[go: up one dir, main page]

GB201514760D0 - Compounds and method of use - Google Patents

Compounds and method of use

Info

Publication number
GB201514760D0
GB201514760D0 GBGB1514760.6A GB201514760A GB201514760D0 GB 201514760 D0 GB201514760 D0 GB 201514760D0 GB 201514760 A GB201514760 A GB 201514760A GB 201514760 D0 GB201514760 D0 GB 201514760D0
Authority
GB
United Kingdom
Prior art keywords
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GBGB1514760.6A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Karus Therapeutics Ltd
Original Assignee
Karus Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Karus Therapeutics Ltd filed Critical Karus Therapeutics Ltd
Priority to GBGB1514760.6A priority Critical patent/GB201514760D0/en
Publication of GB201514760D0 publication Critical patent/GB201514760D0/en
Priority to RS20230255A priority patent/RS64095B1/en
Priority to PT167567635T priority patent/PT3337477T/en
Priority to DK16756763.5T priority patent/DK3337477T3/en
Priority to CN202111104917.2A priority patent/CN113786409B/en
Priority to SM20230063T priority patent/SMT202300063T1/en
Priority to CN201680057437.6A priority patent/CN108348505B/en
Priority to LTEPPCT/GB2016/052575T priority patent/LT3337477T/en
Priority to US15/753,353 priority patent/US10668077B2/en
Priority to EP16756763.5A priority patent/EP3337477B1/en
Priority to KR1020187007564A priority patent/KR20180064387A/en
Priority to ES16756763T priority patent/ES2939815T3/en
Priority to HUE16756763A priority patent/HUE061615T2/en
Priority to PL16756763.5T priority patent/PL3337477T3/en
Priority to MX2018001926A priority patent/MX2018001926A/en
Priority to SI201631666T priority patent/SI3337477T1/en
Priority to FIEP16756763.5T priority patent/FI3337477T3/en
Priority to PCT/GB2016/052575 priority patent/WO2017029517A1/en
Priority to JP2018508757A priority patent/JP2018523689A/en
Priority to CA2995898A priority patent/CA2995898A1/en
Priority to HRP20230376TT priority patent/HRP20230376T1/en
Priority to AU2016307885A priority patent/AU2016307885B2/en
Priority to IL257499A priority patent/IL257499A/en
Priority to HK18110947.3A priority patent/HK1251467A1/en
Priority to US16/855,758 priority patent/US11291669B2/en
Priority to US17/684,020 priority patent/US20230066999A1/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/69—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
GBGB1514760.6A 2015-08-19 2015-08-19 Compounds and method of use Ceased GB201514760D0 (en)

Priority Applications (26)

Application Number Priority Date Filing Date Title
GBGB1514760.6A GB201514760D0 (en) 2015-08-19 2015-08-19 Compounds and method of use
AU2016307885A AU2016307885B2 (en) 2015-08-19 2016-08-19 Compositions comprising phosphoinositide 3-kinase inhibitors and a second antiproliferative agent
HUE16756763A HUE061615T2 (en) 2015-08-19 2016-08-19 Preparations containing phosphoinositide-3-kinase inhibitors and a second antiproliferative agent
MX2018001926A MX2018001926A (en) 2015-08-19 2016-08-19 Compositions comprising phosphoinositide 3-kinase inhibitors and a second antiproliferative agent.
DK16756763.5T DK3337477T3 (en) 2015-08-19 2016-08-19 Compositions comprising phosphoinositide 3-kinase inhibitors and a second antiproliferative agent
CN202111104917.2A CN113786409B (en) 2015-08-19 2016-08-19 Compositions comprising a phosphoinositide 3-kinase inhibitor and a second antiproliferative agent
SM20230063T SMT202300063T1 (en) 2015-08-19 2016-08-19 Compositions comprising phosphoinositide 3-kinase inhibitors and a second antiproliferative agent
CN201680057437.6A CN108348505B (en) 2015-08-19 2016-08-19 Compositions comprising phosphoinositide 3-kinase inhibitors and second antiproliferative agents
LTEPPCT/GB2016/052575T LT3337477T (en) 2015-08-19 2016-08-19 COMPOSITIONS COMPRISING A PHOSPHOINOSITIDE 3-KINASE INHIBITOR AND A SECOND ANTI-PROLIFERATIVE AGENT
US15/753,353 US10668077B2 (en) 2015-08-19 2016-08-19 Compositions comprising phosphoinositide 3-kinase inhibitors and a second antiproliferative agent
EP16756763.5A EP3337477B1 (en) 2015-08-19 2016-08-19 Compositions comprising phosphoinositide 3-kinase inhibitors and a second antiproliferative agent
KR1020187007564A KR20180064387A (en) 2015-08-19 2016-08-19 A composition comprising a phosphoinositide 3-kinase inhibitor and a second anti-proliferative agent
ES16756763T ES2939815T3 (en) 2015-08-19 2016-08-19 Compositions containing phosphositide 3-kinase inhibitors and a second antiproliferative agent
RS20230255A RS64095B1 (en) 2015-08-19 2016-08-19 Compositions comprising phosphoinositide 3-kinase inhibitors and a second antiproliferative agent
PL16756763.5T PL3337477T3 (en) 2015-08-19 2016-08-19 Compositions comprising phosphoinositide 3-kinase inhibitors and a second antiproliferative agent
PT167567635T PT3337477T (en) 2015-08-19 2016-08-19 Compositions comprising phosphoinositide 3-kinase inhibitors and a second antiproliferative agent
SI201631666T SI3337477T1 (en) 2015-08-19 2016-08-19 Compositions comprising phosphoinositide 3-kinase inhibitors and a second antiproliferative agent
FIEP16756763.5T FI3337477T3 (en) 2015-08-19 2016-08-19 Compositions comprising phosphoinositide 3-kinase inhibitors and a second antiproliferative agent
PCT/GB2016/052575 WO2017029517A1 (en) 2015-08-19 2016-08-19 Compositions comprising phosphoinositide 3-kinase inhibitors and a second antiproliferative agent
JP2018508757A JP2018523689A (en) 2015-08-19 2016-08-19 A composition comprising a phosphoinositide 3-kinase inhibitor and a second antiproliferative agent
CA2995898A CA2995898A1 (en) 2015-08-19 2016-08-19 Compositions comprising phosphoinositide 3-kinase inhibitors and a second antiproliferative agent
HRP20230376TT HRP20230376T1 (en) 2015-08-19 2016-08-19 Compositions comprising phosphoinositide 3-kinase inhibitors and a second antiproliferative agent
IL257499A IL257499A (en) 2015-08-19 2018-02-13 Compositions comprising phosphoinositide 3-kinase inhibitors and a second antiproliferative agent
HK18110947.3A HK1251467A1 (en) 2015-08-19 2018-08-24 Compositions comprising phosphoinositide 3-kinase inhibitors and a second antiproliferative agent
US16/855,758 US11291669B2 (en) 2015-08-19 2020-04-22 Compositions comprising phosphoinositide 3-kinase inhibitors and a second antiproliferative agent
US17/684,020 US20230066999A1 (en) 2015-08-19 2022-03-01 Compositions comprising phosphoinositide 3-kinase inhibitors and a second antiproliferative agent

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB1514760.6A GB201514760D0 (en) 2015-08-19 2015-08-19 Compounds and method of use

Publications (1)

Publication Number Publication Date
GB201514760D0 true GB201514760D0 (en) 2015-09-30

Family

ID=54258859

Family Applications (1)

Application Number Title Priority Date Filing Date
GBGB1514760.6A Ceased GB201514760D0 (en) 2015-08-19 2015-08-19 Compounds and method of use

Country Status (23)

Country Link
US (3) US10668077B2 (en)
EP (1) EP3337477B1 (en)
JP (1) JP2018523689A (en)
KR (1) KR20180064387A (en)
CN (2) CN113786409B (en)
AU (1) AU2016307885B2 (en)
CA (1) CA2995898A1 (en)
DK (1) DK3337477T3 (en)
ES (1) ES2939815T3 (en)
FI (1) FI3337477T3 (en)
GB (1) GB201514760D0 (en)
HK (1) HK1251467A1 (en)
HR (1) HRP20230376T1 (en)
HU (1) HUE061615T2 (en)
IL (1) IL257499A (en)
LT (1) LT3337477T (en)
MX (1) MX2018001926A (en)
PL (1) PL3337477T3 (en)
PT (1) PT3337477T (en)
RS (1) RS64095B1 (en)
SI (1) SI3337477T1 (en)
SM (1) SMT202300063T1 (en)
WO (1) WO2017029517A1 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2010286168B2 (en) 2009-08-20 2014-05-15 Karus Therapeutics Limited Tricyclic heterocyclic compounds as phosphoinositide 3-kinase inhibitors
GB201204125D0 (en) 2012-03-08 2012-04-25 Karus Therapeutics Ltd Compounds
GB201402431D0 (en) 2014-02-12 2014-03-26 Karus Therapeutics Ltd Compounds
US10722527B2 (en) 2015-04-10 2020-07-28 Capsugel Belgium Nv Abiraterone acetate lipid formulations
GB201514760D0 (en) * 2015-08-19 2015-09-30 Karus Therapeutics Ltd Compounds and method of use
GB201514758D0 (en) 2015-08-19 2015-09-30 Karus Therapeutics Ltd Formulation
GB201514751D0 (en) 2015-08-19 2015-09-30 Karus Therapeutics Ltd Compounds
GB201514754D0 (en) 2015-08-19 2015-09-30 Karus Therapeutics Ltd Compounds
WO2020059705A1 (en) * 2018-09-18 2020-03-26 株式会社ヤクルト本社 Cancer combination therapy using quinoline carboxamide derivative
PT3930715T (en) * 2019-02-27 2024-08-02 Astrazeneca Ab SARACATINIB FOR USE IN THE TREATMENT OF IDIOPATHIC PULMONARY FIBROSIS
CN111904958B (en) * 2019-05-09 2022-09-13 浙江大学 Application of UMI-77 as mitophagy inducer in preparing medicine for treating inflammation and neurodegenerative disease
GB201909468D0 (en) * 2019-07-01 2019-08-14 Karus Therapeutics Ltd Compounds for treating cancer
CN114533879B (en) * 2020-11-19 2023-09-29 广州顺健生物医药科技有限公司 Combination therapy for the treatment of cancer

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1445742A1 (en) 1963-11-06 1968-12-19 Bayer Ag Process for the preparation of 2-position substituted benzoxazinones
US4017500A (en) 1973-07-16 1977-04-12 Schering Corporation Certain 8-amino-1,7-naphthyridines
BE786081A (en) * 1971-07-13 1973-01-10 Uniroyal Sa APPARATUS AND METHOD FOR MAINTAINING THE LINKAGES OF THE TIRE BOLTS
US5703075A (en) 1988-12-21 1997-12-30 Pharmacia & Upjohn Company Antiatherosclerotic and antithrombotic 1-benzopyran-4-ones and 2-amino-1,3-benzoxazine-4-ones
CN1250294A (en) * 1999-07-27 2000-04-12 邮电部武汉邮电科学研究院 Adaption method for fusion of Ethernet with synchronizing digital system or synchronizing optical network
US6608053B2 (en) 2000-04-27 2003-08-19 Yamanouchi Pharmaceutical Co., Ltd. Fused heteroaryl derivatives
WO2001083456A1 (en) 2000-04-27 2001-11-08 Yamanouchi Pharmaceutical Co., Ltd. Condensed heteroaryl derivatives
AU2001270260A1 (en) 2000-06-30 2002-01-14 Sugen, Inc. 4-heteroaryl-3-heteroarylidenyl-2-indolinones and their use as protein kinase inhibitors
US6905669B2 (en) 2001-04-24 2005-06-14 Supergen, Inc. Compositions and methods for reestablishing gene transcription through inhibition of DNA methylation and histone deacetylase
EP1521747B1 (en) 2002-07-15 2018-09-05 Symphony Evolution, Inc. Receptor-type kinase modulators and methods of use
FR2846657B1 (en) 2002-11-05 2004-12-24 Servier Lab NOVEL PYRIDOPYRIMIDINONE COMPOUNDS, PROCESS FOR THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
US7799775B2 (en) 2004-02-26 2010-09-21 Aska Pharmaceutical Co., Ltd. Pyrimidine derivatives
GB0423653D0 (en) 2004-10-25 2004-11-24 Piramed Ltd Pharmaceutical compounds
EP2354140A1 (en) 2005-05-20 2011-08-10 Vertex Pharmaceuticals Incorporated Pyrrolopyridines useful as inhibitors of protein kinase
EP1979353A2 (en) 2006-01-19 2008-10-15 OSI Pharmaceuticals, Inc. Fused heterobicyclic kinase inhibitors
AU2007242594A1 (en) 2006-04-26 2007-11-01 F. Hoffmann-La Roche Ag Pyrimidine derivatives as PI3K inhibitors
WO2007127183A1 (en) 2006-04-26 2007-11-08 Genentech, Inc. Phosphoinositide 3-kinase inhibitor compounds and pharmaceutical compositions containing them
CN101501035B (en) * 2006-08-08 2013-01-23 中外制药株式会社 Pyrimidine derivative as P13K inhibitor and use thereof
EP2441768A1 (en) 2006-11-13 2012-04-18 Eli Lilly & Co. Thienopyrimidinones for treatment of inflammatory disorders and cancers
MX2009008253A (en) 2007-01-31 2009-10-12 Vertex Pharma Kinase inhibitors.
WO2008121257A1 (en) 2007-03-28 2008-10-09 Merck & Co., Inc. Substituted pyrido[2,3-d]pyrimidine derivatives as cannabinoid-1 receptor modulators
EP2154965A4 (en) 2007-05-29 2011-08-17 Glaxosmithkline Llc Naphthyridine, derivatives as p13 kinase inhibitors
GB0710528D0 (en) 2007-06-01 2007-07-11 Glaxo Group Ltd Novel compounds
ES2537352T3 (en) * 2007-09-12 2015-06-05 Genentech, Inc. Combinations of phosphoinositide 3-kinase inhibitor compounds and chemotherapeutic agents, and methods for their use
WO2010015520A1 (en) 2008-08-05 2010-02-11 Boehringer Ingelheim International Gmbh Substituted naphthyridines and use thereof as medicines
WO2010037765A2 (en) 2008-10-03 2010-04-08 Merck Serono S.A. 4-morpholino-pyrido[3,2-d]pyrimidines
GB2465405A (en) 2008-11-10 2010-05-19 Univ Basel Triazine, pyrimidine and pyridine analogues and their use in therapy
EP2459543B1 (en) 2009-07-29 2017-08-30 Karus Therapeutics Limited Benzo[e][1,3]oxazin-4-one derivatives as phosphoinositide 3-kinase inhibitors
AU2010286168B2 (en) * 2009-08-20 2014-05-15 Karus Therapeutics Limited Tricyclic heterocyclic compounds as phosphoinositide 3-kinase inhibitors
WO2011079231A1 (en) 2009-12-23 2011-06-30 Gatekeeper Pharmaceutical, Inc. Compounds that modulate egfr activity and methods for treating or preventing conditions therewith
GB201007347D0 (en) 2010-04-30 2010-06-16 Karus Therapeutics Ltd Compounds
CN101849934B (en) * 2010-05-25 2011-11-09 苏州大学 Phosphatidylinositol-3-kinase inhibitor and application thereof
PT3686193T (en) 2011-07-27 2022-05-20 Astrazeneca Ab 2-(2,4,5-substituted-anilino)pyrimidine compounds
WO2013017480A1 (en) 2011-07-29 2013-02-07 Cellzome Limited Pyrazolo[4,3-c]pyridine derivatives as jak inhibitors
GB201204125D0 (en) 2012-03-08 2012-04-25 Karus Therapeutics Ltd Compounds
JP6430390B2 (en) 2012-11-20 2018-11-28 ジェネンテック， インコーポレイテッド Aminopyrimidine compounds as inhibitors of EGFR mutants containing T790M
DK2994465T3 (en) 2013-05-10 2018-10-08 Karus Therapeutics Ltd HISTONDEACETYLASE INHIBITORS UNKNOWN
EP3811974A1 (en) * 2013-05-30 2021-04-28 Infinity Pharmaceuticals, Inc. Treatment of cancers using pi3 kinase isoform modulators
EP3052494B1 (en) 2013-06-28 2018-12-26 H. Hoffnabb-La Roche Ag Azaindazole compounds as inhibitors of t790m containing egfr mutants
WO2015054355A1 (en) 2013-10-10 2015-04-16 Acetylon Pharmaceuticals, Inc. Hdac inhibitors, alone or in combination with pi3k inhibitors, for treating non-hodgkin's lymphoma
GB201402431D0 (en) * 2014-02-12 2014-03-26 Karus Therapeutics Ltd Compounds
GB201514758D0 (en) 2015-08-19 2015-09-30 Karus Therapeutics Ltd Formulation
GB201514756D0 (en) * 2015-08-19 2015-09-30 Karus Therapeutics Ltd Compound and method of use
GB201514760D0 (en) * 2015-08-19 2015-09-30 Karus Therapeutics Ltd Compounds and method of use
GB201514754D0 (en) 2015-08-19 2015-09-30 Karus Therapeutics Ltd Compounds
GB201514751D0 (en) * 2015-08-19 2015-09-30 Karus Therapeutics Ltd Compounds

Also Published As

Publication number Publication date
WO2017029517A1 (en) 2017-02-23
US20180243313A1 (en) 2018-08-30
HK1251467A1 (en) 2019-02-01
PL3337477T3 (en) 2023-07-03
KR20180064387A (en) 2018-06-14
CN108348505B (en) 2021-10-12
CN113786409A (en) 2021-12-14
SMT202300063T1 (en) 2023-03-17
CN113786409B (en) 2024-04-02
DK3337477T3 (en) 2023-02-20
HUE061615T2 (en) 2023-07-28
MX2018001926A (en) 2018-06-19
EP3337477B1 (en) 2023-02-01
CA2995898A1 (en) 2017-02-23
RS64095B1 (en) 2023-04-28
LT3337477T (en) 2023-03-10
US10668077B2 (en) 2020-06-02
HRP20230376T1 (en) 2023-06-23
US20230066999A1 (en) 2023-03-02
SI3337477T1 (en) 2023-04-28
AU2016307885B2 (en) 2019-07-25
CN108348505A (en) 2018-07-31
ES2939815T3 (en) 2023-04-27
IL257499A (en) 2018-07-31
EP3337477A1 (en) 2018-06-27
US20210069200A1 (en) 2021-03-11
PT3337477T (en) 2023-03-20
FI3337477T3 (en) 2023-04-27
AU2016307885A1 (en) 2018-03-08
US11291669B2 (en) 2022-04-05
JP2018523689A (en) 2018-08-23

Similar Documents

Publication Publication Date Title
IL286316A (en) Novel micro-dystrophins and related methods of use
HK1253049A1 (en) Glycan-interacting compounds and methods of use
GB201514756D0 (en) Compound and method of use
IL251996A0 (en) Substituted chromanes and method of use
ZA201905677B (en) Glycan-interacting compounds and methods of use
HUE068842T2 (en) Compounds and their methods of use
HUE061672T2 (en) Glycan-interacting compounds and methods of use
GB201514760D0 (en) Compounds and method of use
GB2544180B (en) Cover means and method of use thereof
IL282482A (en) Protoxin-ii variants and methods of use
PL3089971T3 (en) Compounds and methods of use
GB201609786D0 (en) Compounds and method of use
IL282508A (en) Protoxin-ii variants and methods of use
PT3397364T (en) Structured elements and methods of use
GB201904142D0 (en) Improved method of FT-IMS
ZA201606450B (en) Compounds and their methods of use
GB2541786B (en) Jig and method of use thereof
GB201408171D0 (en) Formulation and method of manufacture
GB201403697D0 (en) Compounds and methods of use
GB201416797D0 (en) Contianer and method of use thereof
GB201508694D0 (en) Construction apparatus and method of use thereof
GB201501257D0 (en) Cover means and method of use thereof
GB201419990D0 (en) Hprseshoe and method of manufacture
SG11201610124SA (en) Derrick assembly and method for use of same

Legal Events

Date Code Title Description
AT Applications terminated before publication under section 16(1)