PL3202814T3 - Poli(laktyd/glikolid) o niskim efekcie nagłego uwalniania i sposoby wytwarzania polimerów - Google Patents

Poli(laktyd/glikolid) o niskim efekcie nagłego uwalniania i sposoby wytwarzania polimerów

Info

Publication number: PL3202814T3
Authority: PL; Poland
Prior art keywords: glycolide; lactide; poly; methods; produce polymers
Prior art date: 2007-02-15

Application number

PL15185218T

Other languages

English (en)

Inventor

Eric Dadey

John Middleton

Richard L. Norton

Original Assignee

Tolmar Therapeutics, Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-02-15

Filing date

2008-02-13

Publication date

2020-01-31

2008-02-13 Application filed by Tolmar Therapeutics, Inc. filed Critical Tolmar Therapeutics, Inc.

2020-01-31 Publication of PL3202814T3 publication Critical patent/PL3202814T3/pl

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
- C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
- C08G63/08—Lactones or lactides
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/88—Post-polymerisation treatment
- C08G63/90—Purification; Drying

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Endocrinology (AREA)
Immunology (AREA)
Polymers & Plastics (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Reproductive Health (AREA)
Gastroenterology & Hepatology (AREA)
Communicable Diseases (AREA)
Ophthalmology & Optometry (AREA)
Oncology (AREA)
Pain & Pain Management (AREA)
Inorganic Chemistry (AREA)
Dermatology (AREA)
Rheumatology (AREA)
Diabetes (AREA)
Neurology (AREA)
Gynecology & Obstetrics (AREA)
Physical Education & Sports Medicine (AREA)
Psychiatry (AREA)
Urology & Nephrology (AREA)
Pregnancy & Childbirth (AREA)
Tropical Medicine & Parasitology (AREA)
Virology (AREA)

PL15185218T 2007-02-15 2008-02-13 Poli(laktyd/glikolid) o niskim efekcie nagłego uwalniania i sposoby wytwarzania polimerów PL3202814T3 (pl)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US90143507P	2007-02-15	2007-02-15
EP15185218.3A EP3202814B1 (en)	2007-02-15	2008-02-13	Low burst poly-(lactide/glycolide) and methods to produce polymers
EP08725511.3A EP2115029B1 (en)	2007-02-15	2008-02-13	Low burst poly-(lactide/glycolide) and methods to produce polymers
PCT/US2008/001887 WO2008100532A1 (en)	2007-02-15	2008-02-13	Low burst poly-(lactide/glycolide) and methods to produce polymers

Publications (1)

Publication Number	Publication Date
PL3202814T3 true PL3202814T3 (pl)	2020-01-31

Family

ID=39504385

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
PL08725511T PL2115029T3 (pl)	2007-02-15	2008-02-13	Poli(laktyd/glikolid) o niskim efekcie nagłego uwalniania i sposoby wytwarzania polimerów
PL15185218T PL3202814T3 (pl)	2007-02-15	2008-02-13	Poli(laktyd/glikolid) o niskim efekcie nagłego uwalniania i sposoby wytwarzania polimerów
PL19203071.6T PL3660073T3 (pl)	2007-02-15	2008-02-13	Poli(laktyd-ko-glikolid) o niskim nagłym uwalnianiu

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
PL08725511T PL2115029T3 (pl)	2007-02-15	2008-02-13	Poli(laktyd/glikolid) o niskim efekcie nagłego uwalniania i sposoby wytwarzania polimerów

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
PL19203071.6T PL3660073T3 (pl)	2007-02-15	2008-02-13	Poli(laktyd-ko-glikolid) o niskim nagłym uwalnianiu

Country Status (16)

Country	Link
US (7)	US9187593B2 (pl)
EP (3)	EP2115029B1 (pl)
JP (3)	JP5342459B2 (pl)
CA (1)	CA2678350C (pl)
CY (2)	CY1116785T1 (pl)
DK (3)	DK2115029T3 (pl)
ES (3)	ES2956244T3 (pl)
FI (1)	FI3660073T3 (pl)
HK (1)	HK1138303A1 (pl)
HR (3)	HRP20231117T3 (pl)
HU (3)	HUE063170T2 (pl)
LT (2)	LT3660073T (pl)
PL (3)	PL2115029T3 (pl)
PT (3)	PT3660073T (pl)
SI (3)	SI2115029T1 (pl)
WO (1)	WO2008100532A1 (pl)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8313763B2 (en)	2004-10-04	2012-11-20	Tolmar Therapeutics, Inc.	Sustained delivery formulations of rapamycin compounds
US8852638B2 (en)	2005-09-30	2014-10-07	Durect Corporation	Sustained release small molecule drug formulation
KR20150017777A (ko)	2006-01-18	2015-02-17	포시에이서 파마슈티컬스 인코포레이티드	안정성이 강화된 약학 조성물
HRP20231117T3 (hr)	2007-02-15	2023-12-22	Tolmar International Limited	Poli-(laktid-ko-glikolid) sa smanjenim efektom naglog oslobađanja
MX337286B (es)	2007-05-25	2016-02-22	Indivior Uk Ltd	Formulaciones de transferencia sostenida de compuestos de risperidona.
US8877225B2 (en)	2008-06-03	2014-11-04	Tolmar Therapeutics, Inc.	Controlled release copolymer formulation with improved release kinetics
US10285936B2 (en)	2010-05-31	2019-05-14	Laboratorios Farmacéuticos Rovi, S.A.	Injectable composition with aromatase inhibitor
US10350159B2 (en)	2010-05-31	2019-07-16	Laboratories Farmacéuticos Rovi, S.A.	Paliperidone implant formulation
US10335366B2 (en)	2010-05-31	2019-07-02	Laboratorios Farmacéuticos Rovi, S.A.	Risperidone or paliperidone implant formulation
LT2394663T (lt)	2010-05-31	2022-02-10	Laboratorios Farmaceuticos Rovi, S.A.	Kompozicijos, skirtos įšvirkščiamiems in situ biologiškai skaidiems implantams
US10881605B2 (en)	2010-05-31	2021-01-05	Laboratorios Farmaceuticos Rovi, S.A.	Methods for the preparation of injectable depot compositions
ES2589106T3 (es)	2010-05-31	2016-11-10	Laboratorios Farmaceuticos Rovi, S.A.	Composición inyectable antipsicótica de liberación controlada
US10463607B2 (en)	2010-05-31	2019-11-05	Laboratorios Farmaceutics Rofi S.A.	Antipsychotic Injectable Depot Composition
GB2481017B (en)	2010-06-08	2015-01-07	Rb Pharmaceuticals Ltd	Microparticle buprenorphine suspension
US9272044B2 (en)	2010-06-08	2016-03-01	Indivior Uk Limited	Injectable flowable composition buprenorphine
GB2481018B (en)	2010-06-08	2015-03-18	Rb Pharmaceuticals Ltd	Injectable flowable composition comprising buprenorphine
CN103421172B (zh) *	2012-05-23	2016-01-20	上海现代药物制剂工程研究中心有限公司	一种生物可降解聚酯的纯化工艺
US20140308352A1 (en)	2013-03-11	2014-10-16	Zogenix Inc.	Compositions and methods involving polymer, solvent, and high viscosity liquid carrier material
CA2903769A1 (en)	2013-03-11	2014-10-09	Durect Corporation	Injectable controlled release composition comprising high viscosity liquid carrier
WO2014168134A1 (ja) *	2013-04-11	2014-10-16	三井化学株式会社	乳酸―グリコール酸共重合体の製造法またはその塩の製造法
WO2015085251A1 (en) *	2013-12-06	2015-06-11	Envisia Therapeutics Inc.	Intracameral implant for treatment of an ocular condition
GB201404139D0 (en)	2014-03-10	2014-04-23	Rb Pharmaceuticals Ltd	Sustained release buprenorphine solution formulations
US20160106804A1 (en) *	2014-10-15	2016-04-21	Yuhua Li	Pharmaceutical composition with improved stability
EP3215223B1 (en)	2014-11-07	2020-07-01	Indivior UK Limited	Buprenorphine dosing regimens
US11458041B2 (en)	2015-10-08	2022-10-04	Ocular Therapeutix, Inc.	Punctal plug and bioadhesives
US10646484B2 (en)	2017-06-16	2020-05-12	Indivior Uk Limited	Methods to treat opioid use disorder
CN112545995B (zh) *	2018-05-16	2024-02-23	珠海市丽珠微球科技有限公司	一种阿立哌唑缓释微球及其制备方法
PE20210047A1 (es)	2018-06-12	2021-01-08	Farm Rovi Lab Sa	Composicion inyectable
AU2020284587A1 (en) *	2019-05-27	2022-01-06	Tolmar International Limited	Leuprolide acetate compositions and methods of using the same to treat breast cancer
IL295357A (en)	2020-02-06	2022-10-01	Ocular Therapeutix Inc	Preparations and methods for the treatment of eye diseases
CA3177005A1 (en)	2020-04-27	2021-11-04	Michael Goldstein	Methods of treating allergic conjunctivitis
CN116528876A (zh)	2020-09-30	2023-08-01	托尔玛国际有限公司	用于延长睾酮的递送的生物可降解聚合物递送系统
WO2024168022A2 (en)	2023-02-10	2024-08-15	Tolmar, Inc.	Degarelix polymeric formulations
WO2025008759A1 (en)	2023-07-05	2025-01-09	Tolmar International Limited	Polymeric leuprolide acetate formulations

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2551756B2 (ja) *	1985-05-07	1996-11-06	武田薬品工業株式会社	ポリオキシカルボン酸エステルおよびその製造法
DE3641692A1 (de) *	1986-12-06	1988-06-09	Boehringer Ingelheim Kg	Katalysatorfreie resorbierbare homopolymere und copolymere
DE3708916A1 (de)	1987-03-19	1988-09-29	Boehringer Ingelheim Kg	Verfahren zur reinigung resorbierbarer polyester
US4938763B1 (en)	1988-10-03	1995-07-04	Atrix Lab Inc	Biodegradable in-situ forming implants and method of producing the same
US5702716A (en)	1988-10-03	1997-12-30	Atrix Laboratories, Inc.	Polymeric compositions useful as controlled release implants
US5324519A (en)	1989-07-24	1994-06-28	Atrix Laboratories, Inc.	Biodegradable polymer composition
US5487897A (en)	1989-07-24	1996-01-30	Atrix Laboratories, Inc.	Biodegradable implant precursor
ATE168391T1 (de) *	1990-04-13	1998-08-15	Takeda Chemical Industries Ltd	Biologisch abbaubare hochmolekulare polymere, ihre herstellung und ihre verwendung
USRE37950E1 (en)	1990-04-24	2002-12-31	Atrix Laboratories	Biogradable in-situ forming implants and methods of producing the same
US6353030B1 (en) *	1990-08-01	2002-03-05	Novartis Ag	Relating to organic compounds
AU2605592A (en)	1991-10-15	1993-04-22	Atrix Laboratories, Inc.	Polymeric compositions useful as controlled release implants
EP0560014A1 (en)	1992-03-12	1993-09-15	Atrix Laboratories, Inc.	Biodegradable film dressing and method for its formation
US5681873A (en)	1993-10-14	1997-10-28	Atrix Laboratories, Inc.	Biodegradable polymeric composition
BR9507313A (pt) *	1994-04-08	1997-10-07	Atrix Lab Inc	Composição liquida de liberação adequada para a formação de um implante de liberação controlada sistema polimérico curativo filmico microporoso biodegradável precursor de implante de liberação controlada para a implantação em um indivíduo polímero termoplástico solvente orgánico composicão de pré-polimero liquido componente de liberação controlada agente ativo uso da composição liquida de liberação e processos para forma um implante microporoso de liberação prolongada e para liberar um agente ativo em um individuo
US6346274B1 (en)	1995-03-10	2002-02-12	Roche Diagnostics Gmbh	Polypeptide-containing pharmaceutical forms of administration in the form of microparticles and method for the preparation thereof
US5736152A (en)	1995-10-27	1998-04-07	Atrix Laboratories, Inc.	Non-polymeric sustained release delivery system
US6264970B1 (en) *	1996-06-26	2001-07-24	Takeda Chemical Industries, Ltd.	Sustained-release preparation
JP4317599B2 (ja)	1996-06-26	2009-08-19	武田薬品工業株式会社	徐放性製剤
EP1034207B1 (en)	1997-10-03	2005-03-02	Macromed Inc.	BIODEGRADABLE LOW MOLECULAR WEIGHT TRIBLOCK POLY(LACTIDE-co-GLYCOLIDE) POLYETHYLENE GLYCOL COPOLYMERS HAVING REVERSE THERMAL GELATION PROPERTIES
US6261583B1 (en) *	1998-07-28	2001-07-17	Atrix Laboratories, Inc.	Moldable solid delivery system
US6143314A (en)	1998-10-28	2000-11-07	Atrix Laboratories, Inc.	Controlled release liquid delivery compositions with low initial drug burst
US6565874B1 (en) *	1998-10-28	2003-05-20	Atrix Laboratories	Polymeric delivery formulations of leuprolide with improved efficacy
US6355657B1 (en)	1998-12-30	2002-03-12	Atrix Laboratories, Inc.	System for percutaneous delivery of opioid analgesics
US6461631B1 (en)	1999-11-16	2002-10-08	Atrix Laboratories, Inc.	Biodegradable polymer composition
PT1693054T (pt)	2000-08-07	2016-07-07	Takeda Pharmaceuticals Co	Polímero de ácido láctico e processo para a sua produção
TWI225416B (en) *	2001-06-29	2004-12-21	Takeda Chemical Industries Ltd	Sustained-release composition and process for producing the same
JP5188670B2 (ja) *	2001-06-29	2013-04-24	武田薬品工業株式会社	徐放性組成物およびその製造法
US20060034889A1 (en) *	2004-08-16	2006-02-16	Macromed, Inc.	Biodegradable diblock copolymers having reverse thermal gelation properties and methods of use thereof
BRPI0516308A2 (pt) *	2004-10-04	2010-06-15	Qlt Usa Inc	composição fluida, métodos de tratamento de uma doença ou disfunção, métodos de liberação local ou sistêmica de um agente biológico, implantes, método de formação de um implante, kit de agente biológico e usos de uma composição fluida
AU2005304435B8 (en)	2004-11-10	2011-06-23	Tolmar Therapeutics, Inc.	A stabilized polymeric delivery system
DK2079767T3 (da) *	2006-10-11	2014-10-27	Tolmar Therapeutics Inc	Fremstilling af bionedbrydelige polyestere med lave burst-egenskaber ved ekstraktion med et superkritisk fluid
HRP20231117T3 (hr)	2007-02-15	2023-12-22	Tolmar International Limited	Poli-(laktid-ko-glikolid) sa smanjenim efektom naglog oslobađanja

2008
- 2008-02-13 HR HRP20231117TT patent/HRP20231117T3/hr unknown
- 2008-02-13 WO PCT/US2008/001887 patent/WO2008100532A1/en active Application Filing
- 2008-02-13 HU HUE19203071A patent/HUE063170T2/hu unknown
- 2008-02-13 ES ES19203071T patent/ES2956244T3/es active Active
- 2008-02-13 PT PT192030716T patent/PT3660073T/pt unknown
- 2008-02-13 CA CA2678350A patent/CA2678350C/en not_active Expired - Fee Related
- 2008-02-13 HU HUE08725511A patent/HUE025842T2/en unknown
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Also Published As

Publication number	Publication date
JP2013224339A (ja)	2013-10-31
CA2678350C (en)	2015-11-17
PT3202814T (pt)	2019-11-26
JP5342459B2 (ja)	2013-11-13
HRP20231117T3 (hr)	2023-12-22
US10206970B2 (en)	2019-02-19
JP5848290B2 (ja)	2016-01-27
HUE025842T2 (en)	2016-04-28
SI2115029T1 (sl)	2016-01-29
HUE063170T2 (hu)	2024-01-28
US9187593B2 (en)	2015-11-17
JP2010519218A (ja)	2010-06-03
US11147880B2 (en)	2021-10-19
US11717572B2 (en)	2023-08-08
EP3202814B1 (en)	2019-10-16
DK3660073T3 (da)	2023-09-18
LT3660073T (lt)	2023-10-10
US20160106847A1 (en)	2016-04-21
US20170095560A1 (en)	2017-04-06
HUE047775T2 (hu)	2020-05-28
US9561282B2 (en)	2017-02-07
US20100292195A1 (en)	2010-11-18
HRP20192055T1 (hr)	2020-02-21
CA2678350A1 (en)	2008-08-21
SI3660073T1 (sl)	2023-10-30
EP2115029A1 (en)	2009-11-11
PL2115029T3 (pl)	2016-01-29
US9655970B2 (en)	2017-05-23
US20170216395A1 (en)	2017-08-03
CY1116785T1 (el)	2017-03-15
JP6195587B2 (ja)	2017-09-13
JP2015127351A (ja)	2015-07-09
SI3202814T1 (sl)	2019-12-31
LT3202814T (lt)	2019-12-10
PL3660073T3 (pl)	2023-12-27
PT3660073T (pt)	2023-08-31
DK2115029T3 (en)	2015-10-05
US9974824B2 (en)	2018-05-22
US20180311305A1 (en)	2018-11-01
EP3660073B1 (en)	2023-07-12
HK1138303A1 (en)	2010-08-20
ES2755374T3 (es)	2020-04-22
EP3660073A1 (en)	2020-06-03
PT2115029E (pt)	2015-10-26
EP2115029B1 (en)	2015-09-16
DK3202814T3 (da)	2019-11-25
CY1122304T1 (el)	2021-01-27
US20220202941A1 (en)	2022-06-30
ES2956244T3 (es)	2023-12-15
FI3660073T3 (fi)	2023-09-11
US20190209643A1 (en)	2019-07-11
ES2550014T3 (es)	2015-11-03
HRP20150997T1 (hr)	2015-12-18
EP3202814A1 (en)	2017-08-09
WO2008100532A1 (en)	2008-08-21

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