PL3362450T3 - N1 i n7-podstawione pochodne sybiriliny oraz ich zastosowania jako inhibitory nekroptozy komórkowej - Google Patents
N1 i n7-podstawione pochodne sybiriliny oraz ich zastosowania jako inhibitory nekroptozy komórkowejInfo
- Publication number
- PL3362450T3 PL3362450T3 PL16784435T PL16784435T PL3362450T3 PL 3362450 T3 PL3362450 T3 PL 3362450T3 PL 16784435 T PL16784435 T PL 16784435T PL 16784435 T PL16784435 T PL 16784435T PL 3362450 T3 PL3362450 T3 PL 3362450T3
- Authority
- PL
- Poland
- Prior art keywords
- inhibitors
- substituted
- sibiriline
- derivatives
- cellular necroptosis
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15306623 | 2015-10-13 | ||
| PCT/EP2016/074637 WO2017064216A1 (en) | 2015-10-13 | 2016-10-13 | N1- and n7-substituted sibiriline derivatives and their use as inhibitor of cellular necroptosis |
| EP16784435.6A EP3362450B1 (en) | 2015-10-13 | 2016-10-13 | N1- and n7-substituted sibiriline derivatives and their use as inhibitors of cellular necroptosis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3362450T3 true PL3362450T3 (pl) | 2021-08-23 |
Family
ID=54337711
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL16784435T PL3362450T3 (pl) | 2015-10-13 | 2016-10-13 | N1 i n7-podstawione pochodne sybiriliny oraz ich zastosowania jako inhibitory nekroptozy komórkowej |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US10457678B2 (pl) |
| EP (1) | EP3362450B1 (pl) |
| DK (1) | DK3362450T3 (pl) |
| ES (1) | ES2821971T3 (pl) |
| PL (1) | PL3362450T3 (pl) |
| WO (1) | WO2017064216A1 (pl) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3362449T3 (da) * | 2015-10-13 | 2021-07-19 | Inst Nat Sante Rech Med | Sibirilin-derivater til anvendelse til at forebygge og/eller behandle lidelser associeret med cellulær nekroptose |
| CN111978311B (zh) * | 2019-05-21 | 2024-05-31 | 中国科学院上海有机化学研究所 | 一类细胞程序性坏死抑制剂及其制备方法和用途 |
| WO2022157392A1 (en) * | 2021-01-25 | 2022-07-28 | Seabelife | Use of indole, 6- and 7-azaindole derivatives as inhibitors of ferroptosis regulated cell death |
| WO2024115793A1 (en) | 2022-12-02 | 2024-06-06 | Seabelife | Synergistic combinations of regulated necrosis inhibitors with n-acetylcysteine |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU7132998A (en) | 1997-04-24 | 1998-11-13 | Ortho-Mcneil Corporation, Inc. | Substituted pyrrolopyridines useful in the treatment of inflammatory diseases |
| DK2384753T3 (en) | 2003-08-29 | 2016-04-11 | Brigham & Womens Hospital | Hydantoin derivatives as inhibitors of cell necrosis |
| CA2784807C (en) * | 2009-12-29 | 2021-12-14 | Dana-Farber Cancer Institute, Inc. | Type ii raf kinase inhibitors |
| WO2012125544A2 (en) * | 2011-03-11 | 2012-09-20 | President And Fellows Of Harvard College | Necroptosis inhibitors and methods of use therefor |
-
2016
- 2016-10-13 PL PL16784435T patent/PL3362450T3/pl unknown
- 2016-10-13 DK DK16784435.6T patent/DK3362450T3/da active
- 2016-10-13 US US15/768,395 patent/US10457678B2/en active Active
- 2016-10-13 WO PCT/EP2016/074637 patent/WO2017064216A1/en active Application Filing
- 2016-10-13 ES ES16784435T patent/ES2821971T3/es active Active
- 2016-10-13 EP EP16784435.6A patent/EP3362450B1/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP3362450A1 (en) | 2018-08-22 |
| US20180312502A1 (en) | 2018-11-01 |
| DK3362450T3 (da) | 2020-09-14 |
| US10457678B2 (en) | 2019-10-29 |
| ES2821971T3 (es) | 2021-04-28 |
| EP3362450B1 (en) | 2020-07-01 |
| WO2017064216A1 (en) | 2017-04-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL286316A (en) | New micro-dystrophins and related method of use | |
| HK1259232A1 (zh) | Menin-mll的取代抑制劑及其使用方法 | |
| HK1249513A1 (zh) | Kras的稠合三環抑制劑及其使用方法 | |
| HK1256608A1 (zh) | 類黃酮組合物及其使用方法 | |
| HK1253049A1 (zh) | 糖基相互作用化合物及其使用方法 | |
| IL259801A (en) | ezh2 inhibitors and methods of using them | |
| IL267291A (en) | Actonucleotidase inhibitors and methods of using them | |
| EP3268369A4 (en) | Anti-alphavbeta1 integrin inhibitors and methods of use | |
| GB201514756D0 (en) | Compound and method of use | |
| IL259796A (en) | Aza-benzimidazole inhibitors of pad4 | |
| IL252827A0 (en) | Cell necrosis inhibitors and related methods | |
| SG11201708027XA (en) | Compounds and their use as bace1 inhibitors | |
| GB201514760D0 (en) | Compounds and method of use | |
| PL3313833T3 (pl) | Związki i ich zastosowanie w charakterze inhibitorów transferazy n-mirystoilu | |
| GB201521059D0 (en) | Inhibitors of metallo-beta-lactamases | |
| HK1250926A1 (zh) | 抑制劑及其應用 | |
| HK1250161B (zh) | 6-嗎啉基-2-吡唑基-9h-嘌呤衍生物及其作為pi3k抑制劑的用途 | |
| IL254783B (en) | Combinations for deworming methods for using them | |
| SG11201605915WA (en) | Furo-3-carboxamide derivatives and methods of use | |
| HK1252057A1 (zh) | 新穎的使用方法和組合物 | |
| PL3362450T3 (pl) | N1 i n7-podstawione pochodne sybiriliny oraz ich zastosowania jako inhibitory nekroptozy komórkowej | |
| IL258690A (en) | Pyridone derivatives and their use as kinase inhibitors | |
| HUE040648T2 (hu) | Makrociklusos N-aril-2-amino-4-aril-pirimidin poliéter származékok mint FTL3 és JAK inhibitorok | |
| GB201505971D0 (en) | Inhibitors and their uses | |
| GB201505975D0 (en) | Inhibitors and their uses |