PT3312156T - Processos para a preparação de (s)-1-(3-etoxi-4- metoxifenil)-2-metanossulfoniloetilamina - Google Patents

Processos para a preparação de (s)-1-(3-etoxi-4- metoxifenil)-2-metanossulfoniloetilamina

Info

Publication number: PT3312156T
Authority: PT; Portugal
Prior art keywords: methanesulfonylethylamine; ethoxy; processes; preparation
Prior art date: 2012-02-21

Application number

PT17197504T

Other languages

English (en)

Inventor

Venkateswaralu Jasti

Rajendiran Chinnapillai

Ravikumar Reddy Nallamaddi

Joseph Connolly Terrence

L Ruchelman Alexander

Eckert Jeffrey

Joseph Frank Anthony

Original Assignee

Celgene Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2012-02-21

Filing date

2013-02-20

Publication date

2019-07-19

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47755073&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT3312156(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2013-02-20 Application filed by Celgene Corp filed Critical Celgene Corp

2019-07-19 Publication of PT3312156T publication Critical patent/PT3312156T/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C317/28—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C313/00—Sulfinic acids; Sulfenic acids; Halides, esters or anhydrides thereof; Amides of sulfinic or sulfenic acids, i.e. compounds having singly-bound oxygen atoms of sulfinic or sulfenic groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C313/02—Sulfinic acids; Derivatives thereof
- C07C313/06—Sulfinamides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C315/00—Preparation of sulfones; Preparation of sulfoxides
- C07C315/04—Preparation of sulfones; Preparation of sulfoxides by reactions not involving the formation of sulfone or sulfoxide groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/24—Sulfones; Sulfoxides having sulfone or sulfoxide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pulmonology (AREA)
Immunology (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Pain & Pain Management (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

PT17197504T 2012-02-21 2013-02-20 Processos para a preparação de (s)-1-(3-etoxi-4- metoxifenil)-2-metanossulfoniloetilamina PT3312156T (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US201261601226P	2012-02-21	2012-02-21

Publications (1)

Publication Number	Publication Date
PT3312156T true PT3312156T (pt)	2019-07-19

Family

ID=47755073

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
PT181689696T PT3378850T (pt)	2012-02-21	2013-02-20	Processos para a preparação de (s)-1-(3-etoxi-4-metoxifenil)-2-metanossulfoniletilamina
PT17197504T PT3312156T (pt)	2012-02-21	2013-02-20	Processos para a preparação de (s)-1-(3-etoxi-4- metoxifenil)-2-metanossulfoniloetilamina

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
PT181689696T PT3378850T (pt)	2012-02-21	2013-02-20	Processos para a preparação de (s)-1-(3-etoxi-4-metoxifenil)-2-metanossulfoniletilamina

Country Status (37)

Country	Link
US (3)	US9187417B2 (pt)
EP (4)	EP3312156B1 (pt)
JP (1)	JP2015509496A (pt)
KR (1)	KR101993248B1 (pt)
CN (3)	CN112812044B (pt)
AR (2)	AR090100A1 (pt)
AU (1)	AU2013203283B2 (pt)
BR (3)	BR122021020040B1 (pt)
CA (1)	CA2864517A1 (pt)
CO (1)	CO7061071A2 (pt)
CR (1)	CR20140395A (pt)
CY (2)	CY1121833T1 (pt)
DK (2)	DK3312156T3 (pt)
ES (4)	ES2675168T3 (pt)
HK (1)	HK1205501A1 (pt)
HR (2)	HRP20191249T1 (pt)
HU (2)	HUE044192T2 (pt)
IL (3)	IL234135A (pt)
IN (1)	IN2014DN06740A (pt)
LT (2)	LT3378850T (pt)
MX (2)	MX350731B (pt)
MY (1)	MY168296A (pt)
NI (1)	NI201400093A (pt)
NZ (1)	NZ628028A (pt)
PH (1)	PH12014501865B1 (pt)
PL (2)	PL3378850T3 (pt)
PT (2)	PT3378850T (pt)
RS (2)	RS59071B1 (pt)
RU (1)	RU2632875C2 (pt)
SG (1)	SG11201405035XA (pt)
SI (2)	SI3312156T1 (pt)
SM (2)	SMT202000107T1 (pt)
TR (1)	TR201910430T4 (pt)
TW (1)	TW201336815A (pt)
UA (1)	UA116773C2 (pt)
WO (1)	WO2013126360A2 (pt)
ZA (1)	ZA201405892B (pt)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AR090100A1 (es) *	2012-02-21	2014-10-22	Celgene Corp	Procesos para la preparacion de la (s)-1-(3-etoxi-4-metoxifenil)-2-metanosulfoniletilamina
US9126906B2 (en) *	2012-02-21	2015-09-08	Celgene Corporation	Asymmetric synthetic processes for the preparation of aminosulfone compounds
NZ628329A (en)	2013-06-17	2017-12-22	Celgene Corp	Formulations of (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione
IN2014MU01283A (pt)	2014-04-04	2015-10-09	Cadila Healthcare Ltd
EP3143004B1 (en)	2014-05-11	2020-09-02	Mapi Pharma Limited	Amorphous form of apremilast
EP2949645A1 (en)	2014-05-28	2015-12-02	LEK Pharmaceuticals d.d.	Processes for the preparation of ß-aminosulfone compounds
CN105622380B (zh) *	2014-10-29	2020-06-30	南京安源生物医药科技有限公司	一种阿普斯特的制备方法及其中间体
CN104447445B (zh) *	2014-12-05	2016-07-06	新发药业有限公司	一种合成阿普斯特中间体的制备方法
CN104761474B (zh) *	2015-03-11	2016-11-30	中山奕安泰医药科技有限公司	一种阿普斯特手性胺中间体的合成方法
CN104744323B (zh) *	2015-03-11	2016-08-31	中山奕安泰医药科技有限公司	一种阿普斯特手性胺中间体的合成工艺
CN104803897A (zh) *	2015-04-23	2015-07-29	中山奕安泰医药科技有限公司	一种阿普斯特中间体的合成工艺
WO2016174685A1 (en) *	2015-04-27	2016-11-03	Mylan Laboratories Limited	Process for the enantiomeric resolution of apremilast intermediates
WO2016199031A1 (en) *	2015-06-09	2016-12-15	Dr. Reddy’S Laboratories Limited	Process for preparation of apremilast and its intermediates
EP3106457A1 (en)	2015-06-15	2016-12-21	LEK Pharmaceuticals d.d.	A novel synthetic pathway towards apremilast
EP3144393A1 (en)	2015-09-18	2017-03-22	LEK Pharmaceuticals d.d.	A synthetic pathway towards apremilast
EP3356327A1 (en)	2015-09-29	2018-08-08	Pliva Hrvatska D.O.O.	Processes for the preparation of apremilast and intermediates thereof
US10399942B2 (en)	2015-11-19	2019-09-03	Alembic Pharmaceuticals Limited	Process and novel polymorphic form of Apremilast
CN105330586B (zh) *	2015-11-27	2017-12-22	东华大学	一种阿普斯特的制备方法
CN105461602B (zh) *	2015-11-27	2018-01-02	东华大学	手性S或R‑3‑乙氧基‑4‑甲氧基‑α‑[(甲磺酰基)甲基]苯甲醇的制备方法
WO2017094031A2 (en) *	2015-12-04	2017-06-08	Sun Pharmaceutical Industries Limited	Novel process for preparation of apremilast
CN106866475B (zh) *	2015-12-11	2018-03-30	北大方正集团有限公司	一种阿普斯特中间体及其制备方法
WO2017179065A1 (en)	2016-04-15	2017-10-19	Davuluri Ramamohan Rao	Improved process for the preparation of apremilast
US10196355B2 (en)	2016-06-20	2019-02-05	Johnson Matthey Public Limited Company	Forms of apremilast
CN106543050B (zh) *	2016-09-28	2018-04-10	中南大学湘雅医院	一种阿普斯特中间体的合成工艺
WO2018061034A1 (en) *	2016-09-30	2018-04-05	Sun Pharmaceutical Industries Limited	Novel process for the preparation of 1-(3-ethoxy-4-methoxy-phenyl)-2-methylsulfonyl-ethanamine
JP6684968B2 (ja)	2016-11-10	2020-04-22	エス・エム・エス・グループ・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング	連続鋳造圧延設備内において、金属的なストリップを製造するための方法
CN107445875A (zh) *	2017-03-22	2017-12-08	陕西科技大学	一种用于制备阿普斯特的高纯度中间体的手性拆分方法
SI3606907T1 (sl)	2017-04-04	2021-08-31	Quimica Sintetica, S.A.	Racemične spojine beta-aminosulfona
HUE051684T2 (hu)	2017-04-04	2021-03-29	Quim Sintetica S A	Racém béta-aminoszulfon vegyületek rezolválása
CN107976501B (zh) *	2017-11-23	2020-08-25	中山奕安泰医药科技有限公司	一种1-(3-乙氧基-4-甲氧基苯基)-2-(甲基磺酰基)乙胺的检测方法
CN107941945B (zh) *	2017-11-23	2020-12-22	中山奕安泰医药科技有限公司	一种3-乙氧基-4-甲氧基苯甲腈的检测方法
CN107966509B (zh) *	2017-11-23	2020-06-23	中山奕安泰医药科技有限公司	一种(s)-1-(3-乙氧基-4-甲氧基苯基)-2-(甲基磺酰基)乙胺的检测方法
CN107827722B (zh) *	2017-11-23	2021-02-19	中山奕安泰医药科技有限公司	一种3-乙氧基-4-甲氧基苯甲醛的合成方法
CN108008035B (zh) *	2017-11-23	2020-07-07	中山奕安泰医药科技有限公司	3-乙氧基-4-甲氧基苯甲醛纯度的检测方法
CN108084066A (zh) *	2017-12-12	2018-05-29	中山大学	一种阿普斯特及对映异构体的合成方法
JP6673614B1 (ja) *	2018-10-16	2020-03-25	東芝エレベータ株式会社	防音装置
CN113896674B (zh) *	2021-09-01	2023-10-27	深圳华中科技大学研究院	一种阿普斯特的合成方法
JP2024545712A (ja)	2021-12-21	2024-12-10	ガンチョウヘメイファーマシューティカルカンパニーリミテッド	チオフェン誘導体の調製
CN115850129B (zh) *	2023-02-28	2023-05-16	凯莱英生命科学技术(天津)有限公司	（s）-1-(3-乙氧基-4-甲氧基苯基)-2-（甲磺酰基）乙胺的制备方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3878252A (en) *	1970-09-24	1975-04-15	Burroughs Wellcome Co	Ring substituted beta-hydroxy-phenyethylmethyl sulphone or sulphoxide
GB1261455A (en) *	1969-03-06	1972-01-26	Burroughs Wellcome Co	Improvements in or relating to substituted acrylonitriles
DE2051871A1 (en)	1969-05-16	1971-11-18	The Wellcome Foundation Ltd., London	Beta-amino-alpha-aryloxymethylacrylonitrile - and 2,4-diamino-5-benzylpyrimidine derivs. useful as antibacterial agents
EP0888329A1 (en)	1996-03-22	1999-01-07	Du Pont Pharmaceuticals Company	NOVEL ASYMMETRIC SYNTHESIS OF R-$g(a)-PROPYL-PIPERONYL AMINE AND ITS ANALOGS
US6020358A (en) *	1998-10-30	2000-02-01	Celgene Corporation	Substituted phenethylsulfones and method of reducing TNFα levels
US7893101B2 (en)	2002-03-20	2011-02-22	Celgene Corporation	Solid forms comprising (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, compositions thereof, and uses thereof
US6962940B2 (en)	2002-03-20	2005-11-08	Celgene Corporation	(+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione: methods of using and compositions thereof
ATE449081T1 (de)	2002-12-30	2009-12-15	Celgene Corp	Fluoralkoxy-substituierte 1, 3-dihydro-isoindolyl-verbindungen und ihre pharmazeutischen verwendungen
US7208526B2 (en)	2005-05-20	2007-04-24	Hoffmann-La Roche Inc.	Styrylsulfonamides
KR101709141B1 (ko) *	2008-01-25	2017-02-22	브이티브이 테라퓨틱스 엘엘씨	ＴＮＦ-α 합성의 조절자 및 ＰＤＥ4 억제제로서 3고리 화합물
US8242310B2 (en) *	2008-09-10	2012-08-14	Celgene Corporation	Processes for the preparation of aminosulfone compounds
EP2690092B1 (en) *	2009-06-18	2016-03-16	Concert Pharmaceuticals Inc.	Deuterated isoindoline-1,3-dione derivatives as PDE4 and TNF-alpha inhibitors
AR078581A1 (es)	2009-10-09	2011-11-16	Celgene Corp	Procesos para la preparacion de compuestos 2-(1-feniletil)isoindolin-1-ona
WO2012097116A2 (en)	2011-01-14	2012-07-19	Celgene Corporation	Isotopologues of isoindole derivatives
US9126906B2 (en) *	2012-02-21	2015-09-08	Celgene Corporation	Asymmetric synthetic processes for the preparation of aminosulfone compounds
AR090100A1 (es) *	2012-02-21	2014-10-22	Celgene Corp	Procesos para la preparacion de la (s)-1-(3-etoxi-4-metoxifenil)-2-metanosulfoniletilamina

2013
- 2013-02-19 AR ARP130100512A patent/AR090100A1/es active IP Right Grant
- 2013-02-20 EP EP17197504.8A patent/EP3312156B1/en active Active
- 2013-02-20 ES ES13706898.7T patent/ES2675168T3/es active Active
- 2013-02-20 UA UAA201410289A patent/UA116773C2/uk unknown
- 2013-02-20 EP EP18168969.6A patent/EP3378850B8/en active Active
- 2013-02-20 NZ NZ628028A patent/NZ628028A/en unknown
- 2013-02-20 PL PL18168969T patent/PL3378850T3/pl unknown
- 2013-02-20 SI SI201331526T patent/SI3312156T1/sl unknown
- 2013-02-20 PL PL17197504T patent/PL3312156T3/pl unknown
- 2013-02-20 ES ES18168969T patent/ES2773686T3/es active Active
- 2013-02-20 DK DK17197504.8T patent/DK3312156T3/da active
- 2013-02-20 US US13/771,164 patent/US9187417B2/en active Active
- 2013-02-20 ES ES17197504T patent/ES2735801T3/es active Active
- 2013-02-20 DK DK18168969.6T patent/DK3378850T3/da active
- 2013-02-20 CA CA2864517A patent/CA2864517A1/en not_active Withdrawn
- 2013-02-20 AU AU2013203283A patent/AU2013203283B2/en active Active
- 2013-02-20 RS RS20190895A patent/RS59071B1/sr unknown
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- 2013-02-20 BR BR122021020040-8A patent/BR122021020040B1/pt active IP Right Grant
- 2013-02-20 CN CN202110092737.0A patent/CN112812044B/zh active Active
- 2013-02-20 MY MYPI2014702288A patent/MY168296A/en unknown
- 2013-02-20 SI SI201331685T patent/SI3378850T1/sl unknown
- 2013-02-20 CN CN201710255841.0A patent/CN107033042A/zh active Pending
- 2013-02-20 LT LTEP18168969.6T patent/LT3378850T/lt unknown
- 2013-02-20 SM SM20190397T patent/SMT201900397T1/it unknown
- 2013-02-20 WO PCT/US2013/026780 patent/WO2013126360A2/en active Application Filing
- 2013-02-20 PT PT181689696T patent/PT3378850T/pt unknown
- 2013-02-20 EP EP20150560.9A patent/EP3702347B1/en active Active
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- 2013-02-20 RU RU2014138037A patent/RU2632875C2/ru active
- 2013-02-20 JP JP2014558783A patent/JP2015509496A/ja active Pending
- 2013-02-20 HU HUE17197504 patent/HUE044192T2/hu unknown
- 2013-02-20 BR BR122021020046-7A patent/BR122021020046B1/pt active IP Right Grant
- 2013-02-20 BR BR112014020444-6A patent/BR112014020444B1/pt active IP Right Grant
- 2013-02-20 CN CN201380020005.4A patent/CN104245668B/zh active Active
- 2013-02-20 PT PT17197504T patent/PT3312156T/pt unknown
- 2013-02-20 MX MX2016016157A patent/MX350731B/es unknown
- 2013-02-20 LT LTEP17197504.8T patent/LT3312156T/lt unknown
- 2013-02-20 KR KR1020147026186A patent/KR101993248B1/ko active Active
- 2013-02-20 SG SG11201405035XA patent/SG11201405035XA/en unknown
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- 2013-02-20 MX MX2014010002A patent/MX344190B/es active IP Right Grant
- 2013-02-20 RS RS20200185A patent/RS60036B1/sr unknown
- 2013-02-20 EP EP13706898.7A patent/EP2817288B1/en active Active
- 2013-02-20 IN IN6740DEN2014 patent/IN2014DN06740A/en unknown
- 2013-02-20 HU HUE18168969A patent/HUE048412T2/hu unknown
2014
- 2014-08-12 ZA ZA2014/05892A patent/ZA201405892B/en unknown
- 2014-08-14 IL IL234135A patent/IL234135A/en active IP Right Grant
- 2014-08-18 PH PH12014501865A patent/PH12014501865B1/en unknown
- 2014-08-20 NI NI201400093A patent/NI201400093A/es unknown
- 2014-08-21 CR CR20140395A patent/CR20140395A/es unknown
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2015
- 2015-06-25 HK HK15106059.8A patent/HK1205501A1/xx unknown
- 2015-10-14 US US14/882,564 patent/US9586897B2/en active Active
2017
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- 2017-05-23 IL IL252459A patent/IL252459B/en active IP Right Grant
2019
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- 2019-07-12 HR HRP20191249TT patent/HRP20191249T1/hr unknown
2020
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- 2020-02-13 HR HRP20200245TT patent/HRP20200245T1/hr unknown
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HRP20191249T1 (hr)	2019-10-18
NZ628028A (en)	2016-03-31
KR101993248B1 (ko)	2019-06-26
HUE044192T2 (hu)	2019-10-28
PH12014501865A1 (en)	2014-11-17
ES2971710T3 (es)	2024-06-06
PL3312156T3 (pl)	2019-10-31
ES2735801T3 (es)	2019-12-20
KR20140126389A (ko)	2014-10-30
PH12014501865B1 (en)	2014-11-17
NI201400093A (es)	2016-11-30
CN107033042A (zh)	2017-08-11
BR112014020444B1 (pt)	2021-12-07
CY1122799T1 (el)	2021-05-05
DK3312156T3 (da)	2019-07-22
LT3312156T (lt)	2019-08-12
MX2014010002A (es)	2014-09-08
ZA201405892B (en)	2015-11-25
DK3378850T3 (da)	2020-03-16
IL252459A0 (en)	2017-07-31
CA2864517A1 (en)	2013-08-29
EP2817288A2 (en)	2014-12-31
EP2817288B1 (en)	2018-05-30
CO7061071A2 (es)	2014-09-19
AR117963A2 (es)	2021-09-08
EP3312156A1 (en)	2018-04-25
HUE048412T2 (hu)	2020-07-28
SI3378850T1 (sl)	2020-07-31
HRP20200245T1 (hr)	2020-05-15
RU2014138037A (ru)	2016-04-10
MX350731B (es)	2017-09-15
SG11201405035XA (en)	2014-09-26
EP3378850B8 (en)	2020-03-04
SMT201900397T1 (it)	2019-09-09
EP3378850B1 (en)	2020-01-08
ES2675168T3 (es)	2018-07-09
EP3378850A1 (en)	2018-09-26
IL252459B (en)	2020-03-31
US20170129852A1 (en)	2017-05-11
US9187417B2 (en)	2015-11-17
CN112812044A (zh)	2021-05-18
AU2013203283A1 (en)	2013-09-05
EP3702347A1 (en)	2020-09-02
CR20140395A (es)	2014-11-17
SMT202000107T1 (it)	2020-03-13
SI3312156T1 (sl)	2019-09-30
JP2015509496A (ja)	2015-03-30
US9688623B2 (en)	2017-06-27
BR122021020046B1 (pt)	2022-05-31
BR112014020444A2 (pt)	2020-10-27
HK1205501A1 (en)	2015-12-18
PL3378850T3 (pl)	2020-07-27
TR201910430T4 (tr)	2019-08-21
RS60036B1 (sr)	2020-04-30
US20130217918A1 (en)	2013-08-22
AU2013203283B2 (en)	2015-11-26
RU2632875C2 (ru)	2017-10-11
WO2013126360A3 (en)	2013-10-31
UA116773C2 (uk)	2018-05-10
BR122021020040B1 (pt)	2022-05-31
US9586897B2 (en)	2017-03-07
CY1121833T1 (el)	2020-10-14
WO2013126360A2 (en)	2013-08-29
RS59071B1 (sr)	2019-09-30
AR090100A1 (es)	2014-10-22
MY168296A (en)	2018-10-23
CN104245668B (zh)	2017-05-17
ES2773686T3 (es)	2020-07-14
EP3702347B1 (en)	2023-11-08
IL273050A (en)	2020-04-30
CN112812044B (zh)	2023-05-30
MX344190B (es)	2016-12-08
IL234135A (en)	2017-06-29
US20160031808A1 (en)	2016-02-04
CN104245668A (zh)	2014-12-24
TW201336815A (zh)	2013-09-16
LT3378850T (lt)	2020-04-10
IN2014DN06740A (pt)	2015-05-22
EP3312156B1 (en)	2019-06-05
PT3378850T (pt)	2020-03-06

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HRP20200245T1 (hr)	2020-05-15	Postupci za pripravu (s)-1-(3-etoksi-4metoksifenil)-2-metansulfoniletilamina
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