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MX2016013241A - Animales no humanos que tienen receptores fc gamma humanizados. - Google Patents

Animales no humanos que tienen receptores fc gamma humanizados.

Info

Publication number
MX2016013241A
MX2016013241A MX2016013241A MX2016013241A MX2016013241A MX 2016013241 A MX2016013241 A MX 2016013241A MX 2016013241 A MX2016013241 A MX 2016013241A MX 2016013241 A MX2016013241 A MX 2016013241A MX 2016013241 A MX2016013241 A MX 2016013241A
Authority
MX
Mexico
Prior art keywords
humanized
human animals
gamma receptors
receptors
gamma
Prior art date
Application number
MX2016013241A
Other languages
English (en)
Inventor
J Murphy Andrew
Macdonald Lynn
Tu Naxin
A Meagher Karolina
Curer Cagan
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of MX2016013241A publication Critical patent/MX2016013241A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/01—Animal expressing industrially exogenous proteins
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0337—Animal models for infectious diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A01K2267/0387—Animal model for diseases of the immune system
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Environmental Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Husbandry (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se proporcionan ratones modificados genéticamente y métodos y composiciones para generarlos y usarlos, en donde la modificación genética comprende la humanización de una proteína FcyRl.
MX2016013241A 2014-04-08 2015-04-08 Animales no humanos que tienen receptores fc gamma humanizados. MX2016013241A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461977037P 2014-04-08 2014-04-08
PCT/US2015/024920 WO2015157415A1 (en) 2014-04-08 2015-04-08 Non-human animals having humanized fc-gamma receptors

Publications (1)

Publication Number Publication Date
MX2016013241A true MX2016013241A (es) 2017-05-03

Family

ID=52997579

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016013241A MX2016013241A (es) 2014-04-08 2015-04-08 Animales no humanos que tienen receptores fc gamma humanizados.

Country Status (24)

Country Link
US (4) US9474255B2 (es)
EP (2) EP3693383A1 (es)
JP (2) JP6652931B2 (es)
KR (2) KR102223264B1 (es)
CN (2) CN111690052B (es)
AU (2) AU2015243865C1 (es)
CA (1) CA2935472C (es)
CY (1) CY1123046T1 (es)
DK (1) DK3129400T3 (es)
ES (1) ES2794942T3 (es)
HR (1) HRP20200899T1 (es)
HU (1) HUE051088T2 (es)
IL (2) IL246497B (es)
LT (1) LT3129400T (es)
MX (1) MX2016013241A (es)
PH (1) PH12016501341A1 (es)
PL (1) PL3129400T3 (es)
PT (1) PT3129400T (es)
RS (1) RS60398B1 (es)
RU (2) RU2700484C2 (es)
SG (2) SG11201604886WA (es)
SI (1) SI3129400T1 (es)
SM (1) SMT202000332T1 (es)
WO (1) WO2015157415A1 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102223264B1 (ko) * 2014-04-08 2021-03-09 리제너론 파아마슈티컬스, 인크. 인간화된 Fc-감마 수용체를 갖는 비-인간 동물
NO2785538T3 (es) 2014-05-07 2018-08-04
JP6904707B2 (ja) 2014-06-19 2021-07-21 リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． ヒト化プログラム細胞死１遺伝子を持つ非ヒト動物
US20170164588A1 (en) 2014-11-24 2017-06-15 Regeneron Pharmaceuticals, Inc. Non-human animals expressing humanized cd3 complex
HUE064960T2 (hu) 2014-12-05 2024-04-28 Regeneron Pharma Differenciációs 47 gén humanizált klasztert tartalmazó nem-humán állatok
SI3808775T1 (sl) 2014-12-09 2024-08-30 Regeneron Pharmaceuticals, Inc. Nehumane živali s humaniziranim genom označevalca pripadnosti 274
ES2872799T3 (es) 2015-11-20 2021-11-02 Regeneron Pharma Animales no humanos que tienen un gen 3 de activación linfocitaria humanizado
EP3422845B1 (en) 2016-02-29 2021-06-02 Regeneron Pharmaceuticals, Inc. Rodents having a humanized tmprss gene
CN116064611A (zh) 2017-11-30 2023-05-05 瑞泽恩制药公司 包含人源化trkb基因座的非人动物
KR20210004994A (ko) * 2018-03-26 2021-01-13 리제너론 파마슈티칼스 인코포레이티드 치료제를 시험하기 위한 인간화된 설치류
IL315703A (en) 2018-07-16 2024-11-01 Regeneron Pharma Non-human animal models of DITRA disease and their uses
AU2021400584A1 (en) 2020-12-16 2023-06-29 Regeneron Pharmaceuticals, Inc. Mice expressing humanized fc alpha receptors
US20240081301A1 (en) * 2021-02-02 2024-03-14 Biocytogen Pharmaceuticals (Beijing) Co., Ltd. Genetically modified non-human animal with human or chimeric fcrn

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3740089A (en) 1988-05-27 1989-12-12 Schering Biotech Corporation Human fc-gamma receptor iii
WO1994006908A1 (en) 1992-09-11 1994-03-31 The Regents Of The University Of California Transgenic non-human animals having targeted lymphocyte transduction genes
US5877396A (en) 1993-04-23 1999-03-02 Sloan Kettering Institute For Cancer Research Mice mutant for functional Fc receptors and method of treating autoimmune diseases
US6111166A (en) * 1994-09-19 2000-08-29 Medarex, Incorporated Transgenic mice expressing human Fcα and β receptors
US6676927B1 (en) 1999-01-20 2004-01-13 The Rockefeller University Animal model and methods for its use in the selection of cytotoxic antibodies
FR2807767B1 (fr) 2000-04-12 2005-01-14 Lab Francais Du Fractionnement Anticorps monoclonaux anti-d
WO2002066618A1 (en) * 2001-02-20 2002-08-29 University Of Georgia Research Foundation, Inc. Rapid production of monoclonal antibodies
FR2822161B1 (fr) 2001-03-15 2003-09-19 Genoway Cellule et animal transgenique modelisant les reponses humaines allergiques mediees par les ige, et leurs utilisations
GB0110029D0 (en) * 2001-04-24 2001-06-13 Grosveld Frank Transgenic animal
JP4653915B2 (ja) 2001-10-29 2011-03-16 独立行政法人科学技術振興機構 全身性エリテマトーデスモデル非ヒト動物
US6911321B2 (en) * 2001-12-19 2005-06-28 Genentech, Inc. Non-human primate Fc receptors and methods of use
WO2003104459A1 (en) 2002-06-07 2003-12-18 Arthron Limited Fcyriia transgenic animal model for autoimmune disease
JP2004147535A (ja) 2002-10-29 2004-05-27 Japan Science & Technology Agency ギラン・バレー症候群及び／又はフィッシャー症候群発症モデル非ヒト動物
EP1573314B1 (en) 2002-12-16 2008-07-23 Genentech, Inc. Transgenic mice expressing human cd20
FR2858235B1 (fr) 2003-07-31 2006-02-17 Lab Francais Du Fractionnement Utilisation d'anticorps optimises en adcc pour traiter les patients faibles repondeurs
ES2653570T3 (es) * 2004-05-27 2018-02-07 The Trustees Of The University Of Pennsylvania Células presentadoras de antígeno artificiales novedosas y usos de las mismas
WO2006039418A2 (en) * 2004-09-30 2006-04-13 Medarex, Inc. Human monoclonal antibodies to fc gamma receptor ii (cd32)
JP2009529331A (ja) 2006-03-10 2009-08-20 マクロジェニクス，インコーポレーテッド 変異型重鎖を有する抗体の同定および工学的改変ならびにその使用方法
US20080003225A1 (en) 2006-06-29 2008-01-03 Henri Vie Method for enhancing the antibody-dependent cellular cytotoxicity (ADCC) and uses of T cells expressing CD16 receptors
DE602008006041D1 (de) * 2007-01-30 2011-05-19 Forerunner Pharma Res Co Ltd CHIMÄRER Fc GAMMA REZEPTOR UND VERFAHREN ZUR BESTIMMUNG VON ADCC-AKTIVITÄT UNTER VERWENDUNG DES REZEPTORS
US7816082B2 (en) * 2007-03-06 2010-10-19 The Arizona Board Of Regents On Behalf Of The University Of Arizona Methods of identifying pancreatic cancer cells
CA2725169A1 (en) * 2008-05-23 2009-11-26 Aliva Biopharmaceuticals, Inc. Method of generating single vl domain antibodies in transgenic animals
WO2009158696A1 (en) 2008-06-27 2009-12-30 Zymogenetics, Inc. SOLUBLE HYBRID Fcγ RECEPTORS AND RELATED METHODS
RU2425880C2 (ru) * 2009-07-30 2011-08-10 Учреждение Российской академии наук Институт общей генетики им. Н.И. Вавилова РАН Способ получения трансгенных мышей
EP2509409B1 (en) * 2009-12-10 2016-07-27 Regeneron Pharmaceuticals, Inc. Mice that make heavy chain antibodies
EP3498730A1 (en) 2009-12-21 2019-06-19 Regeneron Pharmaceuticals, Inc. Humanized fc gamma r mice
CA2850387A1 (en) 2011-10-28 2013-05-02 Regeneron Pharmaceuticals, Inc. Genetically modified major histocompatibility complex mice
SI3590332T1 (sl) 2011-10-28 2022-07-29 Regeneron Pharamaceuticals, Inc. Gensko modificirane miši, ki izražajo himerne molekule poglavitnega histokompatibilnostnega kompleksa (MHC) II
MY172726A (en) 2011-10-28 2019-12-11 Regeneron Pharma Humanized il-6 and il-6 receptor
IL311744B1 (en) 2012-11-05 2025-06-01 Regeneron Pharma Genetically modified non-human animals and methods of using them
CA2900832A1 (en) 2013-02-20 2014-08-28 Regeneron Pharmaceuticals, Inc. Mice expressing humanized t-cell co-receptors
CN105164154B (zh) 2013-02-22 2019-06-07 瑞泽恩制药公司 表达人源化主要组织相容性复合物的小鼠
PL3434101T3 (pl) 2013-09-23 2024-02-19 Regeneron Pharmaceuticals, Inc. Zwierzęta inne niż ludzie posiadające humanizowany gen białka regulacji sygnału
EP3071024B1 (en) 2013-11-19 2018-09-05 Regeneron Pharmaceuticals, Inc. Non-human animals having a humanized b-cell activating factor gene
RU2671101C1 (ru) 2013-11-19 2018-10-29 Регенерон Фармасьютикалс, Инк. Отличные от человека животные, содержащие гуманизированный ген индуцирующего пролиферацию лиганда
KR102223264B1 (ko) * 2014-04-08 2021-03-09 리제너론 파아마슈티컬스, 인크. 인간화된 Fc-감마 수용체를 갖는 비-인간 동물

Also Published As

Publication number Publication date
EP3129400B1 (en) 2020-03-25
SG10201908800YA (en) 2019-11-28
US9474255B2 (en) 2016-10-25
LT3129400T (lt) 2020-06-25
IL264364A (en) 2019-02-28
US10555507B2 (en) 2020-02-11
KR102223264B1 (ko) 2021-03-09
SMT202000332T1 (it) 2020-07-08
US20150282463A1 (en) 2015-10-08
KR102439412B1 (ko) 2022-09-02
AU2020217312C1 (en) 2023-10-26
US11503812B2 (en) 2022-11-22
AU2020217312A1 (en) 2020-08-27
CA2935472C (en) 2024-02-20
HRP20200899T1 (hr) 2020-09-04
PL3129400T3 (pl) 2020-09-07
RU2019128394A (ru) 2019-10-07
SG11201604886WA (en) 2016-07-28
EP3129400A1 (en) 2017-02-15
CN106163273B (zh) 2020-07-24
AU2020217312B2 (en) 2023-04-13
RU2016143036A3 (es) 2018-10-24
AU2015243865C1 (en) 2020-11-26
US20170086432A1 (en) 2017-03-30
AU2015243865B2 (en) 2020-05-14
SI3129400T1 (sl) 2020-07-31
AU2015243865A1 (en) 2016-08-18
CN111690052B (zh) 2024-06-04
KR20160142309A (ko) 2016-12-12
CN111690052A (zh) 2020-09-22
RU2700484C2 (ru) 2019-09-17
PT3129400T (pt) 2020-05-27
IL264364B (en) 2021-03-25
RU2016143036A (ru) 2018-05-08
JP6858283B2 (ja) 2021-04-14
IL246497B (en) 2019-06-30
KR20210024249A (ko) 2021-03-04
JP6652931B2 (ja) 2020-02-26
ES2794942T3 (es) 2020-11-19
CN106163273A (zh) 2016-11-23
IL246497A0 (en) 2016-08-31
CA2935472A1 (en) 2015-10-15
EP3693383A1 (en) 2020-08-12
JP2017510285A (ja) 2017-04-13
WO2015157415A1 (en) 2015-10-15
PH12016501341A1 (en) 2016-08-15
RS60398B1 (sr) 2020-07-31
HUE051088T2 (hu) 2021-03-01
JP2020062051A (ja) 2020-04-23
US20200288684A1 (en) 2020-09-17
CY1123046T1 (el) 2021-10-29
US20230232795A1 (en) 2023-07-27
DK3129400T3 (da) 2020-06-08

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