[go: up one dir, main page]

PT3704108T - Inibidor de irak4 em combinação com um inibidor de bcl-2 para utilização no tratamento de cancro - Google Patents

Inibidor de irak4 em combinação com um inibidor de bcl-2 para utilização no tratamento de cancro

Info

Publication number
PT3704108T
PT3704108T PT188737787T PT18873778T PT3704108T PT 3704108 T PT3704108 T PT 3704108T PT 188737787 T PT188737787 T PT 188737787T PT 18873778 T PT18873778 T PT 18873778T PT 3704108 T PT3704108 T PT 3704108T
Authority
PT
Portugal
Prior art keywords
compositions
compounds
hematological disorders
treating hematological
treating
Prior art date
Application number
PT188737787T
Other languages
English (en)
Original Assignee
Curis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Curis Inc filed Critical Curis Inc
Publication of PT3704108T publication Critical patent/PT3704108T/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
PT188737787T 2017-10-31 2018-10-30 Inibidor de irak4 em combinação com um inibidor de bcl-2 para utilização no tratamento de cancro PT3704108T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201762579502P 2017-10-31 2017-10-31

Publications (1)

Publication Number Publication Date
PT3704108T true PT3704108T (pt) 2024-06-11

Family

ID=66328095

Family Applications (1)

Application Number Title Priority Date Filing Date
PT188737787T PT3704108T (pt) 2017-10-31 2018-10-30 Inibidor de irak4 em combinação com um inibidor de bcl-2 para utilização no tratamento de cancro

Country Status (25)

Country Link
US (3) US10758518B2 (pt)
EP (2) EP3704108B1 (pt)
JP (3) JP7241747B2 (pt)
KR (2) KR102697663B1 (pt)
CN (2) CN117064897A (pt)
AU (2) AU2018359248B2 (pt)
BR (1) BR112020008214A2 (pt)
CA (1) CA3079628A1 (pt)
DK (1) DK3704108T3 (pt)
EA (1) EA202090497A1 (pt)
ES (1) ES2979273T3 (pt)
FI (1) FI3704108T3 (pt)
HR (1) HRP20240700T1 (pt)
HU (1) HUE067356T2 (pt)
IL (3) IL308364B2 (pt)
LT (1) LT3704108T (pt)
MX (2) MX2020003666A (pt)
PH (1) PH12020550457A1 (pt)
PL (1) PL3704108T3 (pt)
PT (1) PT3704108T (pt)
RS (1) RS65572B1 (pt)
SG (1) SG11202002386WA (pt)
SI (1) SI3704108T1 (pt)
SM (1) SMT202400216T1 (pt)
WO (1) WO2019089580A1 (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG10201811204RA (en) 2014-01-13 2019-01-30 Aurigene Discovery Tech Ltd Bicyclic heterocyclyl derivatives as irak4 inhibitors
EA201992322A3 (ru) 2017-03-31 2020-09-30 Ориджин Дискавери Текнолоджиз Лимитед Соединения и композиции для лечения гематологических расстройств
PT3704108T (pt) * 2017-10-31 2024-06-11 Curis Inc Inibidor de irak4 em combinação com um inibidor de bcl-2 para utilização no tratamento de cancro
BR112022001568A2 (pt) * 2019-09-24 2022-03-22 Shanghai Meiyue Biotech Dev Co Ltd Composto, método para preparação do composto, composição farmacêutica, e, uso do composto
WO2021204589A1 (en) 2020-04-07 2021-10-14 Bayer Aktiengesellschaft Substituted thiazolopyridines, salts thereof and their use as herbicidally active substances
WO2022031330A1 (en) * 2020-08-03 2022-02-10 Curis, Inc. Compositions and methods for treating diseases and disorders
JP2023550739A (ja) * 2020-11-18 2023-12-05 キュリス，インコーポレイテッド 疾患及び障害を治療する方法
WO2022135338A1 (zh) * 2020-12-25 2022-06-30 南京明德新药研发有限公司 酰胺噁唑类化合物
CA3214747A1 (en) * 2021-04-08 2022-10-13 Reinhard Von Roemeling Combination therapies for the treatment of cancer
CN113402499B (zh) 2021-06-21 2022-05-13 上海勋和医药科技有限公司 一种亚磺酰亚胺取代的吲唑类irak4激酶抑制剂、制备方法及用途
TW202328151A (zh) 2021-09-07 2023-07-16 德商拜耳廠股份有限公司 經取代之2,3-二氫[1,3]噻唑并[4,5-b]吡啶、其鹽及其作為除草活性物質之用途
TW202328150A (zh) 2021-09-07 2023-07-16 德商拜耳廠股份有限公司 經取代之噻唑并吡啶、其鹽及其作為除草活性物質之用途
WO2023116866A1 (zh) * 2021-12-23 2023-06-29 杭州多域生物技术有限公司 一种五元并六元化合物、制备方法、药物组合物和应用

Family Cites Families (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4172896A (en) 1978-06-05 1979-10-30 Dainippon Pharmaceutical Co., Ltd. Methane-sulfonamide derivatives, the preparation thereof and composition comprising the same
RU2084223C1 (ru) 1990-05-18 1997-07-20 Хехст АГ Применение амидов изоказол-4-карбоновой кислоты и амидов гидроксиалкилиденциануксусной кислоты
GB9217295D0 (en) 1992-08-14 1992-09-30 Wellcome Found Controlled released tablets
US5358970A (en) 1993-08-12 1994-10-25 Burroughs Wellcome Co. Pharmaceutical composition containing bupropion hydrochloride and a stabilizer
GB9315856D0 (en) 1993-07-30 1993-09-15 Wellcome Found Stabilized pharmaceutical
US5541231A (en) 1993-07-30 1996-07-30 Glaxo Wellcome Inc. Stabilized Pharmaceutical
DK1348427T3 (da) 1997-07-29 2008-06-30 Alcon Lab Inc Oftalmiske sammensætninger indeholdende galactomannanpolymerer og borater
WO1999038504A1 (en) 1998-01-29 1999-08-05 Sepracor Inc. Pharmaceutical uses of optically pure (-)-bupropion
US8889112B2 (en) 1999-09-16 2014-11-18 Ocularis Pharma, Llc Ophthalmic formulations including selective alpha 1 antagonists
DE10023486C1 (de) 2000-05-09 2002-03-14 Schering Ag Ortho substituierte Anthranilsäureamide und deren Verwendung als Arzneimittel
US20030134836A1 (en) 2001-01-12 2003-07-17 Amgen Inc. Substituted arylamine derivatives and methods of use
US6878714B2 (en) 2001-01-12 2005-04-12 Amgen Inc. Substituted alkylamine derivatives and methods of use
GEP20074236B (en) 2003-05-01 2007-11-12 Bristol Myers Squibb Co Aryl-substituted pyrazole-amide compounds useful as kinase inhibitors
CA2526361C (en) 2003-05-20 2012-05-15 Ajinomoto Co., Inc. Amide derivative
WO2004108133A2 (en) 2003-06-05 2004-12-16 Vertex Pharmaceuticals Incorporated Modulators of vr1 receptor
US20050059744A1 (en) 2003-09-12 2005-03-17 Allergan, Inc. Methods and compositions for the treatment of pain and other alpha 2 adrenergic-mediated conditions
US7338950B2 (en) 2003-10-07 2008-03-04 Renovis, Inc. Amide compounds as ion channel ligands and uses thereof
CA2563941C (en) 2004-04-22 2014-10-07 Bayer Cropscience Lp Method and composition for controlling weeds with a combination of a preemergent, a post emergent and a three-way broadleaf herbicidal compositions
EP1655297A1 (en) 2004-11-03 2006-05-10 Schering Aktiengesellschaft Nicotinamide pyridinureas as vascular endothelial growth factor (VEGF) receptor kinase inhibitors
US7906533B2 (en) 2004-11-03 2011-03-15 Bayer Schering Pharma Ag Nicotinamide pyridinureas as vascular endothelial growth factor (VEGF) receptor kinase inhibitors
TW200628159A (en) 2004-11-10 2006-08-16 Synta Pharmaceuticals Corp IL-12 modulatory compounds
DK1828177T3 (da) 2004-12-17 2008-11-17 Lilly Co Eli Hidtil ukendte MCH-receptorantagonister
US7902356B2 (en) 2004-12-17 2011-03-08 Eli Lilly And Company Thiazolopyridinone derivates as MCH receptor antagonists
EP1674467A1 (en) 2004-12-22 2006-06-28 4Sc Ag 2,5- and 2,6-disubstituted benzazole derivatives useful as protein kinase inhibitors
WO2007058626A1 (en) 2005-11-16 2007-05-24 S*Bio Pte Ltd Indazole compounds
BRPI0708034A2 (pt) 2006-02-10 2011-05-17 Transtech Pharma Inc derivados benzazol, composições e métodos de uso como inibidores aurora quinase
GB0606429D0 (en) 2006-03-30 2006-05-10 Novartis Ag Organic compounds
CA2644910C (en) 2006-03-31 2014-01-28 Abbott Laboratories Indazole compounds
WO2007121154A2 (en) 2006-04-11 2007-10-25 Janssen Pharmaceutica, N.V. Substituted benzothiazole kinase inhibitors
CN101616910A (zh) 2006-09-07 2009-12-30 比奥根艾迪克Ma公司 作为白细胞介素-1受体相关激酶调节剂的吲唑衍生物
WO2008030579A2 (en) 2006-09-07 2008-03-13 Biogen Idec Ma Inc. Irak modulators for treating an inflammatory condition, cell proliferative disorder, immune disorder
US20080153810A1 (en) 2006-11-15 2008-06-26 Forest Laboratories Holdings Limited Indazole derivatives useful as melanin concentrating receptor ligands
US7998995B2 (en) 2006-12-08 2011-08-16 Exelixis Patent Company Llc LXR and FXR modulators
JP4785881B2 (ja) 2007-02-27 2011-10-05 大塚製薬株式会社 医薬
US20090069288A1 (en) 2007-07-16 2009-03-12 Breinlinger Eric C Novel therapeutic compounds
US8110572B2 (en) 2007-07-16 2012-02-07 Abbott Laboratories Inhibitors of protein kinases
US8399448B2 (en) 2007-08-08 2013-03-19 Merck Serono Sa 6-amino-pyrimidine-4-carboxamide derivatives and related compounds which bind to the sphingosine 1-phosphate (S1P) receptor for the treatment of multiple sclerosis
EP2252617A1 (en) 2008-02-13 2010-11-24 CGI Pharmaceuticals, Inc. 6-aryl-imidaz0[l, 2-a]pyrazine derivatives, method of making, and method of use thereof
AU2009316786A1 (en) 2008-11-19 2010-05-27 Merck Sharp & Dohme Corp. Inhibitors of diacylglycerol acyltransferase
US8283360B2 (en) 2008-12-19 2012-10-09 Merck Sharp & Dohme Corp. Bicyclic heterocyclic derivatives and methods of use thereof
JP2012513435A (ja) 2008-12-23 2012-06-14 エフ．ホフマン−ラ ロシュ アーゲー Ｐ２ｘ７調節薬としてのジヒドロピリドンアミド
PL2488486T3 (pl) 2009-10-13 2020-01-31 Ligand Pharmaceuticals Inc. Małocząsteczkowe związki mimetyczne hematopoetycznego czynnika wzrostu i ich zastosowania
US8822447B2 (en) 2010-04-22 2014-09-02 Janssen Pharmaceutica Nv Indazole compounds useful as ketohexokinase inhibitors
EP2563358A4 (en) 2010-04-30 2013-09-25 Merck Sharp & Dohme INHIBITORS OF PHOSPHOINOSITIDE DEPENDENT KINASE 1 (PDK1)
DK2585064T3 (en) 2010-06-24 2017-07-24 Chemocentryx Inc C5aR antagonists
MX340490B (es) 2010-07-13 2016-07-11 F Hoffmann-La Roche Ag * Derivados de pirazolo [1, 5a] pirimidina y de tieno [3, 2b] pirimidina como moduladores de la cinasa asociada al receptor de la interleucina 4 (irak4).
KR101903204B1 (ko) 2010-11-19 2018-11-22 리간드 파마슈티칼스 인코포레이티드 복소환 아민 및 이의 용도
SG191205A1 (en) 2010-12-20 2013-07-31 Merck Serono Sa Indazolyl triazole derivatives as irak inhibitors
CN103608017B (zh) 2011-04-12 2017-02-15 美国卫生和人力服务部 用于治疗或预防疟疾的疟原虫表面阴离子通道抑制剂
WO2013042137A1 (en) 2011-09-19 2013-03-28 Aurigene Discovery Technologies Limited Bicyclic heterocycles as irak4 inhibitors
CA2852936A1 (en) 2011-10-20 2013-04-25 Glaxosmithkline Llc Substituted bicyclic aza-heterocycles and analogues as sirtuin modulators
GB201119401D0 (en) 2011-11-10 2011-12-21 Ucb Pharma Sa Therapeutic agents
KR101385603B1 (ko) 2012-05-17 2014-04-21 한국원자력의학원 벤조티아졸 유도체 및 암 치료를 위한 그의 용도
WO2014003483A1 (en) 2012-06-29 2014-01-03 Hanmi Pharm. Co., Ltd. Fused pyrimidine derivatives having inhibitory activity on fms kinases
WO2014011902A1 (en) 2012-07-11 2014-01-16 Nimbus Iris, Inc. Irak inhibitors and uses thereof
WO2014070979A1 (en) 2012-11-03 2014-05-08 Boehringer Ingelheim International Gmbh Inhibitors of cytomegalovirus
CA2907960C (en) * 2013-05-22 2021-10-19 Children's Hospital Medical Center Combination therapy for mds
TWI652014B (zh) 2013-09-13 2019-03-01 美商艾佛艾姆希公司 雜環取代之雙環唑殺蟲劑
TWI667233B (zh) 2013-12-19 2019-08-01 德商拜耳製藥公司 新穎吲唑羧醯胺，其製備方法、含彼等之醫藥製劑及其製造醫藥之用途
CN106458982A (zh) 2014-01-10 2017-02-22 奥列基因发现技术有限公司 作为irak4抑制剂的吲唑化合物
SG10201811204RA (en) * 2014-01-13 2019-01-30 Aurigene Discovery Tech Ltd Bicyclic heterocyclyl derivatives as irak4 inhibitors
CN106458985B (zh) 2014-02-06 2019-05-03 艾伯维公司 6-杂芳氧基-和6-芳氧基-喹啉-2-甲酰胺及其用途
EA201692418A1 (ru) 2014-06-20 2017-04-28 Ауриджен Дискавери Текнолоджиз Лимитед Замещенные индазольные соединения в качестве irak4 ингибиторов
EA201890308A1 (ru) 2015-07-15 2018-08-31 Ориджин Дискавери Текнолоджиз Лимитед Замещенные азасоединения как ингибиторы irak-4
US20180201609A1 (en) 2015-07-15 2018-07-19 Aurigene Discovery Technologies Limited Indazole and azaindazole compounds as irak-4 inhibitors
CA2993661A1 (en) * 2015-08-04 2017-02-09 Rigel Pharmaceuticals, Inc. Benzazole compounds and methods for making and using the compounds
CA3038130A1 (en) 2016-10-28 2018-05-03 Children's Hospital Medical Center Treatment of diseases associated with activated irak
PT3704108T (pt) * 2017-10-31 2024-06-11 Curis Inc Inibidor de irak4 em combinação com um inibidor de bcl-2 para utilização no tratamento de cancro

Also Published As

Publication number Publication date
EP4410377A3 (en) 2024-11-13
CN111225911A (zh) 2020-06-02
IL274248A (en) 2020-06-30
US10758518B2 (en) 2020-09-01
US20220370422A1 (en) 2022-11-24
IL274248B1 (en) 2024-02-01
PH12020550457A1 (en) 2021-03-22
US20200345704A1 (en) 2020-11-05
ES2979273T3 (es) 2024-09-25
AU2023222890A1 (en) 2023-09-14
CN117064897A (zh) 2023-11-17
BR112020008214A2 (pt) 2020-10-27
EP4410377A2 (en) 2024-08-07
JP2023071915A (ja) 2023-05-23
HRP20240700T1 (hr) 2024-08-16
MX2023010882A (es) 2023-09-27
CN111225911B (zh) 2023-09-01
PL3704108T3 (pl) 2024-07-22
JP2024096919A (ja) 2024-07-17
EP3704108A4 (en) 2021-08-25
IL274248B2 (en) 2024-06-01
IL308364A (en) 2024-01-01
SG11202002386WA (en) 2020-04-29
FI3704108T3 (fi) 2024-05-23
JP7476380B2 (ja) 2024-04-30
HUE067356T2 (hu) 2024-10-28
RS65572B1 (sr) 2024-06-28
AU2018359248B2 (en) 2023-06-01
US20190134010A1 (en) 2019-05-09
DK3704108T3 (da) 2024-06-10
WO2019089580A1 (en) 2019-05-09
EP3704108A1 (en) 2020-09-09
JP2021501145A (ja) 2021-01-14
SMT202400216T1 (it) 2024-07-09
EP3704108B1 (en) 2024-04-24
AU2018359248A1 (en) 2020-03-26
KR20200080254A (ko) 2020-07-06
KR20240130818A (ko) 2024-08-29
SI3704108T1 (sl) 2024-07-31
MX2020003666A (es) 2020-08-03
IL315025A (en) 2024-10-01
CA3079628A1 (en) 2019-05-09
LT3704108T (lt) 2024-06-25
KR102697663B1 (ko) 2024-08-21
JP7241747B2 (ja) 2023-03-17
IL308364B1 (en) 2024-10-01
EA202090497A1 (ru) 2020-11-23
IL308364B2 (en) 2025-02-01

Similar Documents

Publication Publication Date Title
IL293783A (en) Compounds and preparations for the treatment of hematological disorders
IL274248A (en) Compounds and preparations for the treatment of hematological disorders
IL291533A (en) Compounds and preparations including them for the treatment of diseases of the central nervous system
HK1259453A1 (zh) 可用於治療與ntrk相關的病症的化合物和組合物
IL275506A (en) Preparations and methods for the treatment of central nervous system disorders
HK1255330A1 (zh) 適用於治療與ntrk相關的病症的化合物和組合物
HK1252741A1 (zh) 用於治療神經疾病的組合物和方法
IL275562A (en) Preparations and methods for the treatment of central nervous system disorders
PT3250210T (pt) Composições e métodos para o tratamento de distúrbios do snc
EP3280420A4 (en) Compositions and methods for treating cns disorders
IL269637A (en) Preparations and methods for the treatment of synovial diseases
HK1258696A1 (zh) 治療或預防皮膚障礙的新型組合物和方法
IL272061A (en) Preparations for the treatment of stress-related disorders
HK1256298A1 (zh) 用於治療和預防神經退化性病症的組合物和方法
IL269550A (en) Preparations and methods for treating diseases related to alpha-synuclein
HRP20220979T8 (hr) Sastavi za liječenje amiloidoze
EP3322406A4 (en) TRANSPARENT METHODS AND COMPOSITIONS FOR THE TREATMENT OF MAMMARY DISEASES
EP3262065C0 (en) METHODS AND COMPOSITIONS FOR THE TREATMENT OF DYSTROGLYCANOPATHY DISEASES
IL265255A (en) Dementia treatment preparations
RS62891B1 (sr) Kompozicija za lečenje konstipacije