PT2793865T - Composições farmacêuticas de microsferas de triptorrelina - Google Patents

Composições farmacêuticas de microsferas de triptorrelina

Info

Publication number: PT2793865T
Authority: PT; Portugal
Prior art keywords: pharmaceutical compositions; triptorelin microspheres; triptorelin; microspheres; pharmaceutical
Prior art date: 2011-12-22

Application number

PT128607017T

Other languages

English (en)

Inventor

Sun Kaoxiang

Song Tao

Wang Qilin

Han Jie

Wang Tao

Han Jiangbin

Zhang Jianzhao

Wang Shujiang

Original Assignee

Shandong luye pharmaceutical co ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2011-12-22

Filing date

2012-12-18

Publication date

2018-03-19

2012-12-18 Application filed by Shandong luye pharmaceutical co ltd filed Critical Shandong luye pharmaceutical co ltd

2018-03-19 Publication of PT2793865T publication Critical patent/PT2793865T/pt

Links

108010050144 Triptorelin Pamoate Proteins 0.000 title 1
239000004005 microsphere Substances 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
VXKHXGOKWPXYNA-PGBVPBMZSA-N triptorelin Chemical group C([C@@H](C(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 VXKHXGOKWPXYNA-PGBVPBMZSA-N 0.000 title 1
229960004824 triptorelin Drugs 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
- A61P5/04—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Immunology (AREA)
Dermatology (AREA)
Zoology (AREA)
Pregnancy & Childbirth (AREA)
Gynecology & Obstetrics (AREA)
Diabetes (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Biophysics (AREA)
Molecular Biology (AREA)

PT128607017T 2011-12-22 2012-12-18 Composições farmacêuticas de microsferas de triptorrelina PT2793865T (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CN201110435894		2011-12-22

Publications (1)

Publication Number	Publication Date
PT2793865T true PT2793865T (pt)	2018-03-19

Family

ID=48667698

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT128607017T PT2793865T (pt)	2011-12-22	2012-12-18	Composições farmacêuticas de microsferas de triptorrelina

Country Status (8)

Country	Link
US (1)	US20140356442A1 (pt)
EP (1)	EP2793865B1 (pt)
CN (1)	CN104010629B (pt)
ES (1)	ES2662927T3 (pt)
HU (1)	HUE037678T2 (pt)
PL (1)	PL2793865T3 (pt)
PT (1)	PT2793865T (pt)
WO (1)	WO2013091283A1 (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN104523605A (zh) *	2014-12-30	2015-04-22	北京博恩特药业有限公司	一种曲普瑞林微球及其制备方法与应用
CN105169366B (zh) *	2015-08-19	2018-05-22	丽珠医药集团股份有限公司	一种醋酸曲普瑞林缓释微球的制备方法
CN110859811B (zh) *	2019-12-05	2021-12-07	北京博恩特药业有限公司	药物缓释组合物及制备方法
CN112156170B (zh) *	2020-11-03	2022-10-21	北京康欣东弘医药科技有限公司	可供皮下注射的曲普瑞林缓释微球及其制备方法和用途
CN112675132B (zh) *	2020-12-28	2022-06-21	浙江圣兆药物科技股份有限公司	一种窄粒径分布的曲普瑞林微球的制备方法
CN116327712A (zh) *	2023-03-30	2023-06-27	北京博恩特药业有限公司	一种醋酸曲普瑞林缓释微球及其制备方法
WO2025017533A1 (en) *	2023-07-20	2025-01-23	Ferring B.V.	Extended release drug-loaded microparticles
CN118001259B (zh) *	2024-02-06	2024-09-20	上海万良诚科医药科技有限公司	曲普瑞林口颊膜及其制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2270320A1 (en) *	1998-04-28	1999-10-28	Patricia Lee Brubaker	Novel microsphere composition
CN1194688C (zh) *	2001-07-03	2005-03-30	山东绿叶制药股份有限公司	石杉碱甲及其衍生物或其盐的注射用缓释微球及其制备方法
KR20040066548A (ko) *	2003-01-20	2004-07-27	코오롱제약주식회사	생리활성펩타이드의 국소투여용 서방성 마이크로스피어 및그 제조방법
KR100466637B1 (ko) *	2003-06-26	2005-01-13	주식회사 펩트론	서방성 미립구의 혼합 제형을 연속한 단일 공정으로제조하는 방법
CN1876173A (zh) *	2005-06-06	2006-12-13	中国人民解放军军事医学科学院毒物药物研究所	胸腺五肽注射用缓释微球制剂及其制备方法
CN101627966A (zh) *	2008-07-17	2010-01-20	蚌埠丰原医药科技发展有限公司	丙氨瑞林缓释微球注射剂的制备方法
CN102048699B (zh) *	2009-11-03	2012-11-07	长春金赛药业有限责任公司	一种注射用醋酸曲普瑞林的缓释微球的制备方法

2012
- 2012-12-18 CN CN201280059665.9A patent/CN104010629B/zh active Active
- 2012-12-18 WO PCT/CN2012/001712 patent/WO2013091283A1/en active Application Filing
- 2012-12-18 US US14/367,096 patent/US20140356442A1/en not_active Abandoned
- 2012-12-18 ES ES12860701.7T patent/ES2662927T3/es active Active
- 2012-12-18 PT PT128607017T patent/PT2793865T/pt unknown
- 2012-12-18 PL PL12860701T patent/PL2793865T3/pl unknown
- 2012-12-18 HU HUE12860701A patent/HUE037678T2/hu unknown
- 2012-12-18 EP EP12860701.7A patent/EP2793865B1/en active Active

Also Published As

Publication number	Publication date
CN104010629A (zh)	2014-08-27
CN104010629B (zh)	2015-07-08
HUE037678T2 (hu)	2018-09-28
EP2793865A4 (en)	2015-06-17
US20140356442A1 (en)	2014-12-04
PL2793865T3 (pl)	2018-07-31
ES2662927T3 (es)	2018-04-10
EP2793865B1 (en)	2018-01-31
EP2793865A1 (en)	2014-10-29
WO2013091283A1 (en)	2013-06-27

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