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HUE067356T2 - IRAK4 inhibitor és BCL-2 inhibitor kombinációban, rák kezelésére való felhasználásra - Google Patents

IRAK4 inhibitor és BCL-2 inhibitor kombinációban, rák kezelésére való felhasználásra

Info

Publication number
HUE067356T2
HUE067356T2 HUE18873778A HUE18873778A HUE067356T2 HU E067356 T2 HUE067356 T2 HU E067356T2 HU E18873778 A HUE18873778 A HU E18873778A HU E18873778 A HUE18873778 A HU E18873778A HU E067356 T2 HUE067356 T2 HU E067356T2
Authority
HU
Hungary
Prior art keywords
inhibitor
bcl
combination
treating cancer
irak4
Prior art date
Application number
HUE18873778A
Other languages
English (en)
Inventor
Robert Booher
Original Assignee
Curis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Curis Inc filed Critical Curis Inc
Publication of HUE067356T2 publication Critical patent/HUE067356T2/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
HUE18873778A 2017-10-31 2018-10-30 IRAK4 inhibitor és BCL-2 inhibitor kombinációban, rák kezelésére való felhasználásra HUE067356T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201762579502P 2017-10-31 2017-10-31

Publications (1)

Publication Number Publication Date
HUE067356T2 true HUE067356T2 (hu) 2024-10-28

Family

ID=66328095

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE18873778A HUE067356T2 (hu) 2017-10-31 2018-10-30 IRAK4 inhibitor és BCL-2 inhibitor kombinációban, rák kezelésére való felhasználásra

Country Status (25)

Country Link
US (3) US10758518B2 (hu)
EP (2) EP4410377A3 (hu)
JP (3) JP7241747B2 (hu)
KR (2) KR102697663B1 (hu)
CN (2) CN111225911B (hu)
AU (2) AU2018359248B2 (hu)
BR (1) BR112020008214A2 (hu)
CA (1) CA3079628A1 (hu)
DK (1) DK3704108T3 (hu)
EA (1) EA202090497A1 (hu)
ES (1) ES2979273T3 (hu)
FI (1) FI3704108T3 (hu)
HR (1) HRP20240700T1 (hu)
HU (1) HUE067356T2 (hu)
IL (3) IL308364B2 (hu)
LT (1) LT3704108T (hu)
MX (2) MX2020003666A (hu)
PH (1) PH12020550457A1 (hu)
PL (1) PL3704108T3 (hu)
PT (1) PT3704108T (hu)
RS (1) RS65572B1 (hu)
SG (1) SG11202002386WA (hu)
SI (1) SI3704108T1 (hu)
SM (1) SMT202400216T1 (hu)
WO (1) WO2019089580A1 (hu)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102574390B1 (ko) 2014-01-13 2023-09-04 오리진 온콜로지 리미티드 Irak4 억제제로서의 바이시클릭 헤테로시클릴 유도체
JP7333136B2 (ja) 2017-03-31 2023-08-24 アウリジーン オンコロジー リミテッド 血液疾患を処置するための化合物及び組成物
ES2979273T3 (es) * 2017-10-31 2024-09-25 Curis Inc Inhibidor de IRAK4 en combinación con un inhibidor de BCL-2 para uso en el tratamiento del cáncer
PE20220944A1 (es) * 2019-09-24 2022-05-31 Shanghai Meiyue Biotech Dev Co Ltd Inhibidor de irak y metodo de preparacion para el mismo y uso del mismo
AU2021251341A1 (en) 2020-04-07 2022-11-03 Bayer Aktiengesellschaft Substituted thiazolopyridines, salts thereof and their use as herbicidally active substances
JP2023537477A (ja) * 2020-08-03 2023-09-01 キュリス，インコーポレイテッド 疾患及び障害を治療するための組成物及び方法
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JP7620711B2 (ja) 2020-12-25 2025-01-23 メッドシャイン ディスカバリー インコーポレイテッド アミドオキサゾール系化合物
US12178821B2 (en) * 2021-04-08 2024-12-31 Curis, Inc. Combination therapies for the treatment of cancer
CN113402499B (zh) 2021-06-21 2022-05-13 上海勋和医药科技有限公司 一种亚磺酰亚胺取代的吲唑类irak4激酶抑制剂、制备方法及用途
TW202328151A (zh) 2021-09-07 2023-07-16 德商拜耳廠股份有限公司 經取代之2,3-二氫[1,3]噻唑并[4,5-b]吡啶、其鹽及其作為除草活性物質之用途
TW202328150A (zh) 2021-09-07 2023-07-16 德商拜耳廠股份有限公司 經取代之噻唑并吡啶、其鹽及其作為除草活性物質之用途
WO2023116866A1 (zh) 2021-12-23 2023-06-29 杭州多域生物技术有限公司 一种五元并六元化合物、制备方法、药物组合物和应用

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PH12020550457A1 (en) 2021-03-22
US10758518B2 (en) 2020-09-01
RS65572B1 (sr) 2024-06-28
EP3704108A1 (en) 2020-09-09
CN111225911B (zh) 2023-09-01
FI3704108T3 (fi) 2024-05-23
CN111225911A (zh) 2020-06-02
JP2021501145A (ja) 2021-01-14
CN117064897A (zh) 2023-11-17
SG11202002386WA (en) 2020-04-29
US20220370422A1 (en) 2022-11-24
IL308364A (en) 2024-01-01
IL315025A (en) 2024-10-01
US20190134010A1 (en) 2019-05-09
IL274248A (en) 2020-06-30
LT3704108T (lt) 2024-06-25
EP3704108B1 (en) 2024-04-24
KR20240130818A (ko) 2024-08-29
KR102697663B1 (ko) 2024-08-21
JP7241747B2 (ja) 2023-03-17
AU2018359248B2 (en) 2023-06-01
HRP20240700T1 (hr) 2024-08-16
EA202090497A1 (ru) 2020-11-23
KR20200080254A (ko) 2020-07-06
MX2020003666A (es) 2020-08-03
CA3079628A1 (en) 2019-05-09
SMT202400216T1 (it) 2024-07-09
ES2979273T3 (es) 2024-09-25
JP2023071915A (ja) 2023-05-23
WO2019089580A1 (en) 2019-05-09
IL274248B2 (en) 2024-06-01
JP7476380B2 (ja) 2024-04-30
PL3704108T3 (pl) 2024-07-22
US20200345704A1 (en) 2020-11-05
BR112020008214A2 (pt) 2020-10-27
IL274248B1 (en) 2024-02-01
EP4410377A3 (en) 2024-11-13
AU2018359248A1 (en) 2020-03-26
EP3704108A4 (en) 2021-08-25
JP2024096919A (ja) 2024-07-17
IL308364B2 (en) 2025-02-01
DK3704108T3 (da) 2024-06-10
IL308364B1 (en) 2024-10-01
AU2023222890A1 (en) 2023-09-14
EP4410377A2 (en) 2024-08-07
PT3704108T (pt) 2024-06-11
SI3704108T1 (sl) 2024-07-31
MX2023010882A (es) 2023-09-27

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