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PT1418228E - Processo de preparacao de uma biblioteca multicombinatoria de vectores de expressao de genes de anticorpos. - Google Patents

Processo de preparacao de uma biblioteca multicombinatoria de vectores de expressao de genes de anticorpos.

Info

Publication number
PT1418228E
PT1418228E PT03028476T PT03028476T PT1418228E PT 1418228 E PT1418228 E PT 1418228E PT 03028476 T PT03028476 T PT 03028476T PT 03028476 T PT03028476 T PT 03028476T PT 1418228 E PT1418228 E PT 1418228E
Authority
PT
Portugal
Prior art keywords
multicombinator
genes
antibodies
library
vectors
Prior art date
Application number
PT03028476T
Other languages
English (en)
Inventor
Kanti Jain
Albert L Rubin
Original Assignee
Rogosin Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rogosin Inst filed Critical Rogosin Inst
Publication of PT1418228E publication Critical patent/PT1418228E/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/39—Pancreas; Islets of Langerhans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1658—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/04—Enzymes or microbial cells immobilised on or in an organic carrier entrapped within the carrier, e.g. gel or hollow fibres
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0012—Cell encapsulation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0676—Pancreatic cells
    • C12N5/0677—Three-dimensional culture, tissue culture or organ culture; Encapsulated cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/126—Immunoprotecting barriers, e.g. jackets, diffusion chambers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/54—Collagen; Gelatin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/70—Polysaccharides
    • C12N2533/76—Agarose, agar-agar

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Endocrinology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dispersion Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
PT03028476T 1994-01-13 1995-01-12 Processo de preparacao de uma biblioteca multicombinatoria de vectores de expressao de genes de anticorpos. PT1418228E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US18126994A 1994-01-13 1994-01-13

Publications (1)

Publication Number Publication Date
PT1418228E true PT1418228E (pt) 2006-09-29

Family

ID=22663563

Family Applications (3)

Application Number Title Priority Date Filing Date
PT95906814T PT742818E (pt) 1994-01-13 1995-01-12 Celulas secretoras macroencapsuladas
PT06004970T PT1666585E (pt) 1994-01-13 1995-01-12 Células secretoras macroencapsuladas
PT03028476T PT1418228E (pt) 1994-01-13 1995-01-12 Processo de preparacao de uma biblioteca multicombinatoria de vectores de expressao de genes de anticorpos.

Family Applications Before (2)

Application Number Title Priority Date Filing Date
PT95906814T PT742818E (pt) 1994-01-13 1995-01-12 Celulas secretoras macroencapsuladas
PT06004970T PT1666585E (pt) 1994-01-13 1995-01-12 Células secretoras macroencapsuladas

Country Status (18)

Country Link
US (3) US5643569A (pt)
EP (3) EP1666585B1 (pt)
JP (4) JP3948742B2 (pt)
KR (1) KR100474803B1 (pt)
CN (1) CN1087779C (pt)
AT (3) ATE408005T1 (pt)
AU (1) AU681240C (pt)
CA (1) CA2181156C (pt)
DE (3) DE69533437T2 (pt)
DK (2) DK1666585T3 (pt)
ES (3) ES2227544T3 (pt)
FI (1) FI118853B (pt)
IL (1) IL112330A (pt)
NO (2) NO323228B1 (pt)
NZ (3) NZ509363A (pt)
PT (3) PT742818E (pt)
RU (2) RU2177503C2 (pt)
WO (1) WO1995019430A1 (pt)

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JPH11508477A (ja) * 1996-02-23 1999-07-27 サーシ・バイオメディカル・インコーポレーテッド 新規の人工膵臓
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Also Published As

Publication number Publication date
DE69533437T2 (de) 2005-09-15
JP4435134B2 (ja) 2010-03-17
NZ329619A (en) 1999-09-29
IL112330A (en) 1999-01-26
WO1995019430A1 (en) 1995-07-20
NO962955D0 (no) 1996-07-15
KR20050005235A (ko) 2005-01-13
DE69534865T2 (de) 2006-08-17
KR100474803B1 (ko) 2005-03-10
DK1666585T3 (da) 2009-01-12
ATE408005T1 (de) 2008-09-15
NZ509363A (en) 2006-02-24
USRE38027E1 (en) 2003-03-11
ES2309849T3 (es) 2008-12-16
NO324570B1 (no) 2007-11-26
IL112330A0 (en) 1995-03-30
JP3989492B2 (ja) 2007-10-10
NO962955L (no) 1996-09-11
USRE40555E1 (en) 2008-10-28
DE69534865D1 (de) 2006-05-11
ATE320482T1 (de) 2006-04-15
PT1666585E (pt) 2008-12-10
EP0742818A1 (en) 1996-11-20
MX9602765A (es) 1998-06-30
EP1418228A1 (en) 2004-05-12
FI118853B (fi) 2008-04-15
DE69535842D1 (de) 2008-10-23
JPH09510868A (ja) 1997-11-04
US5643569A (en) 1997-07-01
NO323228B1 (no) 2007-02-05
JP2007020585A (ja) 2007-02-01
FI962841L (fi) 1996-09-12
HK1084693A1 (en) 2006-08-04
JP2005137376A (ja) 2005-06-02
AU681240B2 (en) 1997-08-21
DK1418228T3 (da) 2006-07-17
ES2227544T3 (es) 2005-04-01
EP1418228B1 (en) 2006-03-15
PT742818E (pt) 2004-12-31
EP1666585B1 (en) 2008-09-10
EP1666585A1 (en) 2006-06-07
AU1526795A (en) 1995-08-01
AU681240C (en) 2006-12-07
JP3948742B2 (ja) 2007-07-25
CN1087779C (zh) 2002-07-17
CA2181156A1 (en) 1995-07-20
DE69533437D1 (de) 2004-10-07
EP0742818A4 (en) 2002-01-09
JP2006345875A (ja) 2006-12-28
ES2260568T3 (es) 2006-11-01
EP0742818B1 (en) 2004-09-01
CA2181156C (en) 2001-10-16
RU2208636C2 (ru) 2003-07-20
NZ278809A (en) 1998-03-25
NO20051359L (no) 1996-09-11
RU2177503C2 (ru) 2001-12-27
FI962841A0 (fi) 1996-07-12
CN1141650A (zh) 1997-01-29
ATE275194T1 (de) 2004-09-15

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