PL1644019T3 - Związki amfetaminy odporne na nadużywanie - Google Patents
Związki amfetaminy odporne na nadużywanieInfo
- Publication number
- PL1644019T3 PL1644019T3 PL04753925T PL04753925T PL1644019T3 PL 1644019 T3 PL1644019 T3 PL 1644019T3 PL 04753925 T PL04753925 T PL 04753925T PL 04753925 T PL04753925 T PL 04753925T PL 1644019 T3 PL1644019 T3 PL 1644019T3
- Authority
- PL
- Poland
- Prior art keywords
- compounds
- amphetamine
- compositions
- abuse
- bioavailability
- Prior art date
Links
- KWTSXDURSIMDCE-QMMMGPOBSA-N (S)-amphetamine Chemical class C[C@H](N)CC1=CC=CC=C1 KWTSXDURSIMDCE-QMMMGPOBSA-N 0.000 title abstract 5
- 229940025084 amphetamine Drugs 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 4
- 239000000203 mixture Substances 0.000 abstract 4
- 238000000034 method Methods 0.000 abstract 2
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 abstract 1
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 208000035231 inattentive type attention deficit hyperactivity disease Diseases 0.000 abstract 1
- 238000001990 intravenous administration Methods 0.000 abstract 1
- 201000003631 narcolepsy Diseases 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K4/00—Peptides having up to 20 amino acids in an undefined or only partially defined sequence; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/901—Drugs of abuse, e.g. narcotics, amphetamine
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/17—Nitrogen containing
- Y10T436/173845—Amine and quaternary ammonium
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Psychiatry (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Anesthesiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Child & Adolescent Psychology (AREA)
- Addiction (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US47392903P | 2003-05-29 | 2003-05-29 | |
US56780104P | 2004-05-05 | 2004-05-05 | |
PCT/US2004/017204 WO2005000334A1 (en) | 2003-05-29 | 2004-06-01 | Abuse resistant amphetamine compounds |
EP04753925.9A EP1644019B2 (en) | 2003-05-29 | 2004-06-01 | Abuse resistant amphetamine compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
PL1644019T3 true PL1644019T3 (pl) | 2012-07-31 |
PL1644019T5 PL1644019T5 (pl) | 2018-06-29 |
Family
ID=33555349
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL04753925T PL1644019T5 (pl) | 2003-05-29 | 2004-06-01 | Związki amfetaminy odporne na nadużywanie |
Country Status (25)
Country | Link |
---|---|
US (11) | US7223735B2 (pl) |
EP (1) | EP1644019B2 (pl) |
JP (2) | JP4898445B2 (pl) |
KR (2) | KR101170840B1 (pl) |
CN (1) | CN1816346B (pl) |
AT (1) | ATE545427T2 (pl) |
AU (1) | AU2004251647B2 (pl) |
BE (1) | BE2020C543I2 (pl) |
BR (1) | BRPI0410792B8 (pl) |
CA (1) | CA2527646C (pl) |
CY (1) | CY1113130T1 (pl) |
DK (1) | DK1644019T4 (pl) |
EA (1) | EA010295B1 (pl) |
EG (1) | EG26032A (pl) |
ES (1) | ES2380622T5 (pl) |
HK (1) | HK1088254A1 (pl) |
IL (1) | IL172212A (pl) |
MX (1) | MXPA05012850A (pl) |
NL (1) | NL301019I2 (pl) |
NO (1) | NO20056211L (pl) |
NZ (1) | NZ544162A (pl) |
PL (1) | PL1644019T5 (pl) |
PT (1) | PT1644019E (pl) |
SI (1) | SI1644019T2 (pl) |
WO (1) | WO2005000334A1 (pl) |
Families Citing this family (70)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6716452B1 (en) * | 2000-08-22 | 2004-04-06 | New River Pharmaceuticals Inc. | Active agent delivery systems and methods for protecting and administering active agents |
US20070060500A1 (en) * | 2000-08-22 | 2007-03-15 | New River Pharmaceuticals Inc. | Pharmaceutical compositions for prevention of overdose or abuse |
US8394813B2 (en) * | 2000-11-14 | 2013-03-12 | Shire Llc | Active agent delivery systems and methods for protecting and administering active agents |
US7169752B2 (en) | 2003-09-30 | 2007-01-30 | New River Pharmaceuticals Inc. | Compounds and compositions for prevention of overdose of oxycodone |
US7338939B2 (en) * | 2003-09-30 | 2008-03-04 | New River Pharmaceuticals Inc. | Abuse-resistant hydrocodone compounds |
US20060014697A1 (en) * | 2001-08-22 | 2006-01-19 | Travis Mickle | Pharmaceutical compositions for prevention of overdose or abuse |
US7375082B2 (en) * | 2002-02-22 | 2008-05-20 | Shire Llc | Abuse-resistant hydrocodone compounds |
US20070066537A1 (en) * | 2002-02-22 | 2007-03-22 | New River Pharmaceuticals Inc. | Compounds and compositions for prevention of overdose of oxycodone |
US7659253B2 (en) * | 2002-02-22 | 2010-02-09 | Shire Llc | Abuse-resistant amphetamine prodrugs |
US7700561B2 (en) * | 2002-02-22 | 2010-04-20 | Shire Llc | Abuse-resistant amphetamine prodrugs |
US7105486B2 (en) * | 2002-02-22 | 2006-09-12 | New River Pharmaceuticals Inc. | Abuse-resistant amphetamine compounds |
US8133881B2 (en) * | 2003-01-13 | 2012-03-13 | Shire Llc | Carbohydrate conjugates to prevent abuse of controlled substances |
WO2005000334A1 (en) * | 2003-05-29 | 2005-01-06 | New River Pharmaceuticals, Inc. | Abuse resistant amphetamine compounds |
SG147485A1 (en) * | 2003-09-30 | 2008-11-28 | Shire Llc | Pharmaceutical compositions for prevention of overdose or abuse |
ATE509622T1 (de) * | 2006-12-11 | 2011-06-15 | Kempharm Inc | Amphetamin-ornithine konjugate sowie herstellungs-und verwendungsverfahren |
CN101631566A (zh) * | 2007-02-08 | 2010-01-20 | 凯姆制药公司 | 苯丙胺与其它兴奋剂的极性亲水性前体药物及其制造和使用方法 |
EP2187873B1 (en) | 2007-08-13 | 2018-07-25 | Abuse Deterrent Pharmaceutical Llc | Abuse resistant drugs, method of use and method of making |
WO2009035473A2 (en) * | 2007-09-13 | 2009-03-19 | Sanfilippo Louis C | Method of treating binge eating disorder, obesity resulting from binge eating behavior and depressive disorders |
CN101555214B (zh) * | 2008-04-08 | 2012-07-11 | 北京嘉事联博医药科技有限公司 | 苯基环丁基酰胺衍生物及其光学异构体、制备方法和用途 |
JP5706825B2 (ja) | 2008-10-17 | 2015-04-22 | シグネーチャー セラピューティクス, インク.Signature Therapeutics, Inc. | フェノール性オピオイドの放出が減弱された医薬組成物 |
WO2010136803A1 (en) * | 2009-05-26 | 2010-12-02 | Shire Llc | Methods of enhancing selective serotonin reuptake inhibitor effects in mammals |
US8614346B2 (en) | 2009-06-19 | 2013-12-24 | Cambrex Charles City, Inc. | Methods and compositions for preparation of amphetamine conjugates and salts thereof |
BR112012005124B1 (pt) | 2009-09-08 | 2021-11-09 | Signature Therapeutics, Inc. | Pro-fármaco de opioide modificado por cetona, seu método de preparação, sua composição farmacêutica, sua unidade de dose, métodos e usos |
HUE037281T2 (hu) * | 2009-11-20 | 2018-08-28 | Tonix Pharma Holdings Ltd | Eljárás és készítmény poszt-traumás stressz rendellenesség tüneteinek kezelésére ciklobenzaprin alkalmazásával |
JP5094832B2 (ja) * | 2009-12-25 | 2012-12-12 | 日東電工株式会社 | 粘着剤組成物および粘着シート |
US9238020B2 (en) | 2010-04-21 | 2016-01-19 | Signature Therapeutics, Inc. | Compositions comprising enzyme-cleavable phenol-modified tapentadol prodrug |
US20110262355A1 (en) | 2010-04-21 | 2011-10-27 | Jenkins Thomas E | Compositions comprising enzyme-cleavable opioid prodrugs and inhibitors thereof |
WO2011133347A1 (en) * | 2010-04-21 | 2011-10-27 | Pharmacofore, Inc. | Compositions comprising trypsin-cleavable amphetamine prodrugs and inhibitors thereof |
WO2011133348A1 (en) * | 2010-04-21 | 2011-10-27 | Pharmacofore, Inc. | Compositions comprising enzyme-cleavable amphetamine prodrugs and inhibitors thereof |
CA2800220C (en) | 2010-05-21 | 2019-04-30 | Research Triangle Institute | Phenylmorpholines and analogues thereof |
US20110319389A1 (en) | 2010-06-24 | 2011-12-29 | Tonix Pharmaceuticals, Inc. | Methods and compositions for treating fatigue associated with disordered sleep using very low dose cyclobenzaprine |
US20120010216A1 (en) * | 2010-07-06 | 2012-01-12 | Brown Arthur M | Pharmaceutical compositions containing vanoxerine |
WO2012056246A1 (en) | 2010-10-28 | 2012-05-03 | Shire Llc | Combination treatment of major depressive disorder |
US8779191B2 (en) * | 2010-12-20 | 2014-07-15 | Cambrex Charles City, Inc. | Methods and compositions for preparing lisdexamfetamine and salts thereof |
ES2584634T3 (es) | 2011-01-11 | 2016-09-28 | Signature Therapeutics, Inc. | Composiciones que comprenden un profármaco de oxicodona escindible enzimáticamente |
US8497237B2 (en) | 2011-01-11 | 2013-07-30 | Signature Therapeutics, Inc. | Compositions comprising enzyme-cleavable oxycodone prodrug |
US11998516B2 (en) | 2011-03-07 | 2024-06-04 | Tonix Pharma Holdings Limited | Methods and compositions for treating depression using cyclobenzaprine |
US8685916B2 (en) | 2011-03-09 | 2014-04-01 | Signature Therapeutics, Inc. | Opioid prodrugs with heterocyclic linkers |
RU2608305C2 (ru) | 2011-03-09 | 2017-01-17 | Сигничер Терапьютикс, Инк. | Пролекарства действующих веществ гетероциклическими линкерами |
US8927010B2 (en) | 2011-03-23 | 2015-01-06 | Ironshore Pharmaceuticals & Development, Inc. | Compositions for treatment of attention deficit hyperactivity disorder |
US9283214B2 (en) | 2011-03-23 | 2016-03-15 | Ironshore Pharmaceuticals & Development, Inc. | Compositions for treatment of attention deficit hyperactivity disorder |
US11241391B2 (en) | 2011-03-23 | 2022-02-08 | Ironshore Pharmaceuticals & Development, Inc. | Compositions for treatment of attention deficit hyperactivity disorder |
US9498447B2 (en) | 2011-03-23 | 2016-11-22 | Ironshore Pharmaceuticals & Development, Inc. | Compositions for treatment of attention deficit hyperactivity disorder |
US10905652B2 (en) | 2011-03-23 | 2021-02-02 | Ironshore Pharmaceuticals & Development, Inc. | Compositions for treatment of attention deficit hyperactivity disorder |
US9603809B2 (en) | 2011-03-23 | 2017-03-28 | Ironshore Pharmaceuticals & Development, Inc. | Methods of treatment of attention deficit hyperactivity disorder |
US9119809B2 (en) | 2011-03-23 | 2015-09-01 | Ironshore Pharmaceuticals & Development, Inc. | Compositions for treatment of attention deficit hyperactivity disorder |
SG193587A1 (en) | 2011-03-23 | 2013-10-30 | Ironshore Pharmaceuticals & Dev Inc | Methods and compositions for treatment of attention deficit disorder |
US10292937B2 (en) | 2011-03-23 | 2019-05-21 | Ironshore Pharmaceuticals & Development, Inc. | Methods of treatment of attention deficit hyperactivity disorder |
US8916588B2 (en) | 2011-03-23 | 2014-12-23 | Ironshore Pharmaceuticals & Development, Inc. | Methods for treatment of attention deficit hyperactivity disorder |
WO2013011526A1 (en) * | 2011-07-20 | 2013-01-24 | Ind-Swift Laboratories Limited | Process for preparation of lisdexamphetamine and salts thereof |
US20140275149A1 (en) | 2013-03-15 | 2014-09-18 | Inspirion Delivery Technologies, Llc | Abuse deterrent compositions and methods of use |
MX370021B (es) | 2013-03-15 | 2019-11-28 | Tonix Pharmaceuticals Inc | Formulaciones eutécticas de clorhidrato de ciclobenzaprina y de clorhidrato de amitriptilina. |
US12208068B2 (en) * | 2013-12-31 | 2025-01-28 | Pharmapotheca A Inc. | Amphetamine controlled release, prodrug, and abuse-deterrent dosage forms |
US11123310B2 (en) | 2017-02-24 | 2021-09-21 | Pharmapotheca, Llc | Amphetamine controlled release, prodrug, and abuse-deterrent dosage forms |
US10729685B2 (en) | 2014-09-15 | 2020-08-04 | Ohemo Life Sciences Inc. | Orally administrable compositions and methods of deterring abuse by intranasal administration |
CN107072968B (zh) | 2014-09-18 | 2021-01-12 | 通尼克斯制药控股有限公司 | 环苯扎林盐酸盐的低共熔混合物配制剂 |
US10544434B2 (en) | 2015-06-29 | 2020-01-28 | Noramco, Inc. | Process for the preparation of lisdexamfetamine and related derivatives |
MX2019006670A (es) * | 2016-12-11 | 2019-12-16 | Kempharm Inc | Composiciones que comprenden profarmacos de metilfenidato, procedimientos para la elaboracion y uso de los mismos. |
DK3459538T3 (da) | 2017-09-20 | 2020-08-03 | Sandoz Ag | Krystallinske salte af et dextroamfetamin-prodrug |
WO2019076675A1 (en) * | 2017-10-06 | 2019-04-25 | Instituto De Medicina Molecular | TREATMENT OF STATES RELATED TO OBESITY |
GB2571696B (en) | 2017-10-09 | 2020-05-27 | Compass Pathways Ltd | Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced |
JP2021505629A (ja) | 2017-12-11 | 2021-02-18 | トニックス ファーマ ホールディングス リミテッド | 認知症および神経変性状態における興奮、精神病および認知機能低下のためのシクロベンザプリン処置 |
US11136295B2 (en) | 2018-10-29 | 2021-10-05 | Kempharm, Inc. | D-amphetamine compounds, compositions, and processes for making and using the same |
CA3131403A1 (en) * | 2019-03-02 | 2020-09-10 | Chemapotheca, Llc | Process for making levoamphetamine |
US20220175699A1 (en) * | 2019-03-06 | 2022-06-09 | Ensysce Biosciences, Inc. | Compositions comprising enzyme-cleavable amphetamine prodrugs and inhibitors thereof |
US20220169668A1 (en) | 2019-04-17 | 2022-06-02 | Compass Pathfinder Limited | Methods of treating neurocognitive disorders, chronic pain and reducing inflammation |
EP4237007A1 (en) | 2020-11-18 | 2023-09-06 | Mind Medicine, Inc. | Mdma prodrugs to assist psychotherapy |
WO2022235530A1 (en) * | 2021-05-05 | 2022-11-10 | Mind Medicine, Inc. | Mdma enantiomers |
EP4346788A2 (en) | 2021-06-03 | 2024-04-10 | Arcadia Medicine, Inc. | Enantiomeric entactogen compositions and methods of their use |
AU2023326364A1 (en) * | 2022-08-17 | 2025-03-06 | Transcend Therapeutics, Inc. | Phenethylamines and cathinones precursors |
Family Cites Families (144)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US200300A (en) * | 1878-02-12 | Improvement in instruments for smoothing and leveling the teeth of horses | ||
US3028430A (en) * | 1955-03-28 | 1962-04-03 | Parke Davis & Co | Process for the production of optically active isomers of amphetamine |
US3028395A (en) * | 1955-03-28 | 1962-04-03 | Parke Davis & Co | Process for the resolution of optically active acids |
DE1493824A1 (de) * | 1964-01-27 | 1969-05-22 | Hoffmann La Roche | Verfahren zur Herstellung von Aminocarbonsaeureamiden |
CH406567A (de) | 1964-02-10 | 1966-01-31 | Inventio Ag | Einrichtung zur Steuerung der Sollwertgrösse während des Verzögerungsvorganges bei Aufzügen mit drehzahlgeregeltem Antrieb |
GB1091089A (en) | 1965-08-20 | 1967-11-15 | Pierre Wirth | Organic base salts of n-carbamyl-aspartic acids |
GB1112347A (en) | 1965-08-20 | 1968-05-01 | Pierre Wirth | Salts of organic bases with n-carbamyl-l-glutamic acid |
US3846399A (en) * | 1969-04-10 | 1974-11-05 | Merck & Co Inc | Process for controlled stepwise synthesis of polypeptides |
US3676492A (en) * | 1970-12-09 | 1972-07-11 | Aldrich Chem Co Inc | Amino acid amides of disubstituted phenethylamines |
US3843796A (en) † | 1971-04-26 | 1974-10-22 | Merck & Co Inc | Antihypertensive agents |
US3706831A (en) * | 1971-05-14 | 1972-12-19 | Abbott Lab | Method for treatment of drug addiction |
US3975342A (en) * | 1972-05-15 | 1976-08-17 | Biological Developments, Inc. | Tyrosyl-class antigenic conjugates, their preparation and antibodies raised thereto |
US3884898A (en) * | 1972-08-18 | 1975-05-20 | Syva Co | Normorphine derivatives bonded to proteins |
US3843696A (en) * | 1972-09-05 | 1974-10-22 | Syva Co | Methadone analog compounds |
US3878187A (en) * | 1972-09-11 | 1975-04-15 | Syva Co | Polypeptide derivatives of amphetamine and analogs for immunoassays |
US3878487A (en) * | 1973-08-02 | 1975-04-15 | Alexandr Lvovich Irzhavsky | Electromechanical disc filter |
US3998799A (en) * | 1973-11-02 | 1976-12-21 | Interx Research Corporation | Novel, transient pro-drug forms of l-dopa |
US3945342A (en) * | 1973-11-08 | 1976-03-23 | Xerox Corporation | Magnetic brush support member |
US4040907A (en) * | 1974-06-20 | 1977-08-09 | Syva Company | Iodothyronine enzyme conjugates |
GB1507144A (en) * | 1974-07-10 | 1978-04-12 | Post Office | Apparatus for drawing dielectric optical waveguides |
US4000280A (en) * | 1974-08-14 | 1976-12-28 | Astra Lakemedel Aktiebolag | Pharmaceutical compositions containing an amphetamine derivative for the alleviation of anxiety or treatment of depression |
DE2449333A1 (de) * | 1974-10-17 | 1976-04-29 | Bosch Gmbh Robert | Kraftstoffeinspritzpumpe fuer brennkraftmaschinen |
US4025501A (en) * | 1975-03-20 | 1977-05-24 | Syva Company | Polypeptide propoxyphene derivatives for immunoassay reagents |
US4064235A (en) * | 1975-08-21 | 1977-12-20 | Eisai Co., Ltd. | Dopamine derivative compounds, preparation thereof and medicine containing same |
US4043989A (en) * | 1975-09-11 | 1977-08-23 | Syva Company | Oxazepam derivatives for immunoassay reagents |
US4064236A (en) * | 1975-12-23 | 1977-12-20 | Merck & Co., Inc. | Peptide carbazates and pharmaceutical composition |
GB1592552A (en) * | 1976-12-10 | 1981-07-08 | Inst Nat Sante Rech Med | Pseudopeptides used as medicaments |
JPS54155675A (en) * | 1978-05-30 | 1979-12-07 | Matsushita Electronics Corp | Small-sized fluorescent lamp |
JPS557242A (en) | 1978-06-30 | 1980-01-19 | Tanabe Seiyaku Co Ltd | Phenethylamine derivative |
JPS5528915A (en) | 1978-08-18 | 1980-02-29 | Tanabe Seiyaku Co Ltd | Benzyl alcohol derivative and its preparation |
US4356166A (en) * | 1978-12-08 | 1982-10-26 | University Of Utah | Time-release chemical delivery system |
DE3008265A1 (de) * | 1980-03-04 | 1981-09-17 | Siemens AG, 1000 Berlin und 8000 München | Verfahren zum sichtbarmachen von stationaeren waermeuebergangskoeffizientenfeldern auf photochemischem wege |
US4399121A (en) * | 1981-11-04 | 1983-08-16 | Miles Laboratories, Inc. | Iodothyronine immunogens and antibodies |
US4427660A (en) * | 1982-03-03 | 1984-01-24 | Research Corporation | Formyl-methionyl chemotatic peptide antibiotic conjugates useful in treating infections |
HU185535B (en) * | 1982-05-25 | 1985-02-28 | Mta Koezponti Hivatala | Process for preparing new gonadoliberin derivatives |
US4457907A (en) * | 1982-08-05 | 1984-07-03 | Clear Lake Development Group | Composition and method for protecting a therapeutic drug |
US4650675A (en) * | 1983-08-18 | 1987-03-17 | The Children's Medical Center Corporation | Oligonucleotide conjugates |
JPS60166657A (ja) * | 1984-02-10 | 1985-08-29 | Nitto Boseki Co Ltd | アルギニル−3−カルボキシ−4−ヒドロキシアニリド |
ATE60340T1 (de) * | 1984-10-19 | 1991-02-15 | Battelle Memorial Institute | Durch mikroorganismen abbaubares polypeptid und seine verwendung fuer die fortschreitende abgabe von medikamenten. |
GB8500209D0 (en) | 1985-01-04 | 1985-02-13 | Ceskoslovenska Akademie Ved | Synthetic polymeric drugs |
US4863735A (en) * | 1985-02-19 | 1989-09-05 | Massachusetts Institute Of Technology | Biodegradable polymeric drug delivery system with adjuvant activity |
US4801575A (en) * | 1986-07-30 | 1989-01-31 | The Regents Of The University Of California | Chimeric peptides for neuropeptide delivery through the blood-brain barrier |
US4902505A (en) * | 1986-07-30 | 1990-02-20 | Alkermes | Chimeric peptides for neuropeptide delivery through the blood-brain barrier |
IN165717B (pl) * | 1986-08-07 | 1989-12-23 | Battelle Memorial Institute | |
DK406686D0 (da) * | 1986-08-26 | 1986-08-26 | Hans Bundgaard | Carboxylsyrederivater |
US5994392A (en) * | 1988-02-26 | 1999-11-30 | Neuromedica, Inc. | Antipsychotic prodrugs comprising an antipsychotic agent coupled to an unsaturated fatty acid |
US5169933A (en) * | 1988-08-15 | 1992-12-08 | Neorx Corporation | Covalently-linked complexes and methods for enhanced cytotoxicity and imaging |
US5026827A (en) * | 1988-09-02 | 1991-06-25 | Matsushita Electric Industrial Co., Ltd. | Amphetamine-protein complex as immunogen for obtaining antibodies specific to methamphetamine |
US5233025A (en) * | 1988-09-02 | 1993-08-03 | Matsushita Electric Industrial Co., Ltd. | Amphetamine protein complex as immunogen for obtaining antibodies specific to methamphetamine |
US4960790A (en) * | 1989-03-09 | 1990-10-02 | University Of Kansas | Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof |
FR2649247B1 (fr) * | 1989-06-30 | 1991-09-13 | Thomson Csf | Detecteur infrarouge a base de materiau pyroelectrique |
US5767227A (en) | 1989-11-03 | 1998-06-16 | Lotus Biochemical Corp. | Iodothyronine polymers |
US5219564A (en) * | 1990-07-06 | 1993-06-15 | Enzon, Inc. | Poly(alkylene oxide) amino acid copolymers and drug carriers and charged copolymers based thereon |
JPH078853B2 (ja) | 1990-08-30 | 1995-02-01 | 田辺製薬株式会社 | ドーパミン誘導体の製法 |
IT1244873B (it) * | 1990-09-12 | 1994-09-12 | Depha Team Srl | Derivati dell'acido 5-aminosalicilico (5-asa) per la terapia delle infiammazioni croniche intestinali |
DE69103503T2 (de) | 1990-09-28 | 1995-01-05 | Mercian Corp | Adriamycinderivate. |
US5238714A (en) | 1990-10-02 | 1993-08-24 | Board Of Regents, The University Of Texas System | Efficient microcapsule preparation and method of use |
US5863899A (en) * | 1991-04-01 | 1999-01-26 | Cortech, Inc. | Bradykinin antagonists |
JP2613502B2 (ja) * | 1991-05-31 | 1997-05-28 | 東洋紡績株式会社 | 制振材料用粘弾性樹脂組成物 |
US5811447A (en) | 1993-01-28 | 1998-09-22 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
US5470997A (en) | 1992-04-06 | 1995-11-28 | Biosite Diagnostics Incorporated | Amphetamine derivatives and protein and polypeptide amphetamine derivative conjugates and labels |
US5811127A (en) * | 1992-06-15 | 1998-09-22 | Emisphere Technologies, Inc. | Desferrioxamine oral delivery system |
CA2096495C (en) * | 1992-06-16 | 2002-07-09 | Kathy Palmer Ordonez | Dual analyte immunoassay |
GB9213077D0 (en) | 1992-06-19 | 1992-08-05 | Erba Carlo Spa | Polymerbound taxol derivatives |
US5534496A (en) | 1992-07-07 | 1996-07-09 | University Of Southern California | Methods and compositions to enhance epithelial drug transport |
GB9215780D0 (en) | 1992-07-24 | 1992-09-09 | Univ London Pharmacy | Peptide compounds |
US6093391A (en) | 1992-10-08 | 2000-07-25 | Supratek Pharma, Inc. | Peptide copolymer compositions |
US5298410A (en) * | 1993-02-25 | 1994-03-29 | Sterling Winthrop Inc. | Lyophilized formulation of polyethylene oxide modified proteins with increased shelf-life |
US5891459A (en) | 1993-06-11 | 1999-04-06 | The Board Of Trustees Of The Leland Stanford Junior University | Enhancement of vascular function by modulation of endogenous nitric oxide production or activity |
US5792786A (en) * | 1993-08-02 | 1998-08-11 | Commonwealth Scientific And Industrial Research Organisation | Non-steroidal anti-inflammatory fatty acid conjugates and their therapeutic use thereof |
AU5722694A (en) | 1993-11-05 | 1995-05-23 | Astra Aktiebolag | Novel amino acid derivatives |
WO1995014033A1 (en) | 1993-11-19 | 1995-05-26 | Aktiebolaget Astra | Novel dipeptide derivatives |
GB9401891D0 (en) | 1994-02-01 | 1994-03-30 | Boots Co Plc | Therapeutic agents |
US6051685A (en) * | 1994-03-11 | 2000-04-18 | Daiichi Pharmaceuticals Co., Ltd. | Peptide derivatives |
RU2152787C2 (ru) * | 1994-06-02 | 2000-07-20 | Дан Рига | Лекарство против стресса, против снижения уровня активности и против старения и способ его получения |
JP2526811B2 (ja) | 1994-07-22 | 1996-08-21 | 田辺製薬株式会社 | フェネチルアミン誘導体及びその製法 |
US5716614A (en) | 1994-08-05 | 1998-02-10 | Molecular/Structural Biotechnologies, Inc. | Method for delivering active agents to mammalian brains in a complex with eicosapentaenoic acid or docosahexaenoic acid-conjugated polycationic carrier |
US5910569A (en) | 1994-11-22 | 1999-06-08 | Lotus Biochemical Corporation | Iodothyronine polymers |
DE19504387A1 (de) * | 1995-02-11 | 1996-08-22 | Dufa Deutsche Uhrenfabr Gmbh | Schrittmotor |
US5846743A (en) | 1995-02-22 | 1998-12-08 | Brigham And Women's Hospital, Inc. | Polyphoshoinositide binding peptides for intracellular drug delivery |
US5670477A (en) | 1995-04-20 | 1997-09-23 | Joseph F. Poduslo | Method to enhance permeability of the blood/brain blood/nerve bariers to therapeutic agents |
DE69612093T2 (de) | 1995-06-07 | 2001-10-31 | Martin Sevoian | Auf antigen verarbeitende zellen zielgerichtete konjugate ein polyaminosäure rückgrat und ein nicht-steroidales antiphlogistikum enthaltend |
DE19526274A1 (de) * | 1995-07-19 | 1997-01-23 | Bayer Ag | Verbesserung der Verträglichkeit von pharmazeutisch wirksamen beta-Aminosäuren |
US5762909A (en) | 1995-08-31 | 1998-06-09 | General Electric Company | Tumor targeting with polymeric molecules having extended conformation |
US5851536A (en) | 1995-11-22 | 1998-12-22 | University Of Washington | Therapeutic delivery using compounds self-assembled into high axial ratio microstructures |
US6361957B1 (en) * | 1999-08-03 | 2002-03-26 | Glytech, Inc. | Assay for D-serine transport antagonist and use for treating psychosis |
ATE335818T1 (de) * | 1995-12-28 | 2006-09-15 | Takeda Pharmaceutical | Ligand polypeptide für hypophyse g-protein gekoppeltes rezeptor-protein, deren herstellung und anwendung |
SI0932399T1 (sl) | 1996-03-12 | 2006-10-31 | Pg Txl Co Lp | Vodotopna paklitakselna predzdravila |
GB9606975D0 (en) | 1996-04-02 | 1996-06-05 | Univ Birmingham | Anti-tumor agent |
US6030941A (en) | 1996-05-01 | 2000-02-29 | Avi Biopharma, Inc. | Polymer composition for delivering substances in living organisms |
US5922695A (en) | 1996-07-26 | 1999-07-13 | Gilead Sciences, Inc. | Antiviral phosphonomethyoxy nucleotide analogs having increased oral bioavarilability |
US5952294A (en) | 1996-07-31 | 1999-09-14 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Peptidyl prodrugs and methods of making and using the same |
US6013633A (en) | 1997-08-07 | 2000-01-11 | University Of Cincinnati | Compounds for control of appetite, blood pressure, cardiovascular response, libido, and circadian rhythm |
DE19640970A1 (de) * | 1996-10-04 | 1998-04-16 | Bayer Ag | Modifizierte Cytostatika |
US5948750A (en) | 1996-10-30 | 1999-09-07 | Merck & Co., Inc. | Conjugates useful in the treatment of prostate cancer |
WO1998048824A1 (en) | 1997-05-01 | 1998-11-05 | Emory University | Bioactive peptides derived from cocaine and amphetamine regulated transcript protein |
EP0975370B9 (en) | 1997-05-21 | 2004-11-03 | The Board Of Trustees Of The Leland Stanford Junior University | Composition and method for enhancing transport across biological membranes |
TW460478B (en) | 1997-08-15 | 2001-10-21 | Chugai Pharmaceutical Co Ltd | Phenethylamine derivatives |
EP1037649B1 (en) | 1997-12-17 | 2009-09-30 | Enzon, Inc. | Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents |
EP1053238B1 (en) | 1998-01-29 | 2005-12-28 | Monash University | Therapeutic compounds |
US6632922B1 (en) * | 1998-03-19 | 2003-10-14 | The Regents Of The University Of California | Methods and compositions for controlled polypeptide synthesis |
US6680365B1 (en) * | 1998-03-19 | 2004-01-20 | The Regents Of The University Of California | Methods and compositions for controlled polypeptide synthesis |
US6686446B2 (en) * | 1998-03-19 | 2004-02-03 | The Regents Of The University Of California | Methods and compositions for controlled polypeptide synthesis |
US6048736A (en) | 1998-04-29 | 2000-04-11 | Kosak; Kenneth M. | Cyclodextrin polymers for carrying and releasing drugs |
US6473669B2 (en) * | 1998-07-03 | 2002-10-29 | Kimberly-Clark Worldwide, Inc. | Controlling web tension, and accumulating lengths of web, by actively controlling velocity and acceleration of a festoon |
US6696558B2 (en) * | 1998-09-09 | 2004-02-24 | The Burnham Institute | Bag proteins and nucleic acid molecules encoding them |
JP2000173537A (ja) * | 1998-09-29 | 2000-06-23 | Toshiba Lighting & Technology Corp | 低圧水銀蒸気放電灯および照明装置 |
US7083808B2 (en) * | 1998-12-17 | 2006-08-01 | Euro-Celtique S.A. | Controlled/modified release oral methylphenidate formulations |
US7374779B2 (en) | 1999-02-26 | 2008-05-20 | Lipocine, Inc. | Pharmaceutical formulations and systems for improved absorption and multistage release of active agents |
US7060708B2 (en) * | 1999-03-10 | 2006-06-13 | New River Pharmaceuticals Inc. | Active agent delivery systems and methods for protecting and administering active agents |
US6716452B1 (en) | 2000-08-22 | 2004-04-06 | New River Pharmaceuticals Inc. | Active agent delivery systems and methods for protecting and administering active agents |
US6309633B1 (en) | 1999-06-19 | 2001-10-30 | Nobex Corporation | Amphiphilic drug-oligomer conjugates with hydroyzable lipophile components and methods for making and using the same |
US6384020B1 (en) * | 1999-07-14 | 2002-05-07 | Shire Laboratories, Inc. | Rapid immediate release oral dosage form |
CA2277855A1 (fr) | 1999-07-14 | 2001-01-14 | Solvision | Methode et systeme de mesure de la hauteur des billes de soudure d'un circuit imprime |
US6806330B1 (en) * | 1999-12-17 | 2004-10-19 | Dow Global Technologies Inc. | Amine organoborane complex polymerization initiators and polymerizable compositions |
US20020099013A1 (en) | 2000-11-14 | 2002-07-25 | Thomas Piccariello | Active agent delivery systems and methods for protecting and administering active agents |
US20070060500A1 (en) * | 2000-08-22 | 2007-03-15 | New River Pharmaceuticals Inc. | Pharmaceutical compositions for prevention of overdose or abuse |
WO2003034980A2 (en) † | 2000-11-14 | 2003-05-01 | New River Pharmaceuticals Inc. | A novel pharmaceutical compound containing abacavir sulfate and methods of making and using same |
US20020151526A1 (en) | 2000-10-06 | 2002-10-17 | Gallop Mark A. | Bile-acid prodrugs of L-dopa and their use in the sustained treatment of parkinsonism |
US6992076B2 (en) | 2000-10-06 | 2006-01-31 | Xenoport, Inc. | Bile-acid derived compounds for providing sustained systemic concentrations of drugs after oral administration |
US20020098999A1 (en) | 2000-10-06 | 2002-07-25 | Gallop Mark A. | Compounds for sustained release of orally delivered drugs |
CA2427388C (en) * | 2000-11-01 | 2011-12-20 | Sention, Inc. | Pharmaceutical compositions and uses for improving memory and learning impairments |
US6472228B2 (en) * | 2000-12-04 | 2002-10-29 | Lifepoint, Inc. | Composition and methods for synthesis of novel tracers for detecting amphetamine and methamphetamine in samples |
WO2003003498A1 (en) | 2001-06-29 | 2003-01-09 | Ovonic Battery Company, Inc. | Hydrogen storage battery; positive nickel electrode; positive electrode active material and methods for making |
US6740641B2 (en) | 2001-07-27 | 2004-05-25 | Euro-Celtique, S.A. | Sugar derivatives of hydromorphone, dihydromorphine and dihydromorphine, compositions thereof and uses for treating or preventing pain |
US20060014697A1 (en) * | 2001-08-22 | 2006-01-19 | Travis Mickle | Pharmaceutical compositions for prevention of overdose or abuse |
US7338939B2 (en) * | 2003-09-30 | 2008-03-04 | New River Pharmaceuticals Inc. | Abuse-resistant hydrocodone compounds |
US7169752B2 (en) * | 2003-09-30 | 2007-01-30 | New River Pharmaceuticals Inc. | Compounds and compositions for prevention of overdose of oxycodone |
US20070066537A1 (en) * | 2002-02-22 | 2007-03-22 | New River Pharmaceuticals Inc. | Compounds and compositions for prevention of overdose of oxycodone |
US7375082B2 (en) | 2002-02-22 | 2008-05-20 | Shire Llc | Abuse-resistant hydrocodone compounds |
CA2492823A1 (en) * | 2001-09-14 | 2003-03-27 | Martin F. Bachmann | In vivo activation of antigen presenting cells for enhancement of immune responses induced by virus like particles |
US6399828B1 (en) * | 2001-10-29 | 2002-06-04 | Boehringer Ingelheim Chemicals, Inc. | Preparation of amphetamines from phenylpropanolamines |
WO2003057716A2 (en) * | 2002-01-08 | 2003-07-17 | New River Pharmaceuticals, Inc. | Dendritic encapsulation of active agents |
EP2319540A1 (en) | 2002-02-22 | 2011-05-11 | Shire LLC | Sustained release pharmaceutical compounds to prevent abuse of controlled substances |
US7105486B2 (en) * | 2002-02-22 | 2006-09-12 | New River Pharmaceuticals Inc. | Abuse-resistant amphetamine compounds |
JP2005527505A (ja) * | 2002-02-22 | 2005-09-15 | ニュー リバー ファーマシューティカルズ インコーポレイテッド | 薬物血清レベルの患者間変動性を低減するためのペプチド−薬物複合体の使用 |
US7700561B2 (en) * | 2002-02-22 | 2010-04-20 | Shire Llc | Abuse-resistant amphetamine prodrugs |
US7659253B2 (en) † | 2002-02-22 | 2010-02-09 | Shire Llc | Abuse-resistant amphetamine prodrugs |
US6913768B2 (en) * | 2002-09-24 | 2005-07-05 | Shire Laboratories, Inc. | Sustained release delivery of amphetamine salts |
US8133881B2 (en) * | 2003-01-13 | 2012-03-13 | Shire Llc | Carbohydrate conjugates to prevent abuse of controlled substances |
AR042938A1 (es) * | 2003-02-06 | 2005-07-06 | Wyeth Corp | Uso del cci-779 en el tratamiento de la fibrosis hepatica |
DE602004024963D1 (de) | 2003-03-13 | 2010-02-25 | Controlled Chemicals Inc | Oxycodon- konjugate mit niedrigerem missbrauch- potential und ausgedehnter tätigkeitsdauer |
WO2005000334A1 (en) * | 2003-05-29 | 2005-01-06 | New River Pharmaceuticals, Inc. | Abuse resistant amphetamine compounds |
SG147485A1 (en) * | 2003-09-30 | 2008-11-28 | Shire Llc | Pharmaceutical compositions for prevention of overdose or abuse |
-
2004
- 2004-06-01 WO PCT/US2004/017204 patent/WO2005000334A1/en active Application Filing
- 2004-06-01 AU AU2004251647A patent/AU2004251647B2/en active Active
- 2004-06-01 US US10/857,619 patent/US7223735B2/en not_active Expired - Lifetime
- 2004-06-01 KR KR1020057022852A patent/KR101170840B1/ko active IP Right Grant
- 2004-06-01 EP EP04753925.9A patent/EP1644019B2/en not_active Expired - Lifetime
- 2004-06-01 AT AT04753925T patent/ATE545427T2/de active
- 2004-06-01 PL PL04753925T patent/PL1644019T5/pl unknown
- 2004-06-01 BR BRPI0410792A patent/BRPI0410792B8/pt active IP Right Grant
- 2004-06-01 JP JP2006533534A patent/JP4898445B2/ja not_active Expired - Lifetime
- 2004-06-01 CA CA2527646A patent/CA2527646C/en not_active Expired - Lifetime
- 2004-06-01 KR KR1020117011654A patent/KR101159477B1/ko active IP Right Grant
- 2004-06-01 PT PT04753925T patent/PT1644019E/pt unknown
- 2004-06-01 SI SI200431876T patent/SI1644019T2/en unknown
- 2004-06-01 CN CN2004800190890A patent/CN1816346B/zh not_active Expired - Lifetime
- 2004-06-01 ES ES04753925.9T patent/ES2380622T5/es not_active Expired - Lifetime
- 2004-06-01 NZ NZ544162A patent/NZ544162A/en not_active IP Right Cessation
- 2004-06-01 DK DK04753925.9T patent/DK1644019T4/en active
- 2004-06-01 MX MXPA05012850A patent/MXPA05012850A/es active IP Right Grant
- 2004-06-01 EA EA200501895A patent/EA010295B1/ru not_active IP Right Cessation
-
2005
- 2005-11-27 EG EGPCTNA2005000769A patent/EG26032A/en active
- 2005-11-28 IL IL172212A patent/IL172212A/en active IP Right Grant
- 2005-12-28 NO NO20056211A patent/NO20056211L/no not_active Application Discontinuation
-
2006
- 2006-09-20 HK HK06110426.7A patent/HK1088254A1/xx not_active IP Right Cessation
-
2007
- 2007-05-07 US US11/745,019 patent/US7662787B2/en not_active Expired - Lifetime
-
2008
- 2008-08-29 US US12/202,096 patent/US7718619B2/en not_active Expired - Lifetime
- 2008-08-29 US US12/201,739 patent/US7678770B2/en not_active Expired - Lifetime
- 2008-09-02 US US12/203,136 patent/US20090209471A1/en not_active Abandoned
- 2008-09-02 US US12/202,987 patent/US20090192093A1/en not_active Abandoned
- 2008-09-02 US US12/203,108 patent/US20090181898A1/en not_active Abandoned
- 2008-09-26 US US12/239,400 patent/US20090186945A1/en not_active Abandoned
- 2008-09-26 US US12/239,180 patent/US20090186825A1/en not_active Abandoned
- 2008-09-26 US US12/239,087 patent/US20090186828A1/en not_active Abandoned
-
2009
- 2009-10-21 US US12/582,838 patent/US20100105781A1/en not_active Abandoned
-
2011
- 2011-10-04 JP JP2011219941A patent/JP2012006978A/ja active Pending
-
2012
- 2012-04-11 CY CY20121100360T patent/CY1113130T1/el unknown
-
2019
- 2019-11-26 NL NL301019C patent/NL301019I2/nl unknown
-
2020
- 2020-11-10 BE BE2020C543C patent/BE2020C543I2/nl unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BE2020C543I2 (pl) | ||
MX2007012507A (es) | Profarmacos de anfetamina resistentes al abuso. | |
UA83659C2 (ru) | Антагонисты рецепторов p2x7 и их применение, фармацевтическая композиция на их основе, способ их получения (варианты) | |
TW200600506A (en) | Substituted morpholine compounds for the treatment of central nervous system disorders | |
MY150088A (en) | Immunosuppressant compounds and compositions | |
CY1122429T1 (el) | Αμορφη υδροχλωρικη λερκανιδιπινη | |
RS20060129A (en) | /1,8/naphthyridin-2-ones and related compounds for the treatment of schizophrenia | |
UA84208C2 (en) | Tetraazabenzo(e)azulene derivatives and analogs thereof | |
MX2007003108A (es) | Compuestos imidazo-3-il-amina sustituidos y biciclicos. | |
MX2009004108A (es) | Compuestos de tetrahidropirrolopiracina sustituidos teniendo afinidad al canal kcnq2/3 k+ y su uso en farmacos. | |
UA92670C2 (ru) | Пиразолиновые соединения и их фармацевтическое применение, композиция на их основе | |
HK1085675A1 (en) | Anticancer compounds | |
MX2009006010A (es) | Derivados de amina y su uso en enfermedades mediadas por el adrenoreceptor beta 2. | |
WO2008059130A9 (fr) | Thionucléosides et applications pharmaceutiques | |
EP1757558A4 (en) | Method for preparing carbon nanostructure | |
MXPA05003344A (es) | Derivados novedosos de 1,4-diazabicicloalcano, su preparacion y uso. | |
NO20056116L (no) | Tiowolframatanaloger og anvendelse av slike | |
WO2004026237A3 (en) | Compounds for the treatment of premature ejaculation | |
WO2006029210A3 (en) | Acyclic 1,3-diamines and uses therefor | |
EP1813289A4 (en) | MEDICINAL COMPOSITION FOR THE TREATMENT OF CANCER OR DIABETES | |
PL1732902T3 (pl) | Pochodne nukleozydów i ich terapeutyczne zastosowanie | |
WO2006034478A3 (en) | Isomigrastatin analogs in the treatment of cancer | |
ATE403756T1 (de) | Verbesserte induzierte heteroduplex-generatoren | |
MX2007000645A (es) | Derivados de pirazolina, procedimiento para obtenerlos y uso de los mismos como agentes terapeuticos. | |
PL1761480T3 (pl) | Inhibitory mao-b |