[go: up one dir, main page]

LT3484907T - Nauji fosfotriazolo mrnr 5` galo cap analogai, juos apimanti kompozicija, juos turinti rnr molekulė, jų panaudojimas ir rnr molekulės, baltymų ar peptidų sintezės būdas - Google Patents

Nauji fosfotriazolo mrnr 5` galo cap analogai, juos apimanti kompozicija, juos turinti rnr molekulė, jų panaudojimas ir rnr molekulės, baltymų ar peptidų sintezės būdas

Info

Publication number
LT3484907T
LT3484907T LTEP17754482.2T LT17754482T LT3484907T LT 3484907 T LT3484907 T LT 3484907T LT 17754482 T LT17754482 T LT 17754482T LT 3484907 T LT3484907 T LT 3484907T
Authority
LT
Lithuania
Prior art keywords
rna molecular
phosphotriazole
mrnr
peptide
protein
Prior art date
Application number
LTEP17754482.2T
Other languages
English (en)
Inventor
Sylwia WALCZAK
Joanna Kowalska
Jacek Jemielity
Original Assignee
Uniwersytet Warszawski
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uniwersytet Warszawski filed Critical Uniwersytet Warszawski
Publication of LT3484907T publication Critical patent/LT3484907T/lt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16Purine radicals
    • C07H19/20Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/207Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/26Preparation of nitrogen-containing carbohydrates
    • C12P19/28N-glycosides
    • C12P19/30Nucleotides
    • C12P19/34Polynucleotides, e.g. nucleic acids, oligoribonucleotides
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • C12P21/02Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
LTEP17754482.2T 2016-07-16 2017-07-12 Nauji fosfotriazolo mrnr 5` galo cap analogai, juos apimanti kompozicija, juos turinti rnr molekulė, jų panaudojimas ir rnr molekulės, baltymų ar peptidų sintezės būdas LT3484907T (lt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PL417980A PL417980A1 (pl) 2016-07-16 2016-07-16 Nowe fosfotriazolowe analogi kapu końca 5' mRNA, kompozycja je zawierająca, cząsteczka RNA je zawierająca, ich zastosowania i sposób syntezy cząsteczki RNA, białka i peptydu
PCT/IB2017/054221 WO2018015845A1 (en) 2016-07-16 2017-07-12 Novel phosphotriazole mrna 5'-end cap analogs, composition comprising the same, rna molecule incorporating the same, uses thereof and method of synthesizing rna molecule, protein or peptide

Publications (1)

Publication Number Publication Date
LT3484907T true LT3484907T (lt) 2020-09-10

Family

ID=59656110

Family Applications (1)

Application Number Title Priority Date Filing Date
LTEP17754482.2T LT3484907T (lt) 2016-07-16 2017-07-12 Nauji fosfotriazolo mrnr 5` galo cap analogai, juos apimanti kompozicija, juos turinti rnr molekulė, jų panaudojimas ir rnr molekulės, baltymų ar peptidų sintezės būdas

Country Status (14)

Country Link
US (1) US10696709B2 (lt)
EP (1) EP3484907B1 (lt)
CY (1) CY1123516T1 (lt)
DK (1) DK3484907T3 (lt)
ES (1) ES2820242T3 (lt)
HR (1) HRP20201274T1 (lt)
HU (1) HUE051312T2 (lt)
LT (1) LT3484907T (lt)
PL (2) PL417980A1 (lt)
PT (1) PT3484907T (lt)
RS (1) RS60848B1 (lt)
SI (1) SI3484907T1 (lt)
SM (1) SMT202000583T1 (lt)
WO (1) WO2018015845A1 (lt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016146143A1 (en) 2015-03-16 2016-09-22 Amal Therapeutics Sa Cell penetrating peptides and complexes comprising the same
LT3429618T (lt) 2016-03-16 2024-05-10 Amal Therapeutics Sa Imuninės sistemos patikros taško moduliatoriaus ir komplekso, apimančio į ląsteles prasiskverbiantį peptidą, krovinį ir tlr peptido agonistą, derinys, skirtas naudoti medicinoje
IL265479B (en) 2016-09-21 2022-09-01 Amal Therapeutics Sa Fusion comprising a cell penetrating peptide, a multi epitope and a tlr peptide agonist for treatment of cancer
WO2023250528A1 (en) * 2022-06-24 2023-12-28 The Broad Institute, Inc. Compositions and methods for preparing capped circular rna molecules
EP4464713A1 (en) 2023-05-18 2024-11-20 Siec Badawcza Lukasiewicz - PORT Polski Osrodek Rozwoju Technologii Circular rna analogs, preparation and application thereof
WO2025043082A2 (en) 2023-08-23 2025-02-27 The Broad Institute, Inc. Compositions and methods to improve rna properties using base, phosphodiester linkage, sugar backbone, and cap modifications

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013059475A1 (en) 2011-10-18 2013-04-25 Life Technologies Corporation Alkynyl-derivatized cap analogs, preparation and uses thereof

Also Published As

Publication number Publication date
SMT202000583T1 (it) 2020-11-10
HUE051312T2 (hu) 2021-03-01
CY1123516T1 (el) 2022-03-24
WO2018015845A1 (en) 2018-01-25
EP3484907A1 (en) 2019-05-22
US20200055891A1 (en) 2020-02-20
ES2820242T3 (es) 2021-04-20
SI3484907T1 (sl) 2020-12-31
PT3484907T (pt) 2020-09-17
PL3484907T3 (pl) 2021-02-08
RS60848B1 (sr) 2020-10-30
US10696709B2 (en) 2020-06-30
HRP20201274T1 (hr) 2020-12-11
PL417980A1 (pl) 2018-01-29
EP3484907B1 (en) 2020-05-13
DK3484907T3 (da) 2020-08-17

Similar Documents

Publication Publication Date Title
LT3484907T (lt) Nauji fosfotriazolo mrnr 5` galo cap analogai, juos apimanti kompozicija, juos turinti rnr molekulė, jų panaudojimas ir rnr molekulės, baltymų ar peptidų sintezės būdas
MX2022001755A (es) Compuestos de dinucleotidos ciclicos y metodos de uso.
CY1123274T1 (el) Αντισωματα εναντι-οχ40 και χρησεις αυτων
IL271389A (en) Targeted non-viral dna insertions
EP3436588A4 (en) NUCLEIC ACID-POLYPEPTIDE COMPOSITIONS AND USES THEREOF
WO2016170348A3 (en) Sarna compositions and methods of use
HUE061174T2 (hu) 1,3,4-oxadiazol-szulfonamid-származék vegyületek mint hiszton-deacetiláz-6 inhibitorok, és az ilyen vegyületeket tartalmazó gyógyszerkészímény
EA201990071A1 (ru) Композиция пептидной вакцины
EP3429354A4 (en) CONJUGATES OF VITAMIN B AND AMINO ACIDS OF NICOTINOYL RIBOSIDES AND REDUCED NICOTINOYLE RIBOSIDES DERIVATIVES THEREOF, AND PROCESSES FOR THEIR PREPARATION
WO2015168161A3 (en) Multiplexed single cell gene expression analysis using template switch and tagmentation
DK3330259T3 (da) 1,3,4-oxadiazolamidderivativ-forbindelse som histondeacetylase-6-inhibitor og farmaceutisk sammensætning indeholdende denne
MA54411A (fr) Compositions contenant de l'ibrutinib
MX2020006510A (es) Peptido novedoso.
DOP2016000202A (es) Proteínas de fusión uti
EP3344061A4 (en) PROTEINOUS PAVED FULL-UPS
SG11202106327QA (en) Oligomeric nucleic acid molecule and application thereof
FR3041644B1 (fr) Polypeptides cycliques, leur procede d'obtention et leur application en therapeutique
HK1257448A1 (zh) 包含c-c基序趨化因子22(ccl22)或其片段的疫苗組合物
EP3490978A4 (en) SALTS OF 2, 6-DIMETHYLPYRIMIDONE DERIVATIVES AND THEIR USES
FR3044226B1 (fr) Extrait alcoolique de parties aeriennes de solidago virgaurea subsp. alpestris, son procede d'obtention, et composition cosmetique ou dermatologique le contenant
EP3329928A4 (en) Composition containing cyclic dipeptide and sweetening agent
WO2016011201A3 (en) Epha4 cyclic peptide antagonists for neuroprotection and neural repair
EP3475418A4 (en) TATK-CDKL5 FUSION PROTEINS, COMPOSITIONS, FORMULATIONS AND THEIR USE
IL270917A (en) Recombinant ROBO2 proteins, preparations, methods and their use
EP3416975A4 (en) NOVEL ALPHA CONOTOXIN PEPTIDES