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PL431176A1 - 6-Chloro-3'-hydroxyflavone and method of producing 6-chloro-3'-hydroxyflavone - Google Patents

6-Chloro-3'-hydroxyflavone and method of producing 6-chloro-3'-hydroxyflavone

Info

Publication number
PL431176A1
PL431176A1 PL431176A PL43117619A PL431176A1 PL 431176 A1 PL431176 A1 PL 431176A1 PL 431176 A PL431176 A PL 431176A PL 43117619 A PL43117619 A PL 43117619A PL 431176 A1 PL431176 A1 PL 431176A1
Authority
PL
Poland
Prior art keywords
chloro
formula
hydroxyflavone
hydroxy flavone
hours
Prior art date
Application number
PL431176A
Other languages
Polish (pl)
Other versions
PL239720B1 (en
Inventor
Agnieszka Krawczyk-Łebek
Edyta Kostrzewa-Susłow
Monika Dymarska
Tomasz Janeczko
Original Assignee
Uniwersytet Przyrodniczy we Wrocławiu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uniwersytet Przyrodniczy we Wrocławiu filed Critical Uniwersytet Przyrodniczy we Wrocławiu
Priority to PL431176A priority Critical patent/PL239720B1/en
Publication of PL431176A1 publication Critical patent/PL431176A1/en
Publication of PL239720B1 publication Critical patent/PL239720B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Przedmiotem zgłoszenia jest związek o nazwie 6-chloro-3'-hydroksyflawon o wzorze 2. Ponadto, zgłoszenie obejmuje także sposób wytwarzania 6-chloro-3'-hydroksyflawonu, charakteryzujący się tym, że do podłoża odpowiedniego dla grzybów strzępkowych wprowadza się szczep Isaria fumosorosea KCH J2, następnie po upływie co najmniej 72 godzin do hodowli wprowadza się substrat którym jest 6-chloroflawon o wzorze 1, rozpuszczony w rozpuszczalniku organicznym mieszającym się z wodą, transformację prowadzi się w temperaturze od 20 do 30 stopni Celsjusza, przy ciągłym wstrząsaniu, co najmniej 96 godzin, po czym produkt ekstrahuje się rozpuszczalnikiem organicznym niemieszającym się z wodą i oczyszcza chromatograficznie, przy czym 6-chloro-3'-hydroksyflawon o wzorze 2 znajduje się we frakcji o dość dużej polarności, w siódmym paśmie od linii startu.The subject of the application is a compound called 6-chloro-3'-hydroxy flavone of the formula 2. In addition, the application also covers a process for the preparation of 6-chloro-3'-hydroxy flavone, characterized in that the Isaria fumosorosea strain is introduced into a medium suitable for filamentous fungi. KCH J2, then, after at least 72 hours, the substrate is introduced into the culture, which is 6-chloroflavone of formula 1, dissolved in an organic solvent miscible with water, the transformation is carried out at a temperature of 20 to 30 degrees Celsius, with continuous shaking, which for at least 96 hours, after which the product is extracted with a water-immiscible organic solvent and purified by chromatography, the 6-chloro-3'-hydroxy flavone of the formula 2 being in the fairly high polarity fraction, the seventh lane from the starting line.

PL431176A 2019-09-16 2019-09-16 6-Chloro-3'-hydroxyflavone and method of producing 6-chloro-3'-hydroxyflavone PL239720B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL431176A PL239720B1 (en) 2019-09-16 2019-09-16 6-Chloro-3'-hydroxyflavone and method of producing 6-chloro-3'-hydroxyflavone

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL431176A PL239720B1 (en) 2019-09-16 2019-09-16 6-Chloro-3'-hydroxyflavone and method of producing 6-chloro-3'-hydroxyflavone

Publications (2)

Publication Number Publication Date
PL431176A1 true PL431176A1 (en) 2021-03-22
PL239720B1 PL239720B1 (en) 2021-12-27

Family

ID=75107928

Family Applications (1)

Application Number Title Priority Date Filing Date
PL431176A PL239720B1 (en) 2019-09-16 2019-09-16 6-Chloro-3'-hydroxyflavone and method of producing 6-chloro-3'-hydroxyflavone

Country Status (1)

Country Link
PL (1) PL239720B1 (en)

Also Published As

Publication number Publication date
PL239720B1 (en) 2021-12-27

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