PH22748A - Novel process for the synthesis of amikacin - Google Patents

Novel process for the synthesis of amikacin

Info

Publication number: PH22748A
Authority: PH; Philippines
Prior art keywords: amikacin; synthesis; novel process; metal cation; solvent
Prior art date: 1985-10-10

Application number

PH34334A

Other languages

English (en)

Inventor

Alberto Mangia

Vincenzo Giobbio

Giorgio Ornato

Original Assignee

Pierrel Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-10-10

Filing date

1986-10-08

Publication date

1988-11-28

1986-10-08 Application filed by Pierrel Spa filed Critical Pierrel Spa

1988-11-28 Publication of PH22748A publication Critical patent/PH22748A/en

Links

229960004821 amikacin Drugs 0.000 title abstract 2
LKCWBDHBTVXHDL-RMDFUYIESA-N amikacin Chemical compound O([C@@H]1[C@@H](N)C[C@H]([C@@H]([C@H]1O)O[C@@H]1[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O1)O)NC(=O)[C@@H](O)CCN)[C@H]1O[C@H](CN)[C@@H](O)[C@H](O)[C@H]1O LKCWBDHBTVXHDL-RMDFUYIESA-N 0.000 title abstract 2
230000015572 biosynthetic process Effects 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
238000003786 synthesis reaction Methods 0.000 title abstract 2
XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 abstract 2
PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 abstract 2
150000001768 cations Chemical class 0.000 abstract 2
238000006243 chemical reaction Methods 0.000 abstract 2
229910052751 metal Inorganic materials 0.000 abstract 2
239000002184 metal Substances 0.000 abstract 2
RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 abstract 1
HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 abstract 1
230000010933 acylation Effects 0.000 abstract 1
238000005917 acylation reaction Methods 0.000 abstract 1
229910052793 cadmium Inorganic materials 0.000 abstract 1
BDOSMKKIYDKNTQ-UHFFFAOYSA-N cadmium atom Chemical compound [Cd] BDOSMKKIYDKNTQ-UHFFFAOYSA-N 0.000 abstract 1
229910017052 cobalt Inorganic materials 0.000 abstract 1
239000010941 cobalt Substances 0.000 abstract 1
GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 abstract 1
229910052802 copper Inorganic materials 0.000 abstract 1
239000010949 copper Substances 0.000 abstract 1
239000006184 cosolvent Substances 0.000 abstract 1
238000011065 in-situ storage Methods 0.000 abstract 1
229910052742 iron Inorganic materials 0.000 abstract 1
229960000318 kanamycin Drugs 0.000 abstract 1
SBUJHOSQTJFQJX-NOAMYHISSA-N kanamycin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N SBUJHOSQTJFQJX-NOAMYHISSA-N 0.000 abstract 1
229930182823 kanamycin A Natural products 0.000 abstract 1
WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 abstract 1
229910052759 nickel Inorganic materials 0.000 abstract 1
125000006239 protecting group Chemical group 0.000 abstract 1
238000000746 purification Methods 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
229910052725 zinc Inorganic materials 0.000 abstract 1
239000011701 zinc Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
- C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
- C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
- C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Saccharide Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Diaphragms For Electromechanical Transducers (AREA)
Peptides Or Proteins (AREA)
Removal Of Specific Substances (AREA)
Materials For Medical Uses (AREA)
Floor Finish (AREA)
Quinoline Compounds (AREA)

PH34334A 1985-10-10 1986-10-08 Novel process for the synthesis of amikacin PH22748A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT22425/85A IT1200774B (it)	1985-10-10	1985-10-10	Procedimento di sentisi dell'amikacina

Publications (1)

Publication Number	Publication Date
PH22748A true PH22748A (en)	1988-11-28

Family

ID=11196139

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PH34334A PH22748A (en)	1985-10-10	1986-10-08	Novel process for the synthesis of amikacin

Country Status (21)

Country	Link
US (1)	US4902790A (fr)
EP (1)	EP0218292B1 (fr)
JP (1)	JPS6293297A (fr)
KR (1)	KR910005897B1 (fr)
AT (1)	ATE55391T1 (fr)
AU (1)	AU603998B2 (fr)
BG (1)	BG50164A3 (fr)
CA (1)	CA1296331C (fr)
CS (1)	CS257292B2 (fr)
DD (1)	DD258991A1 (fr)
DE (1)	DE3673305D1 (fr)
DK (1)	DK166829B1 (fr)
HU (1)	HU196421B (fr)
IT (1)	IT1200774B (fr)
NO (1)	NO165297C (fr)
NZ (1)	NZ217862A (fr)
PH (1)	PH22748A (fr)
PL (1)	PL147396B1 (fr)
RU (1)	RU1771477C (fr)
YU (1)	YU44579B (fr)
ZA (1)	ZA867440B (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1225484B (it) *	1987-11-27	1990-11-14	Pierrel Spa	Procedimento di sintesi dell'amikacina
IT1237490B (it) *	1989-09-22	1993-06-07	Chementecno S R L Monza Milano	Procedimento per la sintesi della 1 n (s delta ammino alfa idrossibutirril)kamanycin a basato sul trattamento della 1 n (s delta benzilossicarbonilammino alfa idrossibutirril) 3,6' di n benzilossicarbonilkanamycin a con acido formico
YU45590A (sh) *	1990-03-07	1992-07-20	PLIVA FARMACEVTSKA, KEMIJSKA, PREHRAMBENA I KOZMETIČKA INDUSTRIJA s.p.o.	Novi kompleksi odnosno helati antibiotika s dvovalentnim i/ili trovalentnim metalima i postupci za njihovo dobijanje
ATE111917T1 (de) *	1990-03-08	1994-10-15	Opos Biochimica Srl	Verfahren zur herstellung von amikacin- vorläufern.
US6653456B2 (en) *	2001-07-31	2003-11-25	Roche Diagnostics Corporation	Site-specific aminoglycoside derivatives and their use in immunodiagnostic assays
WO2003072735A2 (fr) *	2002-02-22	2003-09-04	New River Pharmaceuticals Inc.	Utilisation de la conjugaison peptide-medicament pour diminuer la variabilite entre sujets de niveaux de serum de medicament
US7794713B2 (en)	2004-04-07	2010-09-14	Lpath, Inc.	Compositions and methods for the treatment and prevention of hyperproliferative diseases
US20090074720A1 (en) *	2005-10-28	2009-03-19	Sabbadini Roger A	Methods for decreasing immune response and treating immune conditions
US20080213274A1 (en) *	2005-10-28	2008-09-04	Sabbadini Roger A	Compositions and methods for the treatment and prevention of fibrotic, inflammatory, and neovascularization conditions of the eye
US7862812B2 (en) *	2006-05-31	2011-01-04	Lpath, Inc.	Methods for decreasing immune response and treating immune conditions
AU2009299118B2 (en) *	2008-10-03	2015-12-17	Glycan Biosciences Llc	Anionic conjugates of glycosylated bacterial metabolite
CN103113429B (zh) *	2013-03-05	2015-02-18	齐鲁天和惠世制药有限公司	一种由阿米卡星制备硫酸阿米卡星的方法
CN105440090B (zh) *	2014-08-27	2018-03-09	北大医药重庆大新药业股份有限公司	一种阿米卡星的合成方法
CN111138505B (zh) *	2020-02-17	2021-10-08	山东安信制药有限公司	一种阿米卡星的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4230847A (en) *	1976-06-17	1980-10-28	Schering Corporation	Aminoglycoside antibiotic compounds
US4136254A (en) *	1976-06-17	1979-01-23	Schering Corporation	Process of selectively blocking amino functions in aminoglycosides using transition metal salts and intermediates used thereby
IE48972B1 (en) *	1978-11-11	1985-06-26	Microbial Chem Res Found	The production of a selectively protected n-acylated derivative of an aminoglycosidic antibiotic
US4424344A (en) *	1980-09-22	1984-01-03	Eli Lilly And Company	2-N-Acylated and 2-N-alkylated derivatives of 4-O-substituted-2-deoxystreptamine aminoglycosides and process
JPS5782399A (en) *	1980-09-22	1982-05-22	Lilly Co Eli	2-deoxystreptamine aminoglycoside derivative and manufacture
US4468513A (en) *	1980-09-22	1984-08-28	Eli Lilly And Company	2'-N-Acylated and 2'-N-alkylated derivatives of 4-O-substituted-2-deoxystreptamine aminoglycosides

1985
- 1985-10-10 IT IT22425/85A patent/IT1200774B/it active
1986
- 1986-06-23 YU YU1086/86A patent/YU44579B/xx unknown
- 1986-06-30 HU HU862726A patent/HU196421B/hu not_active IP Right Cessation
- 1986-07-10 BG BG075682A patent/BG50164A3/xx unknown
- 1986-07-11 DD DD86292400A patent/DD258991A1/de not_active IP Right Cessation
- 1986-07-14 PL PL1986260615A patent/PL147396B1/pl unknown
- 1986-08-07 CS CS865913A patent/CS257292B2/cs unknown
- 1986-09-25 AT AT86201663T patent/ATE55391T1/de active
- 1986-09-25 EP EP86201663A patent/EP0218292B1/fr not_active Expired - Lifetime
- 1986-09-25 DE DE8686201663T patent/DE3673305D1/de not_active Expired - Fee Related
- 1986-09-30 ZA ZA867440A patent/ZA867440B/xx unknown
- 1986-10-02 US US06/914,451 patent/US4902790A/en not_active Expired - Fee Related
- 1986-10-03 DK DK475186A patent/DK166829B1/da not_active IP Right Cessation
- 1986-10-07 CA CA000520035A patent/CA1296331C/fr not_active Expired - Fee Related
- 1986-10-08 KR KR1019860008418A patent/KR910005897B1/ko not_active Expired
- 1986-10-08 NO NO864011A patent/NO165297C/no unknown
- 1986-10-08 PH PH34334A patent/PH22748A/en unknown
- 1986-10-09 AU AU63633/86A patent/AU603998B2/en not_active Ceased
- 1986-10-09 NZ NZ217862A patent/NZ217862A/xx unknown
- 1986-10-09 JP JP61239398A patent/JPS6293297A/ja active Granted
- 1986-10-09 RU SU864028258A patent/RU1771477C/ru active

Also Published As

Publication number	Publication date
EP0218292A1 (fr)	1987-04-15
YU44579B (en)	1990-10-31
AU603998B2 (en)	1990-12-06
DD258991A1 (de)	1988-08-10
EP0218292B1 (fr)	1990-08-08
KR870004050A (ko)	1987-05-07
PL147396B1 (en)	1989-05-31
ZA867440B (en)	1987-06-24
BG50164A3 (en)	1992-05-15
US4902790A (en)	1990-02-20
ATE55391T1 (de)	1990-08-15
YU108686A (en)	1987-12-31
JPH0212958B2 (fr)	1990-03-30
RU1771477C (ru)	1992-10-23
CA1296331C (fr)	1992-02-25
DK166829B1 (da)	1993-07-19
DE3673305D1 (de)	1990-09-13
NZ217862A (en)	1990-06-26
PL260615A1 (en)	1987-06-15
JPS6293297A (ja)	1987-04-28
NO864011L (no)	1987-04-13
NO165297C (no)	1991-01-23
IT1200774B (it)	1989-01-27
NO864011D0 (no)	1986-10-08
IT8522425A0 (it)	1985-10-10
HU196421B (en)	1988-11-28
CS257292B2 (en)	1988-04-15
DK475186A (da)	1987-04-11
NO165297B (no)	1990-10-15
AU6363386A (en)	1987-04-16
KR910005897B1 (ko)	1991-08-06
HUT43084A (en)	1987-09-28
DK475186D0 (da)	1986-10-03

Publication	Publication Date	Title
YU44579B (en)	1990-10-31	Process for amicazine synthesis
IL116126A0 (en)	1996-01-31	Process for the preparation of bacteriochlorophyllis some novel compounds of this type and pharmaceutical compositions comprising them
EP0148094A3 (fr)	1986-04-16	Agent anti-tumeur contenant l'acide O-benzylidène-L-ascorbique ou un de ses sels et préparation de ce dernier composé
PL276047A1 (en)	1989-07-10	Method of obatining amycacine
JPS55139375A (en)	1980-10-31	Production of hydroxyflavan
US4276219A (en)	1981-06-30	5-Keto-L-ascorbic acid-5,5-dimethyl ketal, derivatives thereof and its use as an antioxidant and intermediate
JPS5488242A (en)	1979-07-13	Novel derivative of fortimicin b and its preparation
CA1019853A (en)	1977-10-25	Method of precipitating heavy metals out of acid water solutions
DE3469019D1 (en)	1988-03-03	Process for the preparation of 4-hydroxybenzophenones
JPS5369127A (en)	1978-06-20	Culture soil by utilizing soil provided from water purifying process as raw material
FR2318931A1 (fr)	1977-02-18	Procede d'epaississement d'une boue de scories en granules pour la production de scories en granules
RO95573B1 (ro)	1988-10-01	Procedeu de obtinere a amikacinei
CA1223887A (fr)	1987-07-07	Procede de production de la d, l-homocystine (ii)
JPS5533416A (en)	1980-03-08	Production of hexamethyene bis-dicyandiamide
JPS57109790A (en)	1982-07-08	Furo(3,2-b)1,8-naphthyridine-7-carboxylic acid derivative
JPS5557566A (en)	1980-04-28	N-methyl-8-chloro-3,4-dihydro-2-quinolinone, its preparation, and germicide containing the same
ES466227A1 (es)	1978-10-16	Un metodo para la inhibicion de la corrosion en los sistemasde produccion de acrilonitrilo.
CA1274248C (fr)	1990-09-18	METHODE POUR LA PREPARATION D'ESTERS .alpha.-ARYLACANOIQUES
JPS5721400A (en)	1982-02-04	Novel fortimicin derivative
JPS54144392A (en)	1979-11-10	Cephalosporin derivative
JPS54148743A (en)	1979-11-21	Production of methoclopramide
JPS5481240A (en)	1979-06-28	Production of 3,3,5-trimethylcyclohexyl mandelate
JPS565490A (en)	1981-01-20	Preparation of amine-borane
JPS56152486A (en)	1981-11-26	Production of cephapirin
JPS5535024A (en)	1980-03-11	Novel method of production of 3',4'-dideoxy-6'-n-methylkanamycin b