PL417980A1 - Nowe fosfotriazolowe analogi kapu końca 5' mRNA, kompozycja je zawierająca, cząsteczka RNA je zawierająca, ich zastosowania i sposób syntezy cząsteczki RNA, białka i peptydu - Google Patents
Nowe fosfotriazolowe analogi kapu końca 5' mRNA, kompozycja je zawierająca, cząsteczka RNA je zawierająca, ich zastosowania i sposób syntezy cząsteczki RNA, białka i peptyduInfo
- Publication number
- PL417980A1 PL417980A1 PL417980A PL41798016A PL417980A1 PL 417980 A1 PL417980 A1 PL 417980A1 PL 417980 A PL417980 A PL 417980A PL 41798016 A PL41798016 A PL 41798016A PL 417980 A1 PL417980 A1 PL 417980A1
- Authority
- PL
- Poland
- Prior art keywords
- rna
- molecule
- synthesis
- group
- protein
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 title abstract 2
- 102000004169 proteins and genes Human genes 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 title 2
- KKMDYQUDLZESGL-UHFFFAOYSA-N O=P(=O)C1=CNN=N1 Chemical class O=P(=O)C1=CNN=N1 KKMDYQUDLZESGL-UHFFFAOYSA-N 0.000 title 1
- 108020004999 messenger RNA Proteins 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 238000000338 in vitro Methods 0.000 abstract 2
- 238000001727 in vivo Methods 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 238000004113 cell culture Methods 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 238000010647 peptide synthesis reaction Methods 0.000 abstract 1
- 238000001243 protein synthesis Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/30—Nucleotides
- C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Przedmiotem zgłoszenia jest związek o wzorze (I) lub jego stereoizomer lub sól, w którym R1 i R2 są wybrane z grupy o składzie N, N+-CH3, N+-C2H5, N+-C3H8, N+-C4H5, N+-CH2C6H5, przy czym przynajmniej jedno z R1, R2 nie jest N, n i m są niezależnie wybrane z grupy o składzie 0, 1 oraz 2; X jest wybrane z grupy o składzie O, NH, S, CH2; k to 1 lub 2; Y to albo nic albo jest wybrane z grupy obejmującej -CH2-, -CH2CH2-, -CH2O-, -CH2S-, -CH2NH-, -CH2CH2O-, -CH2CH2NH-, -CH2CH2S-; R3, R4, R5, R6 - są wybrane z grupy o składzie H, OH, OCH3 lub OCH2CH3; przy czym R3 i R4 mogą być takie same lub różne; R5 i R6 mogą być takie same lub różne; jeśli któryś z R3, R4 jest różny od OH wtedy obydwa R5 i R6 to OH; jeśli któryś z R5, R6 jest różny od OH wtedy obydwa R3 i R4 to OH. Przedmiotem zgłoszenia jest również kompozycja obejmująca wyżej wymieniony związek, cząsteczka RNA, która zawiera przedmiotowy związek oraz ich zastosowanie i sposób syntezy, in vitro lub in vivo, cząsteczki RNA jak również sposób syntezy białka lub peptydu in vitro, lub in vivo lub w hodowlach komórkowych, przy czym wymieniony sposób obejmuje translację cząsteczki RNA.
Priority Applications (15)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL417980A PL417980A1 (pl) | 2016-07-16 | 2016-07-16 | Nowe fosfotriazolowe analogi kapu końca 5' mRNA, kompozycja je zawierająca, cząsteczka RNA je zawierająca, ich zastosowania i sposób syntezy cząsteczki RNA, białka i peptydu |
| SM20200583T SMT202000583T1 (it) | 2016-07-16 | 2017-07-12 | Nuovi analoghi del cappuccio fosfotriazolo mrna estremita'-5', composizione che comprende lo stesso, molecola di rna che incorpora lo stesso, usi di questi e metodo di sintetizzazione della molecola, proteine o peptide di rna |
| LTEP17754482.2T LT3484907T (lt) | 2016-07-16 | 2017-07-12 | Nauji fosfotriazolo mrnr 5` galo cap analogai, juos apimanti kompozicija, juos turinti rnr molekulė, jų panaudojimas ir rnr molekulės, baltymų ar peptidų sintezės būdas |
| SI201730371T SI3484907T1 (sl) | 2016-07-16 | 2017-07-12 | Novi analogi 5'-koncev mrnk s fosfotriazolom, sestavek, ki jih vsebuje, molekula rnk, ki jih vsebuje, njihova uporaba in postopek sintetiziranja molekule rnk, beljakovine ali peptida |
| ES17754482T ES2820242T3 (es) | 2016-07-16 | 2017-07-12 | Análogos de caperuza en el extremo 5' de ARNm de fosfotriazol novedosos, composición que comprende los mismos, molécula de ARN que incorpora los mismos, utilizaciones de los mismos y procedimiento de síntesis de molécula de ARN, proteína o péptido |
| HUE17754482A HUE051312T2 (hu) | 2016-07-16 | 2017-07-12 | Új foszfotriazol MRNS-5'-vég-sapka-analógok, ezt tartalmazó kompozíció, ezt tartalmazó RNS-molekula, alkalmazásaik, valamint eljárás RNS-molekula, protein vagy peptid szintetizálására |
| RS20200968A RS60848B1 (sr) | 2016-07-16 | 2017-07-12 | Novi fosfotriazolni analozi 5'-kapice irnk, kompozicije koje ih sadrže, molekul rnk u koji se ugrađuju, njihova primena i postupak sintetisanja molekula rnk, proteina ili peptida |
| PT177544822T PT3484907T (pt) | 2016-07-16 | 2017-07-12 | Novos análogos de cobertura fosfotriazol da extremidade 5' de marn, composição compreendendo os mesmos, molécula de arn incorporando os mesmos, suas utilizações e método de síntese de molécula de arn, proteína ou péptido |
| EP17754482.2A EP3484907B1 (en) | 2016-07-16 | 2017-07-12 | Novel phosphotriazole mrna 5'-end cap analogs, composition comprising the same, rna molecule incorporating the same, uses thereof and method of synthesizing rna molecule, protein or peptide |
| DK17754482.2T DK3484907T3 (da) | 2016-07-16 | 2017-07-12 | Nye phosphotriazol mRNA 5´ende-cap-analoger, sammensætning omfattende det samme, RNA-molekyle der inkorporerer det samme, anvendelser deraf og fremgangsmåde til syntese af RNA-molekyle, protein eller peptid |
| US16/318,126 US10696709B2 (en) | 2016-07-16 | 2017-07-12 | Phosphotriazole MRNA 5′-end cap analogs, composition comprising the same, RNA molecule incorporating the same, uses thereof and method of synthesizing RNA molecule, protein or peptide |
| PCT/IB2017/054221 WO2018015845A1 (en) | 2016-07-16 | 2017-07-12 | Novel phosphotriazole mrna 5'-end cap analogs, composition comprising the same, rna molecule incorporating the same, uses thereof and method of synthesizing rna molecule, protein or peptide |
| PL17754482T PL3484907T3 (pl) | 2016-07-16 | 2017-07-12 | Nowe fosfotriazolowe analogi kapu końca 5’ mRNA, kompozycja je zawierająca, cząsteczka RNA je zawierająca, ich zastosowania i sposób syntezy cząsteczki RNA, białka i peptydu |
| CY20201100762T CY1123516T1 (el) | 2016-07-16 | 2020-08-13 | Νεα αναλογα καλυμματος φωσφοτριαζολιου mrna 5'-ακρου, συνθεση που τα περιλαμβανει, μοριο rna που τα ενσωματωνει, χρησεις τους και μεθοδος συνθεσης μοριου rna, πρωτεϊνης ή πεπτιδιου |
| HRP20201274TT HRP20201274T1 (hr) | 2016-07-16 | 2020-08-13 | Novi fosfotriazoli mrna s analognom cap-a na kraju 5', pripravci koji ih sadržavaju, rna molekule koje ih uključuju u svojem sastavu, njihova upotreba i postupak sinteze rna molekule, proteina ili peptida |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL417980A PL417980A1 (pl) | 2016-07-16 | 2016-07-16 | Nowe fosfotriazolowe analogi kapu końca 5' mRNA, kompozycja je zawierająca, cząsteczka RNA je zawierająca, ich zastosowania i sposób syntezy cząsteczki RNA, białka i peptydu |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL417980A1 true PL417980A1 (pl) | 2018-01-29 |
Family
ID=59656110
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL417980A PL417980A1 (pl) | 2016-07-16 | 2016-07-16 | Nowe fosfotriazolowe analogi kapu końca 5' mRNA, kompozycja je zawierająca, cząsteczka RNA je zawierająca, ich zastosowania i sposób syntezy cząsteczki RNA, białka i peptydu |
| PL17754482T PL3484907T3 (pl) | 2016-07-16 | 2017-07-12 | Nowe fosfotriazolowe analogi kapu końca 5’ mRNA, kompozycja je zawierająca, cząsteczka RNA je zawierająca, ich zastosowania i sposób syntezy cząsteczki RNA, białka i peptydu |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL17754482T PL3484907T3 (pl) | 2016-07-16 | 2017-07-12 | Nowe fosfotriazolowe analogi kapu końca 5’ mRNA, kompozycja je zawierająca, cząsteczka RNA je zawierająca, ich zastosowania i sposób syntezy cząsteczki RNA, białka i peptydu |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US10696709B2 (pl) |
| EP (1) | EP3484907B1 (pl) |
| CY (1) | CY1123516T1 (pl) |
| DK (1) | DK3484907T3 (pl) |
| ES (1) | ES2820242T3 (pl) |
| HR (1) | HRP20201274T1 (pl) |
| HU (1) | HUE051312T2 (pl) |
| LT (1) | LT3484907T (pl) |
| PL (2) | PL417980A1 (pl) |
| PT (1) | PT3484907T (pl) |
| RS (1) | RS60848B1 (pl) |
| SI (1) | SI3484907T1 (pl) |
| SM (1) | SMT202000583T1 (pl) |
| WO (1) | WO2018015845A1 (pl) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016146143A1 (en) | 2015-03-16 | 2016-09-22 | Amal Therapeutics Sa | Cell penetrating peptides and complexes comprising the same |
| LT3429618T (lt) | 2016-03-16 | 2024-05-10 | Amal Therapeutics Sa | Imuninės sistemos patikros taško moduliatoriaus ir komplekso, apimančio į ląsteles prasiskverbiantį peptidą, krovinį ir tlr peptido agonistą, derinys, skirtas naudoti medicinoje |
| IL265479B (en) | 2016-09-21 | 2022-09-01 | Amal Therapeutics Sa | Fusion comprising a cell penetrating peptide, a multi epitope and a tlr peptide agonist for treatment of cancer |
| WO2023250528A1 (en) * | 2022-06-24 | 2023-12-28 | The Broad Institute, Inc. | Compositions and methods for preparing capped circular rna molecules |
| EP4464713A1 (en) | 2023-05-18 | 2024-11-20 | Siec Badawcza Lukasiewicz - PORT Polski Osrodek Rozwoju Technologii | Circular rna analogs, preparation and application thereof |
| WO2025043082A2 (en) | 2023-08-23 | 2025-02-27 | The Broad Institute, Inc. | Compositions and methods to improve rna properties using base, phosphodiester linkage, sugar backbone, and cap modifications |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013059475A1 (en) | 2011-10-18 | 2013-04-25 | Life Technologies Corporation | Alkynyl-derivatized cap analogs, preparation and uses thereof |
-
2016
- 2016-07-16 PL PL417980A patent/PL417980A1/pl unknown
-
2017
- 2017-07-12 LT LTEP17754482.2T patent/LT3484907T/lt unknown
- 2017-07-12 PT PT177544822T patent/PT3484907T/pt unknown
- 2017-07-12 SI SI201730371T patent/SI3484907T1/sl unknown
- 2017-07-12 WO PCT/IB2017/054221 patent/WO2018015845A1/en unknown
- 2017-07-12 US US16/318,126 patent/US10696709B2/en active Active
- 2017-07-12 DK DK17754482.2T patent/DK3484907T3/da active
- 2017-07-12 SM SM20200583T patent/SMT202000583T1/it unknown
- 2017-07-12 PL PL17754482T patent/PL3484907T3/pl unknown
- 2017-07-12 HU HUE17754482A patent/HUE051312T2/hu unknown
- 2017-07-12 RS RS20200968A patent/RS60848B1/sr unknown
- 2017-07-12 ES ES17754482T patent/ES2820242T3/es active Active
- 2017-07-12 EP EP17754482.2A patent/EP3484907B1/en active Active
-
2020
- 2020-08-13 HR HRP20201274TT patent/HRP20201274T1/hr unknown
- 2020-08-13 CY CY20201100762T patent/CY1123516T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SMT202000583T1 (it) | 2020-11-10 |
| HUE051312T2 (hu) | 2021-03-01 |
| CY1123516T1 (el) | 2022-03-24 |
| WO2018015845A1 (en) | 2018-01-25 |
| EP3484907A1 (en) | 2019-05-22 |
| US20200055891A1 (en) | 2020-02-20 |
| ES2820242T3 (es) | 2021-04-20 |
| SI3484907T1 (sl) | 2020-12-31 |
| PT3484907T (pt) | 2020-09-17 |
| PL3484907T3 (pl) | 2021-02-08 |
| RS60848B1 (sr) | 2020-10-30 |
| US10696709B2 (en) | 2020-06-30 |
| HRP20201274T1 (hr) | 2020-12-11 |
| LT3484907T (lt) | 2020-09-10 |
| EP3484907B1 (en) | 2020-05-13 |
| DK3484907T3 (da) | 2020-08-17 |
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