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IN2014DN06740A - - Google Patents

Info

Publication number
IN2014DN06740A
IN2014DN06740A IN6740DEN2014A IN2014DN06740A IN 2014DN06740 A IN2014DN06740 A IN 2014DN06740A IN 6740DEN2014 A IN6740DEN2014 A IN 6740DEN2014A IN 2014DN06740 A IN2014DN06740 A IN 2014DN06740A
Authority
IN
India
Prior art keywords
methoxyphenyl
ethoxy
processes
acetylaminoisoindoline
methanesulfony
Prior art date
Application number
Inventor
Jasti Venkateswaralu
Chinnapillai Rajendiran
Nallamaddi Ravikumar Reddy
Terrence Joseph Connolly
Alexander L Ruchelman
Jeffrey Eckert
Anthony Joseph Frank
Original Assignee
Celgene Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47755073&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IN2014DN06740(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Celgene Corp filed Critical Celgene Corp
Publication of IN2014DN06740A publication Critical patent/IN2014DN06740A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C313/00—Sulfinic acids; Sulfenic acids; Halides, esters or anhydrides thereof; Amides of sulfinic or sulfenic acids, i.e. compounds having singly-bound oxygen atoms of sulfinic or sulfenic groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C313/02—Sulfinic acids; Derivatives thereof
    • C07C313/06—Sulfinamides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/04—Preparation of sulfones; Preparation of sulfoxides by reactions not involving the formation of sulfone or sulfoxide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/24—Sulfones; Sulfoxides having sulfone or sulfoxide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/28—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Provided herein are new processes for the preparation of aminosulfone intermediates for the synthesis of 2 [l (3 ethoxy 4 methoxyphenyl) 2 methylsulfonylethyl] 4 acetylaminoisoindoline l 3 dione which is useful for preventing or treating diseases or conditions related to an abnormally high level or activity of TNF a. Further provided herein are processes for the commercial production of (S) l (3 ethoxy 4 methoxyphenyl) 2 methanesulfony lethy lamine.
IN6740DEN2014 2012-02-21 2013-02-20 IN2014DN06740A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261601226P 2012-02-21 2012-02-21
PCT/US2013/026780 WO2013126360A2 (en) 2012-02-21 2013-02-20 Processes for the preparation of (s)-1-(3-ethoxy-4methoxyphenyl)-2-methanesulfonylethylamine

Publications (1)

Publication Number Publication Date
IN2014DN06740A true IN2014DN06740A (en) 2015-05-22

Family

ID=47755073

Family Applications (1)

Application Number Title Priority Date Filing Date
IN6740DEN2014 IN2014DN06740A (en) 2012-02-21 2013-02-20

Country Status (36)

Country Link
US (3) US9187417B2 (en)
EP (4) EP2817288B1 (en)
JP (1) JP2015509496A (en)
KR (1) KR101993248B1 (en)
CN (3) CN107033042A (en)
AR (2) AR090100A1 (en)
AU (1) AU2013203283B2 (en)
BR (3) BR122021020046B1 (en)
CA (1) CA2864517A1 (en)
CO (1) CO7061071A2 (en)
CR (1) CR20140395A (en)
CY (2) CY1121833T1 (en)
DK (2) DK3312156T3 (en)
ES (4) ES2675168T3 (en)
HR (2) HRP20191249T1 (en)
HU (2) HUE044192T2 (en)
IL (3) IL234135A (en)
IN (1) IN2014DN06740A (en)
LT (2) LT3378850T (en)
MX (2) MX350731B (en)
MY (1) MY168296A (en)
NI (1) NI201400093A (en)
NZ (1) NZ628028A (en)
PH (1) PH12014501865B1 (en)
PL (2) PL3312156T3 (en)
PT (2) PT3312156T (en)
RS (2) RS60036B1 (en)
RU (1) RU2632875C2 (en)
SG (1) SG11201405035XA (en)
SI (2) SI3312156T1 (en)
SM (2) SMT202000107T1 (en)
TR (1) TR201910430T4 (en)
TW (1) TW201336815A (en)
UA (1) UA116773C2 (en)
WO (1) WO2013126360A2 (en)
ZA (1) ZA201405892B (en)

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US9994522B2 (en) 2014-05-11 2018-06-12 Mapi Pharma Ltd. Amorphous form of apremilast
EP2949645A1 (en) 2014-05-28 2015-12-02 LEK Pharmaceuticals d.d. Processes for the preparation of ß-aminosulfone compounds
CN105622380B (en) * 2014-10-29 2020-06-30 南京安源生物医药科技有限公司 Preparation method of apremilast and intermediate thereof
CN104447445B (en) * 2014-12-05 2016-07-06 新发药业有限公司 A kind of preparation method synthesizing Apremilast intermediate
CN104761474B (en) * 2015-03-11 2016-11-30 中山奕安泰医药科技有限公司 A kind of synthetic method of Apremilast chiral amine intermediates
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CN107922326A (en) * 2015-06-09 2018-04-17 雷迪博士实验室有限公司 The Preparation Method And Their Intermediate of Apremilast
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CN105330586B (en) * 2015-11-27 2017-12-22 东华大学 A kind of preparation method of Apremilast
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CN106866475B (en) * 2015-12-11 2018-03-30 北大方正集团有限公司 A kind of Apremilast intermediate and preparation method thereof
US10774041B2 (en) 2016-04-15 2020-09-15 Davuluri Ramamohan Rao Process for the preparation of apremilast
US10196355B2 (en) 2016-06-20 2019-02-05 Johnson Matthey Public Limited Company Forms of apremilast
CN106543050B (en) * 2016-09-28 2018-04-10 中南大学湘雅医院 Synthetic process of apremilast intermediate
WO2018061034A1 (en) * 2016-09-30 2018-04-05 Sun Pharmaceutical Industries Limited Novel process for the preparation of 1-(3-ethoxy-4-methoxy-phenyl)-2-methylsulfonyl-ethanamine
US11000888B2 (en) 2016-11-10 2021-05-11 Sms Group Gmbh Method for producing a metal strip in a cast-rolling installation
CN107445875A (en) * 2017-03-22 2017-12-08 陕西科技大学 A kind of chiral separation method for being used to prepare the high-purity intermediate of Apremilast
EP3606907B1 (en) 2017-04-04 2021-01-20 Quimica Sintetica, S.A. Racemic beta-aminosulfone compounds
ES2829253T3 (en) 2017-04-04 2021-05-31 Quim Sintetica S A Resolution of racemic beta-aminosulfone compounds
CN108008035B (en) * 2017-11-23 2020-07-07 中山奕安泰医药科技有限公司 Method for detecting purity of 3-ethoxy-4-methoxybenzaldehyde
CN107966509B (en) * 2017-11-23 2020-06-23 中山奕安泰医药科技有限公司 A kind of detection method of (S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl) ethylamine
CN107827722B (en) * 2017-11-23 2021-02-19 中山奕安泰医药科技有限公司 Synthetic method of 3-ethoxy-4-methoxybenzaldehyde
CN107976501B (en) * 2017-11-23 2020-08-25 中山奕安泰医药科技有限公司 A kind of detection method of 1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl) ethylamine
CN107941945B (en) * 2017-11-23 2020-12-22 中山奕安泰医药科技有限公司 A kind of detection method of 3-ethoxy-4-methoxybenzonitrile
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Also Published As

Publication number Publication date
TW201336815A (en) 2013-09-16
SMT202000107T1 (en) 2020-03-13
IL234135A (en) 2017-06-29
US9187417B2 (en) 2015-11-17
CY1122799T1 (en) 2021-05-05
EP3378850A1 (en) 2018-09-26
BR112014020444A2 (en) 2020-10-27
HUE044192T2 (en) 2019-10-28
EP3702347A1 (en) 2020-09-02
US20130217918A1 (en) 2013-08-22
EP3312156A1 (en) 2018-04-25
PL3378850T3 (en) 2020-07-27
US9688623B2 (en) 2017-06-27
NZ628028A (en) 2016-03-31
HRP20200245T1 (en) 2020-05-15
HRP20191249T1 (en) 2019-10-18
ES2675168T3 (en) 2018-07-09
CR20140395A (en) 2014-11-17
PH12014501865A1 (en) 2014-11-17
CN104245668B (en) 2017-05-17
US20160031808A1 (en) 2016-02-04
CO7061071A2 (en) 2014-09-19
EP3702347B1 (en) 2023-11-08
CN104245668A (en) 2014-12-24
SG11201405035XA (en) 2014-09-26
MY168296A (en) 2018-10-23
CA2864517A1 (en) 2013-08-29
ES2971710T3 (en) 2024-06-06
CY1121833T1 (en) 2020-10-14
EP3378850B8 (en) 2020-03-04
EP3378850B1 (en) 2020-01-08
PT3312156T (en) 2019-07-19
JP2015509496A (en) 2015-03-30
PL3312156T3 (en) 2019-10-31
PT3378850T (en) 2020-03-06
US9586897B2 (en) 2017-03-07
IL252459B (en) 2020-03-31
HUE048412T2 (en) 2020-07-28
PH12014501865B1 (en) 2014-11-17
US20170129852A1 (en) 2017-05-11
MX344190B (en) 2016-12-08
KR20140126389A (en) 2014-10-30
WO2013126360A2 (en) 2013-08-29
AR117963A2 (en) 2021-09-08
BR122021020040B1 (en) 2022-05-31
EP3312156B1 (en) 2019-06-05
AR090100A1 (en) 2014-10-22
ES2773686T3 (en) 2020-07-14
IL273050A (en) 2020-04-30
AU2013203283A1 (en) 2013-09-05
KR101993248B1 (en) 2019-06-26
SI3378850T1 (en) 2020-07-31
ES2735801T3 (en) 2019-12-20
BR122021020046B1 (en) 2022-05-31
RU2632875C2 (en) 2017-10-11
TR201910430T4 (en) 2019-08-21
DK3378850T3 (en) 2020-03-16
RS60036B1 (en) 2020-04-30
MX350731B (en) 2017-09-15
EP2817288B1 (en) 2018-05-30
DK3312156T3 (en) 2019-07-22
LT3312156T (en) 2019-08-12
MX2014010002A (en) 2014-09-08
SI3312156T1 (en) 2019-09-30
WO2013126360A3 (en) 2013-10-31
NI201400093A (en) 2016-11-30
CN112812044B (en) 2023-05-30
EP2817288A2 (en) 2014-12-31
HK1205501A1 (en) 2015-12-18
UA116773C2 (en) 2018-05-10
RS59071B1 (en) 2019-09-30
IL252459A0 (en) 2017-07-31
SMT201900397T1 (en) 2019-09-09
RU2014138037A (en) 2016-04-10
ZA201405892B (en) 2015-11-25
CN107033042A (en) 2017-08-11
LT3378850T (en) 2020-04-10
BR112014020444B1 (en) 2021-12-07
CN112812044A (en) 2021-05-18
AU2013203283B2 (en) 2015-11-26

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