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PT3129400T - Animais não humanos que possuem recetores fc-gamma humanizados - Google Patents

Animais não humanos que possuem recetores fc-gamma humanizados

Info

Publication number
PT3129400T
PT3129400T PT157180605T PT15718060T PT3129400T PT 3129400 T PT3129400 T PT 3129400T PT 157180605 T PT157180605 T PT 157180605T PT 15718060 T PT15718060 T PT 15718060T PT 3129400 T PT3129400 T PT 3129400T
Authority
PT
Portugal
Prior art keywords
humanized
human animals
gamma receptors
receptors
gamma
Prior art date
Application number
PT157180605T
Other languages
English (en)
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of PT3129400T publication Critical patent/PT3129400T/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/01—Animal expressing industrially exogenous proteins
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0337—Animal models for infectious diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A01K2267/0387—Animal model for diseases of the immune system
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Environmental Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Husbandry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Electric Clocks (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PT157180605T 2014-04-08 2015-04-08 Animais não humanos que possuem recetores fc-gamma humanizados PT3129400T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201461977037P 2014-04-08 2014-04-08

Publications (1)

Publication Number Publication Date
PT3129400T true PT3129400T (pt) 2020-05-27

Family

ID=52997579

Family Applications (1)

Application Number Title Priority Date Filing Date
PT157180605T PT3129400T (pt) 2014-04-08 2015-04-08 Animais não humanos que possuem recetores fc-gamma humanizados

Country Status (24)

Country Link
US (4) US9474255B2 (pt)
EP (2) EP3693383A1 (pt)
JP (2) JP6652931B2 (pt)
KR (2) KR102439412B1 (pt)
CN (2) CN106163273B (pt)
AU (2) AU2015243865C1 (pt)
CA (1) CA2935472C (pt)
CY (1) CY1123046T1 (pt)
DK (1) DK3129400T3 (pt)
ES (1) ES2794942T3 (pt)
HR (1) HRP20200899T1 (pt)
HU (1) HUE051088T2 (pt)
IL (2) IL246497B (pt)
LT (1) LT3129400T (pt)
MX (1) MX2016013241A (pt)
PH (1) PH12016501341A1 (pt)
PL (1) PL3129400T3 (pt)
PT (1) PT3129400T (pt)
RS (1) RS60398B1 (pt)
RU (2) RU2019128394A (pt)
SG (2) SG11201604886WA (pt)
SI (1) SI3129400T1 (pt)
SM (1) SMT202000332T1 (pt)
WO (1) WO2015157415A1 (pt)

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* Cited by examiner, † Cited by third party
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SG11201604886WA (en) * 2014-04-08 2016-07-28 Regeneron Pharma Non-human animals having humanized fc-gamma receptors
NO2785538T3 (pt) 2014-05-07 2018-08-04
BR112016029650A2 (pt) 2014-06-19 2017-10-24 Regeneron Pharma roedor, polipeptídeo pd-1, célula isolada ou tecido de roedor, célula-tronco embrionária de roedor, métodos de produzir um roedor, de reduzir o crescimento de tumor em um roedor, de matar células tumorais em um roedor e de avaliar as propriedades farmacocinéticas de uma droga que direciona pd-1 humano, e, modelo de tumor de roedor?
MX2017006802A (es) 2014-11-24 2018-01-30 Regeneron Pharma Animales no humanos que expresan el complejo cd3 humanizado.
WO2016089692A1 (en) 2014-12-05 2016-06-09 Regeneron Pharmaceuticals, Inc. Non-human animals having a humanized cluster of differentiation 47 gene
CA2968675C (en) 2014-12-09 2023-10-17 Regeneron Pharmaceuticals, Inc. Non-human animals having a humanized cluster of differentiation 274 gene
US10306874B2 (en) 2015-11-20 2019-06-04 Regeneron Pharmaceuticals, Inc. Non-human animals having a humanized lymphocyte-activation gene 3
EP3422845B1 (en) 2016-02-29 2021-06-02 Regeneron Pharmaceuticals, Inc. Rodents having a humanized tmprss gene
CN116064611A (zh) 2017-11-30 2023-05-05 瑞泽恩制药公司 包含人源化trkb基因座的非人动物
WO2019190990A1 (en) 2018-03-26 2019-10-03 Regeneron Pharmaceuticals, Inc. Humanized rodents for testing therapeutic agents
AU2019308205B2 (en) 2018-07-16 2025-11-06 Regeneron Pharmaceuticals, Inc. Non-human animal models of DITRA disease and uses thereof
CN116848254A (zh) 2020-12-16 2023-10-03 瑞泽恩制药公司 表达人源化Fcα受体的小鼠
CN114410643B (zh) * 2021-02-02 2024-08-02 百奥赛图(北京)医药科技股份有限公司 FcRn基因人源化的非人动物及其构建方法和应用

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FR2807767B1 (fr) 2000-04-12 2005-01-14 Lab Francais Du Fractionnement Anticorps monoclonaux anti-d
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JP2004147535A (ja) 2002-10-29 2004-05-27 Japan Science & Technology Agency ギラン・バレー症候群及び／又はフィッシャー症候群発症モデル非ヒト動物
ATE401787T1 (de) 2002-12-16 2008-08-15 Genentech Inc Menschliches cd20 exprimierende transgene mäuse
FR2858235B1 (fr) 2003-07-31 2006-02-17 Lab Francais Du Fractionnement Utilisation d'anticorps optimises en adcc pour traiter les patients faibles repondeurs
AU2005250408B2 (en) * 2004-05-27 2010-09-23 The Trustees Of The University Of Pennsylvania Novel artificial antigen presenting cells and uses therefor
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US7816082B2 (en) * 2007-03-06 2010-10-19 The Arizona Board Of Regents On Behalf Of The University Of Arizona Methods of identifying pancreatic cancer cells
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JP6444895B2 (ja) 2013-02-20 2018-12-26 リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． ヒト化ｔ細胞補助受容体を発現するマウス
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SG11201604886WA (en) * 2014-04-08 2016-07-28 Regeneron Pharma Non-human animals having humanized fc-gamma receptors

Also Published As

Publication number Publication date
EP3129400B1 (en) 2020-03-25
SG11201604886WA (en) 2016-07-28
MX2016013241A (es) 2017-05-03
KR20210024249A (ko) 2021-03-04
EP3693383A1 (en) 2020-08-12
ES2794942T3 (es) 2020-11-19
AU2020217312C1 (en) 2023-10-26
US20200288684A1 (en) 2020-09-17
CN111690052B (zh) 2024-06-04
IL246497A0 (en) 2016-08-31
RU2019128394A (ru) 2019-10-07
AU2020217312B2 (en) 2023-04-13
CN106163273B (zh) 2020-07-24
AU2015243865B2 (en) 2020-05-14
CN106163273A (zh) 2016-11-23
DK3129400T3 (da) 2020-06-08
RU2016143036A3 (pt) 2018-10-24
US20170086432A1 (en) 2017-03-30
RS60398B1 (sr) 2020-07-31
PL3129400T3 (pl) 2020-09-07
CN111690052A (zh) 2020-09-22
PH12016501341A1 (en) 2016-08-15
US10555507B2 (en) 2020-02-11
KR102439412B1 (ko) 2022-09-02
IL264364A (en) 2019-02-28
AU2015243865A1 (en) 2016-08-18
HRP20200899T1 (hr) 2020-09-04
JP6652931B2 (ja) 2020-02-26
JP6858283B2 (ja) 2021-04-14
US9474255B2 (en) 2016-10-25
SMT202000332T1 (it) 2020-07-08
RU2700484C2 (ru) 2019-09-17
CA2935472A1 (en) 2015-10-15
JP2017510285A (ja) 2017-04-13
HUE051088T2 (hu) 2021-03-01
CA2935472C (en) 2024-02-20
US20150282463A1 (en) 2015-10-08
LT3129400T (lt) 2020-06-25
SI3129400T1 (sl) 2020-07-31
EP3129400A1 (en) 2017-02-15
SG10201908800YA (en) 2019-11-28
CY1123046T1 (el) 2021-10-29
AU2015243865C1 (en) 2020-11-26
RU2016143036A (ru) 2018-05-08
KR20160142309A (ko) 2016-12-12
US20230232795A1 (en) 2023-07-27
IL264364B (en) 2021-03-25
US11503812B2 (en) 2022-11-22
WO2015157415A1 (en) 2015-10-15
KR102223264B1 (ko) 2021-03-09
AU2020217312A1 (en) 2020-08-27
IL246497B (en) 2019-06-30
JP2020062051A (ja) 2020-04-23

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