PL1851250T3 - Ludzkie przeciwciało monoklonalne przeciwko antygenowi błony komórkowej komórek prostaty (PSMA) - Google Patents
Ludzkie przeciwciało monoklonalne przeciwko antygenowi błony komórkowej komórek prostaty (PSMA)Info
- Publication number
- PL1851250T3 PL1851250T3 PL06735489T PL06735489T PL1851250T3 PL 1851250 T3 PL1851250 T3 PL 1851250T3 PL 06735489 T PL06735489 T PL 06735489T PL 06735489 T PL06735489 T PL 06735489T PL 1851250 T3 PL1851250 T3 PL 1851250T3
- Authority
- PL
- Poland
- Prior art keywords
- psma
- monoclonal antibody
- human monoclonal
- prostate specific
- specific membrane
- Prior art date
Links
- 102100041003 Glutamate carboxypeptidase 2 Human genes 0.000 title 1
- 101000892862 Homo sapiens Glutamate carboxypeptidase 2 Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Reproductive Health (AREA)
- Cell Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65412505P | 2005-02-18 | 2005-02-18 | |
| US72049905P | 2005-09-26 | 2005-09-26 | |
| US74841705P | 2005-12-08 | 2005-12-08 | |
| EP06735489A EP1851250B1 (en) | 2005-02-18 | 2006-02-17 | Human monoclonal antibody to prostate specific membrane antigen (psma) |
| PCT/US2006/005852 WO2006089230A2 (en) | 2005-02-18 | 2006-02-17 | Human monoclonal antibodies to prostate specific membrane antigen (psma) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL1851250T3 true PL1851250T3 (pl) | 2012-10-31 |
Family
ID=36658707
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL06735489T PL1851250T3 (pl) | 2005-02-18 | 2006-02-17 | Ludzkie przeciwciało monoklonalne przeciwko antygenowi błony komórkowej komórek prostaty (PSMA) |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US20090297438A1 (pl) |
| EP (1) | EP1851250B1 (pl) |
| JP (1) | JP2008529556A (pl) |
| KR (1) | KR20070115967A (pl) |
| CN (1) | CN101124249B (pl) |
| AU (1) | AU2006214031A1 (pl) |
| BR (1) | BRPI0607757A2 (pl) |
| CA (1) | CA2598522A1 (pl) |
| CY (1) | CY1113089T1 (pl) |
| DK (1) | DK1851250T3 (pl) |
| ES (1) | ES2386366T3 (pl) |
| HR (1) | HRP20120709T1 (pl) |
| IL (1) | IL184733A (pl) |
| MX (1) | MX2007009878A (pl) |
| NO (1) | NO20073797L (pl) |
| NZ (1) | NZ556661A (pl) |
| PL (1) | PL1851250T3 (pl) |
| PT (1) | PT1851250E (pl) |
| WO (1) | WO2006089230A2 (pl) |
Families Citing this family (69)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2360169B1 (en) | 2001-10-23 | 2015-10-14 | Psma Development Company, L.L.C. | PSMA antibodies |
| US20050215472A1 (en) | 2001-10-23 | 2005-09-29 | Psma Development Company, Llc | PSMA formulations and uses thereof |
| EP1726650A1 (en) * | 2005-05-27 | 2006-11-29 | Universitätsklinikum Freiburg | Monoclonal antibodies and single chain antibody fragments against cell-surface prostate specific membrane antigen |
| DE102008010363A1 (de) * | 2008-02-18 | 2009-08-20 | Lang, Florian, Prof. Dr.med. | Sgk1 als therapeutisches und diagnostisches Target für karzinomatöse Erkrankungen |
| CA2721169A1 (en) * | 2008-04-14 | 2009-10-22 | Proscan Rx Pharma Inc. | Prostate specific membrane antigen antibodies and antigen binding fragments |
| DK2326350T3 (da) | 2008-09-08 | 2013-12-16 | Psma Dev Company L L C | Forbindelser til at dræbe psma-udtrykkende, taxanresistente cancerceller |
| WO2010037837A2 (en) | 2008-10-01 | 2010-04-08 | Micromet Ag | Bispecific single chain antibodies with specificity for high molecular weight target antigens |
| JP6126782B2 (ja) * | 2008-10-01 | 2017-05-10 | アムゲン リサーチ (ミュンヘン) ゲーエムベーハー | 異種間特異的psma×cd3二重特異性単鎖抗体 |
| CN101891818B (zh) * | 2009-01-16 | 2012-07-25 | 中国人民解放军第四军医大学 | 抗人前列腺特异性膜抗原胞外区单链抗体及其应用 |
| EP2419451A4 (en) * | 2009-04-14 | 2012-11-14 | Proscan Rx Pharma Inc | ANTIBODIES DIRECTED AGAINST THE PROSTATE-SPECIFIC MEMBRANE ANTIGEN |
| EA201290020A1 (ru) | 2009-05-19 | 2013-10-30 | ЭйАйСи БЛЭБ КОМПАНИ | Композитный токоприемник и способы его изготовления |
| US8394922B2 (en) | 2009-08-03 | 2013-03-12 | Medarex, Inc. | Antiproliferative compounds, conjugates thereof, methods therefor, and uses thereof |
| TWI629357B (zh) * | 2009-10-02 | 2018-07-11 | 安進研究(慕尼黑)有限責任公司 | 跨物種特異性的PSMAxCD3雙特異性單鏈抗體 |
| TWI653333B (zh) | 2010-04-01 | 2019-03-11 | 安進研究(慕尼黑)有限責任公司 | 跨物種專一性之PSMAxCD3雙專一性單鏈抗體 |
| US8956859B1 (en) | 2010-08-13 | 2015-02-17 | Aviex Technologies Llc | Compositions and methods for determining successful immunization by one or more vaccines |
| WO2012145714A2 (en) | 2011-04-22 | 2012-10-26 | Emergent Product Development Seattle, Llc | Prostate-specific membrane antigen binding proteins and related compositions and methods |
| US8852599B2 (en) | 2011-05-26 | 2014-10-07 | Bristol-Myers Squibb Company | Immunoconjugates, compositions for making them, and methods of making and use |
| HK1211967A1 (zh) * | 2012-10-05 | 2016-06-03 | Cornell University | 雄激素抑制,前列腺特异性膜抗原和有条件增强漏洞状态的概念 |
| PT2956173T (pt) | 2013-02-14 | 2017-06-26 | Bristol Myers Squibb Co | Compostos de tubulisina, métodos de produção e utilização |
| JP6474404B2 (ja) | 2013-08-14 | 2019-02-27 | ウィリアム マーシュ ライス ユニバーシティWilliam Marsh Rice University | ウンシアラマイシン誘導体、合成方法、および抗腫瘍薬としてのそれらの使用 |
| US10077287B2 (en) | 2014-11-10 | 2018-09-18 | Bristol-Myers Squibb Company | Tubulysin analogs and methods of making and use |
| EP3221346B1 (en) | 2014-11-21 | 2020-09-02 | Bristol-Myers Squibb Company | Antibodies comprising modified heavy constant regions |
| TW201632532A (zh) | 2015-01-14 | 2016-09-16 | 必治妥美雅史谷比公司 | 伸雜芳基-橋聯苯并二氮呯二聚體,其共軛物及製造及使用方法 |
| AU2016229087A1 (en) * | 2015-03-10 | 2017-09-28 | Sorrento Therapeutics, Inc. | Antibody therapeutics that bind PSMA |
| JOP20160154B1 (ar) * | 2015-07-31 | 2021-08-17 | Regeneron Pharma | أجسام ضادة مضاد لل psma، وجزيئات رابطة لمستضد ثنائي النوعية الذي يربط psma و cd3، واستخداماتها |
| CN108367004B (zh) | 2015-09-21 | 2022-09-13 | 阿帕特夫研究和发展有限公司 | Cd3结合多肽 |
| AU2016377371A1 (en) | 2015-12-21 | 2018-08-09 | Bristol-Myers Squibb Company | Variant antibodies for site-specific conjugation |
| JP7190901B2 (ja) | 2016-01-12 | 2022-12-16 | クレッシェンド、バイオロジックス、リミテッド | 前立腺特異的膜抗原(psma)と結合する分子 |
| CN105542008A (zh) * | 2016-02-03 | 2016-05-04 | 南昌大学 | 能特异结合前列腺特异性膜抗原的单域重链抗体 |
| CN105524171A (zh) * | 2016-02-03 | 2016-04-27 | 中国人民解放军第三军医大学第三附属医院 | 一种针对前列腺特异性膜抗原的纳米抗体 |
| CN105504061A (zh) * | 2016-02-03 | 2016-04-20 | 南昌大学 | 针对前列腺特异性膜抗原的纳米抗体 |
| AU2017250191A1 (en) * | 2016-04-13 | 2018-11-08 | Orimabs Ltd. | Anti-PSMA antibodies and use thereof |
| GB201607968D0 (en) | 2016-05-06 | 2016-06-22 | Crescendo Biolog Ltd | Chimeric antigen receptor |
| JP2019518013A (ja) | 2016-05-10 | 2019-06-27 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | 安定性が向上したツブリシン類似体の抗体薬物結合体 |
| GB201614162D0 (en) | 2016-08-18 | 2016-10-05 | Polytherics Ltd | Antibodies, uses thereof and conjugates thereof |
| KR102493853B1 (ko) | 2016-08-19 | 2023-01-30 | 브리스톨-마이어스 스큅 컴퍼니 | 세코-시클로프로파피롤로인돌 화합물, 그의 항체-약물 접합체, 및 제조 및 사용 방법 |
| WO2018075842A1 (en) | 2016-10-20 | 2018-04-26 | Bristol-Myers Squibb Company | Condensed benzodiazepine derivatives and conjugates made therefrom |
| EP3565842A1 (en) | 2017-01-06 | 2019-11-13 | Crescendo Biologics Limited | Single domain antibodies to programmed cell death (pd-1) |
| CN110662762A (zh) | 2017-05-24 | 2020-01-07 | 诺华股份有限公司 | 抗体细胞因子移植蛋白和用于治疗癌症的方法 |
| WO2018218056A1 (en) | 2017-05-25 | 2018-11-29 | Birstol-Myers Squibb Company | Antibodies comprising modified heavy constant regions |
| GB201711068D0 (en) | 2017-07-10 | 2017-08-23 | Crescendo Biologics Ltd | Therapeutic molecules binding PSMA |
| US10472361B2 (en) | 2017-08-16 | 2019-11-12 | Bristol-Myers Squibb Company | Toll-like receptor 7 (TLR7) agonists having a benzotriazole moiety, conjugates thereof, and methods and uses therefor |
| US10508115B2 (en) | 2017-08-16 | 2019-12-17 | Bristol-Myers Squibb Company | Toll-like receptor 7 (TLR7) agonists having heteroatom-linked aromatic moieties, conjugates thereof, and methods and uses therefor |
| US10494370B2 (en) | 2017-08-16 | 2019-12-03 | Bristol-Myers Squibb Company | Toll-like receptor 7 (TLR7) agonists having a pyridine or pyrazine moiety, conjugates thereof, and methods and uses therefor |
| US10457681B2 (en) | 2017-08-16 | 2019-10-29 | Bristol_Myers Squibb Company | Toll-like receptor 7 (TLR7) agonists having a tricyclic moiety, conjugates thereof, and methods and uses therefor |
| US10487084B2 (en) | 2017-08-16 | 2019-11-26 | Bristol-Myers Squibb Company | Toll-like receptor 7 (TLR7) agonists having a heterobiaryl moiety, conjugates thereof, and methods and uses therefor |
| CN118955716A (zh) | 2017-11-13 | 2024-11-15 | 克雷森多生物制剂有限公司 | 结合cd137的单结构域抗体 |
| GB201802573D0 (en) | 2018-02-16 | 2018-04-04 | Crescendo Biologics Ltd | Therapeutic molecules that bind to LAG3 |
| CA3093078A1 (en) | 2018-03-06 | 2019-09-12 | The Trustees Of The University Of Pennsylvania | Prostate-specific membrane antigen cars and methods of use thereof |
| WO2019209811A1 (en) | 2018-04-24 | 2019-10-31 | Bristol-Myers Squibb Company | Macrocyclic toll-like receptor 7 (tlr7) agonists |
| IL278938B2 (en) | 2018-05-29 | 2024-09-01 | Bristol Myers Squibb Co | Modified self-immolating moieties for use in prodrugs and conjugates and methods of using and making |
| MX419677B (es) | 2018-06-21 | 2025-01-14 | Regeneron Pharma | Anticuerpos anti-psma x anti-cd28 biespecíficos y usos de estos |
| US11554120B2 (en) | 2018-08-03 | 2023-01-17 | Bristol-Myers Squibb Company | 1H-pyrazolo[4,3-d]pyrimidine compounds as toll-like receptor 7 (TLR7) agonists and methods and uses therefor |
| CN113348177A (zh) | 2018-11-28 | 2021-09-03 | 百时美施贵宝公司 | 包含经修饰的重链恒定区的抗体 |
| CN113453725A (zh) | 2018-11-30 | 2021-09-28 | 百时美施贵宝公司 | 包含含有谷氨酰胺的轻链c末端延伸的抗体、其缀合物以及方法和用途 |
| US12478686B2 (en) | 2018-12-12 | 2025-11-25 | Bristol-Myers Squibb Company | Antibodies modified for transglutaminase conjugation, conjugates thereof, and methods and uses |
| CN110407939B (zh) * | 2019-03-12 | 2023-09-29 | 广东医科大学附属第二医院 | 一种人源化抗psma单链抗体及其应用 |
| JP7682859B2 (ja) * | 2019-09-11 | 2025-05-26 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア | 前立腺幹細胞抗原(psca)キメラ抗原受容体(car)を含む組成物および方法 |
| US20240377413A1 (en) | 2019-09-16 | 2024-11-14 | Bristol-Myers Squibb Company | Dual capture method for analysis of antibody-drug conjugates |
| CN113024670A (zh) * | 2019-12-25 | 2021-06-25 | 百奥泰生物制药股份有限公司 | Ctla-4抗体及其制备方法 |
| CN116323667A (zh) | 2020-07-08 | 2023-06-23 | 拉法医疗股份有限公司 | 结合PSMA和γ-δT细胞受体的抗体 |
| WO2023088966A1 (en) | 2021-11-19 | 2023-05-25 | Adc Therapeutics Sa | Anti-psma conjugates |
| IL322949A (en) | 2023-03-03 | 2025-10-01 | Arsenal Biosciences Inc | Systems targeting PSMA and CA9 |
| CN116462762B (zh) * | 2023-06-14 | 2023-08-25 | 天健生物制药(天津)有限公司 | 一种抗前列腺特异性抗原单克隆抗体及其应用 |
| CN118027203A (zh) * | 2023-12-11 | 2024-05-14 | 合肥天港免疫药物有限公司 | Psma抗体及其应用 |
| WO2025149029A1 (zh) * | 2024-01-12 | 2025-07-17 | 信达生物制药(苏州)有限公司 | 抗cd28抗体及其用途 |
| WO2025188693A1 (en) | 2024-03-05 | 2025-09-12 | Bristol-Myers Squibb Company | Bicyclic tlr7 agonists and uses thereof |
| US20250282786A1 (en) | 2024-03-05 | 2025-09-11 | Bristol-Myers Squibb Company | Tricyclic TLR7 Agonists and Uses Thereof |
| CN120446482B (zh) * | 2025-07-10 | 2025-09-19 | 杭州华得森生物技术有限公司 | 微流控芯片psma前列腺癌循环肿瘤细胞免疫富集检测试剂盒及制备方法 |
Family Cites Families (86)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4391904A (en) * | 1979-12-26 | 1983-07-05 | Syva Company | Test strip kits in immunoassays and compositions therein |
| US4671958A (en) * | 1982-03-09 | 1987-06-09 | Cytogen Corporation | Antibody conjugates for the delivery of compounds to target sites |
| US4816567A (en) * | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4912227A (en) * | 1984-02-21 | 1990-03-27 | The Upjohn Company | 1,2,8,8A-tetrahydrocyclopropa(c)pyrrolo(3,2-e)-indol-4-(5H)-ones and related compounds |
| US5225539A (en) * | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| EP0271581B1 (en) * | 1986-04-17 | 1993-01-13 | Kyowa Hakko Kogyo Co., Ltd. | Novel compounds dc-88a and dc-89a1 and process for their preparation |
| US5332837A (en) * | 1986-12-19 | 1994-07-26 | The Upjohn Company | CC-1065 analogs |
| US5773435A (en) * | 1987-08-04 | 1998-06-30 | Bristol-Myers Squibb Company | Prodrugs for β-lactamase and uses thereof |
| US5036003A (en) * | 1987-08-21 | 1991-07-30 | Monsanto Company | Antibodies to VPF |
| US4952394A (en) * | 1987-11-23 | 1990-08-28 | Bristol-Myers Company | Drug-monoclonal antibody conjugates |
| US4994578A (en) * | 1987-11-27 | 1991-02-19 | Meiji Seika Kaisha, Ltd. | Certain anti-tumor duocarmycin antibiotics from streptomyces |
| JP2642165B2 (ja) * | 1988-07-22 | 1997-08-20 | 協和醗酵工業株式会社 | 新規dc−89化合物およびその製造法 |
| US5084468A (en) * | 1988-08-11 | 1992-01-28 | Kyowa Hakko Kogyo Co., Ltd. | Dc-88a derivatives |
| US5223409A (en) * | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| US5176996A (en) * | 1988-12-20 | 1993-01-05 | Baylor College Of Medicine | Method for making synthetic oligonucleotides which bind specifically to target sites on duplex DNA molecules, by forming a colinear triplex, the synthetic oligonucleotides and methods of use |
| JP2598116B2 (ja) * | 1988-12-28 | 1997-04-09 | 協和醗酵工業株式会社 | 新規物質dc113 |
| US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5187186A (en) * | 1989-07-03 | 1993-02-16 | Kyowa Hakko Kogyo Co., Ltd. | Pyrroloindole derivatives |
| US5495009A (en) * | 1989-10-24 | 1996-02-27 | Gilead Sciences, Inc. | Oligonucleotide analogs containing thioformacetal linkages |
| US5334528A (en) * | 1989-10-30 | 1994-08-02 | The Regents Of The University Of California | Monoclonal antibodies to cyclodiene insecticides and method for detecting the same |
| US6075181A (en) * | 1990-01-12 | 2000-06-13 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| KR100208957B1 (ko) * | 1990-04-25 | 1999-07-15 | 로렌스 티. 마이젠헬더 | 신규한 cc-1065 유사체 |
| US5427908A (en) * | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| US5137877B1 (en) * | 1990-05-14 | 1996-01-30 | Bristol Myers Squibb Co | Bifunctional linking compounds conjugates and methods for their production |
| US6172197B1 (en) * | 1991-07-10 | 2001-01-09 | Medical Research Council | Methods for producing members of specific binding pairs |
| DE69121334T2 (de) * | 1990-07-26 | 1997-03-20 | Kyowa Hakko Kogyo Kk | DC-89-Derivate als Antitumor-Wirkstoffe |
| US5874299A (en) * | 1990-08-29 | 1999-02-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5625126A (en) * | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5545806A (en) * | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| US5877397A (en) * | 1990-08-29 | 1999-03-02 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US5633425A (en) * | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5770429A (en) * | 1990-08-29 | 1998-06-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| ES2341666T3 (es) * | 1991-12-02 | 2010-06-24 | Medimmune Limited | Produccion de autoanticuerpos de repertorios de segmentos de anticue rpos expresados en la superficie de fagos. |
| US5622929A (en) * | 1992-01-23 | 1997-04-22 | Bristol-Myers Squibb Company | Thioether conjugates |
| US5227471A (en) * | 1992-01-30 | 1993-07-13 | Eastern Virginia Medical School Of The Medical College Of Hampton Roads | Monoclonal antibody PD41 that binds to a prostate mucin antigen that is expressed in human prostatic carcinoma |
| US6004554A (en) * | 1992-03-05 | 1999-12-21 | Board Of Regents, The University Of Texas System | Methods for targeting the vasculature of solid tumors |
| US5965132A (en) * | 1992-03-05 | 1999-10-12 | Board Of Regents, The University Of Texas System | Methods and compositions for targeting the vasculature of solid tumors |
| JP3514490B2 (ja) * | 1992-08-21 | 2004-03-31 | 杏林製薬株式会社 | トリフルオロメチルピロロインドールカルボン酸エステル誘導体及びその製造方法 |
| US5288514A (en) * | 1992-09-14 | 1994-02-22 | The Regents Of The University Of California | Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support |
| US5489525A (en) * | 1992-10-08 | 1996-02-06 | The United States Of America As Represented By The Department Of Health And Human Services | Monoclonal antibodies to prostate cells |
| US5324483B1 (en) * | 1992-10-08 | 1996-09-24 | Warner Lambert Co | Apparatus for multiple simultaneous synthesis |
| JP4204642B2 (ja) * | 1992-11-05 | 2009-01-07 | スローン − ケタリング・インスティテュート・フォー・キャンサー・リサーチ | 前立腺に特異的な膜抗原 |
| US6214345B1 (en) * | 1993-05-14 | 2001-04-10 | Bristol-Myers Squibb Co. | Lysosomal enzyme-cleavable antitumor drug conjugates |
| US5786377A (en) * | 1993-11-19 | 1998-07-28 | Universidad De Santiago De Compostela | Pyrrolo 3,2-E!indol derivatives, process for the preparation thereof and applications |
| WO1995029179A1 (en) * | 1994-04-22 | 1995-11-02 | Kyowa Hakko Kogyo Co., Ltd. | Dc-89 derivative |
| US5773001A (en) * | 1994-06-03 | 1998-06-30 | American Cyanamid Company | Conjugates of methyltrithio antitumor agents and intermediates for their synthesis |
| ATE380559T1 (de) * | 1994-08-19 | 2007-12-15 | Wallone Region | Konjugate enthaltend ein antitumorales mittel und deren verwendung |
| KR100395083B1 (ko) * | 1994-11-29 | 2004-02-05 | 자이단호오징 사가미 츄오 카가쿠겡큐쇼 | 아크릴아미드유도체및그제조방법 |
| US5643786A (en) * | 1995-01-27 | 1997-07-01 | The United States Of America As Represented By The Department Of Health And Human Services | Method for isolating dendritic cells |
| US5773292A (en) * | 1995-06-05 | 1998-06-30 | Cornell University | Antibodies binding portions, and probes recognizing an antigen of prostate epithelial cells but not antigens circulating in the blood |
| US5714586A (en) * | 1995-06-07 | 1998-02-03 | American Cyanamid Company | Methods for the preparation of monomeric calicheamicin derivative/carrier conjugates |
| US5712374A (en) * | 1995-06-07 | 1998-01-27 | American Cyanamid Company | Method for the preparation of substantiallly monomeric calicheamicin derivative/carrier conjugates |
| JPH11513391A (ja) * | 1995-10-03 | 1999-11-16 | ザ スクリップス リサーチ インスティテュート | Cc−1065 及びズオカーマイシンのcbi 類縁体 |
| CA2187969C (en) * | 1995-10-17 | 2006-05-30 | Dale L. Boger | A template for solution phase synthesis of combinatorial libraries |
| ES2195036T3 (es) * | 1995-12-22 | 2003-12-01 | Bristol Myers Squibb Co | Conectores de hidrazona ramificados. |
| US6107090A (en) * | 1996-05-06 | 2000-08-22 | Cornell Research Foundation, Inc. | Treatment and diagnosis of prostate cancer with antibodies to extracellur PSMA domains |
| WO1997045411A1 (en) * | 1996-05-31 | 1997-12-04 | The Scripps Research Institute | Analogs of cc-1065 and the duocarmycins |
| JPH1087666A (ja) * | 1996-09-18 | 1998-04-07 | Kyorin Pharmaceut Co Ltd | デュオカルマイシンsa及びその誘導体の製造中間体と製造方法 |
| US6759509B1 (en) * | 1996-11-05 | 2004-07-06 | Bristol-Myers Squibb Company | Branched peptide linkers |
| US6194152B1 (en) * | 1997-08-20 | 2001-02-27 | Dendreon Corporation | Prostate tumor polynucleotide compositions and methods of detection thereof |
| CA2306420A1 (en) * | 1997-10-14 | 1999-04-22 | The Scripps Research Institute | Iso-cbi and iso-ci analogs of cc-1065 and the duocarmycins |
| US6310209B1 (en) * | 1997-12-08 | 2001-10-30 | The Scripps Research Institute | Synthesis of CC-1065/duocarmycin analogs |
| JP3045706B1 (ja) * | 1998-09-14 | 2000-05-29 | 科学技術振興事業団 | Dnaの特定塩基配列をアルキル化する化合物及びその合成法 |
| CN100400547C (zh) * | 1999-07-29 | 2008-07-09 | 米德列斯公司 | 前列腺特异膜抗原的人类单克隆抗体 |
| WO2001074898A2 (en) * | 2000-03-16 | 2001-10-11 | Genesoft, Inc. | Charged compounds comprising a nucleic acid binding moiety and uses therefor |
| CA2411545A1 (en) * | 2000-06-14 | 2002-01-03 | Medarex, Inc. | Tripeptide prodrug compounds |
| US7115573B2 (en) * | 2000-06-14 | 2006-10-03 | Medarex, Inc. | Prodrug compounds with an isoleucine |
| EP1243276A1 (en) * | 2001-03-23 | 2002-09-25 | Franciscus Marinus Hendrikus De Groot | Elongated and multiple spacers containing activatible prodrugs |
| US20030083263A1 (en) * | 2001-04-30 | 2003-05-01 | Svetlana Doronina | Pentapeptide compounds and uses related thereto |
| US6884869B2 (en) * | 2001-04-30 | 2005-04-26 | Seattle Genetics, Inc. | Pentapeptide compounds and uses related thereto |
| US6762179B2 (en) * | 2001-05-31 | 2004-07-13 | Vertex Pharmaceuticals Incorporated | Thiazole compounds useful as inhibitors of protein kinase |
| KR20030033007A (ko) * | 2001-05-31 | 2003-04-26 | 코울터 파머수티컬, 인코포레이티드 | 세포독소, 약물전구체, 링커 및 이에 유용한 안정화제 |
| ATE504315T1 (de) * | 2001-06-11 | 2011-04-15 | Medarex Inc | Methode für die ausarbeitung von cd10-aktivierten prodrug-verbindungen |
| EP1423110A4 (en) * | 2001-09-07 | 2005-04-27 | Scripps Research Inst | CBI ANALOGUE OF CC-1065 AND DUOCARMYCINES |
| US7091186B2 (en) * | 2001-09-24 | 2006-08-15 | Seattle Genetics, Inc. | p-Amidobenzylethers in drug delivery agents |
| EP2360169B1 (en) * | 2001-10-23 | 2015-10-14 | Psma Development Company, L.L.C. | PSMA antibodies |
| WO2003064606A2 (en) * | 2002-01-28 | 2003-08-07 | Medarex, Inc. | Human monoclonal antibodies to prostate specific membrane antigen (psma) |
| US6534660B1 (en) * | 2002-04-05 | 2003-03-18 | Immunogen, Inc. | CC-1065 analog synthesis |
| BR0309145A (pt) * | 2002-04-09 | 2005-02-01 | Kyowa Hakko Kogyo Kk | Células das quais o genoma é modificado |
| WO2003085118A1 (en) * | 2002-04-09 | 2003-10-16 | Kyowa Hakko Kogyo Co., Ltd. | Process for producing antibody composition |
| US20040032828A1 (en) * | 2002-08-16 | 2004-02-19 | Cellglide Technologies Corp. | Service management in cellular networks |
| WO2004101767A2 (en) * | 2003-05-13 | 2004-11-25 | The Scripps Research Institute | Cbi analogues of the duocarmycins and cc-1065 |
| KR100552478B1 (ko) * | 2003-11-20 | 2006-02-15 | 삼성전자주식회사 | 파워 인렛 소켓 |
| CA2564076C (en) * | 2004-05-19 | 2014-02-18 | Medarex, Inc. | Chemical linkers and conjugates thereof |
| RU2402548C2 (ru) * | 2004-05-19 | 2010-10-27 | Медарекс, Инк. | Химические линкеры и их конъюгаты |
| WO2006089231A2 (en) * | 2005-02-18 | 2006-08-24 | Medarex, Inc. | Monoclonal antibodies against prostate specific membrane antigen (psma) lacking in fucosyl residues |
-
2006
- 2006-02-17 PL PL06735489T patent/PL1851250T3/pl unknown
- 2006-02-17 MX MX2007009878A patent/MX2007009878A/es not_active Application Discontinuation
- 2006-02-17 JP JP2007556368A patent/JP2008529556A/ja active Pending
- 2006-02-17 ES ES06735489T patent/ES2386366T3/es not_active Expired - Lifetime
- 2006-02-17 HR HRP20120709TT patent/HRP20120709T1/hr unknown
- 2006-02-17 BR BRPI0607757-9A patent/BRPI0607757A2/pt not_active Application Discontinuation
- 2006-02-17 NZ NZ556661A patent/NZ556661A/en not_active IP Right Cessation
- 2006-02-17 US US11/918,153 patent/US20090297438A1/en not_active Abandoned
- 2006-02-17 WO PCT/US2006/005852 patent/WO2006089230A2/en not_active Ceased
- 2006-02-17 KR KR1020077021333A patent/KR20070115967A/ko not_active Withdrawn
- 2006-02-17 EP EP06735489A patent/EP1851250B1/en not_active Expired - Lifetime
- 2006-02-17 CN CN2006800053479A patent/CN101124249B/zh not_active Expired - Fee Related
- 2006-02-17 AU AU2006214031A patent/AU2006214031A1/en not_active Abandoned
- 2006-02-17 PT PT06735489T patent/PT1851250E/pt unknown
- 2006-02-17 CA CA002598522A patent/CA2598522A1/en not_active Abandoned
- 2006-02-17 DK DK06735489.4T patent/DK1851250T3/da active
-
2007
- 2007-07-19 IL IL184733A patent/IL184733A/en not_active IP Right Cessation
- 2007-07-20 NO NO20073797A patent/NO20073797L/no not_active Application Discontinuation
-
2012
- 2012-09-04 CY CY20121100788T patent/CY1113089T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO20073797L (no) | 2007-09-12 |
| PT1851250E (pt) | 2012-08-27 |
| CY1113089T1 (el) | 2016-04-13 |
| MX2007009878A (es) | 2007-10-03 |
| EP1851250B1 (en) | 2012-06-06 |
| AU2006214031A1 (en) | 2006-08-24 |
| KR20070115967A (ko) | 2007-12-06 |
| DK1851250T3 (da) | 2012-07-09 |
| BRPI0607757A2 (pt) | 2009-10-06 |
| IL184733A0 (en) | 2007-12-03 |
| WO2006089230A3 (en) | 2006-11-16 |
| CN101124249B (zh) | 2011-06-29 |
| HRP20120709T1 (hr) | 2012-10-31 |
| NZ556661A (en) | 2010-10-29 |
| EP1851250A2 (en) | 2007-11-07 |
| JP2008529556A (ja) | 2008-08-07 |
| IL184733A (en) | 2015-07-30 |
| CA2598522A1 (en) | 2006-08-24 |
| WO2006089230A2 (en) | 2006-08-24 |
| ES2386366T3 (es) | 2012-08-17 |
| US20090297438A1 (en) | 2009-12-03 |
| CN101124249A (zh) | 2008-02-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PL1851250T3 (pl) | Ludzkie przeciwciało monoklonalne przeciwko antygenowi błony komórkowej komórek prostaty (PSMA) | |
| EP1519747A4 (en) | HUMAN MONOCLONAL ANTIBODIES AGAINST PROSTATE-SPECIFIC MEMBRANE ANTIGEN (PSMA) | |
| IL191340A (en) | Monoclonal antibodies against e8o | |
| IL189788A0 (en) | Human monoclonal antibodies to cd70 | |
| HRP20181616T1 (hr) | Potpuno ljudska anti-vap-1 monoklonska antitijela | |
| IL184949A0 (en) | Monoclonal antibodies against prostate specific membrane antigen (psma) lacking in fucosyl residues | |
| IL231169A0 (en) | Human monoclonal antibodies to fucosil - 1gm and methods of using antibodies against fucosil - 1gm | |
| SG10201404801YA (en) | Monoclonal antibody | |
| ZA200802641B (en) | Human monoclonal antibodies to CD70 | |
| IL197636B (en) | Isolated human monoclonal antibodies that specifically bind to the human il-17 receptor | |
| IL206709A0 (en) | Il-31 monoclonal antibodies | |
| IL179672A (en) | Monoclonal antibodies against 3 cd human | |
| IL182012A0 (en) | Monoclonal antibodies to progastrin | |
| EP2021373A4 (en) | MONOCLONAL ANTIBODY VCAM-1 SPECIFIC | |
| IL216381A0 (en) | Antagonistic human light-specific human monoclonal antibodies | |
| ZA200905874B (en) | Monoclonal human tumor-specific antibody | |
| ZA200901165B (en) | Antagonistic human light-specific human monoclonal antibodies | |
| SI1851250T1 (sl) | Humano monoklonsko protitelo proti za prostato specifičnemu membranskemu antigenu (PSMA) | |
| HK1104048A (en) | Human monoclonal antibodies to prostate specific membrane antigen (psma) | |
| ZA200804254B (en) | Human monoclonal antibodies to O8E | |
| GB0415644D0 (en) | Monoclonal antibody | |
| HK1122825A (en) | Human monoclonal antibodies to o8e | |
| HK1079085A (en) | Human monoclonal antibodies to prostate specific membrane antigen (psma) | |
| HK1114106A (en) | Human monoclonal antibodies to cd70 | |
| HK1104310A (en) | Monoclonal antibodies against prostate specific membrane antigen (psma) lacking in fucosyl residues |