PT1086223E - Novos antigénios transmembranares em serpentina expressos em cancros humanos e suas utilizações - Google Patents
Novos antigénios transmembranares em serpentina expressos em cancros humanos e suas utilizações Download PDFInfo
- Publication number
- PT1086223E PT1086223E PT99955273T PT99955273T PT1086223E PT 1086223 E PT1086223 E PT 1086223E PT 99955273 T PT99955273 T PT 99955273T PT 99955273 T PT99955273 T PT 99955273T PT 1086223 E PT1086223 E PT 1086223E
- Authority
- PT
- Portugal
- Prior art keywords
- strap
- family
- prostate
- human
- expressed
- Prior art date
Links
- WYTGDNHDOZPMIW-RCBQFDQVSA-N alstonine Natural products C1=CC2=C3C=CC=CC3=NC2=C2N1C[C@H]1[C@H](C)OC=C(C(=O)OC)[C@H]1C2 WYTGDNHDOZPMIW-RCBQFDQVSA-N 0.000 title abstract 4
- 239000000427 antigen Substances 0.000 title abstract 3
- 102000036639 antigens Human genes 0.000 title abstract 3
- 108091007433 antigens Proteins 0.000 title abstract 3
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 101000642661 Homo sapiens Serine-threonine kinase receptor-associated protein Proteins 0.000 abstract 4
- 102000004169 proteins and genes Human genes 0.000 abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- 101000700752 Homo sapiens Serum response factor-binding protein 1 Proteins 0.000 abstract 2
- 206010060862 Prostate cancer Diseases 0.000 abstract 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 abstract 2
- 102100029282 Serum response factor-binding protein 1 Human genes 0.000 abstract 2
- 102000045678 human STRAP Human genes 0.000 abstract 2
- 230000003834 intracellular effect Effects 0.000 abstract 2
- 210000002307 prostate Anatomy 0.000 abstract 2
- 108090000144 Human Proteins Proteins 0.000 abstract 1
- 102000003839 Human Proteins Human genes 0.000 abstract 1
- 108010052285 Membrane Proteins Proteins 0.000 abstract 1
- 102000018697 Membrane Proteins Human genes 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 210000005267 prostate cell Anatomy 0.000 abstract 1
- 210000001519 tissue Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
- C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
- Y10T436/143333—Saccharide [e.g., DNA, etc.]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Cell Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Pregnancy & Childbirth (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Compounds Of Unknown Constitution (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8752098P | 1998-06-01 | 1998-06-01 | |
| US9118398P | 1998-06-30 | 1998-06-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1086223E true PT1086223E (pt) | 2009-11-03 |
Family
ID=26777066
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT99955273T PT1086223E (pt) | 1998-06-01 | 1999-06-01 | Novos antigénios transmembranares em serpentina expressos em cancros humanos e suas utilizações |
Country Status (13)
| Country | Link |
|---|---|
| US (10) | US6329503B1 (pt) |
| EP (2) | EP2080802B1 (pt) |
| JP (5) | JP4855577B2 (pt) |
| AT (1) | ATE437947T1 (pt) |
| AU (1) | AU757698C (pt) |
| CA (1) | CA2328989C (pt) |
| CY (1) | CY1109509T1 (pt) |
| DE (1) | DE69941187D1 (pt) |
| DK (1) | DK1086223T3 (pt) |
| ES (2) | ES2629442T3 (pt) |
| IL (2) | IL139699A0 (pt) |
| PT (1) | PT1086223E (pt) |
| WO (1) | WO1999062941A2 (pt) |
Families Citing this family (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6136311A (en) | 1996-05-06 | 2000-10-24 | Cornell Research Foundation, Inc. | Treatment and diagnosis of cancer |
| US20020187472A1 (en) * | 2001-03-09 | 2002-12-12 | Preeti Lal | Steap-related protein |
| US20040048798A1 (en) * | 1999-06-01 | 2004-03-11 | Raitano Arthur B. | Nucleic acid and corresponding protein entitle 98P4B6 useful in treatment and detection of cancer |
| US6833438B1 (en) | 1999-06-01 | 2004-12-21 | Agensys, Inc. | Serpentine transmembrane antigens expressed in human cancers and uses thereof |
| US20060052321A1 (en) * | 2002-04-05 | 2006-03-09 | Raitano Arthur B | Nucleic acid and corresponding protein entitled 98P4B6 useful in treatment and detection of cancer |
| PT1086223E (pt) | 1998-06-01 | 2009-11-03 | Agensys Inc | Novos antigénios transmembranares em serpentina expressos em cancros humanos e suas utilizações |
| US20040141975A1 (en) | 1998-06-01 | 2004-07-22 | Raitano Arthur B. | Nucleic acid and corresponding protein entitled 98P4B6 useful in treatment and detection of cancer |
| US20030149531A1 (en) * | 2000-12-06 | 2003-08-07 | Hubert Rene S. | Serpentine transmembrane antigens expressed in human cancers and uses thereof |
| US6902892B1 (en) | 1998-10-19 | 2005-06-07 | Diadexus, Inc. | Method of diagnosing, monitoring, staging, imaging and treating prostate cancer |
| AU5416700A (en) * | 1999-05-20 | 2000-12-12 | Fahri Saatcioglu | Differentially expressed genes in prostate cancer |
| AU775366B2 (en) * | 1999-12-06 | 2004-07-29 | Agensys, Inc. | Serpentine transmembrane antigens expressed in human cancers and uses thereof |
| AU2001236807A1 (en) * | 2000-02-10 | 2001-08-20 | Abbott Laboratories | Antibodies that bind human interleukin-18 and methods of making and using |
| US7611892B2 (en) | 2000-03-24 | 2009-11-03 | President And Fellows Of Harvard College | Prostate-specific or testis-specific nucleic acid molecules, polypeptides, and diagnostic and therapeutic methods |
| US7189565B2 (en) | 2001-03-23 | 2007-03-13 | Fahri Saatcioglu | Prostate-specific or testis-specific nucleic acid molecules, polypeptides, and diagnostic and therapeutic methods |
| AU2001249411B2 (en) * | 2000-03-24 | 2007-02-15 | Fahri Saatcioglu | Novel prostate-specific or testis-specific nucleic acid molecules, polypeptides,and diagnostic and therapeutic methods |
| ES2320421T3 (es) | 2001-01-17 | 2009-05-22 | Intreat Pty Limited | Anticuerpos para el diagnostico de un receptor p2x7 no funcional y el tratamiento de canceres y otras afecciones. |
| US20030194798A1 (en) | 2001-05-24 | 2003-10-16 | Surber Mark W. | Minicell compositions and methods |
| US7494646B2 (en) * | 2001-09-06 | 2009-02-24 | Agensys, Inc. | Antibodies and molecules derived therefrom that bind to STEAP-1 proteins |
| JP2005505271A (ja) * | 2001-09-06 | 2005-02-24 | アジェンシス， インコーポレイテッド | 癌の処置および検出において有用なｓｔｅａｐ−１と名称が与えられる核酸および対応するタンパク質 |
| WO2003053357A2 (en) * | 2001-12-19 | 2003-07-03 | Wilk Patent Development Corporation | Method and related composition employing nanostructures |
| CA2517027A1 (en) | 2002-02-25 | 2003-09-04 | Vaxiion Therapeutics, Inc. | Minicell compositions and methods |
| US7906620B2 (en) * | 2002-08-16 | 2011-03-15 | Yeda Research And Development Co. Ltd. | Tumor associated antigen, peptides thereof, and use of same as anti-tumor vaccines |
| JP5840351B2 (ja) * | 2002-09-06 | 2016-01-06 | アジェンシス，インコーポレイテッド | 癌の処置および検出において有用な９８ｐ４ｂ６と称される、核酸および対応タンパク質 |
| PT1725249E (pt) * | 2003-11-06 | 2014-04-10 | Seattle Genetics Inc | Compostos de monometilvalina capazes de conjugação a ligandos |
| SI1742966T1 (sl) * | 2004-04-22 | 2014-03-31 | Agensys, Inc. | Protitelesa in iz njih izvedene molekule, ki se veĹľejo na STEAP-1 proteine |
| JP2009516757A (ja) * | 2005-10-21 | 2009-04-23 | メディバス エルエルシー | ポリ（エステルウレア）ポリマーおよび使用法 |
| CA2646329C (en) | 2006-03-20 | 2018-07-03 | The Regents Of The University Of California | Engineered anti-prostate stem cell antigen (psca) antibodies for cancer targeting |
| WO2008043145A1 (en) * | 2006-10-10 | 2008-04-17 | Biosceptre International Limited | Hybridomas producing antibodies against non functional p2x7 receptor |
| WO2008043146A1 (en) * | 2006-10-10 | 2008-04-17 | Biosceptre International Limited | Antibodies against non functional p2x7 receptor |
| ES2636089T3 (es) | 2006-10-27 | 2017-10-05 | Genentech, Inc. | Anticuerpos e inmunoconjugados y usos para los mismos |
| CN111499748A (zh) | 2007-07-16 | 2020-08-07 | 健泰科生物技术公司 | 抗cd79b抗体和免疫偶联物及使用方法 |
| NZ583318A (en) | 2007-07-16 | 2012-07-27 | Genentech Inc | Humanized anti-cd79b antibodies and immunoconjugates and methods of use |
| EP3388086B1 (en) | 2007-08-17 | 2020-10-07 | Purdue Research Foundation | Psma binding ligand-linker conjugates and methods for using |
| JP6126773B2 (ja) | 2007-09-04 | 2017-05-10 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 癌のターゲッティングおよび検出のための高親和性抗前立腺幹細胞抗原（ｐｓｃａ）抗体 |
| US8293491B2 (en) | 2007-09-14 | 2012-10-23 | Biosceptre International Limited | Purinergic (P2X) receptors in extra-cellular body fluid |
| AU2008299593B2 (en) | 2007-09-14 | 2013-04-18 | Biosceptre International Limited | Novel P2X7 epitopes |
| EP2740490A1 (en) * | 2007-10-03 | 2014-06-11 | Cornell University | Treatment of proliferative disorders using antibodies to PSMA |
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| NZ590146A (en) | 2008-07-04 | 2012-09-28 | Biosceptre Int Ltd | Antibodies which bind an epitope comprising two different monomers of the P2X7 receptor |
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| EP2966090B1 (en) | 2009-08-20 | 2018-10-10 | Biosceptre (Aust) Pty Ltd | Anti p2x7 receptor antibodies and fragments thereof |
| RU2673908C2 (ru) | 2009-12-02 | 2018-12-03 | Имэджинэб, Инк. | Мини-антитела j591 и цис-диатела для направленной доставки простата-специфичного мембранного антигена (psma) человека и способы их применения |
| ES2667003T3 (es) | 2009-12-24 | 2018-05-09 | Biosceptre (Aust) Pty Ltd | Anticuerpos para receptores P2X7 oligoméricos no funcionales |
| US9951324B2 (en) | 2010-02-25 | 2018-04-24 | Purdue Research Foundation | PSMA binding ligand-linker conjugates and methods for using |
| SG185430A1 (en) | 2010-06-03 | 2012-12-28 | Genentech Inc | Immuno-pet imaging of antibodies and immunoconjugates and uses therefor |
| ES2656971T3 (es) | 2010-09-10 | 2018-03-01 | Biosceptre (Aust) Pty Ltd | Tratamientos para el cáncer en animales de compañía con un anticuerpo anti P2X7 |
| WO2012057765A1 (en) | 2010-10-28 | 2012-05-03 | The Board Of Regents Of The University Of Texas System | Recombinant anti-cd19 monoclonal antibodies |
| AU2015261742B2 (en) * | 2010-11-12 | 2017-10-26 | Inovio Pharmaceuticals, Inc. | Consensus prostate antigens nucleic acid molecule encoding the same and vaccine and uses comprising the same |
| EP2638055B1 (en) * | 2010-11-12 | 2019-01-09 | The Trustees Of The University Of Pennsylvania | Consensus prostate antigens nucleic acid molecule encoding the same and vaccine and uses comprising the same |
| EP2675474B1 (en) | 2011-02-15 | 2019-01-16 | Vaxiion Therapeutics, LLC | Therapeutic compositions and methods for antibody and fc-containing targeting molecule-based targeted delivery of bioactive molecules by bacterial minicells |
| EP2726095B1 (en) | 2011-07-01 | 2018-06-06 | Biosceptre (Aust) Pty Ltd | Combination therapy |
| JP6219304B2 (ja) | 2011-11-29 | 2017-10-25 | ジェネンテック， インコーポレイテッド | 前立腺癌分析のための組成物及び方法 |
| KR20150104092A (ko) | 2012-11-15 | 2015-09-14 | 엔도사이트, 인코포레이티드 | Psma 발현 세포에 의해 야기되는 질병을 치료하기 위한 컨쥬게이트 |
| JP2016516804A (ja) | 2013-04-17 | 2016-06-09 | ファイザー・インク | 心血管疾患を治療するためのｎ−ピペリジン−３−イルベンズアミド誘導体 |
| KR101782623B1 (ko) | 2013-07-10 | 2017-09-28 | 서울대학교산학협력단 | 복합 막횡단 단백질의 세포막외 펩타이드 항원 및 그의 용도 |
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| RS60349B8 (sr) | 2014-09-23 | 2022-10-31 | Hoffmann La Roche | Postupak upotrebe anti-cd79b imunokonjugata |
| US10188759B2 (en) | 2015-01-07 | 2019-01-29 | Endocyte, Inc. | Conjugates for imaging |
| HK1255483A1 (zh) | 2015-06-15 | 2019-08-16 | 基因泰克公司 | 抗体和免疫结合物 |
| JP7026613B2 (ja) | 2015-08-07 | 2022-02-28 | イマジナブ・インコーポレーテッド | 標的分子に対する抗原結合コンストラクト |
| WO2017106806A1 (en) | 2015-12-18 | 2017-06-22 | Federica Cavallo | COMPOSITIONS AND METHODS RELATED TO xCT PEPTIDES |
| EA201990781A9 (ru) * | 2016-09-23 | 2019-11-27 | Анти-steap2 антитела, конъюгаты антитело-лекарственное средство и биспецифические антигенсвязывающие молекулы, которые связывают steap2 и cd3, и их применение | |
| MA46952A (fr) | 2016-12-01 | 2019-10-09 | Regeneron Pharma | Anticorps anti-pd-l1 radiomarqués pour imagerie immuno-pet |
| US11266745B2 (en) | 2017-02-08 | 2022-03-08 | Imaginab, Inc. | Extension sequences for diabodies |
| AU2018247767B2 (en) * | 2017-04-03 | 2025-01-30 | F. Hoffmann-La Roche Ag | Antibodies binding to STEAP-1 |
| WO2018204278A1 (en) | 2017-05-01 | 2018-11-08 | Agilvax, Inc. | COMPOSITIONS AND METHODS RELATED TO xCT ANTIBODIES |
| CN110809583A (zh) | 2017-06-07 | 2020-02-18 | 瑞泽恩制药公司 | 用于内化酶的组合物和方法 |
| US12208102B2 (en) | 2018-04-17 | 2025-01-28 | Endocyte, Inc. | Methods of treating cancer |
| CA3100021A1 (en) | 2018-05-17 | 2019-11-21 | Regeneron Pharmaceuticals, Inc. | Anti-cd63 antibodies, conjugates, and uses thereof |
| PE20211091A1 (es) | 2018-07-02 | 2021-06-14 | Amgen Inc | Proteina de union al antigeno anti-steap1 |
| EP3823993A1 (en) * | 2018-07-18 | 2021-05-26 | Amgen Inc. | Chimeric receptors to steap1 and methods of use thereof |
| CN114096264B (zh) | 2019-05-20 | 2025-03-14 | 因多塞特股份有限公司 | 制备psma缀合物的方法 |
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