SK285433B6 (pt)
TR (1) TR199701710T1 (pt)
UA (1) UA62914C2 (pt)
WO (1) WO1997001536A1 (pt)
ZA (1) ZA965527B (pt)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2762514B1 (fr) * 1997-04-29 1999-10-22 Sanofi Sa Utilisation de derives de la tetrahydropyridine pour la preparation de medicaments pour le traitement des maladies entrainant une demyelinisation
FR2763847B1 (fr) * 1997-05-28 2003-06-06 Sanofi Sa Utilisation de tetrahydropyridines 4-substituees pour fabriquer des medicaments agissant sur le tgf-beta-1
CO4980891A1 (es) * 1997-11-14 2000-11-27 Sanofi Sa Asociacion de principios activos para el tratamiento de la demencia senil de tipo azheimer
FR2771007B1 (fr) * 1997-11-14 2000-12-01 Sanofi Sa Association de principes actifs pour le traitement de la demence senile du type alzheimer
FR2771006B1 (fr) * 1997-11-14 2000-12-01 Sanofi Sa Association de principes actifs pour le traitement de la demence senile du type alzheimer
CA2334677A1 (en) * 1998-06-19 1999-12-23 Vincent Patrick Rocco Preparation of heteroaryl compounds
FR2803593B1 (fr) * 2000-01-06 2002-02-15 Sanofi Synthelabo Nouvelles tetrahydropyridines, procede pour leur preparation et compositions pharmaceutiques les contenant
FR2823748B1 (fr) * 2001-04-20 2004-02-20 Sanofi Synthelabo Tetrahydropyridyl-alkyl-benzodiazines, procede pour leur preparation et compositions pharmaceutiques les contenant
EP1383762B1 (fr) * 2001-04-20 2007-06-20 Sanofi-Aventis Tetrahydropyridyl-alkyl-heterocycles, procede pour leur preparation et compositions pharmaceutiques les contenants
FR2840896B1 (fr) * 2002-06-18 2005-04-08 Sanofi Synthelabo Phenyl-et pyridyl-piperazines, procede pour leur preparation et compositions pharmaceutiques les contenant
US7683069B2 (en) * 2002-12-16 2010-03-23 Mitsubishi Tanabe Pharma Corporation 3-substituted-4-pyrimidone derivatives
US7632950B2 (en) 2003-08-18 2009-12-15 Fujifilm Finechemicals Co., Ltd Pyridyltetrahydropyridines and pyridylpiperidines and method of manufacturing them
TWI350168B (en) * 2004-05-07 2011-10-11 Incyte Corp Amido compounds and their use as pharmaceuticals
EP1758582A4 (en) * 2004-06-24 2008-01-09 Incyte Corp AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICAL PRODUCTS
NZ551603A (en) 2004-06-24 2010-11-26 Incyte Corp N-substituted piperidines and their use as pharmaceuticals
WO2006002350A1 (en) * 2004-06-24 2006-01-05 Incyte Corporation Amido compounds and their use as pharmaceuticals
EP1758882A4 (en) * 2004-06-24 2008-01-23 Incyte Corp AMID COMPOUNDS AND THEIR USE AS MEDICAMENTS
EP1768954A4 (en) 2004-06-24 2008-05-28 Incyte Corp 2-METHYLPROPANAMIDES AND THEIR USE AS PHARMACEUTICALS
JP2008509910A (ja) * 2004-08-10 2008-04-03 インサイト・コーポレイション アミド化合物およびその医薬としての使用
MX2007005527A (es) * 2004-11-10 2007-07-09 Incyte Corp Compuestos de lactama y sus usos como farmaceuticos.
US8110581B2 (en) 2004-11-10 2012-02-07 Incyte Corporation Lactam compounds and their use as pharmaceuticals
CA2587153A1 (en) * 2004-11-18 2006-05-26 Incyte Corporation Inhibitors of 11-.beta. hydroxyl steroid dehydrogenase type 1 and methods of using the same
FR2883285B1 (fr) * 2005-03-17 2007-05-18 Sanofi Aventis Sa Sel besylate de la 7-(2-(4-(3-trifluoromethyl-phenyl) -1,2,3,6-tetrahudro-pyrid-1-yl)ethyl) isoquinoleine, sa preparation et son utilisation en therapeutique
JP4864342B2 (ja) * 2005-04-27 2012-02-01 北興化学工業株式会社 ビアリール化合物の製造方法
US20070066584A1 (en) * 2005-09-21 2007-03-22 Wenqing Yao Amido compounds and their use as pharmaceuticals
JP5475288B2 (ja) * 2005-12-05 2014-04-16 インサイト・コーポレイション ラクタム化合物およびそれを用いる方法
US7998959B2 (en) * 2006-01-12 2011-08-16 Incyte Corporation Modulators of 11-β hydroxyl steroid dehydrogenase type 1, pharmaceutical compositions thereof, and methods of using the same
EA200870216A1 (ru) * 2006-01-31 2009-02-27 Инсайт Корпорейшн Амидо соединения и их применение в качестве лекарственных средств
US20070213311A1 (en) * 2006-03-02 2007-09-13 Yun-Long Li Modulators of 11-beta hydroxyl steroid dehydrogenase type 1, pharmaceutical compositions thereof, and methods of using the same
US20070208001A1 (en) * 2006-03-03 2007-09-06 Jincong Zhuo Modulators of 11- beta hydroxyl steroid dehydrogenase type 1, pharmaceutical compositions thereof, and methods of using the same
US20070293529A1 (en) * 2006-05-01 2007-12-20 Yun-Long Li Tetrasubstituted ureas as modulators of 11-beta hydroxyl steroid dehydrogenase type 1
CA2652375A1 (en) * 2006-05-17 2007-11-29 Incyte Corporation Heterocyclic inhibitors of 11-.beta. hydroxyl steroid dehydrogenase type i and methods of using the same
CL2008001839A1 (es) 2007-06-21 2009-01-16 Incyte Holdings Corp Compuestos derivados de 2,7-diazaespirociclos, inhibidores de 11-beta hidroxil esteroide deshidrogenasa tipo 1; composicion farmaceutica que comprende a dichos compuestos; utiles para tratar la obesidad, diabetes, intolerancia a la glucosa, diabetes tipo ii, entre otras enfermedades.
CA2710477A1 (en) 2007-12-20 2009-07-09 Envivo Pharmaceuticals, Inc. Tetrasubstituted benzenes
KR101773070B1 (ko) * 2010-01-19 2017-09-12 바이엘 인텔렉쳐 프로퍼티 게엠베하 아릴 및 헤테로아릴아세트산 유도체의 제조방법
WO2018195649A1 (en) * 2017-04-26 2018-11-01 Alberta Research Chemicals Inc. Substituted tetrahydropyridine derivatives as ido-1 inhibitors and uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2098248T3 (es) * 1989-05-17 1997-05-01 Pfizer Derivados de 2-piperidino-1-alcanoles como agentes antiisquemicos.
FR2650505B1 (fr) * 1989-08-07 1994-06-03 Midy Spa Utilisation de trifluoromethylphenyltetrahydropyridines pour la preparation de medicaments destines a combattre les troubles de la motricite intestinale
FR2662355B1 (fr) * 1990-05-22 1994-11-10 Sanofi Sa Utilisation de la 1-[2-(2-naphtyl)ethyl]-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine pour la preparation de medicaments destines au traitement de troubles cerebraux et neuronaux.
HU211019B (en) * 1991-12-02 1995-09-28 Richter Gedeon Vegyeszet Process for producing new 1,2,3,6-tetrahydropyridine and piperidine derivatives substituted with n-(hydroxylalkyl) group and compositions comprising such compounds
DE4325855A1 (de) * 1993-08-02 1995-02-09 Boehringer Ingelheim Kg Neue Benzoesäurederivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel

Also Published As

Publication number Publication date
EP0837848B1 (fr) 2002-09-11
NO976079D0 (no) 1997-12-23
PL324216A1 (en) 1998-05-11
JP2001114763A (ja) 2001-04-24
ATE223897T1 (de) 2002-09-15
ES2183965T3 (es) 2003-04-01
ZA965527B (en) 1997-01-24
KR19990028431A (ko) 1999-04-15
CN1153765C (zh) 2004-06-16
JPH11506118A (ja) 1999-06-02
FR2736053B1 (fr) 1997-09-19
UA62914C2 (en) 2004-01-15
CN1189154A (zh) 1998-07-29
EP1216996A3 (fr) 2003-10-15
CZ291075B6 (cs) 2002-12-11
IS4641A (is) 1997-12-23
CY2312B1 (en) 2003-11-14
IS1999B (is) 2005-04-15
KR100460581B1 (ko) 2005-04-14
AU6461996A (en) 1997-01-30
US5981754A (en) 1999-11-09
EP1216996A2 (fr) 2002-06-26
NO976079L (no) 1997-12-23
CA2225746A1 (en) 1997-01-16
HK1014952A1 (en) 1999-10-08
WO1997001536A1 (fr) 1997-01-16
IL122159A (en) 2001-06-14
NZ312723A (en) 1999-10-28
EE03870B1 (et) 2002-10-15
AU715090B2 (en) 2000-01-13
IL122159A0 (en) 1998-04-05
SK285433B6 (sk) 2007-01-04
JP3302351B2 (ja) 2002-07-15
NO310144B1 (no) 2001-05-28
SK283707B6 (sk) 2003-12-02
DK0837848T3 (da) 2003-01-06
DE69623631T2 (de) 2003-08-07
FR2736053A1 (fr) 1997-01-03
TR199701710T1 (xx) 1998-05-21
RU2163237C2 (ru) 2001-02-20
DE69623631D1 (en) 2002-10-17
BR9608662A (pt) 1999-05-04
MX9710472A (es) 1998-03-31
EP0837848A1 (fr) 1998-04-29
HUP9900055A2 (hu) 1999-04-28
PL192353B1 (pl) 2006-10-31
HUP9900055A3 (en) 1999-11-29
SK178197A3 (en) 1998-07-08
CZ422297A3 (cs) 1998-04-15
PL187087B1 (pl) 2004-05-31
CA2225746C (en) 2004-05-18
JP3147906B2 (ja) 2001-03-19
EE9700348A (et) 1998-06-15

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